KEGG   PATHWAY: btax04060
Entry
btax04060                   Pathway                                
Name
Cytokine-cytokine receptor interaction - Budorcas taxicolor (takin)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
Pathway map
btax04060  Cytokine-cytokine receptor interaction
btax04060

Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128065622  CCL1; C-C motif chemokine 1 [KO:K05514]
128051340  CCL25; C-C motif chemokine 25 isoform X1 [KO:K13072]
128052864  CCL19; C-C motif chemokine 19 [KO:K05512]
128052733  CCL21; C-C motif chemokine 21 [KO:K16062]
128064804  C-C motif chemokine 3-like [KO:K05408]
128064806  C-C motif chemokine 3 [KO:K05408]
128064807  C-C motif chemokine 3-like [KO:K05408]
128064809  C-C motif chemokine 3-like [KO:K05408]
128064808  C-C motif chemokine 4 [KO:K12964]
128063809  C-C motif chemokine 17-like [KO:K21083]
128063832  C-C motif chemokine 17-like [KO:K21083]
128064137  CCL22; C-C motif chemokine 22 [KO:K21095]
128064805  C-C motif chemokine 5 [KO:K12499]
128065552  C-C motif chemokine 8 [KO:K16596]
128064801  C-C motif chemokine 14-like [KO:K21092]
128064802  CCL16; C-C motif chemokine 16 [KO:K21093]
128064800  C-C motif chemokine 15-like isoform X1 [KO:K05511]
128065365  C-C motif chemokine 2 [KO:K14624]
128065537  eotaxin [KO:K16597]
128043812  CCL24; C-C motif chemokine 24 [KO:K21097]
128043677  CCL26; C-C motif chemokine 26 [KO:K21096]
128052516  uncharacterized protein LOC128052516 [KO:K16598]
128052872  CCL27; C-C motif chemokine 27 [KO:K16598]
128043869  CCL20; C-C motif chemokine 20 [KO:K14625]
128049546  growth-regulated alpha protein [KO:K05505]
128049610  growth-regulated protein homolog gamma-like [KO:K05505]
128049611  growth-regulated alpha protein-like [KO:K05505]
128049973  C-X-C motif chemokine 6 [KO:K05506]
128049958  CXCL8; interleukin-8 [KO:K10030]
128049944  PPBP; platelet basic protein [KO:K10029]
128050056  platelet factor 4 [KO:K05407]
128050044  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
128050033  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
128050055  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
128050068  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
128047373  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
128064687  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
128051502  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
128063965  CXCL17; LOW QUALITY PROTEIN: C-X-C motif chemokine 17 [KO:K22627]
128064173  C-X-C motif chemokine 17 [KO:K22627]
128061785  cytokine SCM-1 beta-like [KO:K05507]
128061790  XCL1; lymphotactin [KO:K05507]
128063251  CX3CL1; fractalkine isoform X1 [KO:K05508]
128062529  IL2; interleukin-2 [KO:K05429]
128051558  IL4; interleukin-4 [KO:K05430]
128059511  IL7; interleukin-7 [KO:K05431]
128050264  IL9; interleukin-9 [KO:K05432]
128062532  IL15; interleukin-15 [KO:K05433]
128062628  IL21; interleukin-21 [KO:K05434]
128051755  interleukin-3 [KO:K04736]
128051671  IL5; interleukin-5 [KO:K05428]
128051607  CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427]
128051691  IL13; interleukin-13 [KO:K05435]
128043795  EPO; erythropoietin [KO:K05437]
128065055  GH1; somatotropin [KO:K05438]
128056068  LOW QUALITY PROTEIN: chorionic somatomammotropin hormone 2-like [KO:K05439]
128056134  LOW QUALITY PROTEIN: placental prolactin-related protein 1-like [KO:K05439]
128056189  chorionic somatomammotropin hormone 2-like [KO:K05439]
128056261  placental prolactin-related protein 1-like [KO:K05439]
128056286  placental prolactin-related protein 4-like [KO:K05439]
128056321  placental prolactin-related protein 3-like [KO:K05439]
128056535  prolactin [KO:K05439]
128055157  chorionic somatomammotropin hormone [KO:K05439]
128055513  chorionic somatomammotropin hormone 2-like [KO:K05439]
