KEGG   PATHWAY: setr05012
Entry
setr05012                   Pathway                                
Name
Parkinson disease - Suncus etruscus (white-toothed pygmy shrew)
Description
Parkinson disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Both environmental factors and mutations in familial PD-linked genes such as SNCA, Parkin, DJ-1, PINK1 and LRRK2 are associated with PD pathogenesis. These pathogenic mutations and environmental factors are known to cause disease due to oxidative stress, intracellular Ca2+ homeostasis impairment, mitochondrial dysfunctions and altered protein handling compromising key roles of DA neuronal function and survival. The demise of DA neurons located in the SNc leads to a drop in the dopaminergic input to the striatum, which is hypothesized to impede movement by inducing hypo and hyper activity in striatal spiny projection neurons (SPNs) of the direct (dSPNs) and indirect (iSPNs) pathways in the basal ganglia, respectively.
Class
Human Diseases; Neurodegenerative disease
Pathway map
setr05012  Parkinson disease
setr05012

Disease
H00057  Parkinson disease
Organism
Suncus etruscus (white-toothed pygmy shrew) [GN:setr]
Gene
125994826  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [KO:K03964]
125994849  [KO:K02270]
125994914  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
125995089  SEPTIN5; septin-5 [KO:K04557]
125995679  DAXX; death domain-associated protein 6 isoform X1 [KO:K02308]
125995684  SLC39A7; zinc transporter SLC39A7 [KO:K14713]
125995734  [KO:K03029]
125995968  KLC4; kinesin light chain 4 [KO:K10407]
125996022  TUBB2A; tubulin beta-2A chain isoform X1 [KO:K07375]
125996084  [KO:K02739] [EC:3.4.25.1]
125996207  [KO:K02138]
125996360  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
125996434  TUBB; tubulin beta chain [KO:K07375]
125996569  PRKN; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
125996596  [KO:K03945]
125997212  [KO:K00413]
125997221  SLC39A4; zinc transporter ZIP4 [KO:K14710]
125997222  [KO:K14710]
125997317  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
125997347  ATP5PB; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
125997354  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
125997374  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [KO:K03965]
125997442  [KO:K02270]
125997568  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
125998025  TP53; LOW QUALITY PROTEIN: cellular tumor antigen p53 [KO:K04451]
125998103  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
125998124  [KO:K11351]
125998178  [KO:K02128]
125998229  [KO:K02272]
125998756  PSMA6; proteasome subunit alpha type-6 [KO:K02730] [EC:3.4.25.1]
125999158  UBA1; ubiquitin-like modifier-activating enzyme 1 [KO:K03178] [EC:6.2.1.45]
125999202  MAOA; amine oxidase [flavin-containing] A [KO:K00274] [EC:1.4.3.4]
125999206  MAOB; amine oxidase [flavin-containing] B [KO:K00274] [EC:1.4.3.4]
125999297  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial [KO:K11351]
125999312  [KO:K02271]
125999314  PSMC6; 26S proteasome regulatory subunit 10B isoform X1 [KO:K03064]
125999532  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
125999564  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
126000571  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
126000573  [KO:K00417]
126000739  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 [KO:K06693]
126000749  [KO:K02266]
126000779  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
126000782  SLC6A3; sodium-dependent dopamine transporter isoform X1 [KO:K05036]
126000803  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
126000917  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 isoform X1 [KO:K03966]
126000955  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
126000959  [KO:K02270]
126000960  [KO:K00235] [EC:1.3.5.1]
126001165  TUBA4A; tubulin alpha-4A chain [KO:K07374]
126001208  [KO:K07374]
126001232  TRAP1; heat shock protein 75 kDa, mitochondrial [KO:K09488]
126001307  [KO:K02183]
126001412  [KO:K14709]
126001417  PSMB5; proteasome subunit beta type-5 [KO:K02737] [EC:3.4.25.1]
126001465  SLC39A2; zinc transporter ZIP2 [KO:K14709]
126001695  [KO:K02266]
126001751  [KO:K14709]
126001808  [KO:K03949]
126002018  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
126002022  UBC; polyubiquitin-C isoform X1 [KO:K08770]
126002066  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 [KO:K03032]
126002106  [KO:K08738]
126003301  SLC39A14; metal cation symporter ZIP14 [KO:K14720]
126003391  [KO:K15041]
126003395  PSMA8; proteasome subunit alpha-type 8 [KO:K02731] [EC:3.4.25.1]
126003450  SLC39A6; zinc transporter ZIP6 [KO:K14712]
