KEGG   PATHWAY: aamp05167
Entry
aamp05167                   Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Arvicola amphibius (Eurasian water vole)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
aamp05167  Kaposi sarcoma-associated herpesvirus infection
aamp05167

Organism
Arvicola amphibius (Eurasian water vole) [GN:aamp]
Gene
119806181  C3; complement C3 [KO:K03990]
119812470  Tlr3; toll-like receptor 3 isoform X1 [KO:K05401]
119804058  Ticam1; TIR domain-containing adapter molecule 1 [KO:K05842]
119818887  Traf3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
119827931  Ikbke; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
119803361  Tbk1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
119821228  Irf7; interferon regulatory factor 7 isoform X1 [KO:K09447]
121677052  interferon alpha-12-like [KO:K05414]
121677053  interferon alpha-12-like [KO:K05414]
121677054  interferon alpha-9-like [KO:K05414]
119817047  interferon alpha-12-like [KO:K05414]
119817048  LOW QUALITY PROTEIN: interferon alpha-12-like [KO:K05414]
119817051  interferon alpha-12-like [KO:K05414]
119817054  interferon alpha-12-like [KO:K05414]
119817055  interferon alpha-12-like [KO:K05414]
119817056  interferon alpha-12-like [KO:K05414]
119817057  interferon alpha-12-like [KO:K05414]
119817059  interferon alpha-12-like [KO:K05414]
119817275  interferon alpha-12-like [KO:K05414]
119805874  interferon alpha-12-like [KO:K05414]
119805875  interferon alpha-12-like [KO:K05414]
119805877  interferon alpha-12-like [KO:K05414]
119805879  interferon alpha-12-like [KO:K05414]
119805881  interferon alpha-12-like [KO:K05414]
119805882  interferon alpha-12-like [KO:K05414]
119805887  interferon alpha-12-like [KO:K05414]
119805888  interferon alpha-12-like [KO:K05414]
119805889  interferon alpha-12-like [KO:K05414]
119805892  interferon alpha-9-like [KO:K05414]
119802528  Irf3; interferon regulatory factor 3 isoform X1 [KO:K05411]
119822927  Ep300; histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
119811558  LOW QUALITY PROTEIN: CREB-binding protein [KO:K04498] [EC:2.3.1.48]
119816165  Ifnb1; LOW QUALITY PROTEIN: interferon beta [KO:K05415]
119817276  interferon beta-like [KO:K05415]
119825470  Ifnar1; interferon alpha/beta receptor 1 [KO:K05130]
119824686  Ifnar2; interferon alpha/beta receptor 2 [KO:K05131]
119816123  Jak1; tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
119809989  Tyk2; non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
119803912  Stat1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
119803231  Stat2; signal transducer and activator of transcription 2 [KO:K11221]
119799968  Irf9; interferon regulatory factor 9 isoform X1 [KO:K04693]
119808127  Eif2ak2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
119822988  Mapk11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
119823276  Mapk12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
119823839  Mapk13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
119823840  Mapk14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
119827858  Mapkapk2; MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
119825282  LOW QUALITY PROTEIN: MAP kinase-activated protein kinase 2-like [KO:K04443] [EC:2.7.11.1]
119812035  Map2k6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
119820920  Zfp36; mRNA decay activator protein ZFP36 [KO:K15308]
119808459  Il6; interleukin-6 [KO:K05405]
119813689  Csf2; granulocyte-macrophage colony-stimulating factor isoform X1 [KO:K05427]
119809679  probable C-C chemokine receptor type 3 [KO:K04178]
119809618  C-C chemokine receptor type 5-like [KO:K04180]
119810078  C-C chemokine receptor 1-like protein 1 [KO:K04176]
119810084  C-C chemokine receptor type 1 [KO:K04176]
119810842  Ccr4; C-C chemokine receptor type 4 [KO:K04179]
119808795  Ccr8; C-C chemokine receptor type 8 [KO:K04183]
119804936  Fas; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
119802203  Fadd; FAS-associated death domain protein [KO:K02373]
119803862  Casp8; caspase-8 [KO:K04398] [EC:3.4.22.61]
119806482  Bid; BH3-interacting domain death agonist [KO:K04726]
119802627  Bax; apoptosis regulator BAX isoform X1 [KO:K02159]
119823918  Bak1; bcl-2 homologous antagonist/killer [KO:K14021]
119807948  cytochrome c, somatic-like [KO:K08738]
119827640  cytochrome c, somatic-like [KO:K08738]
119812378  cytochrome c, somatic [KO:K08738]
119812503  cytochrome c, somatic-like [KO:K08738]
119819008  cytochrome c, testis-specific [KO:K08738]
119807481  cytochrome c, somatic [KO:K08738]
119817619  Casp9; caspase-9 [KO:K04399] [EC:3.4.22.62]
119812861  Casp3; caspase-3 [KO:K02187] [EC:3.4.22.56]
119808154  Tnfrsf1a; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
119801899  Tradd; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
119818726  Traf2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
119816335  Chuk; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
119812324  Ikbkb; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
119804668  Ikbkg; NF-kappa-B essential modulator isoform X1 [KO:K07210]
119818958  Nfkbia; NF-kappa-B inhibitor alpha [KO:K04734]
119801102  Nfkb1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
119803437  Rela; transcription factor p65 isoform X1 [KO:K04735]
119818608  cellular tumor antigen p53-like [KO:K04451]
119813419  Tp53; cellular tumor antigen p53 [KO:K04451]
119823049  Cdkn1a; cyclin-dependent kinase inhibitor 1 [KO:K06625]
119803317  Cdk4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
119807882  Cdk6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
119800094  Rb1; retinoblastoma-associated protein [KO:K06618]
119815142  E2f1; transcription factor E2F1 [KO:K17454]
119816691  E2f2; transcription factor E2F2 [KO:K09389]
119817711  E2f3; transcription factor E2F3 isoform X1 [KO:K06620]
119822313  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
