KEGG   PATHWAY: cjc04024
Entry
cjc04024                    Pathway                                
Name
cAMP signaling pathway - Callithrix jacchus (white-tufted-ear marmoset)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
cjc04024  cAMP signaling pathway
cjc04024

Other DBs
GO: 0019933
Organism
Callithrix jacchus (white-tufted-ear marmoset) [GN:cjc]
Gene
100385029  LHCGR; lutropin-choriogonadotropic hormone receptor precursor [KO:K04248]
100385316  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
100385359  TSHB; thyrotropin subunit beta isoform X1 [KO:K05251]
100385383  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
100385471  NPY; pro-neuropeptide Y [KO:K05232]
100385658  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100385837  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X3 [KO:K04590]
100386041  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100386514  PLN; cardiac phospholamban [KO:K05852]
100386626  [KO:K07830]
100386819  CALM2; calmodulin-2 isoform X2 [KO:K02183]
100386986  VIP; VIP peptides isoform X1 [KO:K05264]
100387025  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
100387074  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
100387394  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
100387664  ADRB1; beta-1 adrenergic receptor [KO:K04141]
100387686  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100387953  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
100387965  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
100388080  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100388111  CRHR2; corticotropin-releasing factor receptor 2 isoform X3 [KO:K04579]
100388113  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100388195  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X4 [KO:K05211]
100388410  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
100388432  VAV1; proto-oncogene vav [KO:K05730]
100388466  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
100388493  RELA; transcription factor p65 isoform X1 [KO:K04735]
100388904  OXT; oxytocin-neurophysin 1 [KO:K05243]
100389125  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
100389264  CGA; glycoprotein hormones alpha chain precursor [KO:K08522]
100389415  TNNI3; troponin I, cardiac muscle [KO:K12044]
100389557  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2 [KO:K13293] [EC:3.1.4.53]
100390054  FOS; protein c-Fos [KO:K04379]
100390109  MAPK10; mitogen-activated protein kinase 10 isoform X7 [KO:K04440] [EC:2.7.11.24]
100390112  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
100390165  VAV3; guanine nucleotide exchange factor VAV3 isoform X4 [KO:K05730]
100390180  CALM1; calmodulin-1 [KO:K02183]
100390567  POPDC2; popeye domain-containing protein 2 isoform X2 [KO:K26206]
100390614  PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
100390670  ADCYAP1; pituitary adenylate cyclase-activating polypeptide isoform X3 [KO:K05262]
100390844  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
100390938  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100391217  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
100391353  NPPA; natriuretic peptides A [KO:K12334]
100391424  [KO:K04515] [EC:2.7.11.17]
100391612  [KO:K06269] [EC:3.1.3.16]
100391624  ABCC4; ATP-binding cassette sub-family C member 4 isoform X2 [KO:K05673]
100391655  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
100391928  POPDC3; popeye domain-containing protein 3 [KO:K26207]
100392029  GRIA2; glutamate receptor 2 isoform X2 [KO:K05198]
100392123  PRKACG; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
100392161  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X1 [KO:K05214]
100392174  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [KO:K01540]
100392199  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
100392579  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X6 [KO:K09047]
100392639  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
100392721  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100392898  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
100392970  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
100393003  SUCNR1; succinate receptor 1 [KO:K10042]
100393183  RAP1A; ras-related protein Rap-1A [KO:K04353]
100393191  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270]
100393236  RHOA; transforming protein RhoA [KO:K04513]
100393318  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
100393923  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X8 [KO:K13296] [EC:3.1.4.17]
100393991  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100394168  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
100394265  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100394351  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
100394435  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
100394541  CNGA3; cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
100394652  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
100394752  HTR6; 5-hydroxytryptamine receptor 6 isoform X1 [KO:K04162]
100394821  ADORA1; adenosine receptor A1 isoform X1 [KO:K04265]
100394823  ACOX3; LOW QUALITY PROTEIN: peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
100394829  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
100395031  ADORA2A; LOW QUALITY PROTEIN: adenosine receptor A2a [KO:K04266]
