KEGG   PATHWAY: aful04510
Entry
aful04510                   Pathway                                
Name
Focal adhesion - Aythya fuligula (tufted duck)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
aful04510  Focal adhesion
aful04510

Other DBs
GO: 0005925
Organism
Aythya fuligula (tufted duck) [GN:aful]
Gene
116498286  COL1A1; collagen alpha-1(I) chain [KO:K06236]
116485413  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
116500022  COL2A1; LOW QUALITY PROTEIN: collagen alpha-1(II) chain [KO:K19719]
116492113  COL4A1; collagen alpha-1(IV) chain isoform X1 [KO:K06237]
116492458  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
116492768  collagen alpha-4(IV) chain-like [KO:K06237]
116488025  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
116494405  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
116494595  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
116490462  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
116490571  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
116490586  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
116485878  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
116498050  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
116487765  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
116495897  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
116487807  LAMA2; LOW QUALITY PROTEIN: laminin subunit alpha-2 [KO:K05637]
116485522  LAMA1; laminin subunit alpha-1 [KO:K05637]
116495821  LAMA5; laminin subunit alpha-5 [KO:K06240]
116486432  laminin subunit alpha-3-like isoform X1 [KO:K06240]
116488115  LAMA4; laminin subunit alpha-4 [KO:K06241]
116488657  LAMB1; laminin subunit beta-1 [KO:K05636]
116493119  laminin subunit beta-2-like [KO:K06243]
116493120  LAMB2; laminin subunit beta-2 [KO:K06243]
116498926  LAMB3; laminin subunit beta-3 [KO:K06244]
116497011  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
116492057  LAMC1; laminin subunit gamma-1 [KO:K05635]
116492054  LAMC2; laminin subunit gamma-2 [KO:K06246]
116497014  LAMC3; laminin subunit gamma-3 [KO:K06247]
116496737  CHAD; chondroadherin [KO:K06248]
116491986  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
116489983  THBS1; thrombospondin-1 [KO:K16857]
116488156  THBS2; thrombospondin-2 [KO:K04659]
116499240  COMP; cartilage oligomeric matrix protein [KO:K04659]
116499508  THBS3; thrombospondin-3 [KO:K04659]
116501151  THBS4; thrombospondin-4 [KO:K04659]
116490459  FN1; fibronectin isoform X1 [KO:K05717]
116488825  SPP1; osteopontin [KO:K06250]
116497169  VTN; vitronectin [KO:K06251]
116492053  TNN; tenascin-N [KO:K06252]
116500210  tenascin-X-like [KO:K06252]
116491716  TNR; tenascin-R [KO:K06252]
116496828  TNC; tenascin isoform X1 [KO:K06252]
116493693  VWF; von Willebrand factor [KO:K03900]
116489078  IBSP; bone sialoprotein 2 [KO:K06253]
116500835  ITGA1; integrin alpha-1 [KO:K06480]
116500518  ITGA2; integrin alpha-2 [KO:K06481]
116498331  ITGA2B; integrin alpha-IIb [KO:K06476]
116498573  ITGA3; integrin alpha-3 [KO:K06482]
116490629  ITGA4; integrin alpha-4 [KO:K06483]
116490658  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
116499963  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
116486913  ITGA8; integrin alpha-8 [KO:K06584]
116485489  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
116499570  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
116493274  ITGA11; integrin alpha-11 [KO:K06587]
116490600  ITGAV; integrin alpha-V [KO:K06487]
116485474  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
116498494  ITGB3; integrin beta-3 [KO:K06493]
116496563  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
116490808  ITGB5; integrin beta-5 [KO:K06588]
116490871  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
116486140  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
116495506  EMP2; epithelial membrane protein 2 [KO:K26256]
116495257  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
116502269  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
116488844  PDGFC; platelet-derived growth factor C [KO:K05450]
116490799  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
116488496  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
116494460  IGF1; insulin-like growth factor I [KO:K05459]
116488296  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
116490346  PGF; placenta growth factor [KO:K16859]
116502060  VEGFD; vascular endothelial growth factor D [KO:K05449]
116488843  VEGFC; LOW QUALITY PROTEIN: vascular endothelial growth factor C [KO:K05449]
116497145  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
116488453  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
116494711  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
116493472  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
116489139  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
116485864  EGFR; LOW QUALITY PROTEIN: epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
116492016  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
116494267  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
116494987  FLT4; vascular endothelial growth factor receptor 3 [KO:K05097] [EC:2.7.10.1]
116486260  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
116498599  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
116502155  EMP1; epithelial membrane protein 1 [KO:K26255]
116495903  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
116501544  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
116489417  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
116492928  RHOA; transforming protein RhoA [KO:K04513]
116486829  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
116487357  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
116496258  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
116495666  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
116497402  MYL10; myosin regulatory light chain 10 [KO:K12756]
116486339  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
