KEGG   PATHWAY: cang05010
Entry
cang05010                   Pathway                                
Name
Alzheimer disease - Colobus angolensis palliatus (Angola colobus)
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
cang05010  Alzheimer disease
cang05010

Organism
Colobus angolensis palliatus (Angola colobus) [GN:cang]
Gene
105510620  ADAM10; disintegrin and metalloproteinase domain-containing protein 10 [KO:K06704] [EC:3.4.24.81]
105525335  ADAM17; disintegrin and metalloproteinase domain-containing protein 17 isoform X1 [KO:K06059] [EC:3.4.24.86]
105500815  APP; amyloid beta A4 protein isoform X1 [KO:K04520]
105504596  NAE1; NEDD8-activating enzyme E1 regulatory subunit [KO:K04532]
105520535  APBB1; amyloid beta A4 precursor protein-binding family B member 1 isoform X1 [KO:K04529]
105521917  glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [KO:K00134] [EC:1.2.1.12]
105518746  GAPDH; LOW QUALITY PROTEIN: glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
105506854  glyceraldehyde-3-phosphate dehydrogenase isoform X1 [KO:K00134] [EC:1.2.1.12]
105501076  BACE1; beta-secretase 1 isoform X1 [KO:K04521] [EC:3.4.23.46]
105520372  BACE2; beta-secretase 2 [KO:K07747] [EC:3.4.23.45]
105512231  RTN3; reticulon-3 isoform X1 [KO:K20723]
105517858  RTN4; reticulon-4 isoform X1 [KO:K20720]
105516144  PSENEN; gamma-secretase subunit PEN-2 [KO:K06170]
105517190  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
105516694  PSEN2; presenilin-2 isoform X1 [KO:K04522] [EC:3.4.23.-]
105522969  NCSTN; nicastrin isoform X1 [KO:K06171]
105508833  APH1A; gamma-secretase subunit APH-1A [KO:K06172]
105510574  APH1B; gamma-secretase subunit APH-1B [KO:K06172]
105515892  IDE; insulin-degrading enzyme isoform X1 [KO:K01408] [EC:3.4.24.56]
105523937  MME; neprilysin [KO:K01389] [EC:3.4.24.11]
105508648  microtubule-associated protein tau isoform X1 [KO:K04380]
105520290  MAPT; microtubule-associated protein tau [KO:K04380]
105512080  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
105507893  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
105520391  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial isoform X1 [KO:K03944]
105513232  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
105510439  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [KO:K03946]
105519313  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2-like [KO:K03946]
105504891  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
105505706  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3-like [KO:K03947]
105511599  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105512530  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105520322  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105500514  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
105501598  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
105508433  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like [KO:K03949]
105508548  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
105514019  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
105501423  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
105518520  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
105502896  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform X1 [KO:K03954]
105523503  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
105513706  acyl carrier protein, mitochondrial-like [KO:K03955]
105512869  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105506000  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
105500378  NDUFA13; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
105517293  NDUFB1; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
105510354  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial-like [KO:K03958]
105511180  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
105517412  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
105525981  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3-like [KO:K03959]
105516559  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
105510744  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
105519986  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
105520900  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4-like [KO:K03960]
105522269  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [KO:K03961]
105516443  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
105523897  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105519753  NDUFB7; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105500535  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
105507139  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
105516921  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
105526425  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
105509465  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial isoform X1 [KO:K11351]
105517371  NDUFS1; NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 [KO:K03934] [EC:7.1.1.2]
105522939  NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [KO:K03935] [EC:7.1.1.2]
105527142  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
105509861  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
105502042  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
105510340  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
105525778  NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
105521180  NDUFS5; NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 [KO:K03938]
105519689  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
