KEGG   PATHWAY: biu04151
Entry
biu04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Bos indicus (zebu cattle)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
biu04151  PI3K-Akt signaling pathway
biu04151

Other DBs
GO: 0043491
Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109552991  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
109553081  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
109553086  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
109553142  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
109553304  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
109553353  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
109553379  FGF20; fibroblast growth factor 20 [KO:K04358]
109553451  ANGPT2; angiopoietin-2 [KO:K05466]
109553505  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
109553526  VEGFC; vascular endothelial growth factor C [KO:K05449]
109553533  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
109553666  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
109553708  THBS3; thrombospondin-3 [KO:K04659]
109553755  EFNA1; ephrin-A1 [KO:K05462]
109553774  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
109553783  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
109553788  RET; LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
109553835  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
109554117  VEGFB; vascular endothelial growth factor B [KO:K16858]
109554138  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
109554150  FGF19; fibroblast growth factor 19 [KO:K22603]
109554256  [KO:K04358]
109554309  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
109554335  IGF2; insulin-like growth factor II isoform X1 [KO:K13769]
109554336  INS; insulin isoform X1 [KO:K04526]
109554358  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
109554386  BAD; bcl2-associated agonist of cell death [KO:K02158]
109554392  RELA; transcription factor p65 [KO:K04735]
109554418  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
109554439  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
109554474  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
109554577  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1 [KO:K11584]
109554719  CHRM1; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M1 [KO:K04129]
109554812  THEM4; LOW QUALITY PROTEIN: acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
109554937  [KO:K03456]
109555190  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
109555197  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
109555345  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
109555382  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
109555471  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
109555562  FGF16; fibroblast growth factor 16 [KO:K04358]
109555827  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
109555882  NGF; beta-nerve growth factor [KO:K02582]
109555890  NRAS; GTPase NRas [KO:K07828]
109555956  ITGB5; integrin beta-5 [KO:K06588]
109555962  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
109556095  PKN2; serine/threonine-protein kinase N2 isoform X1 [KO:K23691]
109556129  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
109556134  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
109556175  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
109556202  JAK1; LOW QUALITY PROTEIN: tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
109556244  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 [KO:K07198] [EC:2.7.11.31]
109556345  [KO:K02649]
109556449  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
109556495  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
109556565  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
109556725  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
109556891  ARTN; artemin [KO:K25415]
109556958  [KO:K04546]
109557291  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
109557383  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
109557393  LAMB1; laminin subunit beta-1 [KO:K05636]
109557411  MET; LOW QUALITY PROTEIN: hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
109557489  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
109557673  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
109557676  CREB3L2; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
109557793  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
109557810  RHEB; GTP-binding protein Rheb [KO:K07208]
109557823  PIK3CA; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
109557856  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
109557878  HGF; hepatocyte growth factor [KO:K05460]
109557883  [KO:K06249] [EC:3.4.21.-]
109557884  [KO:K06249] [EC:3.4.21.-]
109558062  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
109558077  IL6; interleukin-6 [KO:K05405]
109558203  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
109558211  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
109558214  COL1A2; collagen alpha-2(I) chain [KO:K06236]
109558333  KITLG; kit ligand [KO:K05461]
109558343  ITGA5; integrin alpha-5 [KO:K06484]
109558399  MDM2; E3 ubiquitin-protein ligase Mdm2 [KO:K06643] [EC:2.3.2.27]
109558606  VWF; von Willebrand factor [KO:K03900]
109558630  [KO:K17386]
109558919  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
109558930  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
