KEGG   PATHWAY: hsa04914
Entry
hsa04914                    Pathway                                
Name
Progesterone-mediated oocyte maturation - Homo sapiens (human)
Description
Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.
Class
Organismal Systems; Endocrine system
Pathway map
hsa04914  Progesterone-mediated oocyte maturation
hsa04914

Drug
D00066  Progesterone (JP18/USP/INN)
D00182  Norethindrone (USP)
D00289  Danazol (JP18/USP/INN)
D00585  Mifepristone (JAN/USAN/INN)
D00949  Hydroxyprogesterone caproate (JAN/USP/INN)
D00950  Levonorgestrel (JAN/USP/INN)
D00951  Medroxyprogesterone acetate (JP18/USP)
D00952  Megestrol acetate (USP)
D00953  Norethindrone acetate (USP)
D00954  Norgestrel (JP18/USP/INN)
D01159  Gestonorone caproate (JAN/USAN)
D01217  Dydrogesterone (JP18/USP/INN)
D01294  Ethynodiol diacetate (JAN/USP)
D01299  Chlormadinone acetate (JP18/USAN)
D01374  Allylestrenol (JAN/INN)
D01580  Lynestrenol (JAN/USAN)
D02367  Desogestrel (USAN/INN)
D02996  Asoprisnil (USAN/INN)
D03799  Dienogest (JAN/USAN/INN)
D03917  Drospirenone (JAN/USP/INN)
D04104  Etonogestrel (USAN/INN)
D04315  Gestaclone (USAN/INN)
D04316  Gestodene (USAN/INN)
D04885  Medrogestone (USAN/INN)
D05003  Methynodiol diacetate (USAN)
D05009  Metogest (USAN/INN)
D05205  Norelgestromin (USP/INN)
D05207  Norethynodrel (USAN)
D05209  Norgestimate (USP/INN)
D05308  Oxogestone phenpropionate (USAN)
D05679  Quingestanol acetate (USAN)
D05680  Quingestrone (USAN/INN)
D06003  Tanaproget (USAN/INN)
D06145  Tigestol (USAN/INN)
D06197  Tosagestin (USAN/INN)
D06235  Trimegestone (USAN/INN)
D07096  Aglepristone (INN)
D07220  Norgestrienone (INN)
D07222  Nomegestrol (USAN/INN)
D07223  Demegestone (INN)
D07670  Chlormadinone (INN)
D07939  Etynodiol (INN)
D07968  Flugestone (INN)
D08052  Hydroxyprogesterone (INN)
D08053  Hydroxyprogesterone 17alfa-acetate
D08166  Medroxyprogesterone (INN)
D08167  Megestrol (INN)
D08281  Nomegestrol acetate (USAN)
D08285  Norethisterone enantate
D08431  Promegestone (INN)
D09567  Ulipristal (USAN/INN)
D09571  Onapristone (INN)
D09687  Ulipristal acetate (JAN/USAN)
D09972  Telapristone acetate (USAN)
D10986  Segesterone acetate (USAN)
D10987  Segesterone (USAN/INN)
D11181  Vilaprisan (JAN/USAN/INN)
D12736  Lunresertib (USAN)
Other DBs
GO: 0001556
Organism
Homo sapiens (human) [GN:hsa]
Gene
10000  AKT3; RAC-gamma serine/threonine-protein kinase isoform 1 [KO:K04456] [EC:2.7.11.1]
100101268  SPDYE12; speedy protein E12 [KO:K08694]
100310812  SPDYE2B; speedy protein E2B [KO:K08694]
100505767  SPDYE18; speedy protein E18 isoform 1 [KO:K08694]
100996746  SPDYE11; speedy protein E11 [KO:K08694]
1017  CDK2; cyclin-dependent kinase 2 isoform 1 [KO:K02206] [EC:2.7.11.22]
102723555  SPDYE16; speedy protein E16 isoform 1 [KO:K08694]
102723849  SPDYE17; speedy protein E17 [KO:K08694]
10393  ANAPC10; anaphase-promoting complex subunit 10 isoform 1 [KO:K03357]
10459  MAD2L2; mitotic spindle assembly checkpoint protein MAD2B [KO:K13728]
105180390  SPDYE13; speedy/RINGO cell cycle regulator family member E13 [KO:K08694]
105180391  SPDYE15; speedy protein E15 [KO:K08694]
107  ADCY1; adenylate cyclase type 1 isoform 1 [KO:K08041] [EC:4.6.1.1]
108  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
109  ADCY3; adenylate cyclase type 3 isoform 2 [KO:K08043] [EC:4.6.1.1]
110117499  P3R3URF-PIK3R3; LOC110117498-PIK3R3 readthrough [KO:K02649]
111  ADCY5; adenylate cyclase type 5 isoform 1 [KO:K08045] [EC:4.6.1.1]
112  ADCY6; adenylate cyclase type 6 isoform 1 [KO:K08046] [EC:4.6.1.1]
113  ADCY7; adenylate cyclase type 7 isoform 1 [KO:K08047] [EC:4.6.1.1]
114  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
115  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
119504  ANAPC16; anaphase-promoting complex subunit 16 isoform 1 [KO:K25229]
132864  CPEB2; cytoplasmic polyadenylation element-binding protein 2 isoform C [KO:K02602]
1432  MAPK14; mitogen-activated protein kinase 14 isoform 2 [KO:K04441] [EC:2.7.11.24]
196883  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
