KEGG   PATHWAY: pale04020
Entry
pale04020                   Pathway                                
Name
Calcium signaling pathway - Pteropus alecto (black flying fox)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
Pathway map
pale04020  Calcium signaling pathway
pale04020

Other DBs
GO: 0019722
Organism
Pteropus alecto (black flying fox) [GN:pale]
Gene
102877768  PDE1A; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A isoform X1 [KO:K13755] [EC:3.1.4.17]
102877847  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
102877853  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
102877858  RYR2; LOW QUALITY PROTEIN: ryanodine receptor 2 [KO:K04962]
102877919  [KO:K04634]
102878001  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
102878024  TBXA2R; thromboxane A2 receptor [KO:K04264]
102878133  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X4 [KO:K05126] [EC:2.7.10.1]
102878342  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102878454  PLCD1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1 isoform X2 [KO:K05857] [EC:3.1.4.11]
102878456  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
102878549  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
102878692  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
102878912  GRM1; metabotropic glutamate receptor 1 isoform X1 [KO:K04603]
102879238  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
102879288  FGFR4; fibroblast growth factor receptor 4 isoform X3 [KO:K05095] [EC:2.7.10.1]
102879333  CAMK4; calcium/calmodulin-dependent protein kinase type IV [KO:K05869] [EC:2.7.11.17]
102879399  P2RX4; P2X purinoceptor 4 [KO:K05218]
102879645  P2RX7; P2X purinoceptor 7 [KO:K05220]
102879673  OXTR; oxytocin receptor [KO:K04229]
102879785  P2RX5; P2X purinoceptor 5 isoform X2 [KO:K05219]
102879798  NTRK3; NT-3 growth factor receptor isoform X1 [KO:K05101] [EC:2.7.10.1]
102879929  ADRB3; beta-3 adrenergic receptor [KO:K04143]
102879938  PHKG1; phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform isoform X2 [KO:K00871] [EC:2.7.11.19]
102879945  NOS3; nitric oxide synthase, endothelial isoform X1 [KO:K13242] [EC:1.14.13.39]
102879995  PHKB; LOW QUALITY PROTEIN: phosphorylase b kinase regulatory subunit beta [KO:K07190]
102880014  EDNRB; endothelin receptor type B [KO:K04198]
102880019  CYSLTR1; cysteinyl leukotriene receptor 1 [KO:K04322]
102880029  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102880468  STIM1; stromal interaction molecule 1 [KO:K16059]
102880663  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
102880709  HTR5A; 5-hydroxytryptamine receptor 5A [KO:K04161]
102880752  SLC8A1; sodium/calcium exchanger 1 isoform X4 [KO:K05849]
102880796  ADRB1; beta-1 adrenergic receptor [KO:K04141]
102880857  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
102880869  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta [KO:K04515] [EC:2.7.11.17]
102881051  MCOLN3; mucolipin-3 [KO:K04994]
102881068  P2RX1; P2X purinoceptor 1 [KO:K05215]
102881285  GRIN2C; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 2C [KO:K05211]
102881535  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
102881744  [KO:K02183]
102881783  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
102881925  [KO:K04161]
102882076  CACNA1I; LOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1I [KO:K04856]
102882116  HTR4; 5-hydroxytryptamine receptor 4 isoform X2 [KO:K04160]
102882222  PHKG2; phosphorylase b kinase gamma catalytic chain, liver/testis isoform isoform X2 [KO:K00871] [EC:2.7.11.19]
102882247  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
102882270  PTAFR; platelet-activating factor receptor isoform X2 [KO:K04279]
102882476  ITPKB; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
102882682  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X2 [KO:K04850]
102882713  PHKA2; phosphorylase b kinase regulatory subunit alpha, liver isoform isoform X1 [KO:K07190]
102882716  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
102882861  ADRB2; beta-2 adrenergic receptor [KO:K04142]
102882897  SMIM6; small integral membrane protein 6 [KO:K26468]
102882899  FGFR2; fibroblast growth factor receptor 2 isoform X8 [KO:K05093] [EC:2.7.10.1]
102882910  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102882963  VEGFB; vascular endothelial growth factor B [KO:K16858]
102883078  TACR3; neuromedin-K receptor [KO:K04224]
102883086  ADRA1D; alpha-1D adrenergic receptor [KO:K04137]
102883128  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
102883130  ORAI1; calcium release-activated calcium channel protein 1 isoform X1 [KO:K16056]
102883154  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
102883156  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102883167  GDNF; glial cell line-derived neurotrophic factor isoform X2 [KO:K05452]
102883346  FGF23; fibroblast growth factor 23 [KO:K22428]
102883367  TFEB; LOW QUALITY PROTEIN: transcription factor EB [KO:K15590]
102883382  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
102883443  [KO:K16858]