100395278  EP300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
100395636  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100395984  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
100396039  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
100396068  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
100396171  GIP; gastric inhibitory polypeptide [KO:K05258]
100396360  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
100396371  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
100396453  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100396690  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
100397093  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
100397234  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
100397940  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X11 [KO:K04851]
100397956  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X9 [KO:K04515] [EC:2.7.11.17]
100398261  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X3 [KO:K05853] [EC:7.2.2.10]
100398334  AFDN; afadin isoform X5 [KO:K05702]
100398535  DRD1; D(1A) dopamine receptor [KO:K04144]
100398622  GRIA4; glutamate receptor 4 isoform X4 [KO:K05200]
100398849  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100398993  FSHB; follitropin subunit beta [KO:K05250]
100399039  AKT3; RAC-gamma serine/threonine-protein kinase isoform X6 [KO:K04456] [EC:2.7.11.1]
100399063  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
100399074  GCG; pro-glucagon [KO:K05259]
100399583  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X3 [KO:K08014]
100400002  KCNK2; potassium channel subfamily K member 2 isoform X3 [KO:K04913]
100400356  F2R; proteinase-activated receptor 1 [KO:K03914]
100400411  JUN; transcription factor Jun [KO:K04448]
100400537  [KO:K07830]
100400619  CNGB1; cyclic nucleotide-gated cation channel beta-1 isoform X1 [KO:K04952]
100400670  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
100400700  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100400734  BVES; blood vessel epicardial substance [KO:K21108]
100400737  PRKACA; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100400756  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
100400779  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
100400797  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
100401286  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
100401418  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100401526  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
100401745  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
100401754  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X5 [KO:K04351]
100401859  GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X1 [KO:K05212]
100402067  CNGB3; cyclic nucleotide-gated cation channel beta-3 isoform X2 [KO:K04953]
100402258  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100402266  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100402438  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
100402459  FXYD1; phospholemman isoform X2 [KO:K13360]
100402498  [KO:K12755]
100402702  SOX9; transcription factor SOX-9 [KO:K18435]
100403091  BRAF; serine/threonine-protein kinase B-raf isoform X2 [KO:K04365] [EC:2.7.11.1]
100403160  [KO:K01539] [EC:7.2.2.13]
100403194  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X4 [KO:K05850] [EC:7.2.2.10]
100403358  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
100403494  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100404109  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
100404129  [KO:K04513]
100404341  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
100404447  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100404474  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
100404484  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100404620  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100404815  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100404963  HHIP; hedgehog-interacting protein isoform X1 [KO:K06231]
100404983  FFAR2; free fatty acid receptor 2 [KO:K04328]
100405037  CREBBP; CREB-binding protein isoform X1 [KO:K04498] [EC:2.3.1.48]
100405187  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X2 [KO:K04446]
100405271  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A isoform X1 [KO:K19021] [EC:3.1.4.17]
100405403  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100405475  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
100405745  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 isoform X1 [KO:K04630]
100405903  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100406081  CALM3; calmodulin-3 [KO:K02183]
100406194  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
100406295  OXTR; oxytocin receptor [KO:K04229]
100406408  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
100406441  AMH; muellerian-inhibiting factor isoform X1 [KO:K04665]
100406617  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100406635  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
100406670  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
100406689  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100406735  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X36 [KO:K04850]
100406916  RYR2; ryanodine receptor 2 isoform X7 [KO:K04962]
100407112  TSHR; thyrotropin receptor isoform X1 [KO:K04249]