128050927  THPO; thrombopoietin isoform X1 [KO:K06854]
128065541  CSF3; granulocyte colony-stimulating factor [KO:K05423]
128046617  LEP; leptin [KO:K05424]
128046952  IL6; interleukin-6 [KO:K05405]
128063566  IL11; interleukin-11 [KO:K05417]
128050368  IL12A; interleukin-12 subunit alpha isoform X1 [KO:K05406]
128051514  IL12B; interleukin-12 subunit beta [KO:K05425]
128047301  IL23A; interleukin-23 subunit alpha [KO:K05426]
128043707  IL27; interleukin-27 subunit alpha [KO:K22629]
128051622  EBI3; interleukin-27 subunit beta [KO:K24476]
128069009  CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421]
128060931  CNTF; ciliary neurotrophic factor [KO:K05420]
128043253  CTF1; cardiotrophin-1 [KO:K05422]
128043829  cardiotrophin-2-like [KO:K24382]
128062119  LIF; leukemia inhibitory factor [KO:K05419]
128062617  OSM; oncostatin-M [KO:K05418]
128061792  IL10; interleukin-10 [KO:K05443]
128061793  IL19; interleukin-19 [KO:K05444]
128061821  IL20; interleukin-20 [KO:K22667]
128061741  IL24; interleukin-24 [KO:K22668]
128048882  IL22; interleukin-22 [KO:K05445]
128048928  IL26; interleukin-26 [KO:K05446]
128063710  interferon lambda-3-like [KO:K22669]
128063821  interferon lambda-3-like [KO:K22669]
128052429  interferon alpha-H-like [KO:K05414]
128052430  interferon alpha-H-like [KO:K05414]
128052431  interferon alpha-H [KO:K05414]
128052432  interferon alpha-1-like [KO:K05414]
128052433  interferon alpha-H-like [KO:K05414]
128052459  interferon alpha-H-like [KO:K05414]
128052476  interferon alpha-H-like [KO:K05414]
128052682  LOW QUALITY PROTEIN: interferon alpha-3-like [KO:K05414]
128052694  interferon alpha-H-like [KO:K05414]
128052696  interferon alpha-H-like [KO:K05414]
128052697  interferon alpha-1-like [KO:K05414]
128052706  LOW QUALITY PROTEIN: interferon alpha-2-like [KO:K05414]
128052625  interferon beta-2-like [KO:K05415]
128052626  interferon beta-2-like [KO:K05415]
128052627  interferon beta-2-like [KO:K05415]
128052628  interferon beta-2 [KO:K05415]
128052635  interferon beta-2-like [KO:K05415]
128052636  interferon beta-2-like [KO:K05415]
128052637  interferon beta-2-like [KO:K05415]
128052638  interferon beta-2-like [KO:K05415]
128052639  interferon beta-2-like [KO:K05415]
128052640  interferon beta-2-like [KO:K05415]
128052652  interferon beta-2-like [KO:K05415]
128052039  interferon omega-1-like [KO:K05440]
128052245  interferon omega-1-like [KO:K05440]
128052258  interferon omega-1-like [KO:K05440]
128052262  interferon omega-1-like [KO:K05440]
128052280  interferon omega-1-like [KO:K05440]
128052283  interferon omega-1-like [KO:K05440]
128052288  interferon omega-1-like [KO:K05440]
128052291  interferon omega-1 [KO:K05440]
128052292  interferon omega-1-like [KO:K05440]
128052294  interferon omega-1-like [KO:K05440]
128052295  interferon omega-1-like [KO:K05440]
128052300  interferon omega-1-like [KO:K05440]
128052306  interferon omega-1-like [KO:K05440]
128052318  interferon omega-1-like [KO:K05440]
128052331  interferon omega-1-like [KO:K05440]
128052351  interferon omega-1-like [KO:K05440]
128052435  interferon omega-1-like [KO:K05440]
128052311  interferon tau-like [KO:K05440]
128052304  IFNK; interferon kappa [KO:K05441]
128052870  IFNE; interferon epsilon [KO:K05442]
128048506  IFNG; interferon gamma [KO:K04687]
128056679  IL1A; interleukin-1 alpha [KO:K04383]
128056569  IL1B; interleukin-1 beta [KO:K04519]
128056598  IL1RN; interleukin-1 receptor antagonist protein [KO:K05481]
128056944  IL36RN; interleukin-36 receptor antagonist protein [KO:K05483]
128056791  IL36A; interleukin-36 alpha [KO:K05484]
128055691  IL36B; interleukin-36 beta [KO:K05486]
128055690  IL36G; interleukin-36 gamma [KO:K05487]
128056907  IL1F10; interleukin-1 family member 10 [KO:K05488]
128056730  IL37; LOW QUALITY PROTEIN: interleukin-37 [KO:K05485]