102883609  HRC; sarcoplasmic reticulum histidine-rich calcium-binding protein [KO:K23450]
102883933  CAMK1; calcium/calmodulin-dependent protein kinase type 1 isoform X1 [KO:K08794] [EC:2.7.11.17]
102884106  [KO:K04632]
102884196  CALML6; calmodulin-like protein 6 [KO:K02183]
102884251  VEGFC; vascular endothelial growth factor C [KO:K05449]
102884312  NFATC3; LOW QUALITY PROTEIN: nuclear factor of activated T-cells, cytoplasmic 3 [KO:K17333]
102884379  P2RX3; P2X purinoceptor 3 [KO:K05217]
102884414  ORAI3; protein orai-3 [KO:K16058]
102884470  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
102884516  ADRA1A; alpha-1A adrenergic receptor [KO:K04135]
102884569  NOS1; nitric oxide synthase, brain isoform X2 [KO:K13240] [EC:1.14.13.39]
102884591  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 [KO:K05853] [EC:7.2.2.10]
102884623  CASQ1; calsequestrin-1 [KO:K23468]
102884690  ITPKA; LOW QUALITY PROTEIN: inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
102884893  PLCD4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 [KO:K05857] [EC:3.1.4.11]
102884958  PDE1B; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B isoform X1 [KO:K13755] [EC:3.1.4.17]
102885081  FGF19; fibroblast growth factor 19 [KO:K22603]
102885187  TRHR; thyrotropin-releasing hormone receptor [KO:K04282]
102885207  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
102885216  ASPH; aspartyl/asparaginyl beta-hydroxylase isoform X1 [KO:K00476] [EC:1.14.11.16]
102885300  ERBB2; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
102885387  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X2 [KO:K05850] [EC:7.2.2.10]
102885454  NGF; beta-nerve growth factor [KO:K02582]
102885489  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 [KO:K05853] [EC:7.2.2.10]
102885534  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
102885676  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
102885781  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
102885782  TNNC2; troponin C, skeletal muscle isoform X2 [KO:K12042]
102885812  PLN; cardiac phospholamban [KO:K05852]
102885895  [KO:K05863]
102885953  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
102885990  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
102885993  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
102886001  F2R; proteinase-activated receptor 1 [KO:K03914]
102886058  CALM1; calmodulin-1 [KO:K02183]
102886226  GNAL; guanine nucleotide-binding protein G(olf) subunit alpha isoform X1 [KO:K04633]
102886232  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
102886262  STIM2; stromal interaction molecule 2 [KO:K18196]
102886274  NFATC2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
102886314  ADORA2A; LOW QUALITY PROTEIN: adenosine receptor A2a [KO:K04266]
102886371  ITPKC; LOW QUALITY PROTEIN: inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
102886432  PTK2B; protein-tyrosine kinase 2-beta [KO:K05871] [EC:2.7.10.2]
102886540  FGF21; fibroblast growth factor 21 [KO:K22429]
102886552  HTR2B; 5-hydroxytryptamine receptor 2B [KO:K04157]
102886650  GRPR; gastrin-releasing peptide receptor [KO:K04169]
102886679  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102887036  VDAC1; voltage-dependent anion-selective channel protein 1 [KO:K05862]
102887078  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
102887090  HTR2C; 5-hydroxytryptamine receptor 2C isoform X1 [KO:K04157]
102887168  PLCZ1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 [KO:K05861] [EC:3.1.4.11]
102887299  SPHK2; sphingosine kinase 2 isoform X2 [KO:K04718] [EC:2.7.1.91]
102887448  RYR3; ryanodine receptor 3 [KO:K04963]
102887497  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
102887535  NTSR1; neurotensin receptor type 1 [KO:K04211]
102887613  CASQ2; calsequestrin-2 isoform X1 [KO:K23445]
102887643  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
102887662  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
102887718  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
102887777  FGF7; fibroblast growth factor 7 [KO:K04358]
102887882  FGF9; fibroblast growth factor 9 [KO:K04358]
102888098  FGF20; fibroblast growth factor 20 [KO:K04358]
102888277  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
102888351  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D [KO:K04851]
102888385  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102888619  GNA11; guanine nucleotide-binding protein subunit alpha-11 [KO:K04635]
102888827  NFATC4; nuclear factor of activated T-cells, cytoplasmic 4 [KO:K17334]
102888860  GNA15; guanine nucleotide-binding protein subunit alpha-15 [KO:K04637]
102888961  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
102888982  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta [KO:K04515] [EC:2.7.11.17]
102889039  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X6 [KO:K04854]
102889143  VEGFD; vascular endothelial growth factor D [KO:K05449]
102889420  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
