KEGG   PATHWAY: ko05010
Entry
ko05010                     Pathway                                
Name
Alzheimer disease
Description
Alzheimer disease (AD) is a chronic disorder that slowly destroys neurons and causes serious cognitive disability. AD is associated with senile plaques and neurofibrillary tangles (NFTs). Amyloid-beta (Abeta), a major component of senile plaques, has various pathological effects on cell and organelle function. To date genetic studies have revealed four genes that may be linked to autosomal dominant or familial early onset AD (FAD). These four genes include: amyloid precursor protein (APP), presenilin 1 (PS1), presenilin 2 (PS2) and apolipoprotein E (ApoE). All mutations associated with APP and PS proteins can lead to an increase in the production of Abeta peptides, specfically the more amyloidogenic form, Abeta42. It was proposed that Abeta form Ca2+ permeable pores and bind to and modulate multiple synaptic proteins, including NMDAR, mGluR5 and VGCC, leading to the overfilling of neurons with calcium ions. Consequently, cellular Ca2+ disruptions will lead to neuronal apoptosis, autophagy deficits, mitochondrial abnormality, defective neurotransmission, impaired synaptic plasticity and neurodegeneration in AD. FAD-linked PS1 mutation downregulates the unfolded protein response and leads to vulnerability to ER stress.
Class
Human Diseases; Neurodegenerative disease
Pathway map
ko05010  Alzheimer disease
ko05010

Disease
H00056  Alzheimer disease
Orthology
K00134  GAPDH, gapA; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
K00182  WNT2; wingless-type MMTV integration site family, member 2
K00234  SDHA, SDH1; succinate dehydrogenase (ubiquinone) flavoprotein subunit [EC:1.3.5.1]
K00235  SDHB, SDH2; succinate dehydrogenase (ubiquinone) iron-sulfur subunit [EC:1.3.5.1]
K00236  SDHC, SDH3; succinate dehydrogenase (ubiquinone) cytochrome b560 subunit
K00237  SDHD, SDH4; succinate dehydrogenase (ubiquinone) membrane anchor subunit
K00312  WNT3; wingless-type MMTV integration site family, member 3
K00408  WNT4; wingless-type MMTV integration site family, member 4
K00411  UQCRFS1, RIP1, petA; ubiquinol-cytochrome c reductase iron-sulfur subunit [EC:7.1.1.8]
K00412  CYTB, petB; ubiquinol-cytochrome c reductase cytochrome b subunit
K00413  CYC1, CYT1, petC; ubiquinol-cytochrome c reductase cytochrome c1 subunit
K00414  QCR1, UQCRC1; ubiquinol-cytochrome c reductase core subunit 1
K00415  QCR2, UQCRC2; ubiquinol-cytochrome c reductase core subunit 2
K00416  QCR6, UQCRH; ubiquinol-cytochrome c reductase subunit 6
K00417  QCR7, UQCRB; ubiquinol-cytochrome c reductase subunit 7
K00418  QCR8, UQCRQ; ubiquinol-cytochrome c reductase subunit 8
K00419  QCR9, UCRC; ubiquinol-cytochrome c reductase subunit 9
K00420  QCR10, UQCR; ubiquinol-cytochrome c reductase subunit 10
K00444  WNT5; wingless-type MMTV integration site family, member 5
K00445  WNT6; wingless-type MMTV integration site family, member 6
K00572  WNT7; wingless-type MMTV integration site family, member 7
K00714  WNT8; wingless-type MMTV integration site family, member 8
K00914  PIK3C3, VPS34; phosphatidylinositol 3-kinase [EC:2.7.1.137]
K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K01059  LPL; lipoprotein lipase [EC:3.1.1.34]
K01064  WNT9; wingless-type MMTV integration site family, member 9