116486483  myosin regulatory light chain 2, smooth muscle minor isoform [KO:K12757]
116487559  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
116490257  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
116495978  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
116497380  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
116498840  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
116493811  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
116490524  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
116495849  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
116485603  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
116498329  myosin light chain kinase, smooth muscle-like [KO:K00907] [EC:2.7.11.18]
116499178  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
116499631  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
116501126  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
116487373  actin, cytoplasmic 1-like [KO:K05692]
116493419  actin, cytoplasmic type 5 [KO:K05692]
116495117  ACTB; actin, cytoplasmic 1 [KO:K05692]
116496411  ACTG1; actin, cytoplasmic 2 [KO:K05692]
116493607  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
116487638  calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
116489754  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
116493456  TLN2; talin-2 [KO:K06271]
116500652  TLN1; talin-1 [KO:K06271]
116501282  talin-1-like [KO:K06271]
116493195  FLNB; filamin-B isoform X1 [KO:K27392]
116496331  PXN; paxillin [KO:K05760]
116501897  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
116502334  ZYX; zyxin isoform X1 [KO:K06273]
116491085  VCL; vinculin isoform X1 [KO:K05700]
116502039  PARVB; beta-parvin isoform X1 [KO:K06275]
116489351  PARVA; alpha-parvin isoform X1 [KO:K06275]
116501771  PARVG; gamma-parvin isoform X1 [KO:K06275]
116495306  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
116488009  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116489712  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
116494482  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116485478  CTNNB1; catenin beta-1 [KO:K02105]
116496571  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
116495441  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
116485476  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
116492299  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
116492415  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
116497623  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
116499089  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116501170  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116491758  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
116491269  PTEN; LOW QUALITY PROTEIN: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
116492044  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
116500092  VAV1; proto-oncogene vav [KO:K05730]
116496875  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
116495209  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
116496135  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
116496439  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
116492966  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
116492367  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
116494321  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
116501527  PAK4; LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
116488332  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
116490056  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
116497501  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
116494114  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
116497176  CRK; adapter molecule crk isoform X1 [KO:K04438]
116496037  CRKL; crk-like protein [KO:K04438]
116491116  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
116496876  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
116498770  RAP1A; ras-related protein Rap-1A [KO:K04353]
116487830  RAP1B; ras-related protein Rap-1b [KO:K07836]
116489162  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
116495022  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
116491194  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
116492142  JUN; transcription factor AP-1 [KO:K04448]
116492488  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
116495047  CAV1; caveolin-1 [KO:K06278]
116500629  CAV2; caveolin-2 [KO:K12958]
116493200  CAV3; caveolin-3 [KO:K12959]
116488312  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
116499756  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
116499186  SHC2; SHC-transforming protein 2 [KO:K17447]
116500840  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
116493314  SHC4; SHC-transforming protein 4 [KO:K17449]
116496483  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
116487382  SOS1; son of sevenless homolog 1 [KO:K03099]
116489737  SOS2; son of sevenless homolog 2 [KO:K03099]
116490064  HRAS; GTPase HRas [KO:K02833]
116493064  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116493377  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
116496022  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116490240  CCND1; G1/S-specific cyclin-D1 isoform X1 [KO:K04503]
116494310  CCND2; LOW QUALITY PROTEIN: G1/S-specific cyclin-D2 [KO:K10151]
116498945  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
116491707  inhibitor of apoptosis protein [KO:K16060]
116494556  XIAP; E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
116486210  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
aful04010  MAPK signaling pathway
aful04060  Cytokine-cytokine receptor interaction
aful04070  Phosphatidylinositol signaling system
aful04110  Cell cycle
aful04310  Wnt signaling pathway
aful04512  ECM-receptor interaction
aful04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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