105527622  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
105512074  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
105513709  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
105509624  NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
105519700  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial-like [KO:K00234] [EC:1.3.5.1]
105506040  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
105522928  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
105525991  succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
105513932  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
105524170  succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like isoform X1 [KO:K00237]
105501018  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial isoform X1 [KO:K00237]
105516834  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
105508982  cytochrome c1, heme protein, mitochondrial [KO:K00413]
105509729  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
105504455  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
105515052  cytochrome b-c1 complex subunit 6, mitochondrial isoform X1 [KO:K00416]
105508194  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
105518199  cytochrome b-c1 complex subunit 8 [KO:K00418]
105522986  cytochrome b-c1 complex subunit 9 isoform X1 [KO:K00419]
105527626  cytochrome b-c1 complex subunit 10 [KO:K00420]
105501906  cytochrome c oxidase subunit 4 isoform 1, mitochondrial [KO:K02263]
105524728  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
105505215  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
105522124  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
105509711  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
105516361  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
105524379  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 6B1-like [KO:K02267]
105504864  cytochrome c oxidase subunit 6B2 [KO:K02267]
105504339  cytochrome c oxidase subunit 6C [KO:K02268]
105516433  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
105512479  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
105512577  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
105507432  cytochrome c oxidase subunit 7A-related protein, mitochondrial isoform X1 [KO:K02270]
105501404  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
105515614  cytochrome c oxidase subunit 7B, mitochondrial isoform X1 [KO:K02271]
105512711  cytochrome c oxidase subunit 7B, mitochondrial [KO:K02271]
105518054  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
105518525  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
105512225  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
105517020  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
105500537  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
105518584  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
105527618  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
105506396  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
105505366  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
105503561  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
105524581  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
105511108  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
105513159  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial isoform X1 [KO:K02128]
105527650  ATP synthase F(0) complex subunit C1, mitochondrial-like [KO:K02128]
105511649  ATP5H; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
105517510  ATP5O; ATP synthase subunit O, mitochondrial isoform X1 [KO:K02137]
105500818  ATP5J; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
105514907  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase type-2 isoform X1 [KO:K08683] [EC:1.1.1.35 1.1.1.178]
105524440  PPID; peptidyl-prolyl cis-trans isomerase D [KO:K05864] [EC:5.2.1.8]
105518210  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
105502178  VDAC2; voltage-dependent anion-selective channel protein 2 isoform X1 [KO:K15040]
105525120  VDAC3; voltage-dependent anion-selective channel protein 3 isoform X1 [KO:K15041]
105508149  ADP/ATP translocase 2 [KO:K05863]
105516459  LOW QUALITY PROTEIN: ADP/ATP translocase 3-like [KO:K05863]
105516486  SLC25A5; ADP/ATP translocase 2 [KO:K05863]
105524336  SLC25A4; ADP/ATP translocase 1 [KO:K05863]
105500636  SLC25A6; ADP/ATP translocase 3 [KO:K05863]
105507188  SLC25A31; ADP/ATP translocase 4 isoform X1 [KO:K05863]
105502998  PPIF; peptidyl-prolyl cis-trans isomerase F, mitochondrial [KO:K09565] [EC:5.2.1.8]
105510158  LPL; lipoprotein lipase [KO:K01059] [EC:3.1.1.34]
105526983  APOE; LOW QUALITY PROTEIN: apolipoprotein E [KO:K04524]
105500519  LRP1; prolow-density lipoprotein receptor-related protein 1 [KO:K04550]
105515921  FAS; tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
105518659  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105512314  FADD; FAS-associated death domain protein [KO:K02373]
105517408  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
105514348  BID; BH3-interacting domain death agonist [KO:K04726]
105508278  calmodulin-alpha-like [KO:K02183]
105522538  CALML3; calmodulin-like protein 3 [KO:K02183]
105522539  CALML5; calmodulin-like protein 5 [KO:K02183]
105510515  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
105517053  CALM1; calmodulin isoform X1 [KO:K02183]
105503892  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
105526853  CALM3; calmodulin isoform X1 [KO:K02183]
105507398  CALM2; calmodulin isoform X1 [KO:K02183]