K01357  WNT10; wingless-type MMTV integration site family, member 10
K01367  CAPN1; calpain-1 [EC:3.4.22.52]
K01384  WNT11; wingless-type MMTV integration site family, member 11
K01389  MME, CD10; neprilysin [EC:3.4.24.11]
K01408  IDE; insulysin [EC:3.4.24.56]
K01558  WNT16; wingless-type MMTV integration site family, member 16
K02084  APAF1; apoptotic protease-activating factor
K02085  APC; adenomatosis polyposis coli protein
K02090  CDK5; cyclin-dependent kinase 5 [EC:2.7.11.22]
K02105  CTNNB1; catenin beta 1
K02125  ATPeF08, MTATP8, ATP8; F-type H+-transporting ATPase subunit 8
K02126  ATPeF0A, MTATP6, ATP6; F-type H+-transporting ATPase subunit a
K02127  ATPeF0B, ATP5F1, ATP4; F-type H+-transporting ATPase subunit b
K02128  ATPeF0C, ATP5G, ATP9; F-type H+-transporting ATPase subunit c
K02131  ATPeF0F6, ATP5J; F-type H+-transporting ATPase subunit 6
K02132  ATPeF1A, ATP5A1, ATP1; F-type H+-transporting ATPase subunit alpha
K02133  ATPeF1B, ATP5B, ATP2; F-type H+-transporting ATPase subunit beta [EC:7.1.2.2]
K02134  ATPeF1D, ATP5D, ATP16; F-type H+-transporting ATPase subunit delta
K02135  ATPeF1E, ATP5E, ATP15; F-type H+-transporting ATPase subunit epsilon
K02136  ATPeF1G, ATP5C1, ATP3; F-type H+-transporting ATPase subunit gamma
K02137  ATPeF0O, ATP5O, ATP5; F-type H+-transporting ATPase subunit O
K02138  ATPeF0D, ATP5H, ATP7; F-type H+-transporting ATPase subunit d
K02157  AXIN1; axin 1
K02158  BAD; Bcl-2-antagonist of cell death
K02165  DKK1_2_4; dickkopf 1/2/4
K02183  CALM; calmodulin
K02187  CASP3; caspase 3 [EC:3.4.22.56]
K02235  FZD2; frizzled 2
K02256  COX1; cytochrome c oxidase subunit 1 [EC:7.1.1.9]
K02261  COX2; cytochrome c oxidase subunit 2
K02262  COX3; cytochrome c oxidase subunit 3
K02263  COX4; cytochrome c oxidase subunit 4
K02264  COX5A; cytochrome c oxidase subunit 5a
K02265  COX5B; cytochrome c oxidase subunit 5b
K02266  COX6A; cytochrome c oxidase subunit 6a
K02267  COX6B; cytochrome c oxidase subunit 6b
K02268  COX6C; cytochrome c oxidase subunit 6c
K02270  COX7A; cytochrome c oxidase subunit 7a
K02271  COX7B; cytochrome c oxidase subunit 7b
K02272  COX7C; cytochrome c oxidase subunit 7c
K02273  COX8; cytochrome c oxidase subunit 8
K02329  FZD3; frizzled 3
K02353  DVL; segment polarity protein dishevelled
K02354  FZD4, fz4, CD344; frizzled 4
K02373  FADD; FAS-associated death domain protein
K02375  FZD5_8, fz2; frizzled 5/8
K02376  FZD6; frizzled 6
K02432  FZD1_7, fz; frizzled 1/7
K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02725  PSMA1; 20S proteasome subunit alpha 6 [EC:3.4.25.1]
K02726  PSMA2; 20S proteasome subunit alpha 2 [EC:3.4.25.1]
K02727  PSMA3; 20S proteasome subunit alpha 7 [EC:3.4.25.1]
K02728  PSMA4; 20S proteasome subunit alpha 3 [EC:3.4.25.1]
K02729  PSMA5; 20S proteasome subunit alpha 5 [EC:3.4.25.1]
K02730  PSMA6; 20S proteasome subunit alpha 1 [EC:3.4.25.1]
K02731  PSMA7; 20S proteasome subunit alpha 4 [EC:3.4.25.1]
K02732  PSMB1; 20S proteasome subunit beta 6 [EC:3.4.25.1]
K02734  PSMB2; 20S proteasome subunit beta 4 [EC:3.4.25.1]
K02735  PSMB3; 20S proteasome subunit beta 3 [EC:3.4.25.1]
K02736  PSMB4; 20S proteasome subunit beta 7 [EC:3.4.25.1]
K02737  PSMB5; 20S proteasome subunit beta 5 [EC:3.4.25.1]
K02738  PSMB6; 20S proteasome subunit beta 1 [EC:3.4.25.1]
K02739  PSMB7; 20S proteasome subunit beta 2 [EC:3.4.25.1]
K02833  HRAS; GTPase HRas
K02842  FZD9_10, CD349_50; frizzled 9/10