126003458  SLC39A11; LOW QUALITY PROTEIN: zinc transporter ZIP11 [KO:K14717]
126003485  [KO:K02728] [EC:3.4.25.1]
126003496  [KO:K02270]
126003569  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
126003600  ATP5PD; ATP synthase subunit d, mitochondrial [KO:K02138]
126003621  CALM1; calmodulin-1 [KO:K02183]
126003626  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
126003743  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha [KO:K04633]
126003777  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
126003785  TUBB6; tubulin beta-6 chain [KO:K07375]
126003788  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [KO:K03943] [EC:7.1.1.2]
126003827  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
126003993  [KO:K21356] [EC:3.6.5.-]
126004053  SLC39A9; zinc transporter ZIP9 isoform X1 [KO:K14715]
126004063  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
126004071  PSMA3; proteasome subunit alpha type-3 [KO:K02727] [EC:3.4.25.1]
126004362  [KO:K02272]
126004572  [KO:K02270]
126005312  GPR37; prosaposin receptor GPR37 [KO:K04243]
126005441  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [KO:K03949]
126005939  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
126006060  SNCAIP; LOW QUALITY PROTEIN: synphilin-1 [KO:K04558]
126006323  TXN2; thioredoxin, mitochondrial [KO:K03671]
126006324  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
126006336  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
126006354  [KO:K02272]
126006428  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
126006491  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
126006546  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
126006575  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
126006582  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
126006611  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
126006649  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
126006650  [KO:K00416]
126006652  [KO:K00416]
126006744  UBE2J1; ubiquitin-conjugating enzyme E2 J1 isoform X1 [KO:K10578] [EC:2.3.2.23]
126006857  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
126006887  [KO:K02187] [EC:3.4.22.56]
126007206  [KO:K02187] [EC:3.4.22.56]
126007207  [KO:K02187] [EC:3.4.22.56]
126008758  KIF5C; kinesin heavy chain [KO:K10396]
126008808  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 [KO:K03952]
126008905  SLC39A10; zinc transporter ZIP10 [KO:K14716]
126008957  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
126008988  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
126008992  [KO:K02267]
126009006  NDUFS1; LOW QUALITY PROTEIN: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
126009030  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
126009063  NFE2L2; nuclear factor erythroid 2-related factor 2 isoform X1 [KO:K05638]
126009148  ATP5MC3; ATP synthase F(0) complex subunit C3, mitochondrial [KO:K02128]
126009211  [KO:K11352]
126009406  HSPA5; LOW QUALITY PROTEIN: endoplasmic reticulum chaperone BiP [KO:K09490] [EC:3.6.4.10]
126009491  [KO:K00417]
126009498  [KO:K02268]
126009660  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
126009692  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 [KO:K03962]
126009755  [KO:K08738]
126010782  [KO:K02128]
126010787  [KO:K03967]
126010821  [KO:K03948]
126010922  UBE2J2; ubiquitin-conjugating enzyme E2 J2 [KO:K04554] [EC:2.3.2.23]
126011245  [KO:K07374]
126011300  PSMB2; proteasome subunit beta type-2 [KO:K02734] [EC:3.4.25.1]
126011325  [KO:K00237]
126011332  [KO:K02977]
126011360  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
126011371  [KO:K00416]
126011378  [KO:K03957]
126011478  [KO:K02927]
126011490  [KO:K03945]
126011515  MFN2; mitofusin-2 isoform X1 [KO:K06030] [EC:3.6.5.-]
126011597  PARK7; LOW QUALITY PROTEIN: Parkinson disease protein 7 [KO:K05687] [EC:3.5.1.124]
126011987  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
126012040  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
126012048  MFN1; mitofusin-1 [KO:K21356] [EC:3.6.5.-]
126012058  NDUFB2; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial [KO:K03958]
126012094  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
126012227  DRD1; D(1A) dopamine receptor [KO:K04144]
126012235  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
126013264  NDUFC2; NADH dehydrogenase [ubiquinone] 1 subunit C2 [KO:K03968]
126013289  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
126013295  ATP5F1C; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
126013297  [KO:K02183]
126013298  [KO:K02183]
126013317  GNAS; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
126013324  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