105501948  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105510183  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105512672  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105518142  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105512212  BAD; bcl2-associated agonist of cell death [KO:K02158]
105521896  cytochrome c-like [KO:K08738]
105509147  cytochrome c-like [KO:K08738]
105509351  cytochrome c [KO:K08738]
105516629  cytochrome c-like [KO:K08738]
105506411  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
105510236  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
105524344  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105512245  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
105521472  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
105505014  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
105509299  GRM5; metabotropic glutamate receptor 5 isoform X1 [KO:K04604]
105520744  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
105516588  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1 [KO:K05858] [EC:3.1.4.11]
105510999  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 [KO:K05858] [EC:3.1.4.11]
105505028  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
105512214  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 [KO:K05858] [EC:3.1.4.11]
105522794  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
105525666  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
105520401  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105504901  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
105514888  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
105503912  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
105515441  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
105514987  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
105504320  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
105516898  CHRNA7; neuronal acetylcholine receptor subunit alpha-7 [KO:K04809]
105501787  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
105515489  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105505634  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
105505042  RYR3; ryanodine receptor 3 [KO:K04963]
105508383  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
105515211  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
105514217  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
105515642  ATP2A3; LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3 [KO:K05853] [EC:7.2.2.10]
105505616  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
105507727  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X1 [KO:K05853] [EC:7.2.2.10]
105519596  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
105506618  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
105500505  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
105515989  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
105519668  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
105522700  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105526172  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
105512966  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
105517705  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
105518701  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
105519528  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
105517246  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105527761  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
105500371  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
105523797  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
105509244  PSMA4; proteasome subunit alpha type-4 isoform X1 [KO:K02728] [EC:3.4.25.1]
105516299  LOW QUALITY PROTEIN: proteasome subunit alpha type-7-like [KO:K02731] [EC:3.4.25.1]
105509793  PSMA8; proteasome subunit alpha type-7-like isoform X1 [KO:K02731] [EC:3.4.25.1]
105506420  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
105516070  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
105521905  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
105526019  PSMA3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
105516175  LOW QUALITY PROTEIN: uncharacterized protein LOC105516175 [KO:K02738] [EC:3.4.25.1]
105523530  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
105504113  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
105524542  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
105504748  proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
105521229  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
105503779  PSMB5; proteasome subunit beta type-5 isoform X1 [KO:K02737] [EC:3.4.25.1]
105506677  PSMB1; proteasome subunit beta type-1 [KO:K02732] [EC:3.4.25.1]
105508874  PSMB4; proteasome subunit beta type-4 [KO:K02736] [EC:3.4.25.1]
105501704  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
105517297  PSMC1; 26S protease regulatory subunit 4 [KO:K03062]
105520594  26S protease regulatory subunit 4-like [KO:K03062]
105520745  26S protease regulatory subunit 4 [KO:K03062]
105519171  PSMC4; 26S protease regulatory subunit 6B isoform X1 [KO:K03063]
105510878  26S protease regulatory subunit 10B-like [KO:K03064]
105525976  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
105527136  PSMC3; 26S protease regulatory subunit 6A [KO:K03065]
105515976  PSMC5; 26S protease regulatory subunit 8 [KO:K03066]
105514460  26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
