KEGG   PATHWAY: oga04020
Entry
oga04020                    Pathway                                
Name
Calcium signaling pathway - Otolemur garnettii (small-eared galago)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
oga04020  Calcium signaling pathway
oga04020

Other DBs
GO: 0019722
Organism
Otolemur garnettii (small-eared galago) [GN:oga]
Gene
100940422  NTRK1; high affinity nerve growth factor receptor isoform X2 [KO:K03176] [EC:2.7.10.1]
100940437  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
100940498  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
100940909  F2R; proteinase-activated receptor 1 [KO:K03914]
100940919  ADRB1; beta-1 adrenergic receptor [KO:K04141]
100940920  FGF8; fibroblast growth factor 8 isoform X4 [KO:K04358]
100941250  ADCY2; LOW QUALITY PROTEIN: adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
100941307  PTAFR; platelet-activating factor receptor [KO:K04279]
100941460  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
100941503  HRH2; LOW QUALITY PROTEIN: histamine H2 receptor [KO:K04150]
100941613  CALM3; calmodulin-3 [KO:K02183]
100941807  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
100941825  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
100941952  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
100942099  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform [KO:K00871] [EC:2.7.11.19]
100942104  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
100942216  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
100942290  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100942388  FGF5; fibroblast growth factor 5 [KO:K04358]
100942397  AVPR1B; vasopressin V1b receptor [KO:K04227]
100942592  ADCY3; LOW QUALITY PROTEIN: adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
100942631  FGF2; fibroblast growth factor 2 [KO:K18497]
100942661  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
100942721  [KO:K02183]
100942748  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
100942859  P2RX1; P2X purinoceptor 1 isoform X1 [KO:K05215]
100942914  TFEB; transcription factor EB isoform X1 [KO:K15590]
100943201  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
100943344  CCKAR; cholecystokinin receptor type A [KO:K04194]
100943395  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
100943579  PRKCB; protein kinase C beta type isoform X2 [KO:K19662] [EC:2.7.11.13]
100943663  STIM2; stromal interaction molecule 2 [KO:K18196]
100943767  ADCY9; adenylate cyclase type 9 isoform X2 [KO:K08049] [EC:4.6.1.1]
100944309  GDNF; glial cell line-derived neurotrophic factor isoform X5 [KO:K05452]
100944640  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
100944643  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
100944908  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
100944959  SLC8A1; sodium/calcium exchanger 1 [KO:K05849]
100945275  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100945281  ORAI3; protein orai-3 [KO:K16058]
100945284  HRH1; histamine H1 receptor [KO:K04149]
100945351  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100945380  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100945532  VDAC3; voltage-dependent anion-selective channel protein 3 [KO:K15041]
100945846  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
100945909  CASQ2; calsequestrin-2 [KO:K23445]
100945918  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
100946102  P2RX2; P2X purinoceptor 2 isoform X1 [KO:K05216]
100946148  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
100946218  NGF; beta-nerve growth factor [KO:K02582]
100946241  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
100946340  AVPR1A; vasopressin V1a receptor [KO:K04226]
100946498  CALM2; calmodulin-2 [KO:K02183]
100946509  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
100946783  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
100946834  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H [KO:K04855]
100946888  MST1R; LOW QUALITY PROTEIN: macrophage-stimulating protein receptor [KO:K05100] [EC:2.7.10.1]
100946893  TACR2; substance-K receptor [KO:K04223]
100946982  SLC8A2; sodium/calcium exchanger 2 isoform X1 [KO:K05849]
100947410  MRLN; myoregulin [KO:K22643]
100947419  FGF7; fibroblast growth factor 7 [KO:K04358]
100947467  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
100947599  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X1 [KO:K05857] [EC:3.1.4.11]
100947650  NTSR1; neurotensin receptor type 1 [KO:K04211]
100947727  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 [KO:K05860] [EC:3.1.4.11]
100947735  FGF21; fibroblast growth factor 21 [KO:K22429]
100948029  FGF18; fibroblast growth factor 18 [KO:K04358]
100948046  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
100948063  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
100948089  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
100948132  STIM1; stromal interaction molecule 1 isoform X2 [KO:K16059]
100948196  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
100948288  CALM1; calmodulin-1 [KO:K02183]
100948374  PTGER3; prostaglandin E2 receptor EP3 subtype [KO:K04260]
100948398  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
100948713  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
100948784  P2RX3; P2X purinoceptor 3 [KO:K05217]
100948829  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
100948868  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
100949180  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
100949311  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
100949562  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