128060832  IL18; interleukin-18 [KO:K05482]
128052701  IL33; interleukin-33 [KO:K12967]
128056882  IL17A; interleukin-17A [KO:K05489]
128056923  IL17F; interleukin-17F [KO:K05494]
128051167  IL17B; interleukin-17B isoform X1 [KO:K05490]
128063424  IL17C; interleukin-17C [KO:K05491]
128057655  IL17D; interleukin-17D [KO:K05492]
128054620  IL25; interleukin-25 [KO:K05493]
128066406  IL16; pro-interleukin-16 [KO:K22628]
128043247  uncharacterized protein LOC128043247 isoform X1 [KO:K22632]
128063468  IL34; interleukin-34 [KO:K22633]
128044745  CSF1; macrophage colony-stimulating factor 1 [KO:K05453]
128056772  TNF; tumor necrosis factor [KO:K03156]
128056921  LTA; lymphotoxin-alpha [KO:K05468]
128056911  LTB; lymphotoxin-beta [KO:K03157]
128051638  tumor necrosis factor ligand superfamily member 14-like [KO:K05477]
128061812  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
128052832  TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478]
128055119  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
128070217  EDA; ectodysplasin-A [KO:K05480]
128045179  NGF; beta-nerve growth factor [KO:K02582]
128057835  TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473]
128051706  CD70; CD70 antigen [KO:K05470]
128052843  TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471]
128070488  CD40LG; CD40 ligand [KO:K03161]
128051749  TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472]
128061854  TNFSF4; tumor necrosis factor ligand superfamily member 4 [KO:K05469]
128061852  TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479]
128057828  TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476]
128063320  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
128061503  TGFB2; transforming growth factor beta-2 proprotein [KO:K13376]
128053888  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
128051689  GDF15; growth/differentiation factor 15 [KO:K05504]
128048781  GDF2; growth/differentiation factor 2 [KO:K05503]
128056914  BMP10; bone morphogenetic protein 10 [KO:K22670]
128043799  INHA; inhibin alpha chain [KO:K05500]
128050079  BMP3; bone morphogenetic protein 3 [KO:K05496]
128048950  GDF10; growth/differentiation factor 10 [KO:K22674]
128048512  GDF11; growth/differentiation factor 11 [KO:K22679]
128043256  MSTN; growth/differentiation factor 8 [KO:K05497]
128046938  INHBA; inhibin beta A chain [KO:K04667]
128071076  INHBB; inhibin beta B chain [KO:K22687]
128050890  GDF1; embryonic growth/differentiation factor 1 [KO:K05495]
128048943  GDF3; growth/differentiation factor 3 [KO:K22672]
128048958  NODAL; nodal homolog [KO:K04666]
128051197  GDF9; growth/differentiation factor 9 isoform X1 [KO:K22673]
128049007  INHBC; inhibin beta C chain [KO:K22688]
128048966  INHBE; inhibin beta E chain [KO:K22689]
128051626  AMH; muellerian-inhibiting factor [KO:K04665]
128058649  BMP2; bone morphogenetic protein 2 [KO:K21283]
128054087  BMP4; bone morphogenetic protein 4 [KO:K04662]
128058738  GDF5; growth/differentiation factor 5 [KO:K04664]
128059595  GDF6; growth/differentiation factor 6 [KO:K20012]
128056749  GDF7; growth/differentiation factor 7 [KO:K20013]
128070392  BMP15; bone morphogenetic protein 15 [KO:K05498]
128056305  BMP5; bone morphogenetic protein 5 [KO:K04663]
128055958  BMP6; bone morphogenetic protein 6 [KO:K16620]
128058494  BMP7; bone morphogenetic protein 7 [KO:K16621]
128045045  bone morphogenetic protein 8B [KO:K16622]
128045056  bone morphogenetic protein 8B-like [KO:K16622]
128057171  CCR8; C-C chemokine receptor type 8 [KO:K04183]
128059385  CCR9; C-C chemokine receptor type 9 [KO:K04184]
128049755  ACKR4; atypical chemokine receptor 4 [KO:K04186]
128065529  CCR7; C-C chemokine receptor type 7 [KO:K04182]
128055689  CCR4; C-C chemokine receptor type 4 [KO:K04179]
