KEGG   PATHWAY: fca04640
Entry
fca04640                    Pathway                                
Name
Hematopoietic cell lineage - Felis catus (domestic cat)
Description
Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes.
Class
Organismal Systems; Immune system
Pathway map
fca04640  Hematopoietic cell lineage
fca04640

Organism
Felis catus (domestic cat) [GN:fca]
Gene
100125860  CD19; B-lymphocyte antigen CD19 isoform X2 [KO:K06465]
100169654  DRA; MHC class II antigen DRA precursor [KO:K06752]
100302539  THPO; thrombopoietin precursor [KO:K06854]
101080705  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
101080743  [KO:K06262]
101080762  [KO:K06448]
101080961  IL1R2; interleukin-1 receptor type 2 isoform X2 [KO:K04387]
101081100  CD22; B-cell receptor CD22 isoform X2 [KO:K06467]
101081274  [KO:K06448]
101081364  EPOR; erythropoietin receptor isoform X2 [KO:K05079]
101081745  ITGA4; integrin alpha-4 isoform X1 [KO:K06483]
101083107  CD3D; T-cell surface glycoprotein CD3 delta chain isoform X1 [KO:K06450]
101083293  CD5; T-cell surface glycoprotein CD5 [KO:K06455]
101084179  GP9; platelet glycoprotein IX [KO:K06263]
101084597  IL7; interleukin-7 isoform X1 [KO:K05431]
101085086  IL11; interleukin-11 isoform X2 [KO:K05417]
101085689  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
101085930  IL11RA; interleukin-11 receptor subunit alpha isoform X5 [KO:K05056]
101087516  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
101087936  FCGR1A; LOW QUALITY PROTEIN: high affinity immunoglobulin gamma Fc receptor I [KO:K06498]
101087957  ITGAM; integrin alpha-M isoform X1 [KO:K06461]
101088734  [KO:K06752]
101088996  DRA; HLA class II histocompatibility antigen, DR alpha chain-like precursor [KO:K06752]
101089292  CD3G; T-cell surface glycoprotein CD3 gamma chain [KO:K06452]
101089743  ITGA1; integrin alpha-1 isoform X2 [KO:K06480]
101089787  CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061]
101090237  ITGA2; integrin alpha-2 [KO:K06481]
101090457  GP5; platelet glycoprotein V [KO:K06260]
101090518  [KO:K06752]
101090771  [KO:K06752]
101091467  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
101092159  ITGB3; integrin beta-3 [KO:K06493]
101092210  CD59; CD59 glycoprotein [KO:K04008]
101092307  GP1BA; platelet glycoprotein Ib alpha chain [KO:K06261]
101092454  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
101093156  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
101093842  CD36; platelet glycoprotein 4 [KO:K06259]
101093870  ITGA5; integrin alpha-5 [KO:K06484]
101094153  CSF2; granulocyte-macrophage colony-stimulating factor precursor [KO:K05427]
101094393  CR2; complement receptor type 2 isoform X1 [KO:K04012]
101094644  CD55; complement decay-accelerating factor isoform X1 [KO:K04006]
101096132  CD14; monocyte differentiation antigen CD14 [KO:K04391]
101096277  IL4R; interleukin-4 receptor subunit alpha [KO:K05071]
101096291  FCER2; low affinity immunoglobulin epsilon Fc receptor isoform X3 [KO:K06468]
101097099  DNTT; DNA nucleotidylexotransferase isoform X1 [KO:K00977] [EC:2.7.7.31]
101098275  IL9R; interleukin-9 receptor isoform X3 [KO:K05073]
101098301  [KO:K06752]
101098516  [KO:K06448]
101098744  CD44; CD44 antigen isoform X7 [KO:K06256]
101098769  [KO:K06448]
101099031  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
101099165  CD37; leukocyte antigen CD37 isoform X1 [KO:K06475]
101099264  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
101099272  [KO:K06448]
101100621  [KO:K05066]
101100697  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
101100784  CD1D; antigen-presenting glycoprotein CD1d [KO:K06448]
101100930  ITGA2B; integrin alpha-IIb [KO:K06476]
101101308  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 isoform X1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
102899461  CR1L; complement component receptor 1-like protein isoform X2 [KO:K04011]
102901718  [KO:K05066]
105259666  [KO:K06448]
105260178  [KO:K06448]
105261394  IL3RA; interleukin-3 receptor subunit alpha isoform X1 [KO:K04737]
109498956  GYPA; glycophorin-A isoform X1 [KO:K06575]
111556169  [KO:K06752]
111556173  [KO:K06752]
111556176  [KO:K06752]
