KEGG   PATHWAY: btax04810
Entry
btax04810                   Pathway                                
Name
Regulation of actin cytoskeleton - Budorcas taxicolor (takin)
Class
Cellular Processes; Cell motility
Pathway map
btax04810  Regulation of actin cytoskeleton
btax04810

Other DBs
GO: 0030036
Organism
Budorcas taxicolor (takin) [GN:btax]
Gene
128052575  LPAR1; lysophosphatidic acid receptor 1 [KO:K04289]
128051634  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
128070397  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
128048822  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
128047373  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
128070914  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
128060803  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
128054190  F2R; proteinase-activated receptor 1 [KO:K03914]
128069208  INS; insulin [KO:K04526]
128050008  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
128050845  FGF1; fibroblast growth factor 1 [KO:K18496]
128062082  FGF2; LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
128049947  FGF5; fibroblast growth factor 5 [KO:K04358]
128069166  FGF4; fibroblast growth factor 4 [KO:K04358]
128069196  FGF3; fibroblast growth factor 3 [KO:K04358]
128070322  FGF16; fibroblast growth factor 16 [KO:K04358]
128057718  FGF9; fibroblast growth factor 9 [KO:K04358]
128051703  FGF22; fibroblast growth factor 22 [KO:K04358]
128052704  FGF17; fibroblast growth factor 17 [KO:K04358]
128065968  FGF10; fibroblast growth factor 10 [KO:K04358]
128066262  FGF18; fibroblast growth factor 18 [KO:K04358]
128053785  FGF7; fibroblast growth factor 7 [KO:K04358]
128048008  FGF6; fibroblast growth factor 6 [KO:K04358]
128067938  FGF8; fibroblast growth factor 8 [KO:K04358]
128068355  FGF20; fibroblast growth factor 20 [KO:K04358]
128069264  FGF19; fibroblast growth factor 19 [KO:K22603]
128064178  FGF21; fibroblast growth factor 21 [KO:K22429]
128048959  FGF23; fibroblast growth factor 23 [KO:K22428]
128065733  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
128047817  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
128060743  PDGFD; platelet-derived growth factor D [KO:K05450]
128062428  PDGFC; platelet-derived growth factor C [KO:K05450]
128044482  INSRR; insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
128051614  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
128068375  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
128067669  FGFR2; fibroblast growth factor receptor 2 [KO:K05093] [EC:2.7.10.1]
128049397  FGFR3; fibroblast growth factor receptor 3 [KO:K05094] [EC:2.7.10.1]
128050311  FGFR4; fibroblast growth factor receptor 4 [KO:K05095] [EC:2.7.10.1]
128049579  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
128050429  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
128071425  fibronectin-like [KO:K05717]
128068063  FN1; fibronectin isoform X1 [KO:K05717]
128065939  ITGA1; integrin alpha-1 [KO:K06480]
128066170  ITGA2; integrin alpha-2 [KO:K06481]
128065265  ITGA2B; integrin alpha-IIb [KO:K06476]
128065072  ITGA3; integrin alpha-3 [KO:K06482]
128043513  ITGA4; integrin alpha-4 [KO:K06483]
128048841  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
128063440  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
128048509  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
128058543  ITGA8; integrin alpha-8 [KO:K06584]
128046826  ITGA9; integrin alpha-9 [KO:K06585]
128044498  ITGA10; integrin alpha-10 [KO:K06586]
128054246  ITGA11; integrin alpha-11 [KO:K06587]
128061467  ITGAV; integrin alpha-V [KO:K06487]
128070817  ITGAL; integrin alpha-L [KO:K05718]
128066359  integrin alpha-M-like [KO:K06461]
128067327  ITGAX; integrin alpha-X [KO:K06462]
128068000  ITGAD; integrin alpha-D [KO:K06594]
128064507  ITGAE; integrin alpha-E [KO:K06524]
128058839  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
128047159  ITGB2; integrin beta-2 [KO:K06464]
128064875  ITGB3; integrin beta-3 [KO:K06493]
128064497  ITGB4; integrin beta-4 [KO:K06525]
128061565  ITGB5; integrin beta-5 [KO:K06588]
128068538  ITGB6; integrin beta-6 [KO:K06589]
128048309  ITGB7; LOW QUALITY PROTEIN: integrin beta-7 [KO:K06590]
128046829  ITGB8; integrin beta-8 [KO:K06591]
128054455  KNG1; kininogen-1 [KO:K03898]
128066728  B2 bradykinin receptor-like isoform X1 [KO:K03916]
128068993  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
128046777  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
128048297  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
128060443  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
128054467  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
128052536  C5; complement C5 [KO:K03994]
128066200  C6; complement component C6 [KO:K03995]
128065984  C7; complement component C7 [KO:K03996]
128045666  C8A; complement component C8 alpha chain [KO:K03997]
