KEGG   PATHWAY: lve05168
Entry
lve05168                    Pathway                                
Name
Herpes simplex virus 1 infection - Lipotes vexillifer (Yangtze River dolphin)
Description
Herpes simplex virus 1(HSV-1) is a common human pathogen, which initially infects orofacial mucosal surfaces. The virus replicates in epithelial cells at these sites, causing clinically overt disease characterized by vesicular lesions. HSV-1 then penetrates to the nervous system and establishes latency in sensory neurons. Throughout the lifetime of the host, HSV-1 may reactivate from its latent state and reinitiate a lytic infection cycle. HSV-1 has developed various mechanisms to escape its host innate immune responses and increased its capacity to replicate and to persist. ICP34.5, ICP0, ICP27, Us11 and Vhs (UL41) are the proteins involved in viral interference.
Class
Human Diseases; Infectious disease: viral
Pathway map
lve05168  Herpes simplex virus 1 infection
lve05168

Disease
H00365  Herpes simplex virus infection
Organism
Lipotes vexillifer (Yangtze River dolphin) [GN:lve]
Gene
103068617  [KO:K05414]
103068644  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
103068724  [KO:K14284]
103068842  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
103068921  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103069029  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
103069117  [KO:K11220]
103069127  IFNAR2; LOW QUALITY PROTEIN: interferon alpha/beta receptor 2 [KO:K05131]
103069156  [KO:K08738]
103069181  [KO:K05414]
103069311  SRSF1; serine/arginine-rich splicing factor 1 isoform X1 [KO:K12890]
103069387  CARD9; caspase recruitment domain-containing protein 9 [KO:K12794]
103069618  [KO:K07208]
103069667  [KO:K14284]
103069739  [KO:K05414]
103069785  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
103069848  [KO:K14021]
103069880  IRF9; interferon regulatory factor 9 [KO:K04693]
103069945  POU2F2; POU domain, class 2, transcription factor 2 isoform X1 [KO:K09364]
103070103  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
103070292  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
103070370  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
103070665  SRSF6; serine/arginine-rich splicing factor 6 isoform X1 [KO:K12893]
103070686  B2M; beta-2-microglobulin [KO:K08055]
103070796  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
103070943  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
103070953  [KO:K08055]
103071774  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
103072008  EIF2B4; translation initiation factor eIF-2B subunit delta isoform X1 [KO:K03680]
103072143  TMEM173; stimulator of interferon genes protein [KO:K12654]
103072342  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
103072461  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
103072547  EIF2B3; translation initiation factor eIF-2B subunit gamma isoform X1 [KO:K03241]
103072682  JAK1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
103072764  TAP2; LOW QUALITY PROTEIN: antigen peptide transporter 2 [KO:K05654] [EC:7.4.2.14]
103072768  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
103072994  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
103073041  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
103073066  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
103073219  [KO:K05414]
103073772  [KO:K05415]
103073781  HCFC1; host cell factor 1 [KO:K14966]
103073819  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
103073874  TAPBP; LOW QUALITY PROTEIN: tapasin [KO:K08058]
103073994  ZC3HAV1; zinc finger CCCH-type antiviral protein 1 [KO:K28004]
103074114  TAPBPL; tapasin-related protein [KO:K28445]
103074326  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
103074334  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
103074387  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
103074553  ITGA5; integrin alpha-5 [KO:K06484]
103074707  CCL2; c-C motif chemokine 2 [KO:K14624]
103074746  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
103074882  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
103075051  TRAF5; TNF receptor-associated factor 5 isoform X1 [KO:K09849]
103075340  MAP3K7; mitogen-activated protein kinase kinase kinase 7-like isoform X1 [KO:K04427] [EC:2.7.11.25]
103075350  TSC2; tuberin [KO:K07207]
103075495  [KO:K08738]
103075964  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
103076235  [KO:K06751]
103076365  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103076413  PILRA; paired immunoglobulin-like type 2 receptor alpha [KO:K15411]
103076804  JAK2; tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
103077054  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
103077105  BST2; bone marrow stromal antigen 2 [KO:K06731]
103077222  IRF7; interferon regulatory factor 7 [KO:K09447]
103077294  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
103077320  EIF2B1; translation initiation factor eIF-2B subunit alpha isoform X1 [KO:K03239]
103077382  ALYREF; THO complex subunit 4 [KO:K12881]
103077772  SRPK1; SRSF protein kinase 1 [KO:K15409] [EC:2.7.11.1]
103078463  MAVS; mitochondrial antiviral-signaling protein [KO:K12648]
103078531  BID; BH3-interacting domain death agonist [KO:K04726]
103078725  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
103078847  [KO:K14284]
103079172  PDIA3; protein disulfide-isomerase A3 [KO:K08056] [EC:5.3.4.1]
103079299  IL12A; LOW QUALITY PROTEIN: interleukin-12 subunit alpha [KO:K05406]
103079638  [KO:K08738]