128049778  C-C chemokine receptor type 5 [KO:K04180]
128049678  CCR3; C-C chemokine receptor type 3 [KO:K04178]
128049126  C-C chemokine receptor type 2-like [KO:K04177]
128051420  C-C chemokine receptor type 1 [KO:K04176]
128054958  LOW QUALITY PROTEIN: C-C chemokine receptor type 1-like [KO:K04176]
128065614  CCR10; C-C chemokine receptor type 10 [KO:K04185]
128053575  CCR6; C-C chemokine receptor type 6 [KO:K04181]
128043368  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
128043506  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
128069533  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
128060855  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
128070914  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
128044802  ACKR3; atypical chemokine receptor 3 [KO:K04304]
128059489  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
128056916  XCR1; chemokine XC receptor 1 [KO:K04193]
128056763  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
128058762  IL2RA; interleukin-2 receptor subunit alpha [KO:K05068]
128048204  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
128070243  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
128063317  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
128066211  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
128043537  IL9R; interleukin-9 receptor [KO:K05073]
128058419  IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074]
128043756  IL21R; interleukin-21 receptor [KO:K05075]
128069677  CRLF2; cytokine receptor-like factor 2 [KO:K05078]
128070407  IL3RA; interleukin-3 receptor subunit alpha [KO:K04737]
128047746  CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738]
128054154  IL5RA; interleukin-5 receptor subunit alpha [KO:K05067]
128070001  CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha [KO:K05066]
128069823  IL13RA1; interleukin-13 receptor subunit alpha-1 isoform X1 [KO:K05076]
128070543  IL13RA2; interleukin-13 receptor subunit alpha-2 [KO:K05077]
128051628  EPOR; erythropoietin receptor [KO:K05079]
128065987  GHR; growth hormone receptor isoform X1 [KO:K05080]
128066145  PRLR; prolactin receptor [KO:K05081]
128045373  MPL; thrombopoietin receptor [KO:K05082]
128045256  CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061]
128045230  LEPR; leptin receptor [KO:K05062]
128045517  IL6R; interleukin-6 receptor subunit alpha [KO:K05055]
128066072  IL6ST; interleukin-6 receptor subunit beta [KO:K05060]
128052326  IL11RA; interleukin-11 receptor subunit alpha [KO:K05056]
128051171  IL12RB1; interleukin-12 receptor subunit beta-1 [KO:K05063]
128045352  IL12RB2; interleukin-12 receptor subunit beta-2 [KO:K05064]
128045723  IL23R; interleukin-23 receptor [KO:K05065]
128050825  IL27RA; interleukin-27 receptor subunit alpha [KO:K19598]
128066191  IL31RA; interleukin-31 receptor subunit alpha [KO:K22630]
128052177  CNTFR; ciliary neurotrophic factor receptor subunit alpha isoform X1 [KO:K05059]
128066085  LIFR; leukemia inhibitory factor receptor [KO:K05058]
128066061  OSMR; oncostatin-M-specific receptor subunit beta isoform X1 [KO:K05057]
128060929  IL10RA; interleukin-10 receptor subunit alpha [KO:K05134]
128053481  IL20RA; interleukin-20 receptor subunit alpha [KO:K05136]
128056199  IL20RB; interleukin-20 receptor subunit beta [KO:K05137]
128071495  IL22RA1; interleukin-22 receptor subunit alpha-1 [KO:K05138]
128071166  IFNLR1; interferon lambda receptor 1 [KO:K05140]
128044048  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
128055500  interferon alpha/beta receptor 2 [KO:K05131]
128053263  IFNGR1; interferon gamma receptor 1 isoform X1 [KO:K05132]
128047334  IFNGR2; interferon gamma receptor 2 [KO:K05133]
128056062  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
128054017  IL1RAP; interleukin-1 receptor accessory protein [KO:K04723]
