KEGG   PATHWAY: lav04024
Entry
lav04024                    Pathway                                
Name
cAMP signaling pathway - Loxodonta africana (African savanna elephant)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
lav04024  cAMP signaling pathway
lav04024

Other DBs
GO: 0019933
Organism
Loxodonta africana (African savanna elephant) [GN:lav]
Gene
100653532  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
100653538  GRIN2D; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100653565  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
100653571  CNGA3; cyclic nucleotide-gated cation channel alpha-3 [KO:K04950]
100653709  GLI1; zinc finger protein GLI1 [KO:K16797]
100653731  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100653771  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
100653783  ADORA2A; adenosine receptor A2a [KO:K04266]
100653927  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
100654522  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
100654542  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
100654723  EDNRA; endothelin-1 receptor [KO:K04197]
100654730  RELA; transcription factor p65 isoform X2 [KO:K04735]
100654943  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
100654973  ADRB1; LOW QUALITY PROTEIN: beta-1 adrenergic receptor [KO:K04141]
100655094  ADCY10; adenylate cyclase type 10 isoform X1 [KO:K11265] [EC:4.6.1.1]
100655206  [KO:K04632]
100655542  ATP2B2; plasma membrane calcium-transporting ATPase 2 [KO:K05850] [EC:7.2.2.10]
100655623  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X3 [KO:K04446]
100655666  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 [KO:K01540]
100655727  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100655802  RAPGEF3; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 3 [KO:K08014]
100656098  RRAS; ras-related protein R-Ras isoform X3 [KO:K07829]
100656123  SST; somatostatin [KO:K05237]
100656164  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
100656237  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
100656270  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase A [KO:K19021] [EC:3.1.4.17]
100656297  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
100656346  EDN3; endothelin-3 [KO:K05227]
100656362  ATP2B3; plasma membrane calcium-transporting ATPase 3 [KO:K05850] [EC:7.2.2.10]
100656553  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
100656573  PDE4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D isoform X2 [KO:K13293] [EC:3.1.4.53]
100656647  VIP; VIP peptides [KO:K05264]
100656714  HHIP; hedgehog-interacting protein [KO:K06231]
100656966  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100657108  GABBR1; LOW QUALITY PROTEIN: gamma-aminobutyric acid type B receptor subunit 1 [KO:K04615]
100657131  GLI3; transcriptional activator GLI3 isoform X1 [KO:K06230]
100657212  ARAP3; LOW QUALITY PROTEIN: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 [KO:K12490]
100657418  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
100657536  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100657587  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100657612  [KO:K02183]
100657770  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
100657948  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100657997  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 [KO:K04615]
100658208  [KO:K02183]
100658240  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100658318  PLD2; LOW QUALITY PROTEIN: phospholipase D2 [KO:K01115] [EC:3.1.4.4]
100658340  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100658388  GHRL; appetite-regulating hormone [KO:K05254]
100658415  GRIA4; LOW QUALITY PROTEIN: glutamate receptor 4 [KO:K05200]
100658516  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
100658837  NPY; pro-neuropeptide Y [KO:K05232]
100658857  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100658962  CALML3; calmodulin-like protein 3 [KO:K02183]
100658980  GRIA3; glutamate receptor 3 isoform X1 [KO:K05199]
100659046  TSHR; thyrotropin receptor isoform X1 [KO:K04249]
100659244  OXTR; oxytocin receptor [KO:K04229]
100659551  CRHR1; corticotropin-releasing factor receptor 1 isoform X3 [KO:K04578]
100659992  CACNA1D; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
100660018  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
100660187  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100660199  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100660279  TSHB; thyrotropin subunit beta [KO:K05251]
100660296  POPDC2; popeye domain-containing protein 2 [KO:K26206]
100660595  PLD1; phospholipase D1 isoform X2 [KO:K01115] [EC:3.1.4.4]
100660738  GRIN2B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100660747  RAPGEF4; rap guanine nucleotide exchange factor 4 [KO:K04351]
100660792  ATP1B4; protein ATP1B4 isoform X2 [KO:K01540]
100660802  FSHR; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
100660871  PDE3B; LOW QUALITY PROTEIN: cGMP-inhibited 3',5'-cyclic phosphodiesterase B [KO:K13296] [EC:3.1.4.17]