102889440  AVPR1B; vasopressin V1b receptor [KO:K04227]
102889630  [KO:K04809]
102889755  CD38; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 [KO:K01242] [EC:3.2.2.6 2.4.99.20]
102889764  [KO:K04632]
102889771  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
102889943  GRIN3B; LOW QUALITY PROTEIN: glutamate receptor ionotropic, NMDA 3B [KO:K05214]
102890067  PDE1C; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X3 [KO:K13755] [EC:3.1.4.17]
102890087  CCKBR; gastrin/cholecystokinin type B receptor [KO:K04195]
102890135  TRDN; triadin [KO:K23449]
102890153  FGF16; fibroblast growth factor 16 [KO:K04358]
102890223  TPCN1; two pore calcium channel protein 1 [KO:K16896]
102890353  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X1 [KO:K04260]
102890394  VEGFA; vascular endothelial growth factor A isoform X2 [KO:K05448]
102890460  SLC8A2; sodium/calcium exchanger 2 [KO:K05849]
102890575  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
102890668  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
102890762  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
102890778  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
102890814  LTB4R2; leukotriene B4 receptor 2 [KO:K04297]
102890816  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X2 [KO:K04855]
102890827  HRH1; histamine H1 receptor [KO:K04149]
102890976  SLC8A3; sodium/calcium exchanger 3 [KO:K05849]
102891095  FLT1; vascular endothelial growth factor receptor 1 isoform X2 [KO:K05096] [EC:2.7.10.1]
102891192  ADRA1B; alpha-1B adrenergic receptor [KO:K04136]
102891277  MST1R; macrophage-stimulating protein receptor isoform X1 [KO:K05100] [EC:2.7.10.1]
102891282  P2RX2; P2X purinoceptor 2 [KO:K05216]
102891286  RYR1; ryanodine receptor 1 [KO:K04961]
102891388  HTR2A; 5-hydroxytryptamine receptor 2A [KO:K04157]
102891476  DRD5; D(1B) dopamine receptor [KO:K05840]
102891479  MCOLN2; LOW QUALITY PROTEIN: mucolipin-2 [KO:K04993]
102891552  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
102891673  [KO:K02183]
102891789  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
102891799  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
102891942  [KO:K10785]
102892001  LHCGR; lutropin-choriogonadotropic hormone receptor [KO:K04248]
102892050  [KO:K06856]
102892141  FGF6; fibroblast growth factor 6 [KO:K04358]
102892527  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
102892742  PHKA1; phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform isoform X1 [KO:K07190]
102892759  SPHK1; sphingosine kinase 1 isoform X1 [KO:K04718] [EC:2.7.1.91]
102893109  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
102893226  FGF8; fibroblast growth factor 8 isoform X4 [KO:K04358]
102893244  FGF4; fibroblast growth factor 4 [KO:K04358]
102893265  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
102893322  MST1; hepatocyte growth factor-like protein [KO:K23441]
102893492  TPCN2; two pore calcium channel protein 2 [KO:K14077]
102893495  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102893611  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
102893670  PDGFA; platelet-derived growth factor subunit A [KO:K04359]
102893838  CYSLTR2; cysteinyl leukotriene receptor 2 [KO:K04323]
102893878  CAMK1D; calcium/calmodulin-dependent protein kinase type 1D [KO:K08794] [EC:2.7.11.17]
102894012  PTGER1; prostaglandin E2 receptor EP1 subtype [KO:K04258]
102894115  FGF18; fibroblast growth factor 18 [KO:K04358]
102894122  GRM5; LOW QUALITY PROTEIN: metabotropic glutamate receptor 5 [KO:K04604]
102894123  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
102894192  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
102894226  CALM2; calmodulin-2 isoform X1 [KO:K02183]
102894279  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
102894361  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
102894381  P2RX6; P2X purinoceptor 6 [KO:K05221]
102894404  TACR2; substance-K receptor [KO:K04223]
102894415  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
102894471  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
102894818  CACNA1E; LOW QUALITY PROTEIN: voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
102894821  ADORA2B; adenosine receptor A2b [KO:K04267]
102894982  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102895204  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
102895362  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
102895392  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
102895490  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
102895574  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
102895596  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
102895602  AGTR1; type-1 angiotensin II receptor [KO:K04166]
102895642  FGF5; fibroblast growth factor 5 [KO:K04358]
102895744  GRIN3A; glutamate receptor ionotropic, NMDA 3A isoform X2 [KO:K05213]
102895893  [KO:K03916]
102895922  FGF10; fibroblast growth factor 10 [KO:K04358]
102896030  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
