KEGG   PATHWAY: biu04060
Entry
biu04060                    Pathway                                
Name
Cytokine-cytokine receptor interaction - Bos indicus (zebu cattle)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
biu04060  Cytokine-cytokine receptor interaction
biu04060

Organism
Bos indicus (zebu cattle) [GN:biu]
Gene
109574507  C-C motif chemokine 1-like [KO:K05514]
109574512  C-C motif chemokine 1-like [KO:K05514]
109561657  CCL25; C-C motif chemokine 25 isoform X1 [KO:K13072]
109563200  CCL19; C-C motif chemokine 19 isoform X1 [KO:K05512]
109563202  CCL21; C-C motif chemokine 21 [KO:K16062]
109574585  C-C motif chemokine 3 [KO:K05408]
109574154  C-C motif chemokine 3-like [KO:K05408]
109574476  C-C motif chemokine 3-like [KO:K05408]
109574477  C-C motif chemokine 14-like [KO:K05408]
109574570  C-C motif chemokine 4 [KO:K12964]
109572247  CCL17; C-C motif chemokine 17 [KO:K21083]
109572248  CCL22; C-C motif chemokine 22 [KO:K21095]
109574467  CCL5; C-C motif chemokine 5 [KO:K12499]
109573475  C-C motif chemokine 8 [KO:K16596]
109573439  C-C motif chemokine 8 [KO:K16596]
109574185  C-C motif chemokine 14-like [KO:K21092]
109574184  CCL16; C-C motif chemokine 16 [KO:K21093]
109574411  C-C motif chemokine 15-like [KO:K05511]
109574464  C-C motif chemokine 2 [KO:K14624]
109574578  eotaxin [KO:K16597]
109578810  CCL24; C-C motif chemokine 24 [KO:K21097]
109578811  CCL26; C-C motif chemokine 26 [KO:K21096]
109563197  CCL27; C-C motif chemokine 27 [KO:K16598]
109563198  uncharacterized protein LOC109563198 [KO:K16598]
109575034  CCL28; C-C motif chemokine 28 [KO:K05513]
109576954  CCL20; C-C motif chemokine 20 isoform X1 [KO:K14625]
109560578  growth-regulated protein homolog beta-like [KO:K05505]
109560579  growth-regulated protein homolog beta [KO:K05505]
109560573  growth-regulated protein homolog gamma isoform X1 [KO:K05505]
109560172  C-X-C motif chemokine 6 [KO:K05506]
109560575  C-X-C motif chemokine 15-like isoform X1 [KO:K10030]
109560570  CXCL8; interleukin-8 [KO:K10030]
109560572  PPBP; platelet basic protein [KO:K10029]
109560173  platelet factor 4 [KO:K05407]
109560593  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
109560594  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
109560177  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
109560179  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
109553743  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
109573822  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
109562039  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
109573066  CXCL17; C-X-C motif chemokine 17 [KO:K22627]
109570251  lymphotactin-like [KO:K05507]
109570227  lymphotactin-like [KO:K05507]
109572244  CX3CL1; fractalkine isoform X1 [KO:K05508]
109571028  IL2; interleukin-2 [KO:K05429]
109561213  IL4; interleukin-4 [KO:K05430]
109568650  IL7; interleukin-7 [KO:K05431]
109561070  IL9; interleukin-9 [KO:K05432]
109571474  IL15; interleukin-15 [KO:K05433]
109571034  IL21; interleukin-21 isoform X1 [KO:K05434]
109561219  interleukin-3 [KO:K04736]
109561216  IL5; interleukin-5 [KO:K05428]
109561218  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
109561215  IL13; interleukin-13 [KO:K05435]
109578290  EPO; erythropoietin [KO:K05437]
109574543  somatotropin [KO:K05438]
109577452  placental prolactin-related protein 3-like [KO:K05439]
109577453  LOW QUALITY PROTEIN: placental prolactin-related protein 3-like [KO:K05439]
109576772  placental prolactin-related protein 1 isoform X1 [KO:K05439]
109576773  chorionic somatomammotropin hormone 2 [KO:K05439]
109576787  chorionic somatomammotropin hormone 1 isoform X1 [KO:K05439]
109576792  placental prolactin-related protein 4 [KO:K05439]
109576814  placental prolactin-related protein 3-like [KO:K05439]
109577296  prolactin [KO:K05439]
109576744  LOW QUALITY PROTEIN: chorionic somatomammotropin hormone 2-like [KO:K05439]
109557333  THPO; thrombopoietin isoform X1 [KO:K06854]
109573417  CSF3; granulocyte colony-stimulating factor isoform X1 [KO:K05423]
109557596  LEP; leptin isoform X1 [KO:K05424]
109558077  IL6; interleukin-6 [KO:K05405]
109564477  IL12A; interleukin-12 subunit alpha [KO:K05406]
109561305  IL12B; interleukin-12 subunit beta [KO:K05425]
109559359  IL23A; interleukin-23 subunit alpha [KO:K05426]
109578638  IL27; interleukin-27 subunit alpha [KO:K22629]
109561748  EBI3; interleukin-27 subunit beta [KO:K24476]
109569574  CNTF; ciliary neurotrophic factor isoform X1 [KO:K05420]
109578719  CTF1; cardiotrophin-1 [KO:K05422]
109571543  LIF; leukemia inhibitory factor [KO:K05419]
109570838  OSM; oncostatin-M [KO:K05418]
