KEGG   PATHWAY: hhv04510
Entry
hhv04510                    Pathway                                
Name
Focal adhesion - Hyaena hyaena (striped hyena)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
hhv04510  Focal adhesion
hhv04510

Other DBs
GO: 0005925
Organism
Hyaena hyaena (striped hyena) [GN:hhv]
Gene
120234406  COL1A2; collagen alpha-2(I) chain [KO:K06236]
120229071  COL1A1; collagen alpha-1(I) chain [KO:K06236]
120239042  COL2A1; collagen alpha-1(II) chain isoform X1 [KO:K19719]
120248571  basic proline-rich protein-like [KO:K19719]
120232677  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
120232682  collagen alpha-6(IV) chain-like [KO:K06237]
120228347  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
120228350  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
120249144  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
120249150  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
120238460  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
120238480  collagen alpha-4(VI) chain-like isoform X1 [KO:K06238]
120238481  COL6A5; collagen alpha-5(VI) chain [KO:K06238]
120229528  COL6A3; LOW QUALITY PROTEIN: collagen alpha-3(VI) chain [KO:K06238]
120248667  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
120248672  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
120234938  COL9A3; collagen alpha-3(IX) chain [KO:K08131]
120240927  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
120247870  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
120226842  laminin subunit alpha-2-like [KO:K05637]
120221358  LAMA1; laminin subunit alpha-1 isoform X1 [KO:K05637]
120248554  laminin subunit alpha-2-like [KO:K05637]
120220603  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
120234952  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
120245249  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
120241848  LAMB1; laminin subunit beta-1 [KO:K05636]
120229288  LAMB2; laminin subunit beta-2 [KO:K06243]
120230488  LAMB3; laminin subunit beta-3 [KO:K06244]
120241868  LAMB4; LOW QUALITY PROTEIN: laminin subunit beta-4 [KO:K06245]
120245832  LAMC1; laminin subunit gamma-1 [KO:K05635]
120245845  LAMC2; laminin subunit gamma-2 [KO:K06246]
120230169  LAMC3; laminin subunit gamma-3 [KO:K06247]
120229159  CHAD; chondroadherin [KO:K06248]
120236357  RELN; reelin isoform X1 [KO:K06249] [EC:3.4.21.-]
120232244  THBS1; thrombospondin-1 [KO:K16857]
120229185  cartilage oligomeric matrix protein [KO:K04659]
120242026  THBS4; thrombospondin-4 [KO:K04659]
120222978  THBS2; thrombospondin-2 [KO:K04659]
120244686  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
120232421  FN1; fibronectin isoform X1 [KO:K05717]
120226352  SPP1; osteopontin isoform X1 [KO:K06250]
120244887  VTN; vitronectin [KO:K06251]
120238563  TNN; tenascin-N [KO:K06252]
120238587  TNR; tenascin-R isoform X1 [KO:K06252]
120221928  TNXB; tenascin-X [KO:K06252]
120236956  TNC; tenascin isoform X1 [KO:K06252]
120221153  VWF; von Willebrand factor [KO:K03900]
120226351  bone sialoprotein 2 [KO:K06253]
120248041  ITGA1; integrin alpha-1 [KO:K06480]
120248043  ITGA2; integrin alpha-2 isoform X1 [KO:K06481]
120222277  ITGA2B; integrin alpha-IIb [KO:K06476]
120229011  ITGA3; integrin alpha-3 isoform X1 [KO:K06482]
120236690  ITGA4; integrin alpha-4 [KO:K06483]
120220031  ITGA5; integrin alpha-5 [KO:K06484]
120236401  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
120219960  ITGA7; integrin alpha-7 [KO:K06583]
120236917  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
120235085  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
120220700  ITGA10; integrin alpha-10 [KO:K06586]
120221272  ITGA11; integrin alpha-11 [KO:K06587]
120241461  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
120222633  ITGB1; integrin beta-1 [KO:K05719]
120244266  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
120228176  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
120245869  ITGB5; integrin beta-5 [KO:K06588]
120235312  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
120247227  ITGB7; integrin beta-7 [KO:K06590]
120236225  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
120239842  EMP2; epithelial membrane protein 2 [KO:K26256]
120227991  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
120233377  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
120223081  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
120246757  PDGFD; platelet-derived growth factor D [KO:K05450]
120236138  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
120245431  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
120231199  VEGFA; vascular endothelial growth factor A [KO:K05448]
120240107  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
120232932  VEGFD; vascular endothelial growth factor D [KO:K05449]
120222108  VEGFC; vascular endothelial growth factor C [KO:K05449]
120221164  hepatocyte growth factor-like [KO:K05460]
120245413  HGF; hepatocyte growth factor [KO:K05460]
120222584  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
120236611  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
120233674  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
120243048  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
120238884  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
120247154  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
120225370  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
120223826  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
120229105  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
120236902  EMP1; epithelial membrane protein 1 [KO:K26255]
120228611  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
120241560  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
120241790  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
120229394  RHOA; transforming protein RhoA [KO:K04513]
120249159  transforming protein RhoA-like [KO:K04513]
120234375  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
120220661  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
120231144  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
120247408  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
120222517  MYL5; myosin light chain 5 [KO:K12753]
120238920  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
120228602  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
120239322  MYL10; myosin regulatory light chain 10 [KO:K12756]
120239085  myosin regulatory light polypeptide 9-like [KO:K12757]
120239090  myosin regulatory light chain 12B [KO:K12757]