109559043  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
109559054  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
109559075  NR4A1; nuclear receptor subfamily 4 group A member 1 isoform X1 [KO:K04465]
109559169  COL2A1; collagen alpha-1(II) chain [KO:K19719]
109559308  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
109559378  ERBB3; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
109559386  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
109559400  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
109559448  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
109559454  HSP90B1; endoplasmin [KO:K09487]
109559534  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
109559581  KRAS; GTPase KRas isoform X1 [KO:K07827]
109559597  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
109559641  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
109559734  NTF3; neurotrophin-3 [KO:K04356]
109559742  FGF6; fibroblast growth factor 6 [KO:K04358]
109559743  FGF23; fibroblast growth factor 23 [KO:K22428]
109559745  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
109559805  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
109559825  [KO:K17386]
109559832  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
109559983  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
109560078  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
109560131  IBSP; bone sialoprotein 2 [KO:K06253]
109560175  AREG; amphiregulin [KO:K09782]
109560296  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
109560323  EIF4E; eukaryotic translation initiation factor 4E [KO:K03259]
109560352  SPP1; osteopontin [KO:K06250]
109560475  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
109560477  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
109560478  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
109560583  EREG; proepiregulin [KO:K09784]
109560724  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
109560940  [KO:K02833]
109560989  EIF4E1B; eukaryotic translation initiation factor 4E type 1B [KO:K03259]
109561058  FGF22; fibroblast growth factor 22 [KO:K04358]
109561062  STK11; serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
109561193  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
109561209  PSPN; persephin [KO:K25416]
109561213  IL4; interleukin-4 [KO:K05430]
109561219  [KO:K04736]
109561279  COL6A2; LOW QUALITY PROTEIN: collagen alpha-2(VI) chain [KO:K06238]
109561327  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
109561368  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
109561393  COMP; cartilage oligomeric matrix protein [KO:K04659]
109561418  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
109561426  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
109561489  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
109561546  [KO:K04347]
109561588  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
109561621  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
109561676  COL6A5; LOW QUALITY PROTEIN: collagen alpha-5(VI) chain [KO:K06238]
109561711  NRTN; neurturin [KO:K25414]
109561750  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
109561751  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
109561787  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
109561893  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
109561985  EFNA2; ephrin-A2 [KO:K05462]
109562017  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
109562156  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
109562172  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
109562194  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
109562197  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
109562374  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
109562461  RPS6; 40S ribosomal protein S6 [KO:K02991]
109562638  [KO:K05414]
109562641  [KO:K05414]
109562644  [KO:K05414]
109562652  [KO:K05414]
109562656  [KO:K05414]
109562659  [KO:K05414]
109562660  [KO:K05414]
109562665  [KO:K05414]
109562667  [KO:K05415]
109562668  [KO:K05414]
109562670  [KO:K05414]
109562671  [KO:K05415]
109562673  [KO:K05414]
109562674  [KO:K05415]
109562675  [KO:K05415]
109562825  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
109562847  [KO:K05414]
109562852  [KO:K05415]
109562853  [KO:K05415]
109562855  [KO:K05415]
109562906  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
109563018  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
109563149  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
109563216  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
109563246  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha [KO:K11583]
109563281  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
109563336  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
109563337  [KO:K04289]
109563393  TNC; tenascin isoform X1 [KO:K06252]
109563399  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
109563451  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
109563454  [KO:K06238]
109563465  [KO:K06238]
109563534  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
109563807  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
109563845  FOXO3; LOW QUALITY PROTEIN: forkhead box protein O3 [KO:K09408]
109563967  [KO:K13302] [EC:2.7.11.1]
109563970  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