109570808  IL10; interleukin-10 [KO:K05443]
109570244  IL19; interleukin-19 [KO:K05444]
109570102  IL20; interleukin-20 [KO:K22667]
109570104  IL24; interleukin-24 [KO:K22668]
109558717  IL22; interleukin-22 [KO:K05445]
109558718  IL26; interleukin-26 [KO:K05446]
109562847  interferon alpha-H [KO:K05414]
109562638  interferon alpha-G-like [KO:K05414]
109562641  LOW QUALITY PROTEIN: interferon alpha-1-like [KO:K05414]
109562644  interferon alpha-F [KO:K05414]
109562652  interferon alpha-A [KO:K05414]
109562656  interferon alpha-H-like [KO:K05414]
109562659  interferon alpha-H-like [KO:K05414]
109562660  interferon alpha-H-like [KO:K05414]
109562665  interferon alpha-B-like [KO:K05414]
109562668  interferon alpha-2-like [KO:K05414]
109562670  interferon alpha-2-like [KO:K05414]
109562673  interferon alpha-3-like [KO:K05414]
109562852  interferon beta-2-like [KO:K05415]
109562853  interferon beta-1-like [KO:K05415]
109562855  interferon beta-1 [KO:K05415]
109562667  LOW QUALITY PROTEIN: interferon beta-3-like [KO:K05415]
109562671  interferon beta-2-like [KO:K05415]
109562674  interferon beta-2 [KO:K05415]
109562675  interferon beta-2-like [KO:K05415]
109562844  interferon omega-1-like [KO:K05440]
109562846  interferon omega-1-like [KO:K05440]
109562848  interferon omega-1-like [KO:K05440]
109562634  interferon tau-3 [KO:K05440]
109562635  interferon omega-1 [KO:K05440]
109562636  interferon omega-1-like isoform X1 [KO:K05440]
109562637  interferon omega-1-like [KO:K05440]
109562640  interferon omega-1-like [KO:K05440]
109562642  interferon omega-1-like [KO:K05440]
109562643  interferon omega-1-like [KO:K05440]
109562645  interferon omega-1-like [KO:K05440]
109562646  interferon omega-1-like [KO:K05440]
109562647  interferon omega-1-like [KO:K05440]
109562651  interferon tau-1-like [KO:K05440]
109562653  LOW QUALITY PROTEIN: interferon omega-1-like [KO:K05440]
109562654  interferon omega-1-like [KO:K05440]
109562655  interferon omega-1-like [KO:K05440]
109562657  interferon omega-1-like [KO:K05440]
109562658  interferon omega-1-like [KO:K05440]
109562662  interferon omega-1-like [KO:K05440]
109562663  interferon omega-1-like [KO:K05440]
109562664  interferon omega-1-like [KO:K05440]
109562666  interferon omega-1-like [KO:K05440]
109562827  IFNK; interferon kappa [KO:K05441]
109562628  IFNE; interferon epsilon [KO:K05442]
109558719  IFNG; interferon gamma [KO:K04687]
109566132  IL1A; interleukin-1 alpha [KO:K04383]
109566133  IL1B; interleukin-1 beta [KO:K04519]
109566134  IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481]
109565751  IL36RN; interleukin-36 receptor antagonist protein [KO:K05483]
109565559  interleukin-36 alpha-like [KO:K05484]
109565944  IL36B; interleukin-36 beta [KO:K05486]
109565558  IL36G; interleukin-36 gamma [KO:K05487]
109565960  IL1F10; interleukin-1 family member 10 [KO:K05488]
109565776  IL37; interleukin-37 isoform X1 [KO:K05485]
109569934  IL18; interleukin-18 isoform X1 [KO:K05482]
109562893  IL33; interleukin-33 [KO:K12967]
109576838  IL17A; interleukin-17A [KO:K05489]
109576869  IL17F; interleukin-17F [KO:K05494]
109562187  IL17B; interleukin-17B isoform X1 [KO:K05490]
109567051  IL17D; interleukin-17D [KO:K05492]
109564464  IL25; interleukin-25 [KO:K05493]
109575617  IL16; pro-interleukin-16 isoform X1 [KO:K22628]
109578671  interleukin-32-like [KO:K22632]
109578868  uncharacterized protein LOC109578868 isoform X1 [KO:K22632]
109578670  IL32; interleukin-32 isoform X1 [KO:K22632]
109572583  IL34; interleukin-34 [KO:K22633]
109555962  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
109577428  TNF; tumor necrosis factor [KO:K03156]
109577429  LTA; lymphotoxin-alpha [KO:K05468]
109576828  LTB; lymphotoxin-beta isoform X1 [KO:K03157]
109561687  TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477]
109570480  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109570785  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
109563390  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
109558018  TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X1 [KO:K04721]
109555882  NGF; beta-nerve growth factor [KO:K02582]
109566677  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
109561208  CD70; CD70 antigen [KO:K05470]
109563391  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
109555532  CD40LG; CD40 ligand [KO:K03161]
109561688  TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472]
109570755  TNFSF4; tumor necrosis factor ligand superfamily member 4 isoform X1 [KO:K05469]
109573650  TNFSF13; tumor necrosis factor ligand superfamily member 13 [KO:K05475]