100660875  NPPA; natriuretic peptides A [KO:K12334]
100660893  SSTR2; somatostatin receptor type 2 [KO:K04218]
100660962  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
100661096  EP300; LOW QUALITY PROTEIN: histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
100661156  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
100661342  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
100661393  POPDC3; popeye domain-containing protein 3 [KO:K26207]
100661428  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 [KO:K01539] [EC:7.2.2.13]
100661616  ADCY8; adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
100661656  SOX9; LOW QUALITY PROTEIN: transcription factor SOX-9 [KO:K18435]
100662194  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
100662363  ADCYAP1; pituitary adenylate cyclase-activating polypeptide [KO:K05262]
100662653  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
100662747  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
100663057  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
100663184  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100663321  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
100663405  CNGB3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
100663411  VIPR2; vasoactive intestinal polypeptide receptor 2 [KO:K04590]
100663448  ADCY9; LOW QUALITY PROTEIN: adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
100663507  CALM1; calmodulin-1 [KO:K02183]
100663731  [KO:K04498] [EC:2.3.1.48]
100663779  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
100664119  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
100664204  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100664328  HTR4; 5-hydroxytryptamine receptor 4 isoform X1 [KO:K04160]
100664615  ADRB2; beta-2 adrenergic receptor [KO:K04142]
100664674  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
100664679  CALM2; calmodulin-2 [KO:K02183]
100664784  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
100665045  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100665073  [KO:K08402]
100665157  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100665185  RAP1B; ras-related protein Rap-1b [KO:K07836]
100665326  CNGA4; LOW QUALITY PROTEIN: cyclic nucleotide-gated cation channel alpha-4 [KO:K04951]
100665731  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
100665784  SSTR1; LOW QUALITY PROTEIN: somatostatin receptor type 1 [KO:K04217]
100665933  PLN; cardiac phospholamban [KO:K05852]
100666211  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
100666266  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100666344  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
100666496  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100666579  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [KO:K18438] [EC:3.1.4.17 3.1.4.35]
100666748  FSHB; follitropin subunit beta [KO:K05250]
100667193  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
100667499  PDE4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B [KO:K13293] [EC:3.1.4.53]
100667611  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
100667623  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100667801  [KO:K01539] [EC:7.2.2.13]
100667885  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
100667957  GNAI3; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
100668003  [KO:K04409] [EC:2.7.11.1]
100668073  ACOX3; LOW QUALITY PROTEIN: peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
100668326  ATP1A3; LOW QUALITY PROTEIN: sodium/potassium-transporting ATPase subunit alpha-3 [KO:K01539] [EC:7.2.2.13]
100668387  BAD; bcl2-associated agonist of cell death [KO:K02158]
100668498  DRD1; D(1A) dopamine receptor [KO:K04144]
100668524  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
100668572  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
100668599  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
100668753  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
100668995  F2R; proteinase-activated receptor 1 [KO:K03914]
100669102  POMC; LOW QUALITY PROTEIN: pro-opiomelanocortin [KO:K05228]
100669226  [KO:K04632]
100669239  BVES; blood vessel epicardial substance [KO:K21108]
100669326  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
100669420  AFDN; afadin isoform X2 [KO:K05702]
100669711  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
100669885  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
100670080  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100670234  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
100670244  ADCY5; LOW QUALITY PROTEIN: adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
100670261  SUCNR1; succinate receptor 1 [KO:K10042]
100670356  CNGB1; cyclic nucleotide-gated cation channel beta-1 [KO:K04952]
100670432  JUN; transcription factor AP-1 [KO:K04448]
100670574  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
100670753  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100670874  LIPE; hormone-sensitive lipase [KO:K07188] [EC:3.1.1.79]
100671039  FFAR2; free fatty acid receptor 2 [KO:K04328]