128056702  IL1R2; interleukin-1 receptor type 2 [KO:K04387]
128056624  IL1RL2; LOW QUALITY PROTEIN: interleukin-1 receptor-like 2 [KO:K05172]
128056589  IL18R1; interleukin-18 receptor 1 [KO:K05173]
128056748  IL18RAP; interleukin-18 receptor accessory protein [KO:K05174]
128056714  IL1RL1; interleukin-1 receptor-like 1 [KO:K05171]
128047444  IL17RA; interleukin-17 receptor A isoform X1 [KO:K05164]
128071512  IL17RC; interleukin-17 receptor C isoform X5 [KO:K05166]
128055454  IL17RB; interleukin-17 receptor B [KO:K05165]
128053869  IL17RE; interleukin-17 receptor E [KO:K05168]
128048680  CD4; T-cell surface glycoprotein CD4 [KO:K06454]
128050693  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
128047668  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
128061416  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
128047522  LTBR; tumor necrosis factor receptor superfamily member 3 [KO:K03159]
128067871  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
128061615  TNFRSF25; tumor necrosis factor receptor superfamily member 25 [KO:K05160]
128052079  tumor necrosis factor receptor superfamily member 10C-like [KO:K04722]
128052097  tumor necrosis factor receptor superfamily member 10B-like [KO:K04722]
128052227  tumor necrosis factor receptor superfamily member 10C-like isoform X1 [KO:K04722]
128055888  TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157]
128056245  EDAR; tumor necrosis factor receptor superfamily member EDAR [KO:K05162]
128070025  EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163]
128065569  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
128059488  TNFRSF11B; tumor necrosis factor receptor superfamily member 11B isoform X1 [KO:K05148]
128067381  TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147]
128063307  TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149]
128048734  CD27; CD27 antigen [KO:K05144]
128061689  TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145]
128058688  CD40; tumor necrosis factor receptor superfamily member 5 [KO:K03160]
128061827  TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146]
128061420  TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142]
128061810  TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154]
128043785  TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153]
128065426  TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150]
128048934  TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151]
128057630  TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155]
128060725  RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156]
128050880  RELL2; RELT-like protein 2 [KO:K26541]
128049729  RELL1; RELT-like protein 1 [KO:K26541]
128051987  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
128048354  TGFBR2; TGF-beta receptor type-2 [KO:K04388] [EC:2.7.11.30]
128048929  ACVRL1; serine/threonine-protein kinase receptor R3 [KO:K13594] [EC:2.7.11.30]
128069136  ACVR2A; activin receptor type-2A [KO:K04670] [EC:2.7.11.30]
128068370  BMPR2; bone morphogenetic protein receptor type-2 [KO:K04671] [EC:2.7.11.30]
128047636  ACVR2B; activin receptor type-2B isoform X1 [KO:K13596] [EC:2.7.11.30]
128048879  ACVR1B; activin receptor type-1B [KO:K13567] [EC:2.7.11.30]
128062516  ACVR1C; activin receptor type-1C [KO:K13568] [EC:2.7.11.30]
128043843  ACVR1; activin receptor type-1 [KO:K04675] [EC:2.7.11.30]
128048714  AMHR2; anti-Muellerian hormone type-2 receptor [KO:K04672] [EC:2.7.11.30]
128047255  BMPR1A; bone morphogenetic protein receptor type-1A [KO:K04673] [EC:2.7.11.30]
128050065  BMPR1B; bone morphogenetic protein receptor type-1B [KO:K13578] [EC:2.7.11.30]
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KO pathway
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