KEGG   PATHWAY: bom05206
Entry
bom05206                    Pathway                                
Name
MicroRNAs in cancer - Bos mutus (wild yak)
Description
MicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or the inhibition of protein translation. Using high-throughput profiling, dysregulation of miRNAs has been widely observed in different stages of cancer. The upregulation (overexpression) of specific miRNAs could lead to the repression of tumor suppressor gene expression, and conversely the downregulation of specific miRNAs could result in an increase of oncogene expression; both these situations induce subsequent malignant effects on cell proliferation, differentiation, and apoptosis that lead to tumor growth and progress. The miRNA signatures of cancer observed in various studies differ significantly. These inconsistencies occur due to the differences in the study populations and methodologies used. This pathway map shows the summarized results from various studies in 9 cancers, each of which is presented in a review article.
Class
Human Diseases; Cancer: overview
Pathway map
bom05206  MicroRNAs in cancer
bom05206

Organism
Bos mutus (wild yak) [GN:bom]
Gene
102268478  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102276245  CDKN1B; cyclin dependent kinase inhibitor 1B [KO:K06624]
102277890  TIMP3; TIMP metallopeptidase inhibitor 3 [KO:K16866]
102286500  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102264992  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
102285046  CDC25A; cell division cycle 25A [KO:K06645] [EC:3.1.3.48]
102276738  CDC25B; cell division cycle 25B [KO:K05866] [EC:3.1.3.48]
102287313  CDC25C; cell division cycle 25C [KO:K05867] [EC:3.1.3.48]
102268316  HMGA2; high mobility group AT-hook 2 [KO:K09283]
102270546  CCND1; cyclin D1 [KO:K04503]
102272576  CCND2; cyclin D2 [KO:K10151]
102284697  CCNE2; cyclin E2 [KO:K06626]
102271261  CCNE1; cyclin E1 [KO:K06626]
102277025  CRKL; CRK like proto-oncogene, adaptor protein [KO:K04438]
102271862  HDAC5; histone deacetylase 5 [KO:K11406] [EC:3.5.1.98]
102282588  HDAC4; histone deacetylase 4 [KO:K11406] [EC:3.5.1.98]
102282705  FOXP1; forkhead box P1 [KO:K23582]
102287943  PIM1; Pim-1 proto-oncogene, serine/threonine kinase [KO:K04702] [EC:2.7.11.1]
102285634  MET; MET proto-oncogene, receptor tyrosine kinase [KO:K05099] [EC:2.7.10.1]
102284316  DNMT3A; DNA methyltransferase 3 alpha [KO:K17398] [EC:2.1.1.37]
102272906  DNMT3B; DNA methyltransferase 3 beta [KO:K17399] [EC:2.1.1.37]
102283384  MCL1; BCL2 family apoptosis regulator [KO:K02539]
102277523  induced myeloid leukemia cell differentiation protein Mcl-1 homolog [KO:K02539]
102271776  BCL2L2; BCL2 like 2 [KO:K02163]
102269868  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
102270607  VEGFA; vascular endothelial growth factor A [KO:K05448]
102287314  ZEB1; zinc finger E-box-binding homeobox 1 [KO:K09299]
102283491  TGFB2; transforming growth factor beta 2 [KO:K13376]
102275240  EZR; ezrin [KO:K08007]
102284228  PDCD4; programmed cell death 4 [KO:K16865]
102264880  CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
102273007  EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
102270744  TPM1; tropomyosin 1 (alpha) [KO:K10373]
102270903  SPRY2; sprouty RTK signaling antagonist 2 [KO:K17383]
102268592  BCL2; BCL2, apoptosis regulator [KO:K02161]
102268123  SERPINB5; serpin family B member 5 [KO:K10139]
102277353  ST14; suppression of tumorigenicity 14 [KO:K08670] [EC:3.4.21.109]
102283377  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
102281727  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102285390  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
102272075  1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial [KO:K07436] [EC:1.14.15.16]
102267975  ERBB2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
102273820  ERBB3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
102266301  ABL1; ABL proto-oncogene 1, non-receptor tyrosine kinase [KO:K06619] [EC:2.7.10.2]
102283023  TP63; tumor protein p63 [KO:K10149]