103079796  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
103080104  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
103080271  RHEB; GTP-binding protein Rheb [KO:K07208]
103080339  FADD; FAS-associated death domain protein [KO:K02373]
103080452  [KO:K12892]
103080471  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
103080490  PVRL1; poliovirus receptor-related protein 1 [KO:K06081]
103080519  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
103080704  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
103080887  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
103080924  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
103081090  TLR3; LOW QUALITY PROTEIN: toll-like receptor 3 [KO:K05401]
103081094  SRSF9; serine/arginine-rich splicing factor 9 [KO:K21123]
103081196  POU2F3; POU domain, class 2, transcription factor 3 isoform X1 [KO:K09364]
103081332  TYK2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
103081545  IL6; LOW QUALITY PROTEIN: interleukin-6 [KO:K05405]
103081732  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
103081741  IFNGR2; LOW QUALITY PROTEIN: interferon gamma receptor 2 [KO:K05133]
103081814  TBK1; serine/threonine-protein kinase TBK1 isoform X1 [KO:K05410] [EC:2.7.11.10]
103082113  IFNGR1; LOW QUALITY PROTEIN: interferon gamma receptor 1 [KO:K05132]
103082185  EIF2B5; translation initiation factor eIF-2B subunit epsilon [KO:K03240]
103082401  HCFC2; host cell factor 2 [KO:K27390]
103082415  PVRL2; poliovirus receptor-related protein 2 isoform X1 [KO:K06531]
103082506  EIF2B2; translation initiation factor eIF-2B subunit beta [KO:K03754]
103082644  CALR; calreticulin [KO:K08057]
103082954  MB21D1; LOW QUALITY PROTEIN: cyclic GMP-AMP synthase [KO:K17834] [EC:2.7.7.86]
103082964  TNFSF14; tumor necrosis factor ligand superfamily member 14 isoform X1 [KO:K05477]
103083060  [KO:K06751]
103083173  [KO:K08738]
103083231  TNF; tumor necrosis factor [KO:K03156]
103083505  LTA; lymphotoxin-alpha [KO:K05468]
103083608  BAD; bcl2 antagonist of cell death [KO:K02158]
103083690  C3; complement C3 [KO:K03990]
103083691  [KO:K06752]
103083704  IL12B; interleukin-12 subunit beta [KO:K05425]
103083889  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
103083960  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
103084066  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
103084128  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
103084510  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
103084615  TAP1; LOW QUALITY PROTEIN: antigen peptide transporter 1 [KO:K05653] [EC:7.4.2.14]
103084854  TWF2; toll-like receptor 9-like isoform X1 [KO:K10161]
103084975  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
103085165  [KO:K06751]
103085172  [KO:K06752]
103085220  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
103085303  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
103085336  SRSF5; serine/arginine-rich splicing factor 5 isoform X1 [KO:K12893]
103085441  [KO:K06752]
103085542  IFNG; interferon gamma [KO:K04687]
103085570  CD74; HLA class II histocompatibility antigen gamma chain [KO:K06505]
103085597  C5; LOW QUALITY PROTEIN: complement C5 [KO:K03994]
103086000  [KO:K06752]
103086084  [KO:K06269] [EC:3.1.3.16]
103086100  SRSF4; serine/arginine-rich splicing factor 4 isoform X1 [KO:K12893]
103086745  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
103086796  [KO:K06752]
103086848  IFIH1; interferon-induced helicase C domain-containing protein 1 [KO:K12647] [EC:5.6.2.6]
103086871  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
103086926  POU2F1; POU domain, class 2, transcription factor 1 [KO:K09364]
103086977  [KO:K06751]
103087142  BIRC2; LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 2 [KO:K16060]
103087297  [KO:K06752]
103087304  RELA; transcription factor p65 isoform X1 [KO:K04735]
103087433  OAS1; 2'-5'-oligoadenylate synthase 1-like [KO:K14216] [EC:2.7.7.84]
103087452  [KO:K06752]
103087567  [KO:K06752]
103087703  OAS2; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
103087881  RNASEL; LOW QUALITY PROTEIN: 2-5A-dependent ribonuclease [KO:K01165]
103088205  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
103088206  SP100; LOW QUALITY PROTEIN: SP100 nuclear antigen [KO:K15413]
103088278  TSC1; hamartin isoform X1 [KO:K07206]
103088500  CCL5; c-C motif chemokine 5 [KO:K12499]
103088633  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
103088738  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
103088756  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
103088783  PTPN11; tyrosine-protein phosphatase non-receptor type 11 [KO:K07293] [EC:3.1.3.48]
103088795  [KO:K03175] [EC:2.3.2.27]
103089123  DDX58; LOW QUALITY PROTEIN: DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 [KO:K12646] [EC:5.6.2.6]
103089257  PIK3CD; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
103089875  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
103090179  [KO:K10159]
103090340  PML; protein PML [KO:K10054] [EC:2.3.2.-]
103090438  [KO:K14284]
103090661  [KO:K05414]
103090784  IL1B; interleukin-1 beta [KO:K04519]
103090937  DAXX; death domain-associated protein 6 [KO:K02308]
103091202  [KO:K05414]
103091358  CFP; LOW QUALITY PROTEIN: properdin [KO:K15412]
103091379  SRSF2; serine/arginine-rich splicing factor 2 isoform X1 [KO:K12891]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20640  Cyclic GMP-AMP
C20935  2-5A
Reference
PMID:12787566
  Authors
Granger SW, Rickert S
  Title
LIGHT-HVEM signaling and the regulation of T cell-mediated immunity.