111558969  [KO:K06752]
111560441  [KO:K06752]
111560443  [KO:K06752]
111560806  [KO:K04736]
123381200  [KO:K06262]
493687  IL6; interleukin-6 precursor [KO:K05405]
493700  CSF3; granulocyte colony-stimulating factor precursor [KO:K05423]
493706  CSF1R; macrophage colony-stimulating factor 1 receptor precursor [KO:K05090] [EC:2.7.10.1]
493755  TNF; tumor necrosis factor precursor [KO:K03156]
493766  KIT; mast/stem cell growth factor receptor Kit precursor [KO:K05091] [EC:2.7.10.1]
493775  CD4; T-cell surface glycoprotein CD4 precursor [KO:K06454]
493785  ANPEP; aminopeptidase N [KO:K11140] [EC:3.4.11.2]
493790  CD2; T-cell surface antigen CD2 precursor [KO:K06449]
493796  FLT3LG; fms related tyrosine kinase 3 ligand precursor [KO:K05454]
493799  CD8A; T-cell surface glycoprotein CD8 alpha chain precursor [KO:K06458]
493801  EPO; erythropoietin precursor [KO:K05437]
493803  IL5; interleukin-5 precursor [KO:K05428]
493848  CD7; T-cell antigen CD7 precursor [KO:K06457]
493874  CD9; CD9 antigen [KO:K06460]
493880  TFRC; transferrin receptor protein 1 [KO:K06503]
493884  CD34; hematopoietic progenitor cell antigen CD34 precursor [KO:K06474]
493936  CD3E; T-cell surface glycoprotein CD3 epsilon chain precursor [KO:K06451]
493937  KITLG; kit ligand precursor [KO:K05461]
493944  IL1A; interleukin-1 alpha precursor [KO:K04383]
493948  CD8B; T-cell surface glycoprotein CD8 beta chain precursor [KO:K06459]
493953  IL2RA; interleukin-2 receptor subunit alpha precursor [KO:K05068]
494216  MS4A1; B-lymphocyte antigen CD20 [KO:K06466]
751514  IL4; interleukin-4 precursor [KO:K05430]
768274  IL1B; interleukin-1 beta [KO:K04519]
Reference
  Authors
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ
  Title
Immunobiology - International editon: The immune system in health and disease
  Journal
Harcourt Publishers Ltd, a subsidiary of Harcourt International Ltd (2001)
Reference
  Authors
Abe T
  Title
[Atlas of malignancies in hematopoietic organ - Morphology, immunology, chromosome and gene] (In Japanese)
  Journal
Nihonijishinhousya (2000)
Reference
PMID:15771582
  Authors
Rothenberg EV, Taghon T.
  Title
Molecular genetics of T cell development.
  Journal
Annu Rev Immunol 23:601-49 (2005)
DOI:10.1146/annurev.immunol.23.021704.115737
Reference
PMID:12415312
  Authors
Ceredig R, Rolink T.
  Title
A positive look at double-negative thymocytes.
  Journal
Nat Rev Immunol 2:888-97 (2002)
DOI:10.1038/nri937
Reference
PMID:15156179
  Authors
de Bruijn MF, Speck NA.
  Title
Core-binding factors in hematopoiesis and immune function.
  Journal
Oncogene 23:4238-48 (2004)
DOI:10.1038/sj.onc.1207763
Reference
PMID:14985712
  Authors
Radtke F, Wilson A, Mancini SJ, MacDonald HR.
  Title
Notch regulation of lymphocyte development and function.
  Journal
Nat Immunol 5:247-53 (2004)
DOI:10.1038/ni1045
Reference
PMID:12360214
  Authors
Spits H.
  Title
Development of alphabeta T cells in the human thymus.
  Journal
Nat Rev Immunol 2:760-72 (2002)
DOI:10.1038/nri913
Reference
PMID:9927518
  Authors
Di Santo JP, Aifantis I, Rosmaraki E, Garcia C, Feinberg J, Fehling HJ, Fischer A, von Boehmer H, Rocha B.
  Title
The common cytokine receptor gamma chain and the pre-T cell receptor provide independent but critically overlapping signals in early alpha/beta T cell development.
  Journal
J Exp Med 189:563-74 (1999)
DOI:10.1084/jem.189.3.563
Reference
PMID:11905810
  Authors
Mak TW, Penninger JM, Ohashi PS.
  Title
Knockout mice: a paradigm shift in modern immunology.
  Journal
Nat Rev Immunol 1:11-9 (2001)
DOI:10.1038/35095551
Reference
PMID:15738953
  Authors
Shapiro-Shelef M, Calame K.
  Title
Regulation of plasma-cell development.
  Journal
Nat Rev Immunol 5:230-42 (2005)
DOI:10.1038/nri1572
Reference
PMID:14670296
  Authors
Maillard I, Adler SH, Pear WS.
  Title
Notch and the immune system.
  Journal
Immunity 19:781-91 (2003)
DOI:10.1016/S1074-7613(03)00325-X
Reference
PMID:15629410
  Authors
Alpdogan O, van den Brink MR.
  Title
IL-7 and IL-15: therapeutic cytokines for immunodeficiency.
  Journal
Trends Immunol 26:56-64 (2005)
DOI:10.1016/j.it.2004.11.002
KO pathway
ko04640   

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