KEGG    Network variation - Human papillomavirus (HPV)
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ENTRYnt06166
NameHuman papillomavirus (HPV)
CategoryDisease view; Viral infection
Pathwayhsa05165 Human papillomavirus infection
GenomeT40087 T40088
DiseaseH00030 Cervical cancer
Display drug-target relation   disease type
ERK signaling
N00001      EGF→EGFR→GRB2→SOS→RAS→RAF→MEK→ERK→CCND1
N00367    E5⊣V-ATPase⊣EGFR→GRB2→SOS→RAS→RAF→MEK→ERK
N00015      PDGF→PDGFR→GRB2→SOS→RAS→RAF→MEK→ERK
N00369      E5→PDGFRB
 
PI3K signaling
N00033      EGF→EGFR→PI3K→PIP3→AKT⊣BAD
N00366    E5⊣V-ATPase⊣EGFR
N00039      PDGF→PDGFR→PI3K→PIP3→AKT→MTOR→S6K
N00368      E5→PDGFRB
N00582      IGF1→IGF1R→PI3K→PIP3→AKT⊣(TSC1+TSC2)⊣RHEB→MTOR⊣EIF4EBP1
N00357              (E6+UBE3A)⊣(TSC1+TSC2)
N00220          PTEN⊣PIP3→AKT
N00353      E6⊣SLC9A3R1→PTEN
N00354        E6⊣PTEN
N00355            PP2A⊣AKT
N00356          E7⊣PP2A
 
NOTCH signaling
N00086      (DLL,JAG)→NOTCH→(NICD+RBPJ)⇒(HES1,HEY1)
N00380    E6→JAG1→NOTCH→(NICD+RBPJ+MAML)⇒(HES1,HEY1)
N00381    E6⊣MFNG⊣NOTCH→(NICD+RBPJ+MAML)⇒(HES1,HEY1)
N00382    E6→(NFX1+PSEN1)→NOTCH→(NICD+RBPJ+MAML)⇒(HES1,HEY1)
 
TLR signaling
N00149    TLR3→TICAM1→TRAF3→(IKBKE+TBK1)→IRF3→(CREBBP,EP300)⇒IFNB1
N00346          E6⊣IRF3
 
IFN signaling
N00150    (IFNA,IFNB1)→(IFNAR1+IFNAR2)→(JAK1,TYK2)→(STAT1+STAT2+IRF9)⇒(IRF7,EIF2AK2)
N00377      E6⊣TYK2
N00378        E6⊣(STAT1+STAT2+IRF9)
N00379        E7⊣(STAT1+STAT2+IRF9)
 
TNF signaling
N00374    TNF→TNFRSF1B→IRF1⇒IFNB1
N00375      (E7+HDAC+CHD4)⊣IRF1
 
MHC presentation
N00363    TAP1/2=TAPBP=(PDIA3+CALR)→(MHCI+B2M)
N00364        E5⊣(MHCI+BCAP31)
 
Cell cycle
N00347      (ATM,ATR)→TADA3→EP300→TP53⇒CDKN1A⊣(CCND+CDK4/6)→RB1⌿E2F
N00372    E7→ATM
N00349      E6⊣TADA3
N00348        E6⊣EP300
N00358          (E6+UBE3A)⊣TP53
N00362            E5⊣(CDKN1A,CDKN1B)
N00091            (SCF+SKP2)⊣CDKN1B⊣((CCNA,CCNE)+CDK2)→RB1⌿E2F
N00359            E7⊣(CDKN1A,CDKN1B)
N00360              E7→(CCNE+CDK2)→RB1⌿E2F
N00361                E7→(RB1,RBL1,RBL2)⌿E2F
N00365              E7→PSMC1→RB1
 
TNF signaling
N00145    TNF→TNFRSF1A→(RIPK1+TRADD+TRAF2..→FADD→CASP8→(CASP3,CASP7)
N00350    E6⊣TNFRSF1A
N00351        E6⊣FADD
N00352          E6⊣CASP8
N00098      (PMAIP1,BBC3,BAD,B..⊣(BCL2,BCL2L1)⊣(BAX,BAK1)→CYCS=APAF1→CASP9→(CASP3,CASP7)
N00384    E6⊣BAD
N00383        (E6+UBE3A)⊣BAK1
 
Cytoskeletal regulation
N00340    LLGL=SCRIB=DLG1
N00341      (E6+UBE3A)⊣(DLG1+SCRIB)
N00342      MAGI→PTEN⊣PIP3→AKT
N00343    (E6+UBE3A)⊣MAGI1
N00344    CRB3=MPP5=PATJ
N00345      (E6+UBE3A)⊣PATJ
 
Pyruvate kinase regulation
N00370    PEP−PKM→Pyruvate
N00371    E7⊣PKM
 
Transcription
N00373    (E6+UBE3A)⊣NFX1⫤TERT
N00376    E7⊣TBP