  Journal
Cytokine Growth Factor Rev 14:289-96 (2003)
DOI:10.1016/S1359-6101(03)00031-5
Reference
PMID:19495760
  Authors
Steinberg MW, Shui JW, Ware CF, Kronenberg M
  Title
Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners.
  Journal
Semin Immunopathol 31:207-21 (2009)
DOI:10.1007/s00281-009-0157-4
Reference
PMID:20221426
  Authors
MacLeod IJ, Minson T
  Title
Binding of herpes simplex virus type-1 virions leads to the induction of intracellular signalling in the absence of virus entry.
  Journal
PLoS One 5:e9560 (2010)
DOI:10.1371/journal.pone.0009560
Reference
PMID:23150579
  Authors
Gianni T, Leoni V, Chesnokova LS, Hutt-Fletcher LM, Campadelli-Fiume G
  Title
alphavbeta3-integrin is a major sensor and activator of innate immunity to herpes simplex virus-1.
  Journal
Proc Natl Acad Sci U S A 109:19792-7 (2012)
DOI:10.1073/pnas.1212597109
Reference
PMID:25375272
  Authors
Gianni T, Campadelli-Fiume G
  Title
The epithelial alphavbeta3-integrin boosts the MYD88-dependent TLR2 signaling in response to viral and bacterial components.
  Journal
PLoS Pathog 10:e1004477 (2014)
DOI:10.1371/journal.ppat.1004477
Reference
PMID:15056211
  Authors
Spear PG
  Title
Herpes simplex virus: receptors and ligands for cell entry.
  Journal
Cell Microbiol 6:401-10 (2004)
DOI:10.1111/j.1462-5822.2004.00389.x
Reference
PMID:12855695
  Authors
Boutell C, Everett RD
  Title
The herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 interacts with and Ubiquitinates p53.
  Journal
J Biol Chem 278:36596-602 (2003)
DOI:10.1074/jbc.M300776200
Reference
PMID:24262390
  Authors
Ma Y, He B
  Title
Recognition of herpes simplex viruses: toll-like receptors and beyond.
  Journal
J Mol Biol 426:1133-47 (2014)
DOI:10.1016/j.jmb.2013.11.012
Reference
PMID:26952111
  Authors
Su C, Zhan G, Zheng C
  Title
Evasion of host antiviral innate immunity by HSV-1, an update.
  Journal
Virol J 13:38 (2016)
DOI:10.1186/s12985-016-0495-5
Reference
PMID:21994567
  Authors
Melchjorsen J, Matikainen S, Paludan SR
  Title
Activation and evasion of innate antiviral immunity by herpes simplex virus.
  Journal
Viruses 1:737-59 (2009)
DOI:10.3390/v1030737
Reference
PMID:15276609
  Authors
Morrison LA
  Title
The Toll of herpes simplex virus infection.
  Journal
Trends Microbiol 12:353-6 (2004)
DOI:10.1016/j.tim.2004.06.001
Reference
PMID:29298887
  Authors
Zheng C
  Title
Evasion of Cytosolic DNA-Stimulated Innate Immune Responses by Herpes Simplex Virus 1.
  Journal
J Virol 92:e00099-17 (2018)
DOI:10.1128/JVI.00099-17
Reference
PMID:19344302
  Authors
Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC
  Title
Design and application of oncolytic HSV vectors for glioblastoma therapy.