126013331  ATP5F1E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
126013337  [KO:K04632]
126013393  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
126013516  [KO:K08738]
126013519  [KO:K03967]
126013583  [KO:K03671]
126013605  [KO:K02268]
126013678  UBB; polyubiquitin-B isoform X1 [KO:K08770]
126013705  [KO:K03062]
126013793  [KO:K03968]
126013804  [KO:K02270]
126013837  TUBB1; LOW QUALITY PROTEIN: tubulin beta-1 chain [KO:K07375]
126013904  PSMD6; 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
126013907  [KO:K07374]
126013939  KIF5B; LOW QUALITY PROTEIN: kinesin-1 heavy chain [KO:K10396]
126014052  [KO:K00414]
126014071  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
126014166  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial [KO:K00236]
126014170  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
126014228  [KO:K02728] [EC:3.4.25.1]
126014414  UBA7; LOW QUALITY PROTEIN: ubiquitin-like modifier-activating enzyme 7 [KO:K10698] [EC:6.2.1.45]
126014445  ADRM1; proteasomal ubiquitin receptor ADRM1 [KO:K06691]
126014464  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
126015454  [KO:K03950]
126015663  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
126015739  [KO:K08738]
126015850  [KO:K03939]
126015982  CALML4; calmodulin-like protein 4 [KO:K02183]
126015993  [KO:K02264]
126016071  [KO:K08738]
126016123  [KO:K02270]
126016140  DRD2; D(2) dopamine receptor [KO:K04145]
126016153  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
126016565  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
126017276  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
126017437  BCL2L1; bcl-2-like protein 1 [KO:K04570]
126017461  [KO:K02263]
126017541  [KO:K02738] [EC:3.4.25.1]
126017552  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
126017677  SLC39A13; zinc transporter ZIP13 [KO:K14719]
126017714  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
126017826  PSMC3; 26S proteasome regulatory subunit 6A [KO:K03065]
126017831  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
126017903  [KO:K02270]
126018017  [KO:K02272]
126018066  KLC2; kinesin light chain 2 [KO:K10407]
126018118  [KO:K02128]
126018167  PSMC5; LOW QUALITY PROTEIN: 26S proteasome regulatory subunit 8 [KO:K03066]
126018535  [KO:K04528]
126018709  UBE2L6; ubiquitin/ISG15-conjugating enzyme E2 L6 [KO:K04553] [EC:2.3.2.23]
126018795  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [KO:K03942] [EC:7.1.1.2]
126018962  PSMA1; proteasome subunit alpha type-1 [KO:K02725] [EC:3.4.25.1]
126018992  [KO:K00418]
126019023  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
126019057  TH; tyrosine 3-monooxygenase [KO:K00501] [EC:1.14.16.2]
126019082  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial [KO:K03941] [EC:7.1.1.2]
126019228  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
126019744  ATP5MC1; ATP synthase F(0) complex subunit C1, mitochondrial [KO:K02128]
126020038  [KO:K08738]
126020042  [KO:K08738]
126020075  ATP5F1A; ATP synthase subunit alpha, mitochondrial isoform X1 [KO:K02132]
126020094  [KO:K02271]
126020348  MAPT; LOW QUALITY PROTEIN: microtubule-associated protein tau [KO:K04380]
126020501  TUBB4B; LOW QUALITY PROTEIN: tubulin beta-4B chain [KO:K07375]
126020733  SLC39A1; zinc transporter ZIP1 [KO:K14709]
126021328  UBE2G1; ubiquitin-conjugating enzyme E2 G1 [KO:K10575] [EC:2.3.2.23]
126021964  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [KO:K11352]
126021976  APAF1; apoptotic protease-activating factor 1 [KO:K02084]
126022108  [KO:K07374]
126022167  [KO:K03178] [EC:6.2.1.45]
126022217  KIF5A; kinesin heavy chain isoform X1 [KO:K10396]
126022241  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
126022243  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
126022266  [KO:K07374]
126022354  [KO:K02267]
126022485  SLC11A2; natural resistance-associated macrophage protein 2 [KO:K21398]
126022494  PSMC2; 26S proteasome regulatory subunit 7 [KO:K03061]
126022533  [KO:K07374]
126022586  [KO:K03030]
126022618  TUBA8; tubulin alpha-8 chain [KO:K07374]
126022648  ATP5MC2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
126022760  [KO:K02270]
126022840  ITPR2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
126022841  LRRK2; leucine-rich repeat serine/threonine-protein kinase 2 [KO:K08844] [EC:2.7.11.1]
126022872  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
126022974  ATP5F1B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
126023058  SLC39A5; zinc transporter ZIP5 [KO:K14711]
126023893  [KO:K02270]
126023898  [KO:K03965]
126023953  CALM2; calmodulin-2 [KO:K02183]
126024011  [KO:K08738]
126024081  [KO:K00235] [EC:1.3.5.1]
126024144  [KO:K15041]
