KEGG   PATHWAY: ocu04148
Entry
ocu04148                    Pathway                                
Name
Efferocytosis - Oryctolagus cuniculus (rabbit)
Class
Cellular Processes; Transport and catabolism
Pathway map
ocu04148  Efferocytosis
ocu04148

Organism
Oryctolagus cuniculus (rabbit) [GN:ocu]
Gene
100008615  PPARD; peroxisome proliferator-activated receptor delta [KO:K04504]
100008645  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
100008682  RAB7A; ras-related protein Rab-7a [KO:K07897]
100008701  IL10; interleukin-10 precursor [KO:K05443]
100008723  SGK1; serine/threonine-protein kinase Sgk1 [KO:K13302] [EC:2.7.11.1]
100008735  ITGB3; integrin beta-3 precursor [KO:K06493]
100008757  [KO:K26934]
100008786  EPO; erythropoietin precursor [KO:K05437]
100008814  ARG1; arginase-1 [KO:K01476] [EC:3.5.3.1]
100008820  S1PR1; sphingosine 1-phosphate receptor 1 [KO:K04288]
100008825  [KO:K06259]
100008840  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
100008859  [KO:K17333]
100008874  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
100008892  PPARG; peroxisome proliferator-activated receptor gamma [KO:K08530]
100008956  [KO:K06487]
100008961  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
100008967  ARG2; arginase-2, mitochondrial precursor [KO:K01476] [EC:3.5.3.1]
100008996  ARNT; aryl hydrocarbon receptor nuclear translocator [KO:K09097]
100009050  CALR; calreticulin precursor [KO:K08057]
100009081  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
100009114  ALOX15; polyunsaturated fatty acid lipoxygenase ALOX15 [KO:K00460] [EC:1.13.11.33]
100009229  BSG; basigin precursor [KO:K06535]
100009248  PTGS2; prostaglandin G/H synthase 2 precursor [KO:K11987] [EC:1.14.99.1]
100009314  [KO:K03908]
100009316  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100009369  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
100009438  [KO:K04443] [EC:2.7.11.1]
100009547  [KO:K04550]
100009579  HIF1A; hypoxia-inducible factor 1-alpha [KO:K08268]
100037716  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
100038308  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100101556  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
100101557  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
100101585  [KO:K06834] [EC:3.4.24.-]
100101588  [KO:K01370] [EC:3.4.22.36]
100101591  [KO:K04397] [EC:3.4.22.60]
100101613  [KO:K06059] [EC:3.4.24.86]
100101614  [KO:K06704] [EC:3.4.24.81]
100125988  SLC2A1; solute carrier family 2, facilitated glucose transporter member 1 [KO:K07299]
100337802  [KO:K19500]
100338588  [KO:K01052] [EC:3.1.1.13]
100338597  [KO:K07881]
100339001  [KO:K06535]
100339517  [KO:K07293] [EC:3.1.3.48]
100339553  [KO:K19499]
100339873  [KO:K04392]
100339980  [KO:K23285]
100340377  [KO:K19480]
100341039  [KO:K10223] [EC:1.14.99.38]
100341186  [KO:K09355]
100341327  [KO:K19524] [EC:2.3.1.21]
100341507  [KO:K04515] [EC:2.7.11.17]
100341695  [KO:K04441] [EC:2.7.11.24]
100341714  [KO:K00461] [EC:1.13.11.34]
100342064  [KO:K24068]
100342327  [KO:K04438]
100342405  [KO:K13708]
100342451  [KO:K04515] [EC:2.7.11.17]
100342686  [KO:K26934]
100342822  [KO:K05116] [EC:2.7.10.1]
100342868  [KO:K08535]
100342934  [KO:K17253]
100343142  [KO:K19722]
100343162  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100343722  [KO:K20184]
100344161  [KO:K04441] [EC:2.7.11.24]
100344207  [KO:K19498]
100344216  [KO:K26811]
100344262  [KO:K01581] [EC:4.1.1.17]
100344276  [KO:K20182]
100344431  [KO:K20183]
100344453  [KO:K10048]
100344715  [KO:K17398] [EC:2.1.1.37]
100344731  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100345006  [KO:K04298]
100345035  [KO:K01581] [EC:4.1.1.17]
100346151  [KO:K26934]
100346186  [KO:K05508]
100346214  SLC66A1; lysosomal amino acid transporter 1 homolog [KO:K23678]
100346779  [KO:K26811]
100346795  [KO:K19020]
100346898  [KO:K20178]
100347003  [KO:K17334]
100347345  [KO:K04371] [EC:2.7.11.24]
100347455  [KO:K05725] [EC:2.7.10.2]
100348021  [KO:K07889]
100348135  [KO:K00411] [EC:7.1.1.8]
100348306  [KO:K07888]
100348331  [KO:K08179]
