KEGG   PATHWAY: etf05165
Entry
etf05165                    Pathway                                
Name
Human papillomavirus infection - Echinops telfairi (small Madagascar hedgehog)
Description
Human papillomavirus (HPV) is a non-enveloped, double-stranded DNA virus. HPV infect mucoal and cutaneous epithelium resulting in several types of pathologies, most notably, cervical cancer. All types of HPV share a common genomic structure and encode eight proteins: E1, E2, E4, E5, E6, and E7 (early) and L1 and L2 (late). It has been demonstrated that E1 and E2 are involved in viral transcription and replication. The functions of the E4 protein is not yet fully understood. E5, E6, and E7 act as oncoproteins. E5 inhibits the V-ATPase, prolonging EGFR signaling and thereby promoting cell proliferation. The expression of E6 and E7 not only inhibits the tumor suppressors p53 and Rb, but also alters additional signalling pathways. Among these pathways, PI3K/Akt signalling cascade plays a very important role in HPV-induced carcinogenesis. The L1 and L2 proteins form icosahedral capsids for progeny virion generation.
Class
Human Diseases; Infectious disease: viral
Pathway map
etf05165  Human papillomavirus infection
etf05165

Organism
Echinops telfairi (small Madagascar hedgehog) [GN:etf]
Gene
101648285  WNT1; proto-oncogene Wnt-1 [KO:K03209]
101660424  WNT2B; protein Wnt-2b isoform X2 [KO:K00182]
101651785  WNT2; protein Wnt-2 [KO:K00182]
101638407  WNT3A; protein Wnt-3a [KO:K00312]
101653676  WNT3; proto-oncogene Wnt-3 [KO:K00312]
101647219  WNT4; protein Wnt-4 [KO:K00408]
101658376  WNT5B; protein Wnt-5b [KO:K00444]
101663396  WNT5A; protein Wnt-5a isoform X1 [KO:K00444]
101661610  WNT6; protein Wnt-6 [KO:K00445]
101651048  WNT7A; protein Wnt-7a [KO:K00572]
101656448  WNT7B; protein Wnt-7b [KO:K00572]
101644829  WNT8A; protein Wnt-8a [KO:K00714]
101637931  WNT8B; protein Wnt-8b [KO:K00714]
101653050  WNT9B; protein Wnt-9b [KO:K01064]
101664591  WNT9A; protein Wnt-9a [KO:K01064]
101662542  WNT10A; protein Wnt-10a [KO:K01357]
101648596  WNT10B; protein Wnt-10b [KO:K01357]
101642476  WNT11; protein Wnt-11 [KO:K01384]
101653677  WNT16; protein Wnt-16 [KO:K01558]
101640257  FZD7; frizzled-7 [KO:K02432]
101643067  FZD1; frizzled-1 [KO:K02432]
101643509  FZD2; frizzled-2 [KO:K02235]
101664566  FZD3; frizzled-3 [KO:K02329]
101657948  FZD4; frizzled-4 [KO:K02354]
101647407  FZD5; frizzled-5 [KO:K02375]
101639796  FZD6; frizzled-6 isoform X1 [KO:K02376]
101652101  FZD10; frizzled-10 [KO:K02842]
101650133  FZD9; frizzled-9 [KO:K02842]
101646191  DVL2; segment polarity protein dishevelled homolog DVL-2 [KO:K02353]
101659671  DVL3; segment polarity protein dishevelled homolog DVL-3 isoform X2 [KO:K02353]
101652831  DVL1; segment polarity protein dishevelled homolog DVL-1 isoform X2 [KO:K02353]
101657537  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101647742  AXIN1; axin-1 [KO:K02157]
101646063  AXIN2; axin-2 [KO:K04385]
101656287  APC; adenomatous polyposis coli protein isoform X3 [KO:K02085]
101640142  APC2; adenomatous polyposis coli protein 2 isoform X4 [KO:K02085]
101656388  CTNNB1; catenin beta-1 [KO:K02105]
101650200  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101662490  CSNK1A1; casein kinase I isoform X4 [KO:K08957] [EC:2.7.11.1]
101656891  casein kinase I-like [KO:K08957] [EC:2.7.11.1]
101656544  TERT; telomerase reverse transcriptase [KO:K11126] [EC:2.7.7.49]
101657040  TCF7; transcription factor 7 isoform X2 [KO:K02620]
101655177  TCF7L1; transcription factor 7-like 1 [KO:K04490]
101657493  TCF7L2; transcription factor 7-like 2 isoform X1 [KO:K04491]
101657114  UBE3A; ubiquitin-protein ligase E3A isoform X1 [KO:K10587] [EC:2.3.2.26]
101647976  TLR3; toll-like receptor 3 [KO:K05401]
101649346  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
115873309  LOW QUALITY PROTEIN: TIR domain-containing adapter molecule 1-like [KO:K05842]
101663779  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101647812  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
101649686  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
101651495  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
101650550  IFNB1; interferon beta [KO:K05415]
101641939  CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101647070  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
101642549  TADA3; transcriptional adapter 3 [KO:K11315]
101647784  LOW QUALITY PROTEIN: cellular tumor antigen p53-like [KO:K04451]
101656530  TP53; cellular tumor antigen p53 [KO:K04451]