102268402  ZEB2; zinc finger E-box binding homeobox 2 [KO:K23560]
102268379  FSCN1; fascin actin-bundling protein 1 [KO:K23551]
102286263  RASSF1; Ras association domain family member 1 [KO:K09850]
102282997  HOXD10; homeobox D10 [KO:K09295]
102285482  DDIT4; DNA damage inducible transcript 4 [KO:K08270]
102274343  BMF; Bcl2 modifying factor [KO:K17460]
102269333  PAK4; p21 (RAC1) activated kinase 4 [KO:K05734] [EC:2.7.11.1]
102273141  MMP9; matrix metallopeptidase 9 [KO:K01403] [EC:3.4.24.35]
102268827  SLC7A1; solute carrier family 7 member 1 [KO:K13863]
102267927  CCNG1; cyclin G1 [KO:K10145]
102281265  HMOX1; heme oxygenase 1 [KO:K00510] [EC:1.14.14.18]
102266369  STMN1; stathmin 1 [KO:K04381]
102269741  stathmin [KO:K04381]
102282282  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
102274304  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
102287348  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
102278591  GTPase HRas [KO:K02833]
102277011  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102269203  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102275499  DNMT1; DNA methyltransferase 1 [KO:K00558] [EC:2.1.1.37]
102282143  APC2; APC2, WNT signaling pathway regulator [KO:K02085]
102272116  APC; APC, WNT signaling pathway regulator [KO:K02085]
102284664  IRS1; insulin receptor substrate 1 [KO:K16172]
102266922  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102280296  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102286868  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102278560  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
102274553  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
102274461  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102277548  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102278715  HNRNPK; heterogeneous nuclear ribonucleoprotein K [KO:K12886]
102288346  heterogeneous nuclear ribonucleoprotein K-like [KO:K12886]
102281771  RECK; reversion inducing cysteine rich protein with kazal motifs [KO:K17461]
102270876  E2F3; E2F transcription factor 3 [KO:K06620]
102277930  NOTCH1; notch 1 [KO:K02599]
102272746  NOTCH2; notch 2 [KO:K20994]
102270219  NOTCH3; notch 3 [KO:K20995]
102267612  NOTCH4; notch 4 [KO:K20996]
102272593  BMI1; BMI1 proto-oncogene, polycomb ring finger [KO:K11459]
102269596  MMP16; matrix metallopeptidase 16 [KO:K07996] [EC:3.4.24.-]
102278968  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
102270218  serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
102282706  CD44; CD44 molecule (Indian blood group) [KO:K06256]
102270004  DICER1; dicer 1, ribonuclease III [KO:K11592] [EC:3.1.26.-]
102273339  FZD3; frizzled class receptor 3 [KO:K02329]
102276200  ITGA5; integrin subunit alpha 5 [KO:K06484]
102278956  RDX; radixin [KO:K05762]
102280554  RHOA; ras homolog family member A [KO:K04513]
102278255  PLAU; plasminogen activator, urokinase [KO:K01348] [EC:3.4.21.73]
102266544  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
102265231  ZFPM2; zinc finger protein, FOG family member 2 [KO:K17442]
102268918  ITGB3; integrin subunit beta 3 [KO:K06493]
102275746  UBE2I; ubiquitin conjugating enzyme E2 I [KO:K10577]
102265841  SOX4; transcription factor SOX-4 [KO:K23581]
102287019  TNN; tenascin N [KO:K06252]
102268167  TNXB; tenascin XB [KO:K06252]
102283502  TNC; tenascin C [KO:K06252]
102283906  TNR; tenascin R [KO:K06252]
102267113  multidrug resistance protein 1 [KO:K05658] [EC:7.6.2.2]
102280609  ABCC1; ATP binding cassette subfamily C member 1 [KO:K05665] [EC:7.6.2.3]
102266344  BRCA1; BRCA1, DNA repair associated [KO:K10605] [EC:2.3.2.27]
102268672  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
102282993  EFNA2; ephrin A2 [KO:K05462]
102269650  EFNA4; ephrin A4 [KO:K05462]
102267601  EFNA3; ephrin A3 [KO:K05462]
102267874  EFNA1; ephrin A1 [KO:K05462]
102276040  EFNA5; ephrin A5 [KO:K05462]
102278109  THBS1; thrombospondin 1 [KO:K16857]
102271496  IGF2BP1; insulin like growth factor 2 mRNA binding protein 1 [KO:K17391]