K03028  PSMD2, RPN1; 26S proteasome regulatory subunit N1
K03029  PSMD4, RPN10; 26S proteasome regulatory subunit N10
K03030  PSMD14, RPN11, POH1; 26S proteasome regulatory subunit N11
K03031  PSMD8, RPN12; 26S proteasome regulatory subunit N12
K03032  PSMD1, RPN2; 26S proteasome regulatory subunit N2
K03033  PSMD3, RPN3; 26S proteasome regulatory subunit N3
K03035  PSMD12, RPN5; 26S proteasome regulatory subunit N5
K03036  PSMD11, RPN6; 26S proteasome regulatory subunit N6
K03037  PSMD6, RPN7; 26S proteasome regulatory subunit N7
K03038  PSMD7, RPN8; 26S proteasome regulatory subunit N8
K03039  PSMD13, RPN9; 26S proteasome regulatory subunit N9
K03061  PSMC2, RPT1; 26S proteasome regulatory subunit T1
K03062  PSMC1, RPT2; 26S proteasome regulatory subunit T2
K03063  PSMC4, RPT3; 26S proteasome regulatory subunit T3
K03064  PSMC6, RPT4; 26S proteasome regulatory subunit T4
K03065  PSMC3, RPT5; 26S proteasome regulatory subunit T5
K03066  PSMC5, RPT6; 26S proteasome regulatory subunit T6
K03068  LRP5_6; low density lipoprotein receptor-related protein 5/6
K03069  FRAT1; frequently rearranged in advanced T-cell lymphomas 1
K03083  GSK3B; glycogen synthase kinase 3 beta [EC:2.7.11.26]
K03096  FRAT2; frequently rearranged in advanced T-cell lymphomas 2
K03097  CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]
K03115  CSNK2B; casein kinase II subunit beta
K03156  TNF, TNFA; tumor necrosis factor superfamily, member 2
K03158  TNFRSF1A, TNFR1, CD120a; tumor necrosis factor receptor superfamily member 1A
K03173  TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K03209  WNT1; wingless-type MMTV integration site family, member 1
K03237  EIF2S1; translation initiation factor 2 subunit 1
K03853  CAPN2; calpain-2 [EC:3.4.22.53]
K03878  ND1; NADH-ubiquinone oxidoreductase chain 1 [EC:7.1.1.2]
K03879  ND2; NADH-ubiquinone oxidoreductase chain 2 [EC:7.1.1.2]
K03880  ND3; NADH-ubiquinone oxidoreductase chain 3 [EC:7.1.1.2]
K03881  ND4; NADH-ubiquinone oxidoreductase chain 4 [EC:7.1.1.2]
K03882  ND4L; NADH-ubiquinone oxidoreductase chain 4L [EC:7.1.1.2]
K03883  ND5; NADH-ubiquinone oxidoreductase chain 5 [EC:7.1.1.2]
K03884  ND6; NADH-ubiquinone oxidoreductase chain 6 [EC:7.1.1.2]
K03934  NDUFS1; NADH dehydrogenase (ubiquinone) Fe-S protein 1 [EC:7.1.1.2]
K03935  NDUFS2; NADH dehydrogenase (ubiquinone) Fe-S protein 2 [EC:7.1.1.2]
K03936  NDUFS3; NADH dehydrogenase (ubiquinone) Fe-S protein 3 [EC:7.1.1.2]
K03937  NDUFS4; NADH dehydrogenase (ubiquinone) Fe-S protein 4
K03938  NDUFS5; NADH dehydrogenase (ubiquinone) Fe-S protein 5
K03939  NDUFS6; NADH dehydrogenase (ubiquinone) Fe-S protein 6
K03940  NDUFS7; NADH dehydrogenase (ubiquinone) Fe-S protein 7 [EC:7.1.1.2]
K03941  NDUFS8; NADH dehydrogenase (ubiquinone) Fe-S protein 8 [EC:7.1.1.2]
K03942  NDUFV1; NADH dehydrogenase (ubiquinone) flavoprotein 1 [EC:7.1.1.2]
K03943  NDUFV2; NADH dehydrogenase (ubiquinone) flavoprotein 2 [EC:7.1.1.2]
K03944  NDUFV3; NADH dehydrogenase (ubiquinone) flavoprotein 3
K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
K03946  NDUFA2; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2
K03947  NDUFA3; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 3
K03948  NDUFA4; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4
K03949  NDUFA5; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5