101656580  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X14 [KO:K05631]
101653959  PARD3; partitioning defective 3 homolog [KO:K04237]
101643668  PARD6B; partitioning defective 6 homolog beta [KO:K06093]
101663083  PARD6A; partitioning defective 6 homolog alpha isoform X2 [KO:K06093]
101664515  PARD6G; partitioning defective 6 homolog gamma [KO:K06093]
101657098  PRKCI; protein kinase C iota type [KO:K06069] [EC:2.7.11.13]
101661315  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
101644037  cell division control protein 42 homolog [KO:K04393]
101647533  CDC42; cell division control protein 42 homolog [KO:K04393]
101658199  SCRIB; protein scribble homolog [KO:K16175]
101656004  DLG1; disks large homolog 1 isoform X1 [KO:K12076]
101650983  DLG2; disks large homolog 2 isoform X3 [KO:K12075]
101660119  DLG3; disks large homolog 3 isoform X4 [KO:K21098]
101661647  LLGL2; LLGL scribble cell polarity complex component 2 isoform X1 [KO:K06094]
101649540  LLGL1; lethal(2) giant larvae protein homolog 1 [KO:K06094]
101641786  CRB3; protein crumbs homolog 3 [KO:K06090]
101654562  PATJ; inaD-like protein isoform X1 [KO:K06092]
101648622  PALS1; protein PALS1 isoform X1 [KO:K06091]
101651446  VWF; von Willebrand factor [KO:K03900]
101656527  THBS1; thrombospondin-1 isoform X2 [KO:K16857]
101660448  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
101661187  cartilage oligomeric matrix protein [KO:K04659]
101639732  THBS4; thrombospondin-4 [KO:K04659]
101662616  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
101653760  FN1; fibronectin [KO:K05717]
101647520  COL1A2; collagen alpha-2(I) chain [KO:K06236]
101647433  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
101654123  COL2A1; collagen alpha-1(II) chain [KO:K19719]
101643909  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
101644236  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
101652633  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
101653376  COL4A5; collagen alpha-5(IV) chain isoform X3 [KO:K06237]
101641415  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
101640794  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
101663069  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
101656273  collagen alpha-4(VI) chain-like [KO:K06238]
101655976  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
101640842  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
101655657  collagen alpha-6(VI) chain [KO:K06238]
101661038  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
101649332  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
101638906  COL9A2; collagen alpha-2(IX) chain isoform X1 [KO:K08131]
101661473  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
101656678  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
101644673  LAMA1; laminin subunit alpha-1 [KO:K05637]
101656584  LAMA3; LOW QUALITY PROTEIN: laminin subunit alpha-3 [KO:K06240]
101646645  LAMA5; laminin subunit alpha-5 [KO:K06240]
101638457  LAMA4; laminin subunit alpha-4 [KO:K06241]
101659204  LAMB1; laminin subunit beta-1 [KO:K05636]
101657059  laminin subunit beta-2-like [KO:K06243]
101661367  LAMB2; laminin subunit beta-2 [KO:K06243]
101651331  LAMB3; laminin subunit beta-3 [KO:K06244]
101650046  LAMC1; laminin subunit gamma-1 [KO:K05635]
101649731  LAMC2; laminin subunit gamma-2 [KO:K06246]
101658928  LAMC3; laminin subunit gamma-3 [KO:K06247]
101645956  CHAD; chondroadherin [KO:K06248]
101651758  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
101650745  SPP1; osteopontin [KO:K06250]
101658038  VTN; vitronectin [KO:K06251]
101646924  TNC; tenascin isoform X1 [KO:K06252]
101645767  TNXB; tenascin-X [KO:K06252]
101664456  TNR; tenascin-R [KO:K06252]
101638287  TNN; tenascin-N [KO:K06252]
101656585  bone sialoprotein 2 [KO:K06253]
101651763  ITGA1; integrin alpha-1 [KO:K06480]
101651459  ITGA2; integrin alpha-2 [KO:K06481]
101644908  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
101648576  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
101640152  ITGA4; integrin alpha-4 [KO:K06483]
101640652  ITGA5; integrin alpha-5 [KO:K06484]
101663608  ITGA6; integrin alpha-6 [KO:K06485]
101639933  ITGA7; integrin alpha-7 isoform X2 [KO:K06583]
101659770  ITGA8; integrin alpha-8 [KO:K06584]
101653341  ITGA9; integrin alpha-9 [KO:K06585]
101654263  ITGA10; integrin alpha-10 [KO:K06586]
101653494  ITGA11; integrin alpha-11 [KO:K06587]
101643277  ITGAV; integrin alpha-V [KO:K06487]
101652501  ITGB1; integrin beta-1 isoform X2 [KO:K05719]
101653361  ITGB3; integrin beta-3 [KO:K06493]
