Entry
Name
cAMP signaling pathway - Callithrix jacchus (white-tufted-ear marmoset)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Other DBs
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:
cjc ]
Gene
100385029 LHCGR; lutropin-choriogonadotropic hormone receptor precursor [KO:K04248 ]
100385316 HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955 ]
100385383 PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860 ] [EC:3.1.4.11 ]
100385837 VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X3 [KO:K04590 ]
100386041 CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853 ]
100387025 ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587 ]
100387074 ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490 ]
100388111 CRHR2; corticotropin-releasing factor receptor 2 isoform X3 [KO:K04579 ]
100388113 GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630 ]
100388195 GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X4 [KO:K05211 ]
100390112 CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857 ]
100390165 VAV3; guanine nucleotide exchange factor VAV3 isoform X4 [KO:K05730 ]
100390567 POPDC2; popeye domain-containing protein 2 isoform X2 [KO:K26206 ]
100390614 PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494 ]
100390670 ADCYAP1; pituitary adenylate cyclase-activating polypeptide isoform X3 [KO:K05262 ]
100390844 TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731 ]
100390938 CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
100391624 ABCC4; ATP-binding cassette sub-family C member 4 isoform X2 [KO:K05673 ]
100391655 PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922 ] [EC:2.7.1.153 ]
100392161 GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214 ]
100392174 ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540 ]
100392579 CREB5; cyclic AMP-responsive element-binding protein 5 isoform X6 [KO:K09047 ]
100392639 PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649 ]
100393191 PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270 ]
100394351 CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048 ]
100394435 PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269 ] [EC:3.1.3.16 ]
100394541 CNGA3; cyclic nucleotide-gated cation channel alpha-3 [KO:K04950 ]
100396068 HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957 ]
100397234 GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615 ]
100397940 CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X11 [KO:K04851 ]
100397956 CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X9 [KO:K04515 ] [EC:2.7.11.17 ]
100398849 PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922 ] [EC:2.7.1.153 ]
100399583 RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X3 [KO:K08014 ]
100400002 KCNK2; potassium channel subfamily K member 2 isoform X3 [KO:K04913 ]
100400619 CNGB1; cyclic nucleotide-gated cation channel beta-1 isoform X1 [KO:K04952 ]
100400670 ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056 ]
100400756 RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861 ]
100401754 RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X5 [KO:K04351 ]
100401859 GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212 ]
100402067 CNGB3; cyclic nucleotide-gated cation channel beta-3 isoform X2 [KO:K04953 ]
100403494 PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922 ] [EC:2.7.1.153 ]
100404109 RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392 ]
100404474 GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630 ]
100405187 NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446 ]
100405475 CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578 ]
100405745 GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 isoform X1 [KO:K04630 ]
100405903 CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515 ] [EC:2.7.11.17 ]
100406408 VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730 ]
100406635 CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048 ]
100406689 PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649 ]
100406735 CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X36 [KO:K04850 ]
100407681 CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870 ]
100408515 GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X2 [KO:K04632 ]
100408954 CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048 ]
100409637 CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048 ]
100410249 CNGA4; cyclic nucleotide-gated cation channel alpha-4 isoform X1 [KO:K04951 ]
100410352 CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4 [KO:K04515 ] [EC:2.7.11.17 ]
100410438 GIPR; gastric inhibitory polypeptide receptor isoform X2 [KO:K04580 ]
100411083 CHRM2; muscarinic acetylcholine receptor M2 isoform X2 [KO:K04130 ]
100411140 CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048 ]
100411569 GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X2 [KO:K05209 ]
100412553 ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540 ]
100412651 GABBR2; gamma-aminobutyric acid type B receptor subunit 2 isoform X1 [KO:K04615 ]
100412880 BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158 ]
100413857 GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208 ]
100414358 ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540 ]
100414659 PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649 ]
100415161 FSHR; follicle-stimulating hormone receptor precursor [KO:K04247 ]
100415252 GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210 ]
100415321 NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580 ]
100415661 PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294 ]
103796045 FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538 ]
108590441 PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260 ]
Compound
C01245 D-myo-Inositol 1,4,5-trisphosphate
Reference
Authors
Fimia GM, Sassone-Corsi P
Title
Cyclic AMP signalling.
Journal
J Cell Sci 114:1971-2 (2001)
Reference
Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
Title
Cyclic AMP: master regulator of innate immune cell function.
Journal
Reference
Authors
Oldenburger A, Maarsingh H, Schmidt M
Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
Journal
Reference
Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
Journal
Reference
Authors
Shirshev SV
Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
Journal
Reference
Authors
Roscioni SS, Elzinga CR, Schmidt M
Title
Epac: effectors and biological functions.
Journal
Reference
Authors
Roberts OL, Dart C
Title
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
Journal
Reference
Authors
Schaub MC, Hefti MA, Zaugg M
Title
Integration of calcium with the signaling network in cardiac myocytes.
Journal
Reference
Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
Journal
Reference
Authors
Saucerman JJ, McCulloch AD
Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
Journal
Reference
Authors
Yang JH, Saucerman JJ
Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
Journal
Reference
Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
Title
Anger, emotion, and arrhythmias: from brain to heart.
Journal
Reference
Authors
Bozzi Y, Dunleavy M, Henshall DC
Title
Cell signaling underlying epileptic behavior.
Journal
Reference
Authors
Lizcano JM, Morrice N, Cohen P
Title
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
Journal
Reference
Authors
Gerlo S, Kooijman R, Beck IM, Kolmus K, Spooren A, Haegeman G
Title
Cyclic AMP: a selective modulator of NF-kappaB action.
Journal
Reference
Authors
Lauder JM
Title
Neurotransmitters as growth regulatory signals: role of receptors and second messengers.
Journal
Reference
Authors
Voglis G, Tavernarakis N
Title
The role of synaptic ion channels in synaptic plasticity.
Journal
Reference
Authors
Altarejos JY, Montminy M
Title
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
Journal
Reference
Authors
Bozzi Y, Borrelli E
Title
The role of dopamine signaling in epileptogenesis.
Journal
Reference
Authors
Ceulemans H, Bollen M
Title
Functional diversity of protein phosphatase-1, a cellular economizer and reset button.
Journal
Reference
Authors
Lipinski RJ, Gipp JJ, Zhang J, Doles JD, Bushman W
Title
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.
Journal
Reference
Authors
Lasala C, Schteingart HF, Arouche N, Bedecarras P, Grinspon RP, Picard JY, Josso N, di Clemente N, Rey RA
Title
SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1.
Journal
Reference
Authors
Rosenkranz AC, Rauch BH, Freidel K, Schror K
Title
Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT.
Journal
Reference
Authors
Lazennec G, Canaple L, Saugy D, Wahli W
Title
Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
Journal
Reference
Authors
Murthy KS
Title
Signaling for contraction and relaxation in smooth muscle of the gut.
Journal
Reference
Authors
Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG
Title
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
Journal
Reference
Authors
Houslay MD, Milligan G
Title
Tailoring cAMP-signalling responses through isoform multiplicity.
Journal
Related pathway
KO pathway