K03950  NDUFA6; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6
K03951  NDUFA7; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 7
K03952  NDUFA8; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8
K03953  NDUFA9; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9
K03954  NDUFA10; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10
K03955  NDUFAB1; NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1, acyl-carrier protein
K03956  NDUFA11; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11
K03957  NDUFB1; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 1
K03958  NDUFB2; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 2
K03959  NDUFB3; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 3
K03960  NDUFB4; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4
K03961  NDUFB5; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5
K03962  NDUFB6; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6
K03963  NDUFB7; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7
K03964  NDUFB8; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8
K03965  NDUFB9; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9
K03966  NDUFB10; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10
K03967  NDUFC1; NADH dehydrogenase (ubiquinone) 1 subunit C1
K03968  NDUFC2; NADH dehydrogenase (ubiquinone) 1 subunit C2
K04129  CHRM1; muscarinic acetylcholine receptor M1
K04131  CHRM3; muscarinic acetylcholine receptor M3
K04133  CHRM5; muscarinic acetylcholine receptor M5
K04348  PPP3C, CNA; serine/threonine-protein phosphatase 2B catalytic subunit [EC:3.1.3.16]
K04365  BRAF; B-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04366  RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368  MAP2K1, MEK1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369  MAP2K2, MEK2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371  ERK, MAPK1_3; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
K04380  MAPT, TAU; microtubule-associated protein tau
K04383  IL1A; interleukin 1 alpha
K04385  AXIN2; axin 2
K04390  TNFRSF6, FAS, CD95; tumor necrosis factor receptor superfamily member 6
K04397  CASP7; caspase 7 [EC:3.4.22.60]
K04398  CASP8; caspase 8 [EC:3.4.22.61]
K04399  CASP9; caspase 9 [EC:3.4.22.62]
K04426  MAP3K5, ASK1; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04431  MAP2K7, MKK7; mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]
K04440  JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04452  DDIT3, GADD153; DNA damage-inducible transcript 3
K04456  AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04467  IKBKA, IKKA, CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K04505  PSEN1, PS1; presenilin 1 [EC:3.4.23.-]
K04519  IL1B; interleukin 1 beta
K04520  APP; amyloid beta A4 protein
K04521  BACE1; beta-site APP-cleaving enzyme 1 (memapsin 2) [EC:3.4.23.46]
K04522  PSEN2, PS2; presenilin 2 [EC:3.4.23.-]
K04524  APOE; apolipoprotein E
K04526  INS; insulin
K04527  INSR, CD220; insulin receptor [EC:2.7.10.1]
K04528  SNCA; alpha-synuclein
K04529  APBB1, FE65; amyloid beta A4 precursor protein-binding family B member 1
K04532  NAE1, APPBP1; NEDD8-activating enzyme E1 regulatory subunit
K04550  LRP1, CD91; low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor)
K04604  GRM5; metabotropic glutamate receptor 5
K04634  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha
K04690  FZDN, fz3; frizzled
K04726  BID; BH3 interacting domain death agonist
K04735  RELA; transcription factor p65
K04741  CASP12; caspase 12 [EC:3.4.22.-]
K04809  CHRNA7; nicotinic acetylcholine receptor alpha-7
K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
K04851  CACNA1D, CAV1.3; voltage-dependent calcium channel L type alpha-1D
K04853  CACNA1F, CAV1.4; voltage-dependent calcium channel L type alpha-1F
K04857  CACNA1S, CAV1.1; voltage-dependent calcium channel L type alpha-1S
K04958  ITPR1; inositol 1,4,5-triphosphate receptor type 1
K04959  ITPR2; inositol 1,4,5-triphosphate receptor type 2
K04960  ITPR3; inositol 1,4,5-triphosphate receptor type 3
K04963  RYR3; ryanodine receptor 3
K05208  GRIN1; glutamate receptor ionotropic, NMDA 1
K05209  GRIN2A; glutamate receptor ionotropic, NMDA 2A
K05210  GRIN2B; glutamate receptor ionotropic, NMDA 2B
K05211  GRIN2C; glutamate receptor ionotropic, NMDA 2C
K05212  GRIN2D; glutamate receptor ionotropic, NMDA 2D
K05405  IL6; interleukin 6
K05453  CSF1, MCSF; macrophage colony-stimulating factor 1
K05853  ATP2A; P-type Ca2+ transporter type 2A [EC:7.2.2.10]
K05858  PLCB; phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
K05862  VDAC1; voltage-dependent anion channel protein 1
K05863  SLC25A4S, ANT; solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31
K05864  PPID, CYPD; peptidyl-prolyl isomerase D [EC:5.2.1.8]
K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86]
K06170  PSENEN, PEN2; presenilin enhancer 2
K06171  NCSTN; nicastrin
K06172  APH1; gamma-secretase subunit APH-1
K06268  PPP3R, CNB; serine/threonine-protein phosphatase 2B regulatory subunit
K06691  RPN13; 26S proteasome regulatory subunit N13
K06693  PSMD9, RPN4; 26S proteasome regulatory subunit N4
K06704  ADAM10, CD156c; disintegrin and metalloproteinase domain-containing protein 10 [EC:3.4.24.81]
K07187  IRS2; insulin receptor substrate 2
K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR [EC:2.7.11.1]
K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210  IKBKG, IKKG, NEMO; inhibitor of nuclear factor kappa-B kinase subunit gamma
K07374  TUBA; tubulin alpha
K07375  TUBB; tubulin beta
K07747  BACE2; beta-site APP-cleaving enzyme 2 (memapsin 1) [EC:3.4.23.45]
K07827  KRAS, KRAS2; GTPase KRas
K07828  NRAS; GTPase NRas
K08008  NOX1, MOX1; NADPH oxidase 1
K08269  ULK2, ATG1; serine/threonine-protein kinase ULK2 [EC:2.7.11.1]
K08331  ATG13; autophagy-related protein 13
K08333  PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
K08334  BECN, VPS30, ATG6; beclin
K08683  HSD17B10; 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase [EC:1.1.1.35 1.1.1.178]
K08738  CYC; cytochrome c
K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K08852  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]
K08860  EIF2AK3, PERK; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
K08957  CSNK1A; casein kinase 1, alpha [EC:2.7.11.1]
K08960  CSNK1E; casein kinase 1, epsilon [EC:2.7.11.1]
K09027  XBP1; X box-binding protein 1
K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
K09565  PPIF; peptidyl-prolyl isomerase F (cyclophilin D) [EC:5.2.1.8]
K10396  KIF5; kinesin family member 5 (plus-end-directed kinesin ATPase) [EC:5.6.1.3]
K10407  KLC; kinesin light chain
K10881  SHFM1, DSS1, RPN15; 26 proteasome complex subunit DSS1
K11351  NDUFB11; NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 11