128045434  C8B; complement component C8 beta chain [KO:K03998]
128056557  C8G; complement component C8 gamma chain isoform X1 [KO:K03999]
128066230  C9; complement component C9 [KO:K04000]
128064366  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
128064617  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
128069786  FGD1; FYVE, RhoGEF and PH domain-containing protein 1 isoform X1 [KO:K05720]
128052878  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 [KO:K05722]
128059235  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
128062963  BCAR1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
128064843  CRK; adapter molecule crk isoform X1 [KO:K04438]
128062501  CRKL; crk-like protein [KO:K04438]
128067963  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
128058174  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
128053892  SOS2; son of sevenless homolog 2 [KO:K03099]
128055374  SOS1; son of sevenless homolog 1 [KO:K03099]
128068689  HRAS; GTPase HRas isoform X1 [KO:K02833]
128047937  KRAS; GTPase KRas [KO:K07827]
128044537  NRAS; GTPase NRas [KO:K07828]
128063078  RRAS; ras-related protein R-Ras [KO:K07829]
128060054  RRAS2; ras-related protein R-Ras2 [KO:K07830]
128044902  MRAS; ras-related protein M-Ras [KO:K07831]
128070429  ARHGEF6; rho guanine nucleotide exchange factor 6 [KO:K05729]
128045803  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
128061813  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
128068699  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
128050540  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
128044474  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
128066235  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha [KO:K02649]
128050828  VAV1; proto-oncogene vav [KO:K05730]
128044678  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
128055501  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
128047488  TIAM1; rho guanine nucleotide exchange factor TIAM1 [KO:K05731]
128070468  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
128046969  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
128043403  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
128059660  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
128054045  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
128050664  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
128043958  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
128062160  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
128063870  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128067048  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128061491  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
128057519  RGCC; regulator of cell cycle RGCC [KO:K26108]
128063153  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X1 [KO:K12330]
128060102  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
128064183  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
128044567  RHOA; transforming protein RhoA [KO:K04513]
128043471  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
128047644  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
128065663  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
128066401  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
128068496  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
128057235  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
128069841  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
128062878  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
128058601  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
128054088  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
128057494  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
128064479  GIT1; ARF GTPase-activating protein GIT1 [KO:K05737]
128067328  ROCK1; rho-associated protein kinase 1 [KO:K04514] [EC:2.7.11.1]
128055373  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
128056971  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
128045701  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
128058891  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
128062797  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
128055125  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
128062181  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
128068503  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
128047405  PPP1R12A; protein phosphatase 1 regulatory subunit 12A [KO:K06270]
128061235  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
128063185  PPP1R12C; protein phosphatase 1 regulatory subunit 12C [KO:K17457]
128062159  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
128046447  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
128058295  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