207  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
208  AKT2; RAC-beta serine/threonine-protein kinase isoform 1 [KO:K04456] [EC:2.7.11.1]
22849  CPEB3; cytoplasmic polyadenylation element-binding protein 3 isoform 1 [KO:K02602]
245711  SPDYA; speedy protein A isoform 1 [KO:K08694]
246184  CDC26; anaphase-promoting complex subunit CDC26 [KO:K03359]
25847  ANAPC13; anaphase-promoting complex subunit 13 [KO:K12456]
25906  ANAPC15; anaphase-promoting complex subunit 15 isoform b [KO:K25228]
27330  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform 2 [KO:K04373] [EC:2.7.11.1]
2770  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1 [KO:K04630]
2771  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 1 [KO:K04630]
2773  GNAI3; guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
285955  SPDYE1; speedy protein E1 isoform 2 [KO:K08694]
29882  ANAPC2; anaphase-promoting complex subunit 2 [KO:K03349]
29945  ANAPC4; anaphase-promoting complex subunit 4 isoform 2 [KO:K03351]
3320  HSP90AA1; heat shock protein HSP 90-alpha isoform 2 [KO:K04079]
3326  HSP90AB1; heat shock protein HSP 90-beta isoform a [KO:K04079]
3479  IGF1; insulin-like growth factor 1 isoform 3 preproprotein [KO:K05459]
3480  IGF1R; insulin-like growth factor 1 receptor isoform 1 precursor [KO:K05087] [EC:2.7.10.1]
3630  INS; insulin preproprotein [KO:K04526]
369  ARAF; serine/threonine-protein kinase A-Raf isoform 1 [KO:K08845] [EC:2.7.11.1]
3835  KIF22; kinesin-like protein KIF22 isoform 1 [KO:K10403]
3845  KRAS; GTPase KRas isoform a [KO:K07827]
387778  SPDYC; speedy protein C [KO:K08694]
388333  SPDYE4; speedy protein E4 [KO:K08694]
4085  MAD2L1; mitotic spindle assembly checkpoint protein MAD2A [KO:K02537]
4342  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
441272  SPDYE3; speedy protein E3 [KO:K08694]
441273  SPDYE2; speedy protein E2 [KO:K08694]
442572  SPDYE21; speedy protein E21 [KO:K08694]
442590  SPDYE5; speedy protein E5 [KO:K08694]
51343  FZR1; fizzy-related protein homolog isoform 1 [KO:K03364]
5140  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform 2 [KO:K13296] [EC:3.1.4.17]
51433  ANAPC5; anaphase-promoting complex subunit 5 isoform a [KO:K03352]
51434  ANAPC7; anaphase-promoting complex subunit 7 isoform a [KO:K03354]
51529  ANAPC11; anaphase-promoting complex subunit 11 isoform 2 [KO:K03358]
5241  PGR; progesterone receptor isoform B [KO:K08556]
5290  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
5291  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform 1 [KO:K00922] [EC:2.7.1.153]
5293  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform 1 [KO:K00922] [EC:2.7.1.153]
5295  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform 1 [KO:K02649]
5296  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
5347  PLK1; serine/threonine-protein kinase PLK1 [KO:K06631] [EC:2.7.11.21]
5566  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform Calpha1 [KO:K04345] [EC:2.7.11.11]
5567  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform 2 [KO:K04345] [EC:2.7.11.11]
5568  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
5594  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
5595  MAPK3; mitogen-activated protein kinase 3 isoform 1 [KO:K04371] [EC:2.7.11.24]
5599  MAPK8; mitogen-activated protein kinase 8 isoform alpha2 [KO:K04440] [EC:2.7.11.24]
5600  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
5601  MAPK9; mitogen-activated protein kinase 9 isoform alpha2 [KO:K04440] [EC:2.7.11.24]
5602  MAPK10; mitogen-activated protein kinase 10 isoform 1 [KO:K04440] [EC:2.7.11.24]
5603  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
5604  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform 1 [KO:K04368] [EC:2.7.12.2]
5894  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform b [KO:K04366] [EC:2.7.11.1]
6195  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform a [KO:K04373] [EC:2.7.11.1]
6196  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform a [KO:K04373] [EC:2.7.11.1]