100407118  SSTR5; somatostatin receptor type 5 [KO:K04221]
100407128  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
100407210  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
100407681  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100407692  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100407701  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X2 [KO:K05850] [EC:7.2.2.10]
100407720  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
100408064  HCAR2; hydroxycarboxylic acid receptor 2 [KO:K08402]
100408115  [KO:K04345] [EC:2.7.11.11]
100408128  DRD5; D(1B) dopamine receptor [KO:K05840]
100408139  PDE4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform X2 [KO:K13293] [EC:3.1.4.53]
100408289  CALML3; calmodulin-like protein 3 [KO:K02183]
100408337  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100408428  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
100408515  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X2 [KO:K04632]
100408954  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
100409126  SSTR2; somatostatin receptor type 2 [KO:K04218]
100409206  [KO:K04345] [EC:2.7.11.11]
100409239  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100409350  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1 [KO:K13293] [EC:3.1.4.53]
100409412  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
100409637  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
100410040  CRH; corticoliberin [KO:K05256]
100410223  EDN2; endothelin-2 [KO:K16367]
100410249  CNGA4; cyclic nucleotide-gated cation channel alpha-4 isoform X1 [KO:K04951]
100410276  GHRL; appetite-regulating hormone isoform X1 [KO:K05254]
100410292  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
100410352  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X4 [KO:K04515] [EC:2.7.11.17]
100410387  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
100410438  GIPR; gastric inhibitory polypeptide receptor isoform X2 [KO:K04580]
100410496  [KO:K06269] [EC:3.1.3.16]
100410682  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X1 [KO:K01539] [EC:7.2.2.13]
100410901  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
100410915  EDN3; endothelin-3 isoform X1 [KO:K05227]
100411024  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
100411083  CHRM2; muscarinic acetylcholine receptor M2 isoform X2 [KO:K04130]
100411140  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
100411569  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X2 [KO:K05209]
100411611  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
100411763  [KO:K07836]
100412281  SSTR1; somatostatin receptor type 1 [KO:K04217]
100412553  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
100412651  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 isoform X1 [KO:K04615]
100412782  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
100412880  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
100412902  SST; somatostatin [KO:K05237]
100413220  RAP1B; ras-related protein Rap-1b [KO:K07836]
100413470  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
100413506  HTR4; 5-hydroxytryptamine receptor 4 isoform X2 [KO:K04160]
100413772  RRAS; ras-related protein R-Ras [KO:K07829]
100413857  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X1 [KO:K05208]
100414089  POMC; pro-opiomelanocortin [KO:K05228]
100414106  ADRB2; beta-2 adrenergic receptor isoform X1 [KO:K04142]
100414358  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
100414635  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X1 [KO:K05853] [EC:7.2.2.10]
100414659  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
100414848  EDN1; endothelin-1 [KO:K16366]
100415092  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X3 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
100415141  ADCY4; adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
100415161  FSHR; follicle-stimulating hormone receptor precursor [KO:K04247]
100415165  ADCY3; adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
100415251  CFTR; cystic fibrosis transmembrane conductance regulator isoform X1 [KO:K05031] [EC:5.6.1.6]
100415252  GRIN2B; glutamate receptor ionotropic, NMDA 2B isoform X1 [KO:K05210]
100415300  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100415321  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100415661  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
100895274  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
100895294  [KO:K04392]
100896693  CNGA1; cGMP-gated cation channel alpha-1 isoform X1 [KO:K04948]
103787209  [KO:K04632]
103793141  [KO:K04578]
103794919  ATP1B4; protein ATP1B4 isoform X3 [KO:K01540]
103796045  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
108590441  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
108592443  CALML5; calmodulin-like protein 5 [KO:K02183]
118148021  [KO:K02183]
118151333  [KO:K04345] [EC:2.7.11.11]
118152910  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
128931276  [KO:K07830]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
  Authors
Roberts OL, Dart C
  Title
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
  Journal
Biochem Soc Trans 42:89-97 (2014)
DOI:10.1042/BST20130253
Reference
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
  Authors
Bozzi Y, Dunleavy M, Henshall DC
  Title
Cell signaling underlying epileptic behavior.