126024387  RPS27A; ubiquitin-40S ribosomal protein S27a [KO:K02977]
126024439  [KO:K02265]
126024479  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
126024593  HTRA2; serine protease HTRA2, mitochondrial [KO:K08669] [EC:3.4.21.108]
126024633  TXN; thioredoxin [KO:K03671]
126024691  SEM1; 26S proteasome complex subunit SEM1 [KO:K10881]
126024756  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
126025658  UBE2G2; ubiquitin-conjugating enzyme E2 G2 isoform X1 [KO:K04555] [EC:2.3.2.23]
126025659  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
126026102  ATP5PO; ATP synthase subunit O, mitochondrial [KO:K02137]
126026116  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
126026121  ATP5PF; ATP synthase-coupling factor 6, mitochondrial [KO:K02131]
126026123  [KO:K03958]
126026233  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
126026247  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
126027025  PSMB6; LOW QUALITY PROTEIN: proteasome subunit beta type-6 [KO:K02738] [EC:3.4.25.1]
126027062  NDUFA2; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
126027215  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
126027263  [KO:K00411] [EC:7.1.1.8]
126027421  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
126027455  [KO:K00237]
126027543  SLC39A8; metal cation symporter ZIP8 [KO:K14714]
126027649  [KO:K15040]
126027681  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 [KO:K03031]
126027685  [KO:K02267]
126027687  [KO:K02270]
126027768  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
126027782  [KO:K02263]
126027799  [KO:K00418]
126027880  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
126027939  [KO:K03938]
126028075  [KO:K02267]
126028076  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
126028142  PSMC4; 26S proteasome regulatory subunit 6B [KO:K03063]
126028238  KLC3; kinesin light chain 3 [KO:K10407]
126028268  CALM3; calmodulin-3 [KO:K02183]
126028395  [KO:K07375]
126029465  UBA52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
126029640  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
126029647  ATP5F1D; ATP synthase subunit delta, mitochondrial [KO:K02134]
126029650  [KO:K00420]
126029694  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
126029752  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
126029847  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
126029975  [KO:K02127]
126030288  KEAP1; kelch-like ECH-associated protein 1 [KO:K10456]
126030311  NDUFA13; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
126030328  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
126030545  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
126030676  [KO:K00419]
126030755  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
126030871  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
126030929  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
126030966  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
126030981  [KO:K02266]
126031102  [KO:K08738]
126031154  TUBB4A; tubulin beta-4A chain [KO:K07375]
126031160  SLC39A3; zinc transporter ZIP3 [KO:K14709]
126031189  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 isoform X1 [KO:K03951]
126031235  [KO:K00415]
126031280  [KO:K02183]
126031368  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
126031392  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1 [KO:K09565] [EC:5.2.1.8]
126032054  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
126032375  SNCA; alpha-synuclein isoform X1 [KO:K04528]
126032552  RYR3; ryanodine receptor 3 [KO:K04963]
126033339  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
126033644  [KO:K07374]
126033690  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
126033693  ADORA2A; adenosine receptor A2a [KO:K04266]
126033730  [KO:K07374]
126033740  UBE2L3; ubiquitin-conjugating enzyme E2 L3 isoform X1 [KO:K04552] [EC:2.3.2.23]
Compound
C00002  ATP
C00007  Oxygen
C00008  ADP
C00009  Orthophosphate
C00013  Diphosphate
C00020  AMP
C00027  Hydrogen peroxide
C00034  Manganese
C00076  Calcium cation
C00082  L-Tyrosine
C00165  Diacylglycerol
C00212  Adenosine
C00355  3,4-Dihydroxy-L-phenylalanine
C00575  3',5'-Cyclic AMP
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C03758  Dopamine
C04043  3,4-Dihydroxyphenylacetaldehyde
C04599  1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
C07593  Rotenone
C11310  1-Methyl-4-phenylpyridinium
C14701  Paraquat
C15231  Maneb
C16844  Hydroxyl radical
C17755  Dopamine quinone
C22381  Reactive oxygen species
Reference
PMID:16495942
  Authors
Abou-Sleiman PM, Muqit MM, Wood NW
  Title
Expanding insights of mitochondrial dysfunction in Parkinson's disease.