109564125  THBS2; thrombospondin-2 [KO:K04659]
109564155  [KO:K02539]
109564346  SOS2; son of sevenless homolog 2 [KO:K03099]
109564649  F2R; proteinase-activated receptor 1 [KO:K03914]
109564670  THBS4; thrombospondin-4 [KO:K04659]
109564697  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
109564717  ITGA11; integrin alpha-11 [KO:K06587]
109564787  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
109564916  THBS1; thrombospondin-1 [KO:K16857]
109565125  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
109565142  FGF7; fibroblast growth factor 7 [KO:K04358]
109565236  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
109565356  PGF; placenta growth factor isoform X1 [KO:K16859]
109565507  [KO:K04570]
109565710  BCL2L11; bcl-2-like protein 11 isoform X1 [KO:K16341]
109565743  ITGAV; integrin alpha-V [KO:K06487]
109565881  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
109565956  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
109566002  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
109566270  ATF2; LOW QUALITY PROTEIN: cyclic AMP-dependent transcription factor ATF-2 [KO:K04450]
109566402  YWHAQ; 14-3-3 protein theta [KO:K16197]
109566462  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
109566521  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
109566555  LAMC3; laminin subunit gamma-3 [KO:K06247]
109566571  TSC1; hamartin isoform X1 [KO:K07206]
109566619  RXRA; retinoic acid receptor RXR-alpha [KO:K08524]
109566714  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
109566823  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
109566959  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
109567013  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
109567047  FGF9; fibroblast growth factor 9 [KO:K04358]
109567101  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
109567207  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
109567262  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
109567303  PCK1; LOW QUALITY PROTEIN: phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
109567329  ANGPT4; angiopoietin-4 [KO:K05467]
109567345  BCL2L1; bcl-2-like protein 1 [KO:K04570]
109567473  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
109567659  LAMA5; laminin subunit alpha-5 [KO:K06240]
109567701  SGK2; serine/threonine-protein kinase Sgk2 [KO:K13303] [EC:2.7.11.1]
109567924  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
109567961  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
109567974  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
109568429  PTK2; LOW QUALITY PROTEIN: focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
109568476  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
109568481  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
109568578  SGK3; serine/threonine-protein kinase Sgk3 isoform X1 [KO:K13304] [EC:2.7.11.1]
109568594  MYC; myc proto-oncogene protein [KO:K04377]
109568635  ANGPT1; angiopoietin-1 [KO:K05465]
109568650  IL7; interleukin-7 [KO:K05431]
109569212  BDNF; brain-derived neurotrophic factor [KO:K04355]
109569423  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
109569805  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
109569868  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
109570093  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
109570286  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
109570361  LAMC1; laminin subunit gamma-1 [KO:K05635]
109570386  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
109570401  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
109570415  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
109570433  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
109570478  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
109570480  [KO:K04389]
109570495  LAMC2; laminin subunit gamma-2 [KO:K06246]
109570535  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
109570638  LAMB3; laminin subunit beta-3 [KO:K06244]
109570783  TNR; tenascin-R isoform X1 [KO:K06252]
109570785  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109570804  TNN; tenascin-N [KO:K06252]
109570838  OSM; oncostatin-M [KO:K05418]
109570879  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
109570959  YWHAH; 14-3-3 protein eta [KO:K16198]
109570973  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
109571028  IL2; interleukin-2 [KO:K05429]
109571278  [KO:K02991]
109571355  IRS1; insulin receptor substrate 1 [KO:K16172]
109571374  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
109571395  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
109571498  TLR2; toll-like receptor 2 [KO:K10159]
109571966  [KO:K00693] [EC:2.4.1.11]
109571969  NTF4; neurotrophin-4 [KO:K12457]
109571970  [KO:K12457]
109572074  FGF21; fibroblast growth factor 21 [KO:K22429]
109572117  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
109572216  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
109572446  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
109572496  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
109572614  [KO:K05131]
109572651  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
109572765  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 [KO:K16340] [EC:3.1.3.16]
109572914  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
109572992  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