119822317  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119822318  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
119822319  class I histocompatibility antigen, Non-RT1.A alpha-1 chain-like [KO:K06751]
119822320  patr class I histocompatibility antigen, B-2 alpha chain-like [KO:K06751]
119822321  H-2 class I histocompatibility antigen, D-37 alpha chain-like isoform X1 [KO:K06751]
119822487  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X1 [KO:K06751]
119822489  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119822615  class I histocompatibility antigen, Gogo-A*0501 alpha chain-like [KO:K06751]
119822485  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119822617  class I histocompatibility antigen, Gogo-A*0501 alpha chain-like [KO:K06751]
119823810  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119823811  LOW QUALITY PROTEIN: HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
119823305  H-2 class I histocompatibility antigen, Q10 alpha chain-like [KO:K06751]
119823809  patr class I histocompatibility antigen, A-2 alpha chain-like [KO:K06751]
119823812  popy Class I histocompatibility antigen, A-1 alpha chain-like [KO:K06751]
119821190  Ifngr1; interferon gamma receptor 1 [KO:K05132]
119810539  Icam1; intercellular adhesion molecule 1 [KO:K06490]
119825204  Cd86; T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
119807102  C-type lectin domain family 2 member H-like [KO:K10071]
119807910  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
119827772  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
119801833  ubiquitin-60S ribosomal protein L40-like isoform X1 [KO:K02927]
119826235  ubiquitin-60S ribosomal protein L40-like [KO:K02927]
119813257  Uba52; ubiquitin-60S ribosomal protein L40 [KO:K02927]
119820410  ubiquitin-like isoform X1 [KO:K02927]
119807985  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
119822323  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
119822363  Rps27a; ubiquitin-40S ribosomal protein S27a [KO:K02977]
119820601  ubiquitin-40S ribosomal protein S27a-like [KO:K02977]
119812055  Ubb; polyubiquitin-B [KO:K08770]
119825557  Ubc; polyubiquitin-C [KO:K08770]
119812489  Becn1; beclin-1 [KO:K08334]
119800037  Atg14; beclin 1-associated autophagy-related key regulator [KO:K17889]
119815605  Pik3c3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
119824492  Atg3; ubiquitin-like-conjugating enzyme ATG3 [KO:K08343]
119808221  microtubule-associated proteins 1A/1B light chain 3B-like [KO:K10435]
119815781  Map1lc3a; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
119802123  Map1lc3b; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
119816464  Gnb1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
119824505  Gnb2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
119806987  Gnb3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
119826318  Gnb4; guanine nucleotide-binding protein subunit beta-4 isoform X1 [KO:K04538]
119809908  Gnb5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
119800221  Gng2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
119802568  Gng3; LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
119817037  Gng4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
119827664  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
119800840  Gng5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
119816264  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
119811057  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5-like [KO:K04542]
119819148  Gng7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
119821677  Gng8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
119825980  Gng10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
119826883  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11-like [KO:K04546]
119807595  Gng11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
119801689  Gng14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
119807698  Gng12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
119812877  Gng13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
119808263  Gngt1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
119812508  Gngt2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
119800249  Hras; GTPase HRas isoform X1 [KO:K02833]
119804230  GTPase KRas-like [KO:K07827]
119806318  Kras; GTPase KRas isoform X1 [KO:K07827]
119801497  Nras; GTPase NRas [KO:K07828]
119808272  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
119805902  LOW QUALITY PROTEIN: RAF proto-oncogene serine/threonine-protein kinase-like [KO:K04366] [EC:2.7.11.1]
119809903  Map2k1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
119827491  Map2k2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
119824680  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
119813356  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
119818988  Hif1a; hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
119816694  Jun; transcription factor AP-1 [KO:K04448]
119819161  Fos; proto-oncogene c-Fos [KO:K04379]
119819055  Pik3cg; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
119812089  Pik3r5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
119812321  Pik3r6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
119816315  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119810503  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
119826317  Pik3ca; LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
119808979  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
119817743  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
119812102  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
119818643  Akt1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119820487  Akt2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
119827246  Akt3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
119816408  Mtor; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