102286289  TRIM71; tripartite motif containing 71 [KO:K12035] [EC:2.3.2.27]
102286969  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
102281443  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
102271174  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
102272368  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102284931  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102278724  PRKCA; protein kinase C alpha [KO:K02677] [EC:2.7.11.13]
102274116  PRKCB; protein kinase C beta [KO:K19662] [EC:2.7.11.13]
102265831  PRKCG; protein kinase C gamma [KO:K19663] [EC:2.7.11.13]
102286241  GRB2; growth factor receptor bound protein 2 [KO:K04364]
102264670  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
102283727  RPS6KA5; ribosomal protein S6 kinase A5 [KO:K04445] [EC:2.7.11.1]
102272370  TP53; tumor protein p53 [KO:K04451]
102287490  MDM2; MDM2 proto-oncogene [KO:K06643] [EC:2.3.2.27]
102269169  MDM4; MDM4, p53 regulator [KO:K10127]
102282598  PDGFRA; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
102265099  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
102285300  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
102288216  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102280670  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102271710  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102286943  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO:K03099]
102277585  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO:K03099]
102265814  SHC1; SHC adaptor protein 1 [KO:K06279]
102271219  PDGFA; platelet derived growth factor subunit A [KO:K04359]
102284488  SHC4; SHC adaptor protein 4 [KO:K17449]
102266290  PDGFB; platelet derived growth factor subunit B [KO:K17386]
102270608  PDGFRB; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
102284461  CDKN2A; cyclin dependent kinase inhibitor 2A [KO:K06621]
102274863  E2F1; E2F transcription factor 1 [KO:K17454]
102268181  E2F2; E2F transcription factor 2 [KO:K09389]
102276156  BCL2L11; BCL2 like 11 [KO:K16341]
102280729  MARCKS; myristoylated alanine rich protein kinase C substrate [KO:K12561]
102276585  BMPR2; bone morphogenetic protein receptor type 2 [KO:K04671] [EC:2.7.11.30]
102279602  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
102265183  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
102287858  EZH2; enhancer of zeste 2 polycomb repressive complex 2 subunit [KO:K11430] [EC:2.1.1.356]
102283226  GLS; glutaminase [KO:K01425] [EC:3.5.1.2]
102279390  GLS2; glutaminase 2 [KO:K01425] [EC:3.5.1.2]
102276604  SIRT1; sirtuin 1 [KO:K11411] [EC:2.3.1.286]
102275609  WNT3A; Wnt family member 3A [KO:K00312]
102281377  WNT3; Wnt family member 3 [KO:K00312]
102285720  CDCA5; cell division cycle associated 5 [KO:K17390]
106700511  uncharacterized LOC106700511 [KO:K17390]
102288352  KIF23; kinesin family member 23 [KO:K17387]
102284712  ROCK1; Rho associated coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
102266941  PRKCE; protein kinase C epsilon [KO:K18050] [EC:2.7.11.13]
102283594  protein kinase C epsilon type [KO:K18050] [EC:2.7.11.13]
102279428  SLC45A3; solute carrier family 45 member 3 [KO:K15379]
102283001  VIM; vimentin [KO:K07606]
Reference
PMID:18817506
  Authors
Lee YS, Dutta A
  Title
MicroRNAs in cancer.
  Journal
Annu Rev Pathol 4:199-227 (2009)
DOI:10.1146/annurev.pathol.4.110807.092222
Reference
PMID:21402473
  Authors
Babashah S, Soleimani M
  Title
The oncogenic and tumour suppressive roles of microRNAs in cancer and apoptosis.
  Journal
Eur J Cancer 47:1127-37 (2011)
DOI:10.1016/j.ejca.2011.02.008
Reference
PMID:19630570
  Authors
Garzon R, Calin GA, Croce CM
  Title
MicroRNAs in Cancer.
  Journal
Annu Rev Med 60:167-79 (2009)
DOI:10.1146/annurev.med.59.053006.104707
Reference
PMID:23075324
  Authors
Chen PS, Su JL, Hung MC
  Title
Dysregulation of microRNAs in cancer.
  Journal
J Biomed Sci 19:90 (2012)
DOI:10.1186/1423-0127-19-90
Reference
PMID:22035854
  Authors
Ling H, Zhang W, Calin GA
  Title
Principles of microRNA involvement in human cancers.