120234698  myosin regulatory light polypeptide 9-like [KO:K12757]
120242286  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
120233909  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
120239251  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
120235890  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
120233963  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
120228862  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
120239719  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
120237364  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
120238194  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
120235452  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
120241448  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
120243401  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
120241303  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
120242042  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
120228024  ACTB; actin, cytoplasmic 1 [KO:K05692]
120228303  ACTG1; actin, cytoplasmic 2 [KO:K05692]
120219964  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
120234148  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
120237417  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
120220627  ACTN4; alpha-actinin-4 [KO:K05699]
120221286  TLN1; talin-1 isoform X1 [KO:K06271]
120221524  TLN2; talin-2 isoform X1 [KO:K06271]
120227474  FLNA; filamin-A isoform X1 [KO:K04437]
120238632  FLNB; LOW QUALITY PROTEIN: filamin-B [KO:K27392]
120230646  PXN; paxillin isoform X1 [KO:K05760]
120221442  ILK; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
120238972  ZYX; zyxin [KO:K06273]
120241826  vasodilator-stimulated phosphoprotein isoform X1 [KO:K06274]
120233762  VCL; vinculin isoform X1 [KO:K05700]
120237529  PARVA; alpha-parvin [KO:K06275]
120234681  PARVB; beta-parvin [KO:K06275]
120235237  PARVG; gamma-parvin isoform X1 [KO:K06275]
120241500  PDPK1; 3-phosphoinositide-dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
120235277  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120244696  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120247774  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
120242922  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
120230647  CTNNB1; catenin beta-1 [KO:K02105]
120234190  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
120233260  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
120239766  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
120232325  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
120233608  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
120220979  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
120246696  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
120219997  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
120239233  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
120247089  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
120235953  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
120226858  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
120247171  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
120247312  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
120227958  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
120241186  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
120228188  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
120229608  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
120244384  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
120241977  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
120242769  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
120226240  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
120232303  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
120233626  cell division control protein 42 homolog [KO:K04393]
120231260  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
120248194  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
120238810  CRKL; crk-like protein [KO:K04438]
120245519  CRK; adapter molecule crk isoform X1 [KO:K04438]
120244330  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
120230122  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
120247125  RAP1A; ras-related protein Rap-1A [KO:K04353]
120240794  RAP1B; ras-related protein Rap-1b [KO:K07836]
120244180  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
120232781  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
120245677  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
120236252  JUN; transcription factor AP-1 [KO:K04448]
120232948  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
120223824  CAV1; caveolin-1 isoform X1 [KO:K06278]
120223825  CAV2; caveolin-2 [KO:K12958]
120231339  CAV3; caveolin-3 [KO:K12959]
120245246  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
120244661  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
120242345  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
120237954  SHC3; SHC-transforming protein 3 isoform X1 [KO:K17448]
120220858  SHC4; SHC-transforming protein 4 [KO:K17449]
120228194  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
120220282  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
120244628  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
120223392  HRAS; GTPase HRas isoform X1 [KO:K02833]
120231327  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
120221655  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
120238830  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
120242212  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
120219889  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
120233874  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
120247732  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
120238692  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
120219677  LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 3-like [KO:K16060]
120219681  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
120236173  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
120240137  BAD; bcl2-associated agonist of cell death [KO:K02158]
120245032  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
hhv04010  MAPK signaling pathway
hhv04060  Cytokine-cytokine receptor interaction
hhv04070  Phosphatidylinositol signaling system
hhv04110  Cell cycle
hhv04151  PI3K-Akt signaling pathway
hhv04310  Wnt signaling pathway
hhv04512  ECM-receptor interaction
hhv04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
LinkDB

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