101660073  ITGB4; integrin beta-4 [KO:K06525]
101645557  ITGB5; LOW QUALITY PROTEIN: integrin beta-5 [KO:K06588]
101653236  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
101660910  ITGB7; integrin beta-7 [KO:K06590]
101662870  ITGB8; integrin beta-8 [KO:K06591]
101647889  PTK2; focal adhesion kinase 1 isoform X12 [KO:K05725] [EC:2.7.10.2]
101653688  PXN; paxillin [KO:K05760]
101654642  TNF; tumor necrosis factor [KO:K03156]
101657422  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101643813  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X3 [KO:K03171]
101638051  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
101643856  CASP3; caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101639119  SLC9A3R1; Na(+)/H(+) exchange regulatory cofactor NHE-RF1 [KO:K13365]
101644319  serine/threonine-protein phosphatase 2A catalytic subunit beta isoform-like [KO:K04382] [EC:3.1.3.16]
101644179  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
101657344  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
101645417  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform [KO:K03456]
101647744  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform-like [KO:K03456]
101663474  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
101662513  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma [KO:K04354]
101662642  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform [KO:K04354]
101657966  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
101659001  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform [KO:K04354]
101660860  PPP2R3B; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
101659349  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X1 [KO:K11583]
101651322  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X2 [KO:K11583]
101655698  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform [KO:K11584]
101642174  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
101641890  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
101639916  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [KO:K11584]
101657070  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
101654757  TSC1; hamartin isoform X2 [KO:K07206]
101663717  TSC2; tuberin isoform X1 [KO:K07207]
101648247  RHEB; GTP-binding protein Rheb [KO:K07208]
101664135  MTOR; serine/threonine-protein kinase mTOR isoform X1 [KO:K07203] [EC:2.7.11.1]
101645648  eukaryotic translation initiation factor 4E-binding protein 1-like [KO:K07205]
101651127  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
101652873  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
101653358  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
101656097  BAK1; bcl-2 homologous antagonist/killer [KO:K14021]
101658729  BAD; bcl2-associated agonist of cell death [KO:K02158]
101650381  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
101641853  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101654217  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
101640675  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101655654  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101659995  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101657368  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
101643102  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101649881  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101655315  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101661221  FOXO1; forkhead box protein O1 [KO:K07201]
101641071  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
101660587  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
101657154  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
101657079  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
101639447  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
101654378  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
101645619  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
101651720  CCNE2; G1/S-specific cyclin-E2 [KO:K06626]
101649401  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
101642843  CDK2; cyclin-dependent kinase 2 isoform X2 [KO:K02206] [EC:2.7.11.22]
101646101  RB1; retinoblastoma-associated protein isoform X5 [KO:K06618]
101644403  RBL1; retinoblastoma-like protein 1 [KO:K04681]
101658150  RBL2; retinoblastoma-like protein 2 [KO:K16332]
101654357  PSMC1; 26S proteasome regulatory subunit 4 [KO:K03062]
101660509  E2F1; transcription factor E2F1 [KO:K17454]
101657266  CCNA1; cyclin-A1 [KO:K06627]
101642639  CCNA2; cyclin-A2 [KO:K06627]