109566957  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
109572866  TGFB1; transforming growth factor beta-1 [KO:K13375]
109570509  TGFB2; transforming growth factor beta-2 isoform X1 [KO:K13376]
109565371  TGFB3; transforming growth factor beta-3 [KO:K13377]
109561163  GDF15; growth/differentiation factor 15 [KO:K05504]
109553929  GDF2; growth/differentiation factor 2 [KO:K05503]
109566234  BMP10; bone morphogenetic protein 10 [KO:K22670]
109571211  INHA; inhibin alpha chain [KO:K05500]
109560621  BMP3; bone morphogenetic protein 3 [KO:K05496]
109553945  GDF10; growth/differentiation factor 10 [KO:K22674]
109559392  GDF11; growth/differentiation factor 11 [KO:K22679]
109565565  MSTN; growth/differentiation factor 8 [KO:K05497]
109557561  INHBA; inhibin beta A chain [KO:K04667]
109561392  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
109559697  GDF3; growth/differentiation factor 3 [KO:K22672]
109553668  NODAL; nodal homolog [KO:K04666]
109562005  GDF9; growth/differentiation factor 9 isoform X1 [KO:K22673]
109559328  INHBC; inhibin beta C chain [KO:K22688]
109559329  INHBE; inhibin beta E chain [KO:K22689]
109561802  AMH; LOW QUALITY PROTEIN: muellerian-inhibiting factor [KO:K04665]
109567176  BMP2; bone morphogenetic protein 2 [KO:K21283]
109565174  BMP4; bone morphogenetic protein 4 isoform X1 [KO:K04662]
109567755  GDF5; growth/differentiation factor 5 [KO:K04664]
109568721  GDF6; growth/differentiation factor 6 [KO:K20012]
109566350  GDF7; growth/differentiation factor 7 [KO:K20013]
109576536  BMP5; bone morphogenetic protein 5 [KO:K04663]
109577137  BMP6; bone morphogenetic protein 6 [KO:K16620]
109567307  BMP7; bone morphogenetic protein 7 [KO:K16621]
109556908  bone morphogenetic protein 8A-like [KO:K16622]
109576481  CCR8; C-C chemokine receptor type 8 [KO:K04183]
109576480  CCR9; C-C chemokine receptor type 9 [KO:K04184]
109560309  ACKR4; atypical chemokine receptor 4 [KO:K04186]
109574484  CCR7; C-C chemokine receptor type 7 [KO:K04182]
109576474  CCR4; C-C chemokine receptor type 4 isoform X1 [KO:K04179]
109576398  CCR5; C-C chemokine receptor type 5 [KO:K04180]
109575798  CCR3; C-C chemokine receptor type 3 [KO:K04178]
109576396  C-C chemokine receptor type 1-like [KO:K04176]
109576397  C-C chemokine receptor type 1 [KO:K04176]
109573309  CCR10; C-C chemokine receptor type 10 [KO:K04185]
109564117  CCR6; C-C chemokine receptor type 6 [KO:K04181]
109570482  C-X-C chemokine receptor type 2 [KO:K04175]
109570475  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
109555556  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
109569588  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
109568167  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
109556563  ACKR3; atypical chemokine receptor 3 [KO:K04304]
109576034  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
109576496  XCR1; chemokine XC receptor 1 [KO:K04193]
109575984  CX3CR1; CX3C chemokine receptor 1 isoform X1 [KO:K04192]
109567961  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
109559534  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
109555190  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
109578521  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
109575020  IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072]
109578826  interleukin-9 receptor-like [KO:K05073]
109567895  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
109578841  IL21R; interleukin-21 receptor [KO:K05075]
109559524  CSF2RB; cytokine receptor common subunit beta [KO:K04738]
109575848  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
109568669  LOW QUALITY PROTEIN: granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066]
109561621  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
109574810  GHR; growth hormone receptor isoform X1 [KO:K05080]
109574973  PRLR; prolactin receptor isoform X1 [KO:K05081]
109557096  MPL; thrombopoietin receptor [KO:K05082]
109556495  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
109556197  LEPR; leptin receptor [KO:K05062]
109554138  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
109574817  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
109563195  IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
109561420  IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063]
109556179  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
109556180  IL23R; interleukin-23 receptor isoform X1 [KO:K05065]
109560896  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
109575060  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
109563190  CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059]