100348469  [KO:K26814]
100348561  [KO:K04371] [EC:2.7.11.24]
100348648  [KO:K05697] [EC:3.1.3.48]
100349271  [KO:K11411] [EC:2.3.1.286]
100349647  [KO:K26936]
100350151  [KO:K20414]
100350199  [KO:K26935]
100350239  [KO:K06551]
100350311  [KO:K08765] [EC:2.3.1.21]
100350323  [KO:K05726]
100350417  [KO:K08057]
100350430  [KO:K16857]
100350480  [KO:K06551]
100350614  [KO:K04441] [EC:2.7.11.24]
100350655  [KO:K26935]
100350716  [KO:K08765] [EC:2.3.1.21]
100350787  [KO:K00411] [EC:7.1.1.8]
100350923  [KO:K07887]
100350986  [KO:K07897]
100351485  [KO:K06551]
100351542  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100351999  [KO:K05870]
100352081  [KO:K12366]
100352301  [KO:K13375]
100352378  [KO:K04446]
100352900  NR1H3; oxysterols receptor LXR-alpha [KO:K08536]
100353038  [KO:K26935]
100353138  [KO:K19523] [EC:2.3.1.21]
100353244  [KO:K05117] [EC:2.7.10.1]
100353546  [KO:K06588]
100353754  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100353824  [KO:K17332]
100353953  [KO:K20181]
100354017  [KO:K20180]
100354544  [KO:K26813]
100354976  [KO:K05853] [EC:7.2.2.10]
100355104  [KO:K14802] [EC:7.6.2.1]
100355109  [KO:K20177]
100355190  [KO:K19013]
100355284  [KO:K06129] [EC:3.1.1.5]
100355350  [KO:K05079]
100355470  [KO:K06266]
100356355  [KO:K24068]
100356765  [KO:K05641]
100357603  [KO:K24318]
100357605  [KO:K06471]
100357790  [KO:K04718] [EC:2.7.1.91]
100358094  [KO:K14802] [EC:7.6.2.1]
100358134  [KO:K04447] [EC:2.7.10.2]
100358139  [KO:K03443]
100358230  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
100358481  [KO:K20179]
100358580  [KO:K04272]
100358767  [KO:K26811]
100358828  [KO:K05115] [EC:2.7.10.1]
100358874  [KO:K14802] [EC:7.6.2.1]
103344944  [KO:K04269]
103345448  [KO:K13375]
103345753  [KO:K07909]
103346035  [KO:K04441] [EC:2.7.11.24]
103346370  [KO:K04718] [EC:2.7.1.91]
103346593  [KO:K08765] [EC:2.3.1.21]
103347939  [KO:K20413]
103348976  [KO:K04459] [EC:3.1.3.16 3.1.3.48]
103350560  [KO:K06266]
103350994  [KO:K07898]
127482788  [KO:K03987]
127487421  [KO:K07888]
127489461  [KO:K04368] [EC:2.7.12.2]
127490931  [KO:K16343] [EC:3.1.1.4]
127493058  [KO:K19722]
Compound
C00002  ATP
C00003  NAD+
C00019  S-Adenosyl-L-methionine
C00031  D-Glucose
C00062  L-Arginine
C00073  L-Methionine
C00075  UTP
C00077  L-Ornithine
C00134  Putrescine
C00162  Fatty acid
C00186  (S)-Lactate
C00187  Cholesterol
C00584  Prostaglandin E2
C02530  Cholesterol ester
C02737  Phosphatidylserine
C04230  1-Acyl-sn-glycero-3-phosphocholine
C06124  Sphingosine 1-phosphate
C06314  Lipoxin A4
C15519  25-Hydroxycholesterol
C15610  Cholest-5-ene-3beta,26-diol
C18178  Resolvin D1
Reference
PMID:31822793
  Authors
Doran AC, Yurdagul A Jr, Tabas I
  Title
Efferocytosis in health and disease.
  Journal
Nat Rev Immunol 20:254-267 (2020)
DOI:10.1038/s41577-019-0240-6
Reference
PMID:36028471
  Authors
Zhang J, Ding W, Zhao M, Liu J, Xu Y, Wan J, Wang M
  Title
Mechanisms of efferocytosis in determining inflammation resolution: Therapeutic potential and the association with cardiovascular disease.
  Journal
Br J Pharmacol 179:5151-5171 (2022)
DOI:10.1111/bph.15939
Reference
PMID:30165442
  Authors
Kawano M, Nagata S
  Title
Efferocytosis and autoimmune disease.
  Journal
Int Immunol 30:551-558 (2018)
DOI:10.1093/intimm/dxy055
Reference
PMID:35650427
  Authors
Mehrotra P, Ravichandran KS
  Title
Drugging the efferocytosis process: concepts and opportunities.
  Journal
Nat Rev Drug Discov 21:601-620 (2022)
DOI:10.1038/s41573-022-00470-y
Reference
PMID:28496201
  Authors
Park SY, Kim IS
  Title
Engulfment signals and the phagocytic machinery for apoptotic cell clearance.
  Journal
Exp Mol Med 49:e331 (2017)
DOI:10.1038/emm.2017.52
Reference
PMID:28137963
  Authors
Kojima Y, Weissman IL, Leeper NJ
  Title
The Role of Efferocytosis in Atherosclerosis.
  Journal
Circulation 135:476-489 (2017)
DOI:10.1161/CIRCULATIONAHA.116.025684
Related
pathway
ocu00010  Glycolysis / Gluconeogenesis
ocu04140  Autophagy - animal
ocu04145  Phagosome
KO pathway
ko04148   

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