K11352  NDUFA12; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12
K11353  NDUFA13; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13
K11716  CDK5R1; cyclin-dependent kinase 5 activator 1
K11987  PTGS2, COX2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K13240  NOS1; nitric-oxide synthase, brain [EC:1.14.13.39]
K13241  NOS2; nitric-oxide synthase, inducible [EC:1.14.13.39]
K14709  SLC39A1_2_3, ZIP1_2_3; solute carrier family 39 (zinc transporter), member 1/2/3
K14710  SLC39A4, ZIP4; solute carrier family 39 (zinc transporter), member 4
K14711  SLC39A5, ZIP5; solute carrier family 39 (zinc transporter), member 5
K14712  SLC39A6, LIV1, ZIP6; solute carrier family 39 (zinc transporter), member 6
K14713  SLC39A7, KE4, ZIP7; solute carrier family 39 (zinc transporter), member 7
K14714  SLC39A8, ZIP8; solute carrier family 39 (zinc transporter), member 8
K14715  SLC39A9, ZIP9; solute carrier family 39 (zinc transporter), member 9
K14716  SLC39A10, ZIP10; solute carrier family 39 (zinc transporter), member 10
K14717  SLC39A11, ZIP11; solute carrier family 39 (zinc transporter), member 11
K14718  SLC39A12, ZIP12; solute carrier family 39 (zinc transporter), member 12
K14719  SLC39A13, ZIP13; solute carrier family 39 (zinc transporter), member 13
K14720  SLC39A14, ZIP14; solute carrier family 39 (zinc transporter), member 14
K15040  VDAC2; voltage-dependent anion channel protein 2
K15041  VDAC3; voltage-dependent anion channel protein 3
K16172  IRS1; insulin receptor substrate 1
K16195  EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
K17445  IRS3; insulin receptor substrate 3
K17446  IRS4; insulin receptor substrate 4
K17589  RB1CC1; RB1-inducible coiled-coil protein 1
K17889  ATG14L, ATG14; beclin 1-associated autophagy-related key regulator
K17906  ATG2; autophagy-related protein 2
K17908  WIPI1_2, ATG18; autophagy-related protein 18
K17985  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1
K19722  AGER, RAGE; receptor for advanced glycosylation end products
K19730  ATG101; autophagy-related protein 101
K20720  RTN4; reticulon-4
K20723  RTN3; reticulon-3
K20858  MCU; calcium uniporter protein, mitochondrial
K21246  NRBF2; nuclear receptor-binding factor 2
K21357  ULK1; serine/threonine-protein kinase ULK1 [EC:2.7.11.1]
K21398  SLC11A2, DMT1, NRAMP2; natural resistance-associated macrophage protein 2
K21421  NOX2, GP91, CYBB; NADPH oxidase 2 [EC:1.-.-.-]
K21423  NOX4, RENOX; NADPH oxidase 4 [EC:1.6.3.-]
Compound
C00027  Hydrogen peroxide
C00038  Zinc cation
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01319  Hg
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C14818  Fe2+
C16514  Amyloid beta protein 40
C16515  Amyloid beta protein 42
C16845  Peroxynitrite
C19610  Manganese(2+)
C21011  [Protein]-N(epsilon)-(carboxymethyl)lysine
C21012  [Protein]-N(epsilon)-(carboxyethyl)lysine
C21013  [Protein]-pyrraline
C21014  [Protein]-pentosidine
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Related
pathway
ko00190  Oxidative phosphorylation
ko03050  Proteasome
ko04020  Calcium signaling pathway
ko04140  Autophagy - animal
ko04141  Protein processing in endoplasmic reticulum
ko04210  Apoptosis
ko04310  Wnt signaling pathway
ko04910  Insulin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications

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