  Journal
Nat Rev Neurosci 7:207-19 (2006)
DOI:10.1038/nrn1868
Reference
PMID:12938733
  Authors
Lim KL, Lim TM
  Title
Molecular mechanisms of neurodegeneration in Parkinson's disease: clues from Mendelian syndromes.
  Journal
IUBMB Life 55:315-22 (2003)
DOI:10.1080/1521654031000153030
Reference
PMID:26501339
  Authors
Bobela W, Aebischer P, Schneider BL
  Title
Alphalpha-Synuclein as a Mediator in the Interplay between Aging and Parkinson's Disease.
  Journal
Biomolecules 5:2675-700 (2015)
DOI:10.3390/biom5042675
Reference
PMID:15767499
  Authors
Eriksen JL, Wszolek Z, Petrucelli L
  Title
Molecular pathogenesis of Parkinson disease.
  Journal
Arch Neurol 62:353-7 (2005)
DOI:10.1001/archneur.62.3.353
Reference
PMID:16972273
  Authors
Olanow CW, McNaught KS
  Title
Ubiquitin-proteasome system and Parkinson's disease.
  Journal
Mov Disord 21:1806-23 (2006)
DOI:10.1002/mds.21013
Reference
PMID:18047737
  Authors
Lim KL, Tan JM
  Title
Role of the ubiquitin proteasome system in Parkinson's disease.
  Journal
BMC Biochem 8 Suppl 1:S13 (2007)
DOI:10.1186/1471-2091-8-S1-S13
Reference
PMID:29090092
  Authors
Maiti P, Manna J, Dunbar GL
  Title
Current understanding of the molecular mechanisms in Parkinson's disease: Targets for potential treatments.
  Journal
Transl Neurodegener 6:28 (2017)
DOI:10.1186/s40035-017-0099-z
Reference
PMID:12814656
  Authors
Dev KK, van der Putten H, Sommer B, Rovelli G
  Title
Part I: parkin-associated proteins and Parkinson's disease.
  Journal
Neuropharmacology 45:1-13 (2003)
DOI:10.1016/s0028-3908(02)00337-4
Reference
PMID:20495568
  Authors
Obeso JA, Rodriguez-Oroz MC, Goetz CG, Marin C, Kordower JH, Rodriguez M, Hirsch EC, Farrer M, Schapira AH, Halliday G
  Title
Missing pieces in the Parkinson's disease puzzle.
  Journal
Nat Med 16:653-61 (2010)
DOI:10.1038/nm.2165
Reference
PMID:24781149
  Authors
Cali T, Ottolini D, Brini M
  Title
Calcium signaling in Parkinson's disease.
  Journal
Cell Tissue Res 357:439-54 (2014)
DOI:10.1007/s00441-014-1866-0
Reference
PMID:19230774
  Authors
Bezprozvanny I
  Title
Calcium signaling and neurodegenerative diseases.
  Journal
Trends Mol Med 15:89-100 (2009)
DOI:10.1016/j.molmed.2009.01.001
Reference
PMID:28468938
  Authors
Zaichick SV, McGrath KM, Caraveo G
  Title
The role of Ca(2+) signaling in Parkinson's disease.