105518834  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
105503108  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
105516329  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
105517795  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
105508735  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
105515383  PSMD6; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
105525795  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
105503182  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 isoform X1 [KO:K03039]
105508868  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [KO:K03029]
105515320  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
105519129  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 isoform X1 [KO:K03031]
105506381  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
105512768  SHFM1; 26S proteasome complex subunit DSS1 isoform X1 [KO:K10881]
105501186  LOW QUALITY PROTEIN: inactive caspase-12-like [KO:K04741] [EC:3.4.22.-]
105502297  NOS1; LOW QUALITY PROTEIN: nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
105512339  CAPN1; calpain-1 catalytic subunit [KO:K01367] [EC:3.4.22.52]
105502824  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
105508736  CDK5R1; cyclin-dependent kinase 5 activator 1 isoform X1 [KO:K11716]
105501989  SLC39A1; zinc transporter ZIP1 isoform X1 [KO:K14709]
105503835  SLC39A2; zinc transporter ZIP2 isoform X1 [KO:K14709]
105527652  SLC39A3; zinc transporter ZIP3 [KO:K14709]
105509095  SLC39A4; zinc transporter ZIP4 [KO:K14710]
105500550  SLC39A5; zinc transporter ZIP5 [KO:K14711]
105512976  SLC39A6; zinc transporter ZIP6 isoform X1 [KO:K14712]
105514237  SLC39A7; zinc transporter SLC39A7 isoform X1 [KO:K14713]
105512674  SLC39A8; zinc transporter ZIP8 isoform X1 [KO:K14714]
105517226  SLC39A9; zinc transporter ZIP9 isoform X1 [KO:K14715]
105518890  SLC39A10; zinc transporter ZIP10 isoform X1 [KO:K14716]
105506780  SLC39A11; zinc transporter ZIP11 [KO:K14717]
105527539  SLC39A12; zinc transporter ZIP12 isoform X1 [KO:K14718]
105527133  SLC39A13; zinc transporter ZIP13 [KO:K14719]
105510182  SLC39A14; zinc transporter ZIP14 [KO:K14720]
105503641  SLC11A2; natural resistance-associated macrophage protein 2 isoform X1 [KO:K21398]
105511330  CDK5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
105510739  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105501792  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
105509528  DKK1; dickkopf-related protein 1 [KO:K02165]
105525121  DKK4; dickkopf-related protein 4 [KO:K02165]
105514390  DKK2; dickkopf-related protein 2 [KO:K02165]
105507640  WNT1; proto-oncogene Wnt-1 [KO:K03209]
105508518  WNT2; protein Wnt-2 [KO:K00182]
105505351  WNT2B; protein Wnt-2b isoform X1 [KO:K00182]
105524998  WNT3A; protein Wnt-3a [KO:K00312]
105520280  WNT3; proto-oncogene Wnt-3 [KO:K00312]
105505976  WNT4; protein Wnt-4 [KO:K00408]
105515434  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
105503903  WNT5B; protein Wnt-5b isoform X1 [KO:K00444]
105504714  WNT6; protein Wnt-6 [KO:K00445]
105517901  WNT7A; protein Wnt-7a [KO:K00572]
105506562  WNT7B; protein Wnt-7b [KO:K00572]
105506967  WNT8A; protein Wnt-8a [KO:K00714]
105507141  WNT8B; protein Wnt-8b [KO:K00714]
105520282  WNT9B; protein Wnt-9b [KO:K01064]
105504785  WNT10A; protein Wnt-10a [KO:K01357]
105507641  WNT10B; protein Wnt-10b [KO:K01357]
105511852  WNT11; protein Wnt-11 [KO:K01384]
105508531  WNT16; protein Wnt-16 [KO:K01558]
105521875  FZD1; frizzled-1 [KO:K02432]
105517398  FZD7; frizzled-7 [KO:K02432]
105510410  FZD2; frizzled-2 [KO:K02235]
105513645  FZD3; frizzled-3 [KO:K02329]
105509307  FZD4; frizzled-4 [KO:K02354]
105521864  FZD8; frizzled-8 [KO:K02375]
105517355  FZD5; frizzled-5 [KO:K02375]
105503962  FZD6; frizzled-6 isoform X1 [KO:K02376]
105503772  FZD9; frizzled-9 [KO:K02842]
105525538  FZD10; frizzled-10 [KO:K02842]
105512067  LRP5; low-density lipoprotein receptor-related protein 5 isoform X1 [KO:K03068]
105520153  LRP6; low-density lipoprotein receptor-related protein 6 isoform X1 [KO:K03068]
105527785  casein kinase I isoform epsilon [KO:K08960] [EC:2.7.11.1]
105522019  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X1 [KO:K02353]
105523586  DVL2; segment polarity protein dishevelled homolog DVL-2 isoform X1 [KO:K02353]
105514470  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X1 [KO:K02353]
105518300  FRAT2; GSK-3-binding protein FRAT2 [KO:K03096]
105509552  CSNK2A2; casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
105524962  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
105513740  CSNK2B; casein kinase II subunit beta isoform X1 [KO:K03115]
105524707  AXIN1; axin-1 [KO:K02157]
105514689  AXIN2; axin-2 [KO:K04385]
105523472  APC; adenomatous polyposis coli protein isoform X1 [KO:K02085]
105527685  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
105518088  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
105504217  CSNK1A1; casein kinase I isoform alpha isoform X1 [KO:K08957] [EC:2.7.11.1]
105512534  CSNK1A1L; casein kinase I isoform alpha-like [KO:K08957] [EC:2.7.11.1]
105512588  KIF5C; kinesin heavy chain isoform 5C [KO:K10396]
105519579  KIF5B; LOW QUALITY PROTEIN: kinesin-1 heavy chain [KO:K10396]
105500501  KIF5A; kinesin heavy chain isoform 5A isoform X1 [KO:K10396]
105524961  KLC4; kinesin light chain 4 [KO:K10407]
105518428  kinesin light chain 1 isoform X1 [KO:K10407]
105512132  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
105526978  KLC3; kinesin light chain 3 [KO:K10407]