119814867  Prex1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
119814535  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
119824999  Rac1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
119811270  Mapk9; LOW QUALITY PROTEIN: mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
119813574  Mapk10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
119827427  Mapk8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
119824240  cell surface glycoprotein CD200 receptor 2-like [KO:K21668]
119824242  cell surface glycoprotein CD200 receptor 2-like [KO:K21668]
119824244  cell surface glycoprotein CD200 receptor 5-like [KO:K21668]
119824238  cell surface glycoprotein CD200 receptor 5-like [KO:K21668]
119825126  Cd200r1; cell surface glycoprotein CD200 receptor 1 [KO:K21668]
119817382  Syk; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
119814345  Src; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
119814087  Hck; LOW QUALITY PROTEIN: tyrosine-protein kinase HCK [KO:K08893] [EC:2.7.10.2]
119826164  Lyn; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
119813036  Map2k4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
119824883  Map2k7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
119801950  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
119814207  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
119806390  Itpr1; inositol 1,4,5-trisphosphate receptor type 1 isoform X1 [KO:K04958]
119806213  Itpr2; LOW QUALITY PROTEIN: inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
119823109  Itpr3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
119821021  Calm3; calmodulin-3 [KO:K02183]
119808332  Calm2; calmodulin-2 [KO:K02183]
119808754  Calml4; calmodulin-like protein 4 [KO:K02183]
119809106  calmodulin-1 [KO:K02183]
119815477  calmodulin-1 [KO:K02183]
119817551  Calml3; calmodulin-like protein 3 [KO:K02183]
119817552  calmodulin-4-like [KO:K02183]
119818370  Calm1; calmodulin-1 [KO:K02183]
119800939  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform [KO:K04348] [EC:3.1.3.16]
119800012  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119800123  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
119823004  Ppp3r1; calcineurin subunit B type 1 [KO:K06268]
119826596  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
119814795  Nfatc1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
119815528  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
119801672  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
119800411  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
119827843  Ptgs2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
119816212  growth-regulated alpha protein [KO:K05505]
119816216  C-X-C motif chemokine 2-like [KO:K05505]
119825307  Rcan1; calcipressin-1 isoform X1 [KO:K17901]
119826229  Fgf2; fibroblast growth factor 2 [KO:K18497]
119822340  vascular endothelial growth factor A-like [KO:K05448]
119822341  vascular endothelial growth factor A-like isoform X1 [KO:K05448]
119823283  Pdgfb; platelet-derived growth factor subunit B [KO:K17386]
119813161  Angpt2; angiopoietin-2 [KO:K05466]
119808804  Il6st; interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
119822265  Jak2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
119811206  Stat3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
119824224  Gsk3b; LOW QUALITY PROTEIN: glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
119808978  Ctnnb1; catenin beta-1 [KO:K02105]
119812304  Tcf7; transcription factor 7 isoform X1 [KO:K02620]
119807723  Tcf7l1; transcription factor 7-like 1 isoform X1 [KO:K04490]
119806595  Tcf7l2; transcription factor 7-like 2 isoform X1 [KO:K04491]
119800683  Lef1; lymphoid enhancer-binding factor 1 [KO:K04492]
119820446  Creb1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
119827335  Ccnd1; G1/S-specific cyclin-D1 [KO:K04503]
119822940  Myc; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
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J Gen Virol 87:1781-804 (2006)
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Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
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Trends Microbiol 17:119-29 (2009)
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Mark L, Spiller OB, Villoutreix BO, Blom AM
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Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
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Mol Immunol 44:11-22 (2007)
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Eur J Immunol 31:2458-66 (2001)
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KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
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Blood 95:1151-7 (2000)
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Curr Opin Virol 14:116-28 (2015)
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Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
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The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
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J Exp Med 189:1993-8 (1999)
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Choi YB, Nicholas J
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Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
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J Virol 82:6501-13 (2008)
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McCormick C, Ganem D
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The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
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Science 307:739-41 (2005)
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Wang HW, Boshoff C
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Linking Kaposi virus to cancer-associated cytokines.
