KEGG   PATHWAY: dnm04024
Entry
dnm04024                    Pathway                                
Name
cAMP signaling pathway - Dasypus novemcinctus (nine-banded armadillo)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
dnm04024  cAMP signaling pathway
dnm04024

Other DBs
GO: 0019933
Organism
Dasypus novemcinctus (nine-banded armadillo) [GN:dnm]
Gene
101410777  GIPR; gastric inhibitory polypeptide receptor [KO:K04580]
101410978  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
101411010  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
101411559  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101411573  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101411890  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101411989  BRAF; LOW QUALITY PROTEIN: serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101411996  CRHR2; corticotropin-releasing factor receptor 2 [KO:K04579]
101412001  JUN; transcription factor AP-1 [KO:K04448]
101412051  VIP; VIP peptides isoform X1 [KO:K05264]
101412263  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1 [KO:K13293] [EC:3.1.4.53]
101412342  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
101412472  [KO:K04353]
101412730  NFKBIA; LOW QUALITY PROTEIN: NF-kappa-B inhibitor alpha [KO:K04734]
101412798  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
101412843  CALML4; calmodulin-like protein 4 isoform X2 [KO:K02183]
101413154  POMC; pro-opiomelanocortin [KO:K05228]
101413339  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
101413434  RHOA; transforming protein RhoA [KO:K04513]
101413464  [KO:K01539] [EC:7.2.2.13]
101413809  [KO:K04345] [EC:2.7.11.11]
101414043  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101414060  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101414190  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
101414407  BAD; bcl2-associated agonist of cell death [KO:K02158]
101414637  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101414723  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101415315  HTR1A; LOW QUALITY PROTEIN: 5-hydroxytryptamine receptor 1A [KO:K04153]
101415633  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
101415638  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X2 [KO:K12490]
101416102  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101416281  ATP1A1; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
101416357  [KO:K04950]
101416433  [KO:K11265] [EC:4.6.1.1]
101416459  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
101416595  CALM2; calmodulin-2 [KO:K02183]
101416895  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
101417075  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
101417326  GCG; glucagon isoform X1 [KO:K05259]
101417345  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101417556  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
101417819  RAPGEF3; rap guanine nucleotide exchange factor 3 [KO:K08014]
101417885  RELA; transcription factor p65 [KO:K04735]
101417995  CALM1; calmodulin-1 [KO:K02183]
101418035  [KO:K04578]
101418064  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
101418402  KCNK2; potassium channel subfamily K member 2 [KO:K04913]
101418484  [KO:K04851]
101419022  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101419186  CREBBP; LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101419332  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
101419564  [KO:K00232] [EC:1.3.3.6]
101419875  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
101420117  POPDC2; popeye domain-containing protein 2 isoform X1 [KO:K26206]
101420546  [KO:K04369] [EC:2.7.12.2]
101420660  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
101420793  PLN; cardiac phospholamban [KO:K05852]
101421086  RAC1; LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101421103  RAP1B; ras-related protein Rap-1b [KO:K07836]
101421211  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101421427  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
101421718  ADCY10; adenylate cyclase type 10 [KO:K11265] [EC:4.6.1.1]
101421932  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
101422031  CNGA4; LOW QUALITY PROTEIN: cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
101422060  [KO:K05850] [EC:7.2.2.10]
101422669  [KO:K06225]
101422732  [KO:K08048] [EC:4.6.1.1]
101423692  PRKACB; LOW QUALITY PROTEIN: cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101423710  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
101423744  [KO:K02649]
101423833  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
101423913  VIPR2; vasoactive intestinal polypeptide receptor 2 [KO:K04590]
101424607  EDN3; endothelin-3 isoform X1 [KO:K05227]
101424631  CREB3L3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
101424766  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
101424874  RRAS; ras-related protein R-Ras [KO:K07829]
101425370  SUCNR1; succinate receptor 1 [KO:K10042]
101426212  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
101426391  CNGB3; LOW QUALITY PROTEIN: cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
101426399  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
101426465  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
101426647  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
101426945  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101426965  CALM3; calmodulin-3 [KO:K02183]
101427056  NPPA; natriuretic peptides A [KO:K12334]
101427192  DRD1; D(1A) dopamine receptor [KO:K04144]
101427247  [KO:K00232] [EC:1.3.3.6]
101427262  PDE3A; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
101427403  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
101427610  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
101427882  NFATC1; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 1 [KO:K04446]
101427908  GLI1; zinc finger protein GLI1 [KO:K16797]
101427927  ADCY7; LOW QUALITY PROTEIN: adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101428036  SF3A2; splicing factor 3A subunit 2 [KO:K04665]
101428152  [KO:K04632]
101428161  [KO:K17388] [EC:2.7.11.1]
101428221  CAMK4; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
101428552  BDNF; brain-derived neurotrophic factor [KO:K04355]
101428607  EDN2; endothelin-2 [KO:K16367]
101428799  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101429453  GIP; gastric inhibitory polypeptide [KO:K05258]
101429462  SSTR5; somatostatin receptor type 5 [KO:K04221]
101429528  LHB; lutropin subunit beta [KO:K08521]
101429660  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
101429691  GLI3; transcriptional activator GLI3 isoform X4 [KO:K06230]
101429693  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
101430071  CRH; corticoliberin [KO:K05256]
101430150  ADORA2A; adenosine receptor A2a [KO:K04266]
101430243  PPARA; peroxisome proliferator-activated receptor alpha isoform X4 [KO:K07294]
101430250  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
101430299  [KO:K02183]
101430559  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
101430570  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101430812  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
101430977  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