109574806  LIFR; leukemia inhibitory factor receptor isoform X1 [KO:K05058]
109574945  OSMR; oncostatin-M-specific receptor subunit beta [KO:K05057]
109569863  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
109571300  IL10RB; interleukin-10 receptor subunit beta isoform X1 [KO:K05135]
109563983  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
109560001  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
109577127  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
109573827  IFNLR1; interferon lambda receptor 1 [KO:K05140]
109570535  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
109572614  interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
109563984  IFNGR1; interferon gamma receptor 1 [KO:K05132]
109569763  IFNGR2; interferon gamma receptor 2 [KO:K05133]
109565502  IL1R1; interleukin-1 receptor type 1 [KO:K04386]
109556715  IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723]
109565866  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
109565707  IL1RL2; interleukin-1 receptor-like 2 [KO:K05172]
109565872  IL18R1; interleukin-18 receptor 1 isoform X1 [KO:K05173]
109565875  IL18RAP; LOW QUALITY PROTEIN: interleukin-18 receptor accessory protein [KO:K05174]
109565871  IL1RL1; interleukin-1 receptor-like 1 isoform X1 [KO:K05171]
109558616  IL17RA; interleukin-17 receptor A [KO:K05164]
109576231  IL17RC; interleukin-17 receptor C isoform X1 [KO:K05166]
109576358  IL17RB; interleukin-17 receptor B isoform X1 [KO:K05165]
109576232  IL17RE; interleukin-17 receptor E [KO:K05168]
109558922  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
109562194  CSF1R; macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
109559729  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
109570565  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141]
109559730  LTBR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 3 [KO:K03159]
109567245  TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143]
109579171  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
109570673  TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X1 [KO:K05160]
109563119  tumor necrosis factor receptor superfamily member 10B-like isoform X1 [KO:K04722]
109563117  tumor necrosis factor receptor superfamily member 10C-like isoform X1 [KO:K22701]
109563127  tumor necrosis factor receptor superfamily member 10D-like isoform X1 [KO:K22702]
109576656  tumor necrosis factor receptor superfamily member 21-like [KO:K05157]
109576658  tumor necrosis factor receptor superfamily member 21 [KO:K05157]
109565550  EDAR; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
109574393  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
109568703  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148]
109577693  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
109578649  TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
109559727  CD27; CD27 antigen isoform X1 [KO:K05144]
109570765  TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
109567510  CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160]
109570817  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
109570570  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
109570728  TNFRSF18; tumor necrosis factor receptor superfamily member 18 isoform X1 [KO:K05154]
109578256  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
109574554  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B isoform X1 [KO:K05150]
109558848  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
109566846  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
109569555  RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
109562144  RELL2; RELT-like protein 2 [KO:K26541]
109560392  RELL1; RELT-like protein 1 [KO:K26541]
109563078  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
109576148  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
109559078  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
109567962  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
109575608  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
109576299  ACVR2B; activin receptor type-2B [KO:K13596] [EC:2.7.11.30]
109559077  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
109567491  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
109567478  ACVR1; activin receptor type-1 isoform X1 [KO:K04675] [EC:2.7.11.30]
109558345  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
109553752  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
109560330  BMPR1B; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
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