Entry Name JAK-STAT signaling pathway - Bos indicus (zebu cattle)
Description The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map Other DBs Organism Bos indicus (zebu cattle) [GN:
biu ]
Gene 109555079 FHL1; four and a half LIM domains protein 1 isoform X1 [KO:K14365 ]
109555382 MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539 ]
109555834 PIAS3; E3 SUMO-protein ligase PIAS3 isoform X1 [KO:K16064 ] [EC:2.3.2.-]
109556495 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
109557823 PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
109559334 STAT6; signal transducer and activator of transcription 6 [KO:K11225 ]
109559357 STAT2; signal transducer and activator of transcription 2 [KO:K11221 ]
109559805 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922 ] [EC:2.7.1.153 ]
109559983 EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357 ]
109561218 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
109561418 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
109561420 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
109563190 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
109567597 STAM2; LOW QUALITY PROTEIN: signal transducing adapter molecule 2 [KO:K04705 ]
109567895 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
109567984 STAM; signal transducing adapter molecule 1 isoform X1 [KO:K04705 ]
109568771 STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220 ]
109570415 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922 ] [EC:2.7.1.153 ]
109571300 IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135 ]
109573417 CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423 ]
109573773 STAT5B; signal transducer and activator of transcription 5B isoform X1 [KO:K11224 ]
109573817 STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692 ]
109574805 PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649 ]
109575020 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
109575487 STAT4; signal transducer and activator of transcription 4 [KO:K11222 ]
109577247 CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625 ]
109577794 PIAS2; E3 SUMO-protein ligase PIAS2 isoform X1 [KO:K16063 ] [EC:2.3.2.-]
109578521 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
109578611 PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359 ]
Reference Authors Harrison DA
Title The Jak/STAT pathway.
Journal Reference Authors Kiu H, Nicholson SE
Title Biology and significance of the JAK/STAT signalling pathways.
Journal Reference Authors Hervas-Stubbs S, Perez-Gracia JL, Rouzaut A, Sanmamed MF, Le Bon A, Melero I
Title Direct effects of type I interferons on cells of the immune system.
Journal Reference Authors Fish EN, Platanias LC
Title Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.
Journal Reference Authors Ivanenkov YA, Balakin KV, Lavrovsky Y
Title Small molecule inhibitors of NF-kB and JAK/STAT signal transduction pathways as promising anti-inflammatory therapeutics.
Journal Reference Authors O'Shea JJ, Schwartz DM, Villarino AV, Gadina M, McInnes IB, Laurence A
Title The JAK-STAT pathway: impact on human disease and therapeutic intervention.
Journal Reference Authors Zoranovic T, Grmai L, Bach EA
Title Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Journal Reference Authors Ungureanu D, Silvennoinen O
Title SLIM trims STATs: ubiquitin E3 ligases provide insights for specificity in the regulation of cytokine signaling.
Journal Reference Authors Richard AJ, Stephens JM
Title The role of JAK-STAT signaling in adipose tissue function.
Journal Reference Authors Sun Y, Lehmbecker A, Kalkuhl A, Deschl U, Sun W, Rohn K, Tzvetanova ID, Nave KA, Baumgartner W, Ulrich R
Title STAT3 represents a molecular switch possibly inducing astroglial instead of oligodendroglial differentiation of oligodendroglial progenitor cells in Theiler's murine encephalomyelitis.
Journal Reference Authors Hirano T, Ishihara K, Hibi M
Title Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors.
Journal Reference Authors Rane SG, Reddy EP
Title Janus kinases: components of multiple signaling pathways.
Journal Reference Authors Heim MH
Title The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus.
Journal Reference Authors Morris R, Kershaw NJ, Babon JJ
Title The molecular details of cytokine signaling via the JAK/STAT pathway.
Journal Reference Authors Tzeng HT, Chyuan IT, Lai JH
Title Targeting the JAK-STAT pathway in autoimmune diseases and cancers: A focus on molecular mechanisms and therapeutic potential.
Journal Reference Authors Salas A, Hernandez-Rocha C, Duijvestein M, Faubion W, McGovern D, Vermeire S, Vetrano S, Vande Casteele N
Title JAK-STAT pathway targeting for the treatment of inflammatory bowel disease.
Journal Related biu04060 Cytokine-cytokine receptor interaction
KO pathway