  Journal
Front Behav Neurosci 5:45 (2011)
DOI:10.3389/fnbeh.2011.00045
Reference
  Authors
Lizcano JM, Morrice N, Cohen P
  Title
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
  Journal
Biochem J 349:547-57 (2000)
DOI:10.1042/bj3490547
Reference
  Authors
Gerlo S, Kooijman R, Beck IM, Kolmus K, Spooren A, Haegeman G
  Title
Cyclic AMP: a selective modulator of NF-kappaB action.
  Journal
Cell Mol Life Sci 68:3823-41 (2011)
DOI:10.1007/s00018-011-0757-8
Reference
PMID:7688165
  Authors
Lauder JM
  Title
Neurotransmitters as growth regulatory signals: role of receptors and second messengers.
  Journal
Trends Neurosci 16:233-40 (1993)
DOI:10.1016/0166-2236(93)90162-F
Reference
  Authors
Voglis G, Tavernarakis N
  Title
The role of synaptic ion channels in synaptic plasticity.
  Journal
EMBO Rep 7:1104-10 (2006)
DOI:10.1038/sj.embor.7400830
Reference
  Authors
Altarejos JY, Montminy M
  Title
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
  Journal
Nat Rev Mol Cell Biol 12:141-51 (2011)
DOI:10.1038/nrm3072
Reference
  Authors
Bozzi Y, Borrelli E
  Title
The role of dopamine signaling in epileptogenesis.
  Journal
Front Cell Neurosci 7:157 (2013)
DOI:10.3389/fncel.2013.00157
Reference
  Authors
Ceulemans H, Bollen M
  Title
Functional diversity of protein phosphatase-1, a cellular economizer and reset button.
  Journal
Physiol Rev 84:1-39 (2004)
DOI:10.1152/physrev.00013.2003
Reference
  Authors
Lipinski RJ, Gipp JJ, Zhang J, Doles JD, Bushman W
  Title
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.
  Journal
Exp Cell Res 312:1925-38 (2006)
DOI:10.1016/j.yexcr.2006.02.019
Reference
  Authors
Lasala C, Schteingart HF, Arouche N, Bedecarras P, Grinspon RP, Picard JY, Josso N, di Clemente N, Rey RA
  Title
SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1.
  Journal
Am J Physiol Endocrinol Metab 301:E539-47 (2011)
DOI:10.1152/ajpendo.00187.2011
Reference
  Authors
Rosenkranz AC, Rauch BH, Freidel K, Schror K
  Title
Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT.
  Journal
Cardiovasc Res 83:778-84 (2009)
DOI:10.1093/cvr/cvp163
Reference
  Authors
Lazennec G, Canaple L, Saugy D, Wahli W
  Title
Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
  Journal
Mol Endocrinol 14:1962-75 (2000)
DOI:10.1210/mend.14.12.0575
Reference
  Authors
Murthy KS
  Title
Signaling for contraction and relaxation in smooth muscle of the gut.
  Journal
Annu Rev Physiol 68:345-74 (2006)
DOI:10.1146/annurev.physiol.68.040504.094707
Reference
  Authors
Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG
  Title
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
  Journal
J Cell Physiol 215:715-24 (2008)
DOI:10.1002/jcp.21354
Reference
PMID:9204709
  Authors
Houslay MD, Milligan G
  Title
Tailoring cAMP-signalling responses through isoform multiplicity.
  Journal
Trends Biochem Sci 22:217-24 (1997)
DOI:10.1016/S0968-0004(97)01050-5
Related
pathway
cjc00071  Fatty acid degradation
cjc04015  Rap1 signaling pathway
cjc04020  Calcium signaling pathway
cjc04151  PI3K-Akt signaling pathway
cjc04210  Apoptosis
cjc04260  Cardiac muscle contraction
cjc04340  Hedgehog signaling pathway
cjc04720  Long-term potentiation
cjc04740  Olfactory transduction
cjc04972  Pancreatic secretion
cjc04976  Bile secretion
KO pathway
ko04024   

DBGET integrated database retrieval system