100671072  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100671323  [KO:K04328]
100671333  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X1 [KO:K05869] [EC:2.7.11.17]
100671401  SSTR5; somatostatin receptor type 5 [KO:K04221]
100671572  PDE4C; LOW QUALITY PROTEIN: cAMP-specific 3',5'-cyclic phosphodiesterase 4C [KO:K13293] [EC:3.1.4.53]
100671604  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100671668  PDE4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4A [KO:K13293] [EC:3.1.4.53]
100671775  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X6 [KO:K05853] [EC:7.2.2.10]
100671961  NPR1; atrial natriuretic peptide receptor 1 [KO:K12323] [EC:4.6.1.2]
100671978  DRD2; D(2) dopamine receptor [KO:K04145]
100672434  DRD5; D(1B) dopamine receptor [KO:K05840]
100672436  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100672459  EDN1; endothelin-1 isoform X1 [KO:K16366]
100672505  CRHR2; corticotropin-releasing factor receptor 2 [KO:K04579]
100672699  LHB; lutropin subunit beta [KO:K08521]
100672824  GIP; gastric inhibitory polypeptide [KO:K05258]
100673077  CRH; LOW QUALITY PROTEIN: corticoliberin [KO:K05256]
100673089  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100673242  VAV1; LOW QUALITY PROTEIN: proto-oncogene vav [KO:K05730]
100673395  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
100673490  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
100673570  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100673668  ABCC4; multidrug resistance-associated protein 4 isoform X1 [KO:K05673]
100673694  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
100673756  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
100673814  PPP1CA; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100673911  CGA; glycoprotein hormones alpha chain [KO:K08522]
100673922  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270]
100673977  EDN2; endothelin-2 [KO:K16367]
100674070  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
100674195  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
100674229  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
100674245  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
100674374  CHRM1; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M1 [KO:K04129]
100674649  CACNA1F; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
100674677  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
100674724  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100674799  FOS; LOW QUALITY PROTEIN: proto-oncogene c-Fos [KO:K04379]
100675079  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
100675162  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
100675292  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
100675466  TIAM1; LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
100675496  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100675525  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
100675651  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
100675687  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
100675931  PTGER2; LOW QUALITY PROTEIN: prostaglandin E2 receptor EP2 subtype [KO:K04259]
100676123  PTCH1; protein patched homolog 1 [KO:K06225]
100676198  GCG; glucagon [KO:K05259]
100676204  GIPR; LOW QUALITY PROTEIN: gastric inhibitory polypeptide receptor [KO:K04580]
100676220  RAP1A; ras-related protein Rap-1A [KO:K04353]
100676453  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2 [KO:K05853] [EC:7.2.2.10]
100676506  ADORA1; adenosine receptor A1 isoform X1 [KO:K04265]
100676526  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
100676565  GRIA1; glutamate receptor 1 isoform X2 [KO:K05197]
100676729  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
100676989  [KO:K04962]
100677150  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X2 [KO:K04587]
100677344  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
100677422  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
100677444  PLCE1; LOW QUALITY PROTEIN: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
100677447  RHOA; transforming protein RhoA [KO:K04513]
104846071  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha [KO:K04515] [EC:2.7.11.17]
104846349  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
104846717  GRIA2; glutamate receptor 2 [KO:K05198]
111752838  FXYD2; sodium/potassium-transporting ATPase subunit gamma [KO:K01538]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
PMID:24450633
  Authors
Roberts OL, Dart C
  Title
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
  Journal
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Related
pathway
lav00071  Fatty acid degradation
lav04015  Rap1 signaling pathway
lav04020  Calcium signaling pathway
lav04151  PI3K-Akt signaling pathway
lav04210  Apoptosis
lav04260  Cardiac muscle contraction
lav04340  Hedgehog signaling pathway
lav04720  Long-term potentiation
lav04740  Olfactory transduction
lav04972  Pancreatic secretion
lav04976  Bile secretion
KO pathway
ko04024   

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