105522542  TUBAL3; tubulin alpha chain-like 3 isoform X1 [KO:K07374]
105504700  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
105527496  tubulin alpha-3 chain-like [KO:K07374]
105514344  TUBA8; tubulin alpha-8 chain [KO:K07374]
105507630  TUBA1C; tubulin alpha-1C chain isoform X1 [KO:K07374]
105507633  tubulin alpha-1B chain isoform X1 [KO:K07374]
105507635  tubulin alpha-1A chain isoform X1 [KO:K07374]
105507915  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
105501863  tubulin beta-3 chain isoform X1 [KO:K07375]
105508947  tubulin beta-8 chain isoform X1 [KO:K07375]
105522676  tubulin beta chain isoform X1 [KO:K07375]
105516962  tubulin beta-8 chain-like [KO:K07375]
105519024  LOW QUALITY PROTEIN: tubulin beta-8 chain-like [KO:K07375]
105512889  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
105526783  tubulin beta-1 chain-like [KO:K07375]
105506397  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
105513957  TUBB; tubulin beta chain isoform X1 [KO:K07375]
105507167  tubulin beta-2A chain [KO:K07375]
105513780  AGER; advanced glycosylation end product-specific receptor isoform X1 [KO:K19722]
105503192  HRAS; GTPase HRas isoform X1 [KO:K02833]
105515217  KRAS; GTPase KRas isoform X1 [KO:K07827]
105504520  GTPase NRas [KO:K07828]
105505387  NRAS; GTPase NRas [KO:K07828]
105509473  ARAF; serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
105511179  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
105519101  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105510526  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105512832  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
105520704  NOX1; NADPH oxidase 1 [KO:K08008]
105511774  cytochrome b-245 heavy chain isoform X1 [KO:K21421] [EC:1.-.-.-]
105509295  NOX4; NADPH oxidase 4 isoform X1 [KO:K21423] [EC:1.6.3.-]
105512156  RELA; transcription factor p65 [KO:K04735]
105512675  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
105520008  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
105506149  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
105513728  TNF; tumor necrosis factor [KO:K03156]
105513330  IL6; interleukin-6 isoform X1 [KO:K05405]
105519633  IL1A; interleukin-1 alpha [KO:K04383]
105519632  IL1B; interleukin-1 beta isoform X1 [KO:K04519]
105516054  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
105504944  SNCA; alpha-synuclein isoform X1 [KO:K04528]
105507534  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
105507149  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
105525125  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105527033  IKBKG; NF-kappa-B essential modulator [KO:K07210]
105512899  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
105518803  IRS1; insulin receptor substrate 1 [KO:K16172]
105505962  IRS2; insulin receptor substrate 2 [KO:K07187]
105518616  IRS4; insulin receptor substrate 4 [KO:K17446]
105524169  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105500411  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105515019  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
105523405  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
105523708  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105507333  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
105518411  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105519178  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105521497  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105507357  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105525659  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
105523484  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
105503619  ATG101; autophagy-related protein 101 [KO:K19730]
105527116  ATG13; autophagy-related protein 13 [KO:K08331]
105508699  RB1CC1; RB1-inducible coiled-coil protein 1 isoform X1 [KO:K17589]
105527115  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 [KO:K17985]
105503140  BECN1; beclin-1 [KO:K08334]
105513393  LOW QUALITY PROTEIN: beclin-1-like [KO:K08334]
105521488  BECN2; beclin-2 [KO:K08334]
105505746  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
105526001  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
105512981  LOW QUALITY PROTEIN: nuclear receptor-binding factor 2-like [KO:K21246]
105513253  NRBF2; nuclear receptor-binding factor 2 [KO:K21246]
105527545  nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
105519272  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
105518487  ATG2B; autophagy-related protein 2 homolog B [KO:K17906]
105512193  ATG2A; autophagy-related protein 2 homolog A [KO:K17906]
105525896  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
105527057  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X2 [KO:K17908]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Apoptotic mechanisms in Alzheimer neurofibrillary degeneration: cause or effect?
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J Clin Invest 114:23-7 (2004)
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Calcium channel blockers and Alzheimer's disease.
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Related
pathway
cang00190  Oxidative phosphorylation
cang03050  Proteasome
cang04020  Calcium signaling pathway
cang04140  Autophagy - animal
cang04141  Protein processing in endoplasmic reticulum
cang04210  Apoptosis
cang04310  Wnt signaling pathway
cang04910  Insulin signaling pathway
cang04933  AGE-RAGE signaling pathway in diabetic complications
KO pathway
ko05010   
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