KEGG    Network variation - Herpes simplex virus 1 (HSV-1)
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ENTRYnt06168
NameHerpes simplex virus 1 (HSV-1)
CategoryDisease view; Viral infection
Pathwayhsa05168 Herpes simplex virus 1 infection
GenomeT40073
DiseaseH00365 Herpes simplex virus infection
Display drug-target relation   disease type
PI3K signaling
N00582    IGF1IGF1RPI3KPIP3AKT(TSC1+TSC2)RHEBMTOREIF4EBP1
N00583      VP11/12PI3K
N00584            US3(TSC1+TSC2)
 
TLR signaling
N00435      (TLR1,TLR2,TLR4)(TIRAP+MYD88)(IRAK4+IRAK1)(TRAF6+TAK1+TAB2)IKKNFKBIANFKB(TNF,IL6,IL12A,IL1..
N00561      ICP0MYD88
N00562          US3(TRAF6+TAK1+TAB2)
N00563      TLR3TICAM1TRAF6TAK1IKKNFKBIANFKB
N00564    US3TLR3
 
RLR signaling
N00469    RNARIGIMAVSTRAF3(TANK+NAP1+SINTBAD..(TBK1+IKBKE)(IRF7,IRF3)(IFNA,IFNB1)
N00565    US11(RIGI,MDA5)
N00566        UL36USPTRAF3
N00567            ICP34.5(TBK1+IKBKE)
N00568              US3IRF3
 
CGAS-STING signaling
N00395    DNACGAScGAMPSTING1TBK1IRF3(IFNA,IFNB)
N00569    UL41CGAS
N00570        ICP0STING1
 
NLR signaling
N00515      OAS2-5ARNASEL
N00574    US11OAS
 
PKR-eIF2alpha signaling
N00571      EIF2AK2EIF2S1EIF2B
N00573    US11EIF2AK2
N00572    ICP34.5=PPP1CEIF2S1
 
Complement cascade
N01489    C3(C4b+C2a)C3b(C4b+C2a+C3b)
N00589      GCC3b
 
IFN signaling
N00150    (IFNA,IFNB1)(IFNAR1+IFNAR2)(JAK1,TYK2)(STAT1+STAT2+IRF9)(IRF7,EIF2AK2)
N00576    (UL41,UL13)SOCS3JAK1
N00577      UL41JAK1
N00578        UL41(STAT1+STAT2+IRF9)
N00575        ICP27(STAT1+STAT2+IRF9)
 
TNF signaling
N00559    TNFSF14TNFRSF14TRAF2/5IKKNFKBIANFKB
N00560    GDTNFRSF14TRAF2/5IKKNFKBIANFKB(BIRC2,BIRC3,NFKB1..
 
MHC presentation
N00363      TAP1/2=TAPBP=(PDIA3+CALR)(MHCI+B2M)
N00581    ICP47TAP1/2
N00590          CD74MHCII
N00591        GBCD74
 
Apoptosis
N00145    TNFTNFRSF1A(RIPK1+TRADD+TRAF2..FADDCASP8(CASP3,CASP7)
N00579          ICP6CASP8
N00146      (FASLG,TNFSF10)(FAS,TNFRSF10B)FADD(CASP8,CASP10)BID(BAX,BAK1)CYCS=APAF1CASP9(CASP3,CASP7)
N00580                      ICP0CASP3
N00098            (PMAIP1,BBC3,BAD,B..(BCL2,BCL2L1)(BAX,BAK1)CYCS=APAF1CASP9(CASP3,CASP7)
N00585          US3BAD
 
Nuclear export of mRNA
N00586      SRPK1SRSF1=NXF1
N00587    ICP27SRPK1SRSF1=NXF1
 
Transcription
N00592    ICP0TP53
N00588    (VP16+HCF+POU2F1)(ICP0,ICP4,ICP22,I..