  Journal
Chin J Cancer 30:739-48 (2011)
DOI:10.5732/cjc.011.10243
Reference
PMID:22351564
  Authors
Iorio MV, Croce CM
  Title
MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review.
  Journal
EMBO Mol Med 4:143-59 (2012)
DOI:10.1002/emmm.201100209
Reference
PMID:21742789
  Authors
Sayed D, Abdellatif M
  Title
MicroRNAs in development and disease.
  Journal
Physiol Rev 91:827-87 (2011)
DOI:10.1152/physrev.00006.2010
Reference
PMID:22345301
  Authors
Wang Q, Wang S, Wang H, Li P, Ma Z
  Title
MicroRNAs: novel biomarkers for lung cancer diagnosis, prediction and treatment.
  Journal
Exp Biol Med (Maywood) 237:227-35 (2012)
DOI:10.1258/ebm.2011.011192
Reference
PMID:22580099
  Authors
Song JH, Meltzer SJ
  Title
MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers.
  Journal
Gastroenterology 143:35-47.e2 (2012)
DOI:10.1053/j.gastro.2012.05.003
Reference
PMID:23462054
  Authors
Chu Y, Zhu H, Lv L, Zhou Y, Huo J
  Title
MiRNA s in oesophageal squamous cancer.
  Journal
Neth J Med 71:69-75 (2013)
Reference
PMID:19773200
  Authors
Kan T, Meltzer SJ
  Title
MicroRNAs in Barrett's esophagus and esophageal adenocarcinoma.
  Journal
Curr Opin Pharmacol 9:727-32 (2009)
DOI:10.1016/j.coph.2009.08.009
Reference
PMID:20128019
  Authors
Smith CM, Watson DI, Michael MZ, Hussey DJ
  Title
MicroRNAs, development of Barrett's esophagus, and progression to esophageal adenocarcinoma.
  Journal
World J Gastroenterol 16:531-7 (2010)
DOI:10.3748/wjg.v16.i5.531
Reference
PMID:23165235
  Authors
Song S, Ajani JA
  Title
The role of microRNAs in cancers of the upper gastrointestinal tract.
  Journal
Nat Rev Gastroenterol Hepatol 10:109-18 (2013)
DOI:10.1038/nrgastro.2012.210
Reference
PMID:21565290
  Authors
Liu WH, Yeh SH, Chen PJ
  Title
Role of microRNAs in hepatitis B virus replication and pathogenesis.
  Journal
Biochim Biophys Acta 1809:678-85 (2011)
DOI:10.1016/j.bbagrm.2011.04.008
Reference
PMID:23091478
  Authors
Hrasovec S, Glavac D
  Title
MicroRNAs as Novel Biomarkers in Colorectal Cancer.
  Journal
Front Genet 3:180 (2012)
DOI:10.3389/fgene.2012.00180
Reference
PMID:22926415
  Authors
Liu H
  Title
MicroRNAs in breast cancer initiation and progression.
  Journal
Cell Mol Life Sci 69:3587-99 (2012)
DOI:10.1007/s00018-012-1128-9
Reference
PMID:20345848
  Authors
Li SD, Zhang JR, Wang YQ, Wan XP
  Title
The role of microRNAs in ovarian cancer initiation and progression.
  Journal
J Cell Mol Med 14:2240-9 (2010)
DOI:10.1111/j.1582-4934.2010.01058.x
Reference
PMID:23316212
  Authors
Zabolotneva AA, Zhavoronkov A, Garazha AV, Roumiantsev SA, Buzdin AA
  Title
Characteristic patterns of microRNA expression in human bladder cancer.
  Journal
Front Genet 3:310 (2012)
DOI:10.3389/fgene.2012.00310
Reference
PMID:20221895
  Authors
Saini S, Majid S, Dahiya R
  Title
Diet, microRNAs and prostate cancer.
  Journal
Pharm Res 27:1014-26 (2010)
DOI:10.1007/s11095-010-0086-x
Related
pathway
bom05210  Colorectal cancer
bom05214  Glioma
bom05215  Prostate cancer
bom05219  Bladder cancer
bom05222  Small cell lung cancer
bom05223  Non-small cell lung cancer
KO pathway
ko05206   
LinkDB

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