  Journal
Dis Model Mech 10:519-535 (2017)
DOI:10.1242/dmm.028738
Reference
PMID:28838811
  Authors
Ludtmann MHR, Abramov AY
  Title
Mitochondrial calcium imbalance in Parkinson's disease.
  Journal
Neurosci Lett 663:86-90 (2018)
DOI:10.1016/j.neulet.2017.08.044
Reference
PMID:19663908
  Authors
Sandebring A, Dehvari N, Perez-Manso M, Thomas KJ, Karpilovski E, Cookson MR, Cowburn RF, Cedazo-Minguez A
  Title
Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling.
  Journal
FEBS J 276:5041-52 (2009)
DOI:10.1111/j.1742-4658.2009.07201.x
Reference
PMID:23352769
  Authors
Mercado G, Valdes P, Hetz C
  Title
An ERcentric view of Parkinson's disease.
  Journal
Trends Mol Med 19:165-75 (2013)
DOI:10.1016/j.molmed.2012.12.005
Reference
PMID:27103567
  Authors
Mercado G, Castillo V, Soto P, Sidhu A
  Title
ER stress and Parkinson's disease: Pathological inputs that converge into the secretory pathway.
  Journal
Brain Res 1648:626-632 (2016)
DOI:10.1016/j.brainres.2016.04.042
Reference
PMID:26297973
  Authors
Tsujii S, Ishisaka M, Hara H
  Title
Modulation of endoplasmic reticulum stress in Parkinson's disease.
  Journal
Eur J Pharmacol 765:154-6 (2015)
DOI:10.1016/j.ejphar.2015.08.033
Reference
PMID:31100053
  Authors
Shah A, Chao J, Legido-Quigley C, Chang RC
  Title
Oxyresveratrol exerts ATF4- and Grp78-mediated neuroprotection against endoplasmic reticulum stress in experimental Parkinson's disease.
  Journal
Nutr Neurosci 1-16 (2019)
DOI:10.1080/1028415X.2019.1613764
Reference
PMID:24548101
  Authors
Segura-Aguilar J, Paris I, Munoz P, Ferrari E, Zecca L, Zucca FA
  Title
Protective and toxic roles of dopamine in Parkinson's disease.
  Journal
J Neurochem 129:898-915 (2014)
DOI:10.1111/jnc.12686
Reference
PMID:31587020
  Authors
Jesko H, Lenkiewicz AM, Wilkaniec A, Adamczyk A
  Title
The interplay between parkin and alpha-synuclein; possible implications for the pathogenesis of Parkinson's disease.
  Journal
Acta Neurobiol Exp (Wars) 79:276-289 (2019)
Reference
PMID:15189334
  Authors
Perez RG, Hastings TG
  Title
Could a loss of alpha-synuclein function put dopaminergic neurons at risk?
  Journal
J Neurochem 89:1318-24 (2004)
DOI:10.1111/j.1471-4159.2004.02423.x
Reference
PMID:26487845
  Authors
Segura-Aguilar J
  Title
A new mechanism for protection of dopaminergic neurons mediated by astrocytes.
  Journal
Neural Regen Res 10:1225-7 (2015)
DOI:10.4103/1673-5374.162750
Reference
PMID:27546335
  Authors
Bose A, Beal MF
  Title
Mitochondrial dysfunction in Parkinson's disease.
  Journal
J Neurochem 139 Suppl 1:216-231 (2016)
DOI:10.1111/jnc.13731
Reference
PMID:27581196
  Authors
Cieri D, Brini M, Cali T
  Title
Emerging (and converging) pathways in Parkinson's disease: keeping mitochondrial wellness.
  Journal
Biochem Biophys Res Commun 483:1020-1030 (2017)
DOI:10.1016/j.bbrc.2016.08.153
Reference
PMID:27829983
  Authors
Mack JM, Schamne MG, Sampaio TB, Pertile RA, Fernandes PA, Markus RP, Prediger RD
  Title
Melatoninergic System in Parkinson's Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms.
  Journal
Oxid Med Cell Longev 2016:3472032 (2016)
DOI:10.1155/2016/3472032
Reference
PMID:21674642
  Authors
Cali T, Ottolini D, Brini M
  Title
Mitochondria, calcium, and endoplasmic reticulum stress in Parkinson's disease.