109573005  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
109573250  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
109573366  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
109573417  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
109573568  ITGA2B; integrin alpha-IIb [KO:K06476]
109573698  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
109573726  RPS6KB1; ribosomal protein S6 kinase beta-1 [KO:K04688] [EC:2.7.11.1]
109573749  COL1A1; collagen alpha-1(I) chain [KO:K06236]
109573755  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
109573771  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
109573874  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
109573971  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
109574040  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
109574049  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
109574071  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
109574140  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
109574171  CHAD; chondroadherin [KO:K06248]
109574210  ITGA3; integrin alpha-3 [KO:K06482]
109574238  TP53; cellular tumor antigen p53 [KO:K04451]
109574284  G6PC; glucose-6-phosphatase isoform X1 [KO:K01084] [EC:3.1.3.9]
109574379  VTN; vitronectin [KO:K06251]
109574393  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
109574415  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
109574543  [KO:K05438]
109574695  [KO:K07198] [EC:2.7.11.31]
109574718  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
109574799  ITGA1; integrin alpha-1 [KO:K06480]
109574805  PIK3R1; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
109574810  GHR; growth hormone receptor isoform X1 [KO:K05080]
109574812  [KO:K07198] [EC:2.7.11.31]
109574862  ITGA2; integrin alpha-2 [KO:K06481]
109574945  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
109574973  PRLR; prolactin receptor isoform X1 [KO:K05081]
109575020  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
109575026  FGF18; fibroblast growth factor 18 [KO:K04358]
109575031  GDNF; glial cell line-derived neurotrophic factor [KO:K05452]
109575038  FGF10; fibroblast growth factor 10 [KO:K04358]
109575129  [KO:K05087] [EC:2.7.10.1]
109575321  TCL1B; T-cell leukemia/lymphoma protein 1B [KO:K16836]
109575345  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
109575398  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
109575432  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
109575457  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
109575470  [KO:K11584]
109575885  [KO:K06243]
109575895  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
109575927  [KO:K06243]
109576048  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
109576053  RAF1; LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase [KO:K04366] [EC:2.7.11.1]
109576115  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
109576217  ITGA9; integrin alpha-9 [KO:K06585]
109576447  G6PC2; glucose-6-phosphatase 2 [KO:K01084] [EC:3.1.3.9]
109576576  VEGFA; LOW QUALITY PROTEIN: vascular endothelial growth factor A [KO:K05448]
109576744  [KO:K05439]
109576772  [KO:K05439]
109576773  [KO:K05439]
109576787  [KO:K05439]
109576792  [KO:K05439]
109576814  [KO:K05439]
109576847  TNXB; tenascin-X [KO:K06252]
109576848  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
109576873  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
109577125  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
109577151  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
109577247  CDKN1A; cyclin-dependent kinase inhibitor 1 isoform X1 [KO:K06625]
109577296  [KO:K05439]
109577452  [KO:K05439]
109577453  [KO:K05439]
109577653  [KO:K06240]
109577655  [KO:K06240]
109577666  LAMA1; laminin subunit alpha-1 [KO:K05637]
109577782  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
109578066  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
109578140  CD19; B-lymphocyte antigen CD19 [KO:K06465]
109578192  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
109578279  TSC2; tuberin isoform X1 [KO:K07207]
109578290  EPO; erythropoietin [KO:K05437]
109578415  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
109578441  YWHAG; 14-3-3 protein gamma [KO:K16198]
109578505  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
109578521  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
109578611  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
109578667  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
109578787  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
109579044  PPP2R2D; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
109579084  FGF8; fibroblast growth factor 8 [KO:K04358]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
biu00010  Glycolysis / Gluconeogenesis
biu04010  MAPK signaling pathway
biu04012  ErbB signaling pathway
biu04062  Chemokine signaling pathway
biu04064  NF-kappa B signaling pathway
biu04068  FoxO signaling pathway
biu04110  Cell cycle
biu04115  p53 signaling pathway
biu04150  mTOR signaling pathway
biu04210  Apoptosis
biu04370  VEGF signaling pathway
biu04510  Focal adhesion
biu04620  Toll-like receptor signaling pathway
biu04630  JAK-STAT signaling pathway
biu04662  B cell receptor signaling pathway
biu04910  Insulin signaling pathway
KO pathway
ko04151   

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