100949638  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
100949743  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X4 [KO:K05850] [EC:7.2.2.10]
100950262  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
100950265  MCU; calcium uniporter protein, mitochondrial isoform X1 [KO:K20858]
100950273  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
100950274  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
100950302  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100950557  TRDN; triadin [KO:K23449]
100950571  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
100950655  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
100950688  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
100950947  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
100951002  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
100951253  VEGFD; vascular endothelial growth factor D [KO:K05449]
100951391  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
100951544  NTRK3; NT-3 growth factor receptor isoform X2 [KO:K05101] [EC:2.7.10.1]
100951606  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100951651  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
100951765  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
100951795  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X2 [KO:K05853] [EC:7.2.2.10]
100951857  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 [KO:K05858] [EC:3.1.4.11]
100952034  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
100952295  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X2 [KO:K13755] [EC:3.1.4.17]
100952720  TBXA2R; thromboxane A2 receptor [KO:K04264]
100952734  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
100952803  [KO:K02183]
100952813  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
100952938  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100953245  TPCN1; two pore calcium channel protein 1 [KO:K16896]
100953265  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X2 [KO:K00871] [EC:2.7.11.19]
100953298  FGF16; fibroblast growth factor 16 [KO:K04358]
100953359  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
100953462  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [KO:K05858] [EC:3.1.4.11]
100953477  CASQ1; calsequestrin-1 [KO:K23468]
100953579  TACR3; neuromedin-K receptor [KO:K04224]
100953767  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X2 [KO:K04851]
100953783  GRPR; gastrin-releasing peptide receptor [KO:K04169]
100953964  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
100954101  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
100954364  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
100954406  ATP2B4; plasma membrane calcium-transporting ATPase 4 [KO:K05850] [EC:7.2.2.10]
100954477  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
100954512  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100954515  FGF10; fibroblast growth factor 10 [KO:K04358]
100954570  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
100954924  AGTR1; type-1 angiotensin II receptor [KO:K04166]
100955105  ITPKC; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
100955117  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
100955162  CCKBR; gastrin/cholecystokinin type B receptor isoform X1 [KO:K04195]
100955208  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X15 [KO:K04854]
100955220  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
100955327  EDNRA; endothelin-1 receptor [KO:K04197]
100955472  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
100955513  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X2 [KO:K08794] [EC:2.7.11.17]
100955570  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
100955681  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X2 [KO:K04515] [EC:2.7.11.17]
100955914  ADRB2; beta-2 adrenergic receptor [KO:K04142]
100955936  MCOLN2; mucolipin-2 isoform X1 [KO:K04993]
100955943  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
100956147  [KO:K02183]
100956224  HTR4; 5-hydroxytryptamine receptor 4 isoform X3 [KO:K04160]
100956289  RYR3; ryanodine receptor 3 [KO:K04963]
100956463  HTR2A; 5-hydroxytryptamine receptor 2A isoform X1 [KO:K04157]
100956668  ASPH; aspartyl/asparaginyl beta-hydroxylase [KO:K00476] [EC:1.14.11.16]
100956703  NOS3; nitric oxide synthase, endothelial [KO:K13242] [EC:1.14.13.39]
100956846  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X2 [KO:K04515] [EC:2.7.11.17]
100956865  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
100956868  MST1; hepatocyte growth factor-like protein isoform X1 [KO:K23441]
100956877  PRKCG; protein kinase C gamma type isoform X2 [KO:K19663] [EC:2.7.11.13]
100956924  PHKB; phosphorylase b kinase regulatory subunit beta isoform X1 [KO:K07190]
100956925  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
100957042  SLC8A3; sodium/calcium exchanger 3 isoform X8 [KO:K05849]
100957337  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
100957646  P2RX7; P2X purinoceptor 7 [KO:K05220]
100957667  FGFR4; fibroblast growth factor receptor 4 isoform X4 [KO:K05095] [EC:2.7.10.1]
100957818  ADORA2A; adenosine receptor A2a [KO:K04266]
100957902  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
100958098  FGF23; fibroblast growth factor 23 [KO:K22428]
100958276  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
100958290  P2RX4; P2X purinoceptor 4 isoform X2 [KO:K05218]
100958585  FGF22; fibroblast growth factor 22 [KO:K04358]
100958618  NOS2; LOW QUALITY PROTEIN: nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
100958629  FGF4; fibroblast growth factor 4 [KO:K04358]
100958789  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