101431063  PPP1R1B; protein phosphatase 1 regulatory subunit 1B isoform X1 [KO:K15494]
101431151  F2R; proteinase-activated receptor 1 [KO:K03914]
101431251  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
101431301  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X9 [KO:K04850]
101431334  GHRL; appetite-regulating hormone [KO:K05254]
101431384  ADRB2; beta-2 adrenergic receptor [KO:K04142]
101431477  [KO:K07836]
101431586  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
101431654  RAP1A; ras-related protein Rap-1A [KO:K04353]
101431782  FOS; proto-oncogene c-Fos [KO:K04379]
101431824  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
101431998  OXT; oxytocin-neurophysin 1 [KO:K05243]
101432404  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
101432615  ADORA1; adenosine receptor A1 [KO:K04265]
101432953  GRIA1; glutamate receptor 1 [KO:K05197]
101433347  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101433426  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X1 [KO:K13293] [EC:3.1.4.53]
101433568  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
101433830  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
101433838  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
101434003  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
101434213  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
101434262  CGA; glycoprotein hormones alpha chain [KO:K08522]
101434860  CREB1; cyclic AMP-responsive element-binding protein 1 [KO:K05870]
101434958  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
101435045  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
101435137  HHIP; hedgehog-interacting protein isoform X1 [KO:K06231]
101435246  GRIA2; glutamate receptor 2 isoform X7 [KO:K05198]
101435268  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101435311  [KO:K05210]
101435351  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101435604  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101435652  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101435683  DRD5; D(1B) dopamine receptor [KO:K05840]
101435742  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101436856  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
101437293  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X1 [KO:K04587]
101437415  [KO:K02183]
101437556  NFKB1; LOW QUALITY PROTEIN: nuclear factor NF-kappa-B p105 subunit [KO:K02580]
101437569  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
101438280  FSHR; follicle-stimulating hormone receptor [KO:K04247]
101438462  SOX9; LOW QUALITY PROTEIN: transcription factor SOX-9 [KO:K18435]
101438577  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540]
101438594  [KO:K05860] [EC:3.1.4.11]
101438701  NPR1; LOW QUALITY PROTEIN: atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
101438745  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X4 [KO:K04515] [EC:2.7.11.17]
101438981  SST; somatostatin [KO:K05237]
101439024  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101439506  ROCK1; rho-associated protein kinase 1 isoform X2 [KO:K04514] [EC:2.7.11.1]
101439627  FFAR2; free fatty acid receptor 2 [KO:K04328]
101439804  SSTR1; somatostatin receptor type 1 isoform X1 [KO:K04217]
101439891  SSTR2; somatostatin receptor type 2 [KO:K04218]
101440135  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
101440357  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101440391  EDN1; endothelin-1 [KO:K16366]
101440531  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
101440576  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
101441254  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
101441265  TSHR; thyrotropin receptor [KO:K04249]
101441300  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
101441349  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
101441754  [KO:K01115] [EC:3.1.4.4]
101441846  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
101441858  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
101442310  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
101442429  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2 [KO:K04515] [EC:2.7.11.17]
101442901  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101442950  ADCY6; adenylate cyclase type 6 [KO:K08046] [EC:4.6.1.1]
101443141  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101443248  [KO:K07860]
101443396  [KO:K04513]
101443500  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
101443520  TSHB; thyrotropin subunit beta [KO:K05251]
101443761  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101444276  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101444293  ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
101444307  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
101444335  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
101444372  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
101444408  AFDN; afadin [KO:K05702]
101444637  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
101444762  PPP1CA; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101444838  [KO:K08402]
101445509  [KO:K01539] [EC:7.2.2.13]
101445596  [KO:K04345] [EC:2.7.11.11]
101445683  CAMK2B; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
101445733  EDNRA; endothelin-1 receptor [KO:K04197]
101445813  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101445951  PLD2; phospholipase D2 [KO:K01115] [EC:3.1.4.4]
101445986  CNGB1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
101446375  POPDC3; popeye domain-containing protein 3 [KO:K26207]
101446392  FSHB; follitropin subunit beta [KO:K05250]
101446748  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
101446836  [KO:K05250]
101446956  ABCC4; LOW QUALITY PROTEIN: multidrug resistance-associated protein 4 [KO:K05673]
101446965  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
101447413  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
101447438  BVES; LOW QUALITY PROTEIN: blood vessel epicardial substance [KO:K21108]
101447550  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
101447587  NPY; pro-neuropeptide Y [KO:K05232]
101447782  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
101447857  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
101447951  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X2 [KO:K04630]
105744587  [KO:K02183]
105745722  TNNI3; troponin I, cardiac muscle [KO:K12044]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
PMID:24450633
  Authors
Roberts OL, Dart C
  Title
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
  Journal
Biochem Soc Trans 42:89-97 (2014)
DOI:10.1042/BST20130253
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
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Related
pathway
dnm00071  Fatty acid degradation
dnm04015  Rap1 signaling pathway
dnm04020  Calcium signaling pathway
dnm04151  PI3K-Akt signaling pathway
dnm04210  Apoptosis
dnm04260  Cardiac muscle contraction
dnm04340  Hedgehog signaling pathway
dnm04720  Long-term potentiation
dnm04740  Olfactory transduction
dnm04972  Pancreatic secretion
dnm04976  Bile secretion
KO pathway
ko04024   

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