  Journal
Expert Rev Neurother 9:505-17 (2009)
DOI:10.1586/ern.09.9
Reference
PMID:23115300
  Authors
Lussignol M, Queval C, Bernet-Camard MF, Cotte-Laffitte J, Beau I, Codogno P, Esclatine A
  Title
The herpes simplex virus 1 Us11 protein inhibits autophagy through its interaction with the protein kinase PKR.
  Journal
J Virol 87:859-71 (2013)
DOI:10.1128/JVI.01158-12
Reference
PMID:17229694
  Authors
Sanchez R, Mohr I
  Title
Inhibition of cellular 2'-5' oligoadenylate synthetase by the herpes simplex virus type 1 Us11 protein.
  Journal
J Virol 81:3455-64 (2007)
DOI:10.1128/JVI.02520-06
Reference
PMID:12826401
  Authors
Wysocka J, Herr W
  Title
The herpes simplex virus VP16-induced complex: the makings of a regulatory switch.
  Journal
Trends Biochem Sci 28:294-304 (2003)
DOI:10.1016/S0968-0004(03)00088-4
Reference
PMID:27367734
  Authors
Fleming SB
  Title
Viral Inhibition of the IFN-Induced JAK/STAT Signalling Pathway: Development of Live Attenuated Vaccines by Mutation of Viral-Encoded IFN-Antagonists.
  Journal
Vaccines (Basel) 4:23 (2016)
DOI:10.3390/vaccines4030023
Reference
PMID:15163721
  Authors
Yokota S, Yokosawa N, Okabayashi T, Suzutani T, Miura S, Jimbow K, Fujii N
  Title
Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 contributes to inhibition of the interferon signaling pathway.
  Journal
J Virol 78:6282-6 (2004)
DOI:10.1128/JVI.78.12.6282-6286.2004
Reference
PMID:23864622
  Authors
Gu H, Zheng Y, Roizman B
  Title
Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
  Journal
J Virol 87:10244-54 (2013)
DOI:10.1128/JVI.01487-13
Reference
PMID:21994592
  Authors
Tavalai N, Stamminger T
  Title
Interplay between Herpesvirus Infection and Host Defense by PML Nuclear Bodies.
  Journal
Viruses 1:1240-64 (2009)
DOI:10.3390/v1031240
Reference
PMID:21146386
  Authors
Horst D, Verweij MC, Davison AJ, Ressing ME, Wiertz EJ
  Title
Viral evasion of T cell immunity: ancient mechanisms offering new applications.
  Journal
Curr Opin Immunol 23:96-103 (2011)
DOI:10.1016/j.coi.2010.11.005
Reference
PMID:12960333
  Authors
Neumann J, Eis-Hubinger AM, Koch N
  Title
Herpes simplex virus type 1 targets the MHC class II processing pathway for immune evasion.
  Journal
J Immunol 171:3075-83 (2003)
DOI:10.4049/jimmunol.171.6.3075
Reference
PMID:25798530
  Authors
Liu X, Cohen JI
  Title
The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside.
  Journal
Virology 479-480:568-77 (2015)
DOI:10.1016/j.virol.2015.02.040
Reference
PMID:28468873
  Authors
Vink EI, Smiley JR, Mohr I
  Title
Subversion of Host Responses to Energy Insufficiency by Us3 Supports Herpes Simplex Virus 1 Replication during Stress.
  Journal
J Virol 91:e00295-17 (2017)
DOI:10.1128/JVI.00295-17
Reference
PMID:18508584
  Authors
Sandri-Goldin RM
  Title
The many roles of the regulatory protein ICP27 during herpes simplex virus infection.
  Journal
Front Biosci 13:5241-56 (2008)
DOI:10.2741/3078
Reference
PMID:15078920
  Authors
Sandri-Goldin RM
  Title
Viral regulation of mRNA export.
  Journal
J Virol 78:4389-96 (2004)
DOI:10.1128/JVI.78.9.4389-4396.2004
Reference
PMID:27154074
  Authors
Yu X, He S
  Title
The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways.
  Journal
Virol J 13:77 (2016)
DOI:10.1186/s12985-016-0528-0
Related
pathway
lve03040  Spliceosome
lve03050  Proteasome
lve04115  p53 signaling pathway
lve04151  PI3K-Akt signaling pathway
lve04210  Apoptosis
lve04610  Complement and coagulation cascades
lve04612  Antigen processing and presentation
lve04620  Toll-like receptor signaling pathway
lve04622  RIG-I-like receptor signaling pathway
lve04630  JAK-STAT signaling pathway
KO pathway
ko05168   

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