100958794  CAMK1D; LOW QUALITY PROTEIN: calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
100958960  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
100959023  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
100959235  TGFA; protransforming growth factor alpha isoform X2 [KO:K08774]
100959561  ORAI1; calcium release-activated calcium channel protein 1 [KO:K16056]
100959574  GRM5; metabotropic glutamate receptor 5 [KO:K04604]
100959686  EGF; pro-epidermal growth factor [KO:K04357]
100959761  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
100959766  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
100959828  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
100960156  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X3 [KO:K13755] [EC:3.1.4.17]
100960242  OXTR; oxytocin receptor [KO:K04229]
100960272  VEGFA; vascular endothelial growth factor A [KO:K05448]
100960533  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
100960577  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
100960687  ITPKA; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
100960708  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
100960938  FGF3; fibroblast growth factor 3 [KO:K04358]
100961013  ADRA1A; alpha-1A adrenergic receptor isoform X1 [KO:K04135]
100961025  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
100961067  SPHK2; sphingosine kinase 2 isoform X1 [KO:K04718] [EC:2.7.1.91]
100961245  FGF6; fibroblast growth factor 6 [KO:K04358]
100961253  FGF19; fibroblast growth factor 19 [KO:K22603]
100961338  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
100961754  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
100961886  TPCN2; two pore calcium channel protein 2 [KO:K14077]
100961894  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
100962049  GRIN3B; glutamate receptor ionotropic, NMDA 3B [KO:K05214]
100962105  RYR2; ryanodine receptor 2 [KO:K04962]
100962219  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
100962391  FGF9; fibroblast growth factor 9 [KO:K04358]
100962519  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
100962637  MCOLN3; mucolipin-3 [KO:K04994]
100962660  PDGFD; platelet-derived growth factor D [KO:K05450]
100962683  CACNA1S; LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
100962804  RYR1; ryanodine receptor 1 isoform X1 [KO:K04961]
100962856  BDKRB2; B2 bradykinin receptor [KO:K03916]
100962937  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
100962947  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
100963038  DRD5; D(1B) dopamine receptor [KO:K05840]
100963108  TACR1; substance-P receptor [KO:K04222]
100963130  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
100963177  BDKRB1; B1 bradykinin receptor [KO:K03915]
100963188  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
100963467  HGF; hepatocyte growth factor isoform X2 [KO:K05460]
100963635  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X2 [KO:K05208]
100964083  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
100964267  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
100964319  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
100964408  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
100964437  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
100964485  ADRB3; beta-3 adrenergic receptor [KO:K04143]
100964580  PDGFC; platelet-derived growth factor C [KO:K05450]
100964661  MCOLN1; mucolipin-1 [KO:K04992]
100964773  EDNRB; endothelin receptor type B [KO:K04198]
100964809  FGF20; fibroblast growth factor 20 [KO:K04358]
100964836  HTR7; 5-hydroxytryptamine receptor 7 isoform X2 [KO:K04163]
100965032  P2RX5; P2X purinoceptor 5 [KO:K05219]
100965129  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
100965212  ORAI2; protein orai-2 [KO:K16057]
100965293  TNNC2; troponin C, skeletal muscle [KO:K12042]
100965377  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
100965453  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X2 [KO:K04633]
100965454  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
100965513  ADORA2B; adenosine receptor A2b [KO:K04267]
100966029  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
100966077  FGF1; fibroblast growth factor 1 [KO:K18496]
100966114  CALML5; calmodulin-like protein 5 [KO:K02183]
100966182  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X2 [KO:K05858] [EC:3.1.4.11]
100966244  [KO:K04632]
100966253  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
100966333  SPHK1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
100966508  PLN; cardiac phospholamban [KO:K05852]
100966533  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
100966563  [KO:K04632]
100966615  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
100966817  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
100966936  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
100967027  DRD1; D(1A) dopamine receptor [KO:K04144]
100967099  VEGFC; vascular endothelial growth factor C [KO:K05449]
105886540  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105886677  SMIM6; small integral membrane protein 6 [KO:K26468]
105887316  CALML6; calmodulin-like protein 6 [KO:K02183]
105887331  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
105888031  CUNH4orf3; uncharacterized protein C4orf3 homolog [KO:K26467]
105888186  [KO:K05221]
111722502  SLN; sarcolipin [KO:K22642]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
oga04010  MAPK signaling pathway
oga04070  Phosphatidylinositol signaling system
oga04210  Apoptosis
oga04720  Long-term potentiation
oga04730  Long-term depression
KO pathway
ko04020   

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