6197  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform 1 [KO:K04373] [EC:2.7.11.1]
6300  MAPK12; mitogen-activated protein kinase 12 isoform 1 [KO:K04441] [EC:2.7.11.24]
641776  SPDYE14; speedy protein E14 [KO:K08694]
643862  SPDYE10; speedy protein E10 [KO:K08694]
643909  SPDYE9; speedy/RINGO cell cycle regulator family member E9 [KO:K08694]
64506  CPEB1; cytoplasmic polyadenylation element-binding protein 1 isoform 2 [KO:K02602]
64682  ANAPC1; anaphase-promoting complex subunit 1 [KO:K03348]
673  BRAF; serine/threonine-protein kinase B-raf isoform 1 [KO:K04365] [EC:2.7.11.1]
6790  AURKA; aurora kinase A isoform 1 [KO:K11481] [EC:2.7.11.1]
6793  STK10; serine/threonine-protein kinase 10 [KO:K08837] [EC:2.7.11.1]
699  BUB1; mitotic checkpoint serine/threonine-protein kinase BUB1 isoform 1 [KO:K02178] [EC:2.7.11.1]
728524  SPDYE8; speedy protein E8 [KO:K08694]
729597  SPDYE6; speedy protein E6 [KO:K08694]
80315  CPEB4; cytoplasmic polyadenylation element-binding protein 4 isoform a [KO:K02602]
8379  MAD1L1; mitotic spindle assembly checkpoint protein MAD1 isoform a [KO:K06679]
8503  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform 1 [KO:K02649]
85417  CCNB3; G2/mitotic-specific cyclin-B3 isoform 3 [KO:K21771]
8697  CDC23; cell division cycle protein 23 homolog [KO:K03355]
8881  CDC16; cell division cycle protein 16 homolog isoform 1 [KO:K03353]
890  CCNA2; cyclin-A2 [KO:K06627]
8900  CCNA1; cyclin-A1 [KO:K06627]
891  CCNB1; G2/mitotic-specific cyclin-B1 isoform 1 [KO:K05868]
9088  PKMYT1; membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform 1 [KO:K06633] [EC:2.7.11.1]
9133  CCNB2; G2/mitotic-specific cyclin-B2 [KO:K21770]
983  CDK1; cyclin-dependent kinase 1 isoform 1 [KO:K02087] [EC:2.7.11.22 2.7.11.23]
993  CDC25A; M-phase inducer phosphatase 1 isoform a [KO:K06645] [EC:3.1.3.48]
994  CDC25B; M-phase inducer phosphatase 2 isoform 1 [KO:K05866] [EC:3.1.3.48]
995  CDC25C; M-phase inducer phosphatase 3 isoform a [KO:K05867] [EC:3.1.3.48]
996  CDC27; cell division cycle protein 27 homolog isoform 2 [KO:K03350]
Compound
C00410  Progesterone
C00575  3',5'-Cyclic AMP
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:12045215
  Authors
Schmitt A, Nebreda AR.
  Title
Signalling pathways in oocyte meiotic maturation.
  Journal
J Cell Sci 115:2457-9 (2002)
Reference
PMID:12084906
  Authors
Cato AC, Nestl A, Mink S.
  Title
Rapid actions of steroid receptors in cellular signaling pathways.
  Journal
Sci STKE 2002:RE9 (2002)
DOI:10.1126/stke.2002.138.re9
Reference
PMID:11730319
  Authors
Maller JL, Schwab MS, Roberts BT, Gross SD, Taieb FE, Tunquist BJ.
  Title
The pathway of MAP kinase mediation of CSF arrest in Xenopus oocytes.
  Journal
Biol Cell 93:27-33 (2001)
DOI:10.1016/S0248-4900(01)01127-3
Reference
PMID:11063930
  Authors
Nebreda AR, Ferby I.
  Title
Regulation of the meiotic cell cycle in oocytes.
  Journal
Curr Opin Cell Biol 12:666-75 (2000)
DOI:10.1016/S0955-0674(00)00150-2
Reference
PMID:10497333
  Authors
Ferrell JE Jr.
  Title
Xenopus oocyte maturation: new lessons from a good egg.
  Journal
Bioessays 21:833-42 (1999)
DOI:10.1002/(SICI)1521-1878(199910)21:10<833::AID-BIES5>3.0.CO;2-P
Reference
PMID:12374568
  Authors
Andersen CB, Sakaue H, Nedachi T, Kovacina KS, Clayberger C, Conti M, Roth RA.
  Title
Protein kinase B/Akt is essential for the insulin- but not progesterone-stimulated resumption of meiosis in Xenopus oocytes.
  Journal
Biochem J 369:227-38 (2003)
DOI:10.1042/BJ20021243
Reference
PMID:12477927
  Authors
Duckworth BC, Weaver JS, Ruderman JV.
  Title
G2 arrest in Xenopus oocytes depends on phosphorylation of cdc25 by protein kinase A.
  Journal
Proc Natl Acad Sci U S A 99:16794-9 (2002)
DOI:10.1073/pnas.222661299
Reference
PMID:11148128
  Authors
Abrieu A, Doree M, Fisher D.
  Title
The interplay between cyclin-B-Cdc2 kinase (MPF) and MAP kinase during maturation of oocytes.
  Journal
J Cell Sci 114:257-67 (2001)
Related
pathway
hsa04010  MAPK signaling pathway
hsa04110  Cell cycle
KO pathway
ko04914   

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