102896085  CAMK1G; calcium/calmodulin-dependent protein kinase type 1G [KO:K08794] [EC:2.7.11.17]
102896136  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
102896228  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102896287  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
102896356  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 isoform X1 [KO:K04959]
102896364  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
102896366  MCOLN1; mucolipin-1 isoform X2 [KO:K04992]
102896575  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
102896580  TACR1; substance-P receptor [KO:K04222]
102896638  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
102896686  PLCD3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 [KO:K05857] [EC:3.1.4.11]
102896789  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
102896895  FGF22; fibroblast growth factor 22 [KO:K04358]
102897108  SLN; sarcolipin [KO:K22642]
102897273  CALM3; calmodulin-3 [KO:K02183]
102897294  SLC25A31; ADP/ATP translocase 4 [KO:K05863]
102897468  PTGFR; prostaglandin F2-alpha receptor isoform X1 [KO:K04262]
102897540  TNNC1; troponin C, slow skeletal and cardiac muscles [KO:K05865]
102897699  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
102897814  DRD1; D(1A) dopamine receptor [KO:K04144]
102898031  ORAI2; protein orai-2 [KO:K16057]
102898127  AVPR1A; LOW QUALITY PROTEIN: vasopressin V1a receptor [KO:K04226]
102898148  EDNRA; endothelin-1 receptor [KO:K04197]
102898192  VDAC2; voltage-dependent anion-selective channel protein 2 [KO:K15040]
102898316  HRH2; histamine H2 receptor [KO:K04150]
102898318  HTR7; 5-hydroxytryptamine receptor 7 isoform X1 [KO:K04163]
102898319  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1 [KO:K05860] [EC:3.1.4.11]
102898336  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
102898423  [KO:K10785]
102898473  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
102898527  CCKAR; cholecystokinin receptor type A [KO:K04194]
102898943  FGFR1; fibroblast growth factor receptor 1 isoform X9 [KO:K04362] [EC:2.7.10.1]
102899020  GNA14; guanine nucleotide-binding protein subunit alpha-14 [KO:K04636]
107195905  MRLN; myoregulin [KO:K22643]
107196088  FGF2; fibroblast growth factor 2 [KO:K18497]
112469042  [KO:K05096] [EC:2.7.10.1]
112472150  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
Compound
C00002  ATP
C00004  NADH
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01330  Sodium cation
C06124  Sphingosine 1-phosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
C13050  Cyclic ADP-ribose
C13051  Nicotinic acid adenine dinucleotide phosphate
Reference
PMID:12838335
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:15111104
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
PMID:11299192
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
DOI:10.1152/ajpheart.2001.280.5.H1928
Reference
PMID:11698232
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
DOI:10.1152/ajpcell.2001.281.6.C1743
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
PMID:15000521
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
PMID:10997573
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
PMID:14572802
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
PMID:10331643
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
DOI:10.1007/978-1-4419-8740-2_13
Reference
PMID:11080247
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
PMID:10508738
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
PMID:12972622
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
PMID:14517314
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
PMID:21338471
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
PMID:22129055
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
PMID:22002090
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
PMID:19172794
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
Reference
PMID:19475418
  Authors
Galione A, Evans AM, Ma J, Parrington J, Arredouani A, Cheng X, Zhu MX
  Title
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.
  Journal
Pflugers Arch 458:869-76 (2009)
DOI:10.1007/s00424-009-0682-y
Reference
PMID:19434403
  Authors
Beard NA, Wei L, Dulhunty AF
  Title
Ca(2+) signaling in striated muscle: the elusive roles of triadin, junctin, and calsequestrin.
  Journal
Eur Biophys J 39:27-36 (2009)
DOI:10.1007/s00249-009-0449-6
Reference
PMID:26228554
  Authors
Marty I
  Title
Triadin regulation of the ryanodine receptor complex.
  Journal
J Physiol 593:3261-6 (2015)
DOI:10.1113/jphysiol.2014.281147
Reference
PMID:20807542
  Authors
Arvanitis DA, Vafiadaki E, Sanoudou D, Kranias EG
  Title
Histidine-rich calcium binding protein: the new regulator of sarcoplasmic reticulum calcium cycling.
  Journal
J Mol Cell Cardiol 50:43-9 (2011)
DOI:10.1016/j.yjmcc.2010.08.021
Related
pathway
pale04010  MAPK signaling pathway
pale04070  Phosphatidylinositol signaling system
pale04210  Apoptosis
pale04720  Long-term potentiation
pale04730  Long-term depression
KO pathway
ko04020   

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