  Journal
Biofactors 37:228-40 (2011)
DOI:10.1002/biof.159
Reference
PMID:24522549
  Authors
Gaki GS, Papavassiliou AG
  Title
Oxidative stress-induced signaling pathways implicated in the pathogenesis of Parkinson's disease.
  Journal
Neuromolecular Med 16:217-30 (2014)
DOI:10.1007/s12017-014-8294-x
Reference
PMID:25761946
  Authors
Franco-Iborra S, Vila M, Perier C
  Title
The Parkinson Disease Mitochondrial Hypothesis: Where Are We at?
  Journal
Neuroscientist 22:266-77 (2016)
DOI:10.1177/1073858415574600
Reference
PMID:22926193
  Authors
de Vries RL, Przedborski S
  Title
Mitophagy and Parkinson's disease: be eaten to stay healthy.
  Journal
Mol Cell Neurosci 55:37-43 (2013)
DOI:10.1016/j.mcn.2012.07.008
Reference
PMID:20736035
  Authors
Deas E, Wood NW, Plun-Favreau H
  Title
Mitophagy and Parkinson's disease: the PINK1-parkin link.
  Journal
Biochim Biophys Acta 1813:623-33 (2011)
DOI:10.1016/j.bbamcr.2010.08.007
Reference
PMID:25611507
  Authors
Pickrell AM, Youle RJ
  Title
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease.
  Journal
Neuron 85:257-73 (2015)
DOI:10.1016/j.neuron.2014.12.007
Reference
PMID:27911343
  Authors
Truban D, Hou X, Caulfield TR, Fiesel FC, Springer W
  Title
PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?
  Journal
J Parkinsons Dis 7:13-29 (2017)
DOI:10.3233/JPD-160989
Reference
PMID:28823929
  Authors
Biosa A, Sandrelli F, Beltramini M, Greggio E, Bubacco L, Bisaglia M
  Title
Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease.
  Journal
Neurobiol Dis 108:65-72 (2017)
DOI:10.1016/j.nbd.2017.08.005
Reference
PMID:29147906
  Authors
Oh SE, Mouradian MM
  Title
Regulation of Signal Transduction by DJ-1.
  Journal
Adv Exp Med Biol 1037:97-131 (2017)
DOI:10.1007/978-981-10-6583-5_8
Reference
PMID:31054074
  Authors
Dolgacheva LP, Berezhnov AV, Fedotova EI, Zinchenko VP, Abramov AY
  Title
Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease.
  Journal
J Bioenerg Biomembr 51:175-188 (2019)
DOI:10.1007/s10863-019-09798-4
Reference
PMID:30370500
  Authors
Melo TQ, Copray SJCVM, Ferrari MFR
  Title
Alpha-Synuclein Toxicity on Protein Quality Control, Mitochondria and Endoplasmic Reticulum.
  Journal
Neurochem Res 43:2212-2223 (2018)
DOI:10.1007/s11064-018-2673-x
Reference
PMID:30937538
  Authors
Zhai S, Shen W, Graves SM, Surmeier DJ
  Title
Dopaminergic modulation of striatal function and Parkinson's disease.
  Journal
J Neural Transm (Vienna) 126:411-422 (2019)
DOI:10.1007/s00702-019-01997-y
Reference
PMID:29720658
  Authors
Parker JG, Marshall JD, Ahanonu B, Wu YW, Kim TH, Grewe BF, Zhang Y, Li JZ, Ding JB, Ehlers MD, Schnitzer MJ
  Title
Diametric neural ensemble dynamics in parkinsonian and dyskinetic states.
  Journal
Nature 557:177-182 (2018)
DOI:10.1038/s41586-018-0090-6
Related
pathway
setr00190  Oxidative phosphorylation
setr00350  Tyrosine metabolism
setr03050  Proteasome
setr04020  Calcium signaling pathway
setr04120  Ubiquitin mediated proteolysis
setr04137  Mitophagy - animal
setr04141  Protein processing in endoplasmic reticulum
setr04210  Apoptosis
setr04728  Dopaminergic synapse
KO pathway
ko05012   

DBGET integrated database retrieval system