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Trends Mol Med 11:309-12 (2005)
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Cell signaling pathways engaged by KSHV.
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Biochim Biophys Acta 1766:140-58 (2006)
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PMID:12032073
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Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
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Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
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EMBO J 21:2602-15 (2002)
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PMID:10510092
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Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
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The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
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J Exp Med 190:1025-32 (1999)
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Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
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Oncogene 18:5738-46 (1999)
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KSHV vFLIP binds to IKK-gamma to activate IKK.
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J Cell Sci 116:3721-8 (2003)
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Kaposi's sarcoma and its associated herpesvirus.
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Nat Rev Cancer 10:707-19 (2010)
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PMID:10799607
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Ishido S, Wang C, Lee BS, Cohen GB, Jung JU
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Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
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J Virol 74:5300-9 (2000)
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PMID:17166914
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Li Q, Means R, Lang S, Jung JU
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Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
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J Virol 81:2117-27 (2007)
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Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
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Proc Natl Acad Sci U S A 105:1656-61 (2008)
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PMID:11413168
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A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
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J Clin Invest 107:1599-606 (2001)
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How human tumor viruses make use of autophagy.
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Cells 1:617-30 (2012)
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Schulz TF, Moore PS
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Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
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Trends Microbiol 7:196-200 (1999)
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Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
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Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
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FEMS Microbiol Lett 222:155-63 (2003)
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The molecular pathology of Kaposi's sarcoma-associated herpesvirus.
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Biochim Biophys Acta 1602:1-22 (2002)
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Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
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J Virol 78:7667-76 (2004)
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PMID:10987301
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Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS
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The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
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Cancer Res 60:4873-80 (2000)
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Abere B, Schulz TF
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KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
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Curr Opin Virol 20:11-19 (2016)
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Sodhi A, Montaner S, Gutkind JS
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Viral hijacking of G-protein-coupled-receptor signalling networks.
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Nat Rev Mol Cell Biol 5:998-1012 (2004)
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PMID:17329974
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Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.
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Cell Cycle 6:438-43 (2007)
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PMID:23028325
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Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Havemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF
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Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
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PLoS Pathog 8:e1002927 (2012)
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PMID:10318948
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Lagunoff M, Majeti R, Weiss A, Ganem D
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Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
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Proc Natl Acad Sci U S A 96:5704-9 (1999)
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PMID:26192396
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Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein.
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Rev Med Virol 25:273-85 (2015)
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Havemeier A, Gramolelli S, Pietrek M, Jochmann R, Sturzl M, Schulz TF
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Activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-kappaB-inducing kinase, IkappaB kinases, and phosphorylation of p65.
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J Virol 88:13161-72 (2014)
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Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF
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Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
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J Virol 81:42-58 (2007)
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PMID:16585191
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Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B
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Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
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Cancer Res 66:3658-66 (2006)
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Reference
PMID:22521915
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Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M
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The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
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Virology 428:112-20 (2012)
DOI:10.1016/j.virol.2012.03.013
Reference
PMID:25594835
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Purushothaman P, Uppal T, Verma SC
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Molecular biology of KSHV lytic reactivation.
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Viruses 7:116-53 (2015)
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Reference
PMID:14991150
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Fujimuro M, Hayward SD
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Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
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J Mol Med (Berl) 82:223-31 (2004)
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Reference
PMID:26870016
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Purushothaman P, Dabral P, Gupta N, Sarkar R, Verma SC
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KSHV Genome Replication and Maintenance.
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Front Microbiol 7:54 (2016)
DOI:10.3389/fmicb.2016.00054
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pathway
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aamp04064  NF-kappa B signaling pathway
aamp04110  Cell cycle
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aamp04144  Endocytosis
aamp04151  PI3K-Akt signaling pathway
aamp04210  Apoptosis
aamp04310  Wnt signaling pathway
aamp04610  Complement and coagulation cascades
aamp04620  Toll-like receptor signaling pathway
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KO pathway
ko05167   
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