Entry |
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Name |
Motor proteins - Homo sapiens (human) |
Class |
Cellular Processes; Cell motility
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Pathway map |
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Drug |
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Organism |
Homo sapiens (human) [GN: hsa]
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Gene |
1778 | DYNC1H1; dynein cytoplasmic 1 heavy chain 1 [KO:K10413] |
79659 | DYNC2H1; dynein cytoplasmic 2 heavy chain 1 [KO:K10414] |
1780 | DYNC1I1; dynein cytoplasmic 1 intermediate chain 1 [KO:K10415] |
1781 | DYNC1I2; dynein cytoplasmic 1 intermediate chain 2 [KO:K10415] |
1783 | DYNC1LI2; dynein cytoplasmic 1 light intermediate chain 2 [KO:K10416] |
51143 | DYNC1LI1; dynein cytoplasmic 1 light intermediate chain 1 [KO:K10416] |
51626 | DYNC2LI1; dynein cytoplasmic 2 light intermediate chain 1 [KO:K10417] |
8655 | DYNLL1; dynein light chain LC8-type 1 [KO:K10418] |
83658 | DYNLRB1; dynein light chain roadblock-type 1 [KO:K10419] |
83657 | DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419] |
6993 | DYNLT1; dynein light chain Tctex-type 1 [KO:K10420] |
6990 | DYNLT3; dynein light chain Tctex-type 3 [KO:K10420] |
6991 | DYNLT2; dynein light chain Tctex-type 2 [KO:K25419] |
200132 | DYNLT5; dynein light chain Tctex-type family member 5 [KO:K25421] |
1767 | DNAH5; dynein axonemal heavy chain 5 [KO:K10408] |
1768 | DNAH6; dynein axonemal heavy chain 6 [KO:K10408] |
1770 | DNAH9; dynein axonemal heavy chain 9 [KO:K10408] |
8701 | DNAH11; dynein axonemal heavy chain 11 [KO:K10408] |
1769 | DNAH8; dynein axonemal heavy chain 8 [KO:K10408] |
8632 | DNAH17; dynein axonemal heavy chain 17 [KO:K10408] |
27019 | DNAI1; dynein axonemal intermediate chain 1 [KO:K10409] |
64446 | DNAI2; dynein axonemal intermediate chain 2 [KO:K11143] |
126820 | DNAI3; dynein axonemal intermediate chain 3 [KO:K24722] |
79819 | DNAI4; dynein axonemal intermediate chain 4 [KO:K24723] |
7802 | DNALI1; dynein axonemal light intermediate chain 1 [KO:K10410] |
829 | CAPZA1; capping actin protein of muscle Z-line subunit alpha 1 [KO:K10364] |
830 | CAPZA2; capping actin protein of muscle Z-line subunit alpha 2 [KO:K10364] |
93661 | CAPZA3; capping actin protein of muscle Z-line subunit alpha 3 [KO:K10364] |
832 | CAPZB; capping actin protein of muscle Z-line subunit beta [KO:K10365] |
92558 | BICDL1; BICD family like cargo adaptor 1 [KO:K16756] |
84376 | HOOK3; hook microtubule tethering protein 3 [KO:K16536] |
7280 | TUBB2A; tubulin beta 2A class IIa [KO:K07375] |
547 | KIF1A; kinesin family member 1A [KO:K10392] |
57519 | STARD9; StAR related lipid transfer domain containing 9 [KO:K16491] |
9585 | KIF20B; kinesin family member 20B [KO:K10402] |
58 | ACTA1; actin alpha 1, skeletal muscle [KO:K10354] |
59 | ACTA2; actin alpha 2, smooth muscle [KO:K12313] |
70 | ACTC1; actin alpha cardiac muscle 1 [KO:K12314] |
72 | ACTG2; actin gamma 2, smooth muscle [KO:K12315] |
7134 | TNNC1; troponin C1, slow skeletal and cardiac type [KO:K05865] |
7135 | TNNI1; troponin I1, slow skeletal type [KO:K10371] |
7138 | TNNT1; troponin T1, slow skeletal type [KO:K10372] |
7125 | TNNC2; troponin C2, fast skeletal type [KO:K12042] |
7136 | TNNI2; troponin I2, fast skeletal type [KO:K12043] |
7140 | TNNT3; troponin T3, fast skeletal type [KO:K12046] |
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Reference |
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Authors |
Hirokawa N, Niwa S, Tanaka Y |
Title |
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease. |
Journal |
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Reference |
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Authors |
Schmidt H, Zalyte R, Urnavicius L, Carter AP |
Title |
Structure of human cytoplasmic dynein-2 primed for its power stroke. |
Journal |
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Reference |
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Authors |
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G |
Title |
The 2.8 A crystal structure of the dynein motor domain. |
Journal |
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Reference |
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Authors |
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE |
Title |
Structural basis for microtubule binding and release by dynein. |
Journal |
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Reference |
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Authors |
Gibbs KL, Greensmith L, Schiavo G |
Title |
Regulation of Axonal Transport by Protein Kinases. |
Journal |
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Reference |
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Authors |
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP |
Title |
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated. |
Journal |
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Reference |
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Authors |
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP |
Title |
The structure of the dynactin complex and its interaction with dynein. |
Journal |
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Reference |
PMID: 29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A) |
Authors |
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP |
Title |
Cryo-EM shows how dynactin recruits two dyneins for faster movement. |
Journal |
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Reference |
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Authors |
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP |
Title |
The cytoplasmic dynein transport machinery and its many cargoes. |
Journal |
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Reference |
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Authors |
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H |
Title |
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases. |
Journal |
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Reference |
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Authors |
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C |
Title |
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head. |
Journal |
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Reference |
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Authors |
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E |
Title |
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility. |
Journal |
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Reference |
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Authors |
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM |
Title |
Three-dimensional structure of myosin subfragment-1: a molecular motor. |
Journal |
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Reference |
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Authors |
Parker D, Bryant Z, Delp SL |
Title |
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics. |
Journal |
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Reference |
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Authors |
Dominguez R, Holmes KC |
Title |
Actin structure and function. |
Journal |
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Reference |
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Authors |
Yamada Y, Namba K, Fujii T |
Title |
Cardiac muscle thin filament structures reveal calcium regulatory mechanism. |
Journal |
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Reference |
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Authors |
Kruppa AJ, Buss F |
Title |
Motor proteins at the mitochondria-cytoskeleton interface. |
Journal |
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KO pathway |
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LinkDB |
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