128071534  MYL10; myosin regulatory light chain 10 [KO:K12756]
128067326  myosin regulatory light polypeptide 9 isoform X1 [KO:K12757]
128063455  MYL11; myosin regulatory light chain 11 [KO:K12758]
128043499  MYH11; myosin-11 isoform X1 [KO:K10352]
128063353  MYH14; myosin-14 [KO:K10352]
128065145  MYH10; myosin-10 isoform X1 [KO:K10352]
128047692  MYH9; myosin-9 isoform X1 [KO:K10352]
128051121  DIAPH1; protein diaphanous homolog 1 [KO:K05740]
128070104  DIAPH2; protein diaphanous homolog 2 [KO:K05741]
128063641  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
128051310  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
128045470  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
128052473  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
128058125  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
128064859  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
128047306  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
128070200  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
128066654  LIMK1; LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
128062055  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
128057559  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
128064998  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
128061203  ENAH; protein enabled homolog isoform X1 [KO:K05746]
128046475  WASL; actin nucleation-promoting factor WASL [KO:K23612]
128063929  LOW QUALITY PROTEIN: actin-binding protein WASF2-like [KO:K05748]
128065181  WASF2; actin-binding protein WASF2 [KO:K05748]
128050390  CYFIP2; cytoplasmic FMR1-interacting protein 2 [KO:K05749]
128043924  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
128063083  NCKAP1; nck-associated protein 1 [KO:K05750]
128047955  NCKAP1L; nck-associated protein 1-like [KO:K05750]
128043185  ABI2; abl interactor 2 [KO:K05751]
128047551  BRK1; protein BRICK1 [KO:K05752]
128054894  probable protein BRICK1 [KO:K05752]
128053380  WASF1; actin-binding protein WASF1 [KO:K05753]
128055441  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
128047021  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
128066761  ACTR3; actin-related protein 3 [KO:K18584]
128061543  actin-related protein 3-like [KO:K18584]
128064601  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
128052285  actin-related protein 2/3 complex subunit 1A-like [KO:K05757]
128066903  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
128058627  actin-related protein 2/3 complex subunit 2 [KO:K05758]
128068927  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
128052330  actin-related protein 2/3 complex subunit 3 [KO:K05756]
128062574  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
128043440  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
128051119  actin-related protein 2/3 complex subunit 4-like [KO:K05755]
128056088  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
128061514  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
128043956  ACTB; actin, cytoplasmic 1 [KO:K05692]
128064385  ACTG1; actin, cytoplasmic 2 [KO:K05692]
128056358  PFN4; profilin-4 [KO:K05759]
128069719  profilin-2-like [KO:K05759]
128064400  PFN1; profilin-1 isoform X1 [KO:K05759]
128051473  profilin-1-like [KO:K05759]
128071297  profilin-4 [KO:K05759]
128051718  PFN3; profilin-3 [KO:K05759]
128053399  PFN2; profilin-2 isoform X1 [KO:K05759]
128062630  PXN; paxillin isoform X1 [KO:K05760]
128053049  EZR; ezrin [KO:K08007]
128059812  RDX; radixin [KO:K05762]
128070048  MSN; moesin [KO:K05763]
128066553  CFL2; cofilin-2 [KO:K05765]
128068771  CFL1; cofilin-1 [KO:K05765]
128065570  SSH2; protein phosphatase Slingshot homolog 2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
128062221  SSH1; protein phosphatase Slingshot homolog 1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
128068767  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
128047281  VCL; vinculin isoform X1 [KO:K05700]
128066364  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
128044781  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
128053744  IQGAP2; ras GTPase-activating-like protein IQGAP2 [KO:K05767]
128046470  SCIN; scinderin [KO:K05768]
128052846  GSN; gelsolin isoform X1 [KO:K05768]
128063664  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
128053759  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
128050459  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
128053813  APC; adenomatous polyposis coli protein [KO:K02085]
128057615  SPATA13; spermatogenesis-associated protein 13 [KO:K05769]
128060382  ARHGEF4; rho guanine nucleotide exchange factor 4 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
btax04010  MAPK signaling pathway
btax04510  Focal adhesion
btax04520  Adherens junction
KO pathway
ko04810   
LinkDB

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