101649302  ATM; serine-protein kinase ATM [KO:K04728] [EC:2.7.11.1]
101647559  ATR; serine/threonine-protein kinase ATR [KO:K06640] [EC:2.7.11.1]
101655464  VEGFA; vascular endothelial growth factor A [KO:K05448]
101649582  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101657011  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
101648136  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
101662652  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101663870  RELA; transcription factor p65 [KO:K04735]
101658440  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
101643221  NFX1; transcriptional repressor NF-X1 isoform X2 [KO:K12236]
101664320  HDAC2; histone deacetylase 2 [KO:K06067] [EC:3.5.1.98]
101664236  HDAC1; histone deacetylase 1 [KO:K06067] [EC:3.5.1.98]
101660252  CHD4; chromodomain-helicase-DNA-binding protein 4 isoform X3 [KO:K11643] [EC:5.6.2.-]
101653393  IRF1; interferon regulatory factor 1 isoform X1 [KO:K09444]
101649806  TATA-box-binding protein [KO:K03120]
101655218  TBPL1; TATA box-binding protein-like 1 [KO:K03120]
101650612  TBPL2; TATA box-binding protein-like 2 [KO:K03120]
105979518  LOW QUALITY PROTEIN: patr class I histocompatibility antigen, B-2 alpha chain-like [KO:K06751]
101659346  class I histocompatibility antigen, Gogo-C*0203 alpha chain isoform X1 [KO:K06751]
101648901  HLA class I histocompatibility antigen, alpha chain G-like [KO:K06751]
101651706  HLA class I histocompatibility antigen, B alpha chain-like isoform X2 [KO:K06751]
101651748  patr class I histocompatibility antigen, A-2 alpha chain-like isoform X2 [KO:K06751]
101656976  HLA class I histocompatibility antigen, alpha chain G-like isoform X1 [KO:K06751]
101663300  B-cell receptor-associated protein 31-like [KO:K14009]
101655844  BCAP31; B-cell receptor-associated protein 31 [KO:K14009]
101649727  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
101654319  ATP6V1B1; LOW QUALITY PROTEIN: V-type proton ATPase subunit B, kidney isoform [KO:K02147]
101646801  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
101640424  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
101645441  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X3 [KO:K02148]
101648922  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
101655573  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
101645375  ATP6V1E2; V-type proton ATPase subunit E 2 isoform X1 [KO:K02150]
101655427  V-type proton ATPase subunit F-like [KO:K02151]
101663630  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
101638768  V-type proton ATPase subunit G 1-like [KO:K02152]
101653266  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
101645980  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
101655832  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
101660096  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
101642891  ATP6V0A2; V-type proton ATPase 116 kDa subunit a2 [KO:K02154]
101661946  ATP6V0A1; V-type proton ATPase 116 kDa subunit a1 [KO:K02154]
101655807  TCIRG1; V-type proton ATPase 116 kDa subunit a3 [KO:K02154]
101663969  ATP6V0A4; V-type proton ATPase 116 kDa subunit a [KO:K02154]
101660301  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
101638374  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
115869976  V-type proton ATPase subunit e 1-like [KO:K02153]
101646098  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
101652929  V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
101637885  V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
101639603  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
101649798  ATP6AP1; V-type proton ATPase subunit S1 [KO:K03662]
101645300  EGF; pro-epidermal growth factor [KO:K04357]
101652848  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
101660259  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101649001  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101646109  SOS2; son of sevenless homolog 2 [KO:K03099]
101663997  HRAS; GTPase HRas isoform X1 [KO:K02833]
101639926  KRAS; GTPase KRas isoform X3 [KO:K07827]
101649328  GTPase NRas-like [KO:K07828]
101653520  NRAS; GTPase NRas [KO:K07828]
101656360  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
101650474  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101643986  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101648971  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101661786  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101653785  PTGS2; prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101642817  PTGER4; prostaglandin E2 receptor EP4 subtype [KO:K04261]
101654894  guanine nucleotide-binding protein G(s) subunit alpha [KO:K04632]
101650626  neuroendocrine secretory protein 55 [KO:K04632]
101649991  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
101645802  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X2 [KO:K04345] [EC:2.7.11.11]
101646711  BAX; apoptosis regulator BAX [KO:K02159]
101646557  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101653565  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
101648900  CREB3; cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
101654666  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X2 [KO:K09048]
101654039  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X3 [KO:K09048]
101639977  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
101648034  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X2 [KO:K09047]
101653241  UBR4; E3 ubiquitin-protein ligase UBR4 [KO:K10691] [EC:2.3.2.27]
101663527  TUBG1; tubulin gamma-1 chain [KO:K10389]
101637951  tubulin gamma-1 chain-like [KO:K10389]
101656931  PKM; pyruvate kinase PKM [KO:K00873] [EC:2.7.1.40]
101650862  interferon alpha-2-like [KO:K05414]
101640204  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
101639566  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
101664197  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
101663486  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
101650838  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101661602  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
101663983  IRF9; LOW QUALITY PROTEIN: interferon regulatory factor 9 [KO:K04693]
101640829  EIF2AK2; interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
101656814  2'-5'-oligoadenylate synthase-like protein 2 [KO:K14608]
101662359  OASL; 2'-5'-oligoadenylate synthase-like protein [KO:K14608]
101649656  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
101649338  interferon-induced GTP-binding protein Mx1 isoform X1 [KO:K14754]
105979129  ubiquitin-like protein ISG15 [KO:K12159]
101642978  ISG15; ubiquitin-like protein ISG15 [KO:K12159]
101645683  JAG1; protein jagged-1 [KO:K06052]
101652666  NOTCH1; neurogenic locus notch homolog protein 1 [KO:K02599]
101648334  NOTCH2; neurogenic locus notch homolog protein 2 [KO:K20994]
101662942  NOTCH3; neurogenic locus notch homolog protein 3 [KO:K20995]
101647029  NOTCH4; neurogenic locus notch homolog protein 4 [KO:K20996]
101660004  PSEN1; presenilin-1 [KO:K04505] [EC:3.4.23.-]
101659758  RFNG; beta-1,3-N-acetylglucosaminyltransferase radical fringe [KO:K05948] [EC:2.4.1.222]
101663521  LFNG; beta-1,3-N-acetylglucosaminyltransferase lunatic fringe [KO:K05948] [EC:2.4.1.222]
101656253  MFNG; beta-1,3-N-acetylglucosaminyltransferase manic fringe [KO:K05948] [EC:2.4.1.222]
101649857  MAML3; mastermind-like protein 3 [KO:K06061]
123522539  mastermind-like protein 2 [KO:K06061]
101656629  MAML1; mastermind-like protein 1 [KO:K06061]
101652087  RBPJ; recombining binding protein suppressor of hairless isoform X1 [KO:K06053]
101657883  RBPJL; recombining binding protein suppressor of hairless-like protein [KO:K06053]
101660711  HES1; transcription factor HES-1 [KO:K06054]
101660814  HES7; transcription factor HES-7 isoform X2 [KO:K09087]
101643298  HES4; transcription factor HES-4 [KO:K09089]
101649721  HES5; transcription factor HES-5 [KO:K06055]
101650529  HEY2; hairy/enhancer-of-split related with YRPW motif protein 2 isoform X2 [KO:K09091]
101641049  HEY1; hairy/enhancer-of-split related with YRPW motif protein 1 [KO:K09091]
101641937  HEYL; hairy/enhancer-of-split related with YRPW motif-like protein isoform X1 [KO:K09091]
Compound
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C05981  Phosphatidylinositol-3,4,5-trisphosphate
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NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes.
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Related
pathway
etf04064  NF-kappa B signaling pathway
etf04110  Cell cycle
etf04115  p53 signaling pathway
etf04150  mTOR signaling pathway
etf04151  PI3K-Akt signaling pathway
etf04210  Apoptosis
etf04310  Wnt signaling pathway
etf04330  Notch signaling pathway
etf04510  Focal adhesion
etf04520  Adherens junction
etf04530  Tight junction
etf04612  Antigen processing and presentation
etf04620  Toll-like receptor signaling pathway
etf04630  JAK-STAT signaling pathway
KO pathway
ko05165   
LinkDB

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