KEGG   PATHWAY: llv04936
Entry
llv04936                    Pathway                                
Name
Alcoholic liver disease - Lutra lutra (Eurasian river otter)
Description
Alcoholic liver disease (ALD) refers to the damages to the liver and its functions due to alcohol overconsumption. It ranges from simple steatosis to steatohepatitis, cirrhosis, and even hepatocellular carcinoma. Alcohol consumption promotes liver inflammation by increasing the translocation of gut-derived endotoxins to the portal circulation and activating Kupffer cells to produce TNF-alpha through the LPS/Toll like receptor (TLR) 4 pathways. TNF-alpha induces hepatocellular damage. When alcohol intake is chronic and heavy, steatosis is caused via generation of acetaldehyde, reactive oxygen species (ROS) and ER stress. ROS inhibits key hepatic transcriptional regulators such as AMP-activated kinase (AMPK) and peroxisome proliferator-activated receptor alpha (PPAR-alpha), which are responsible for fatty acid oxidation and export via ACC and CPT-1. The blockade of AMPK also leads to overexpression of SREBP-1, resulting in an increase of de novo lipogenesis. Moreover, excessive intracellular ROS production induced by ethanol and its metabolite have a critical role in ethanol-induced apoptosis, which may be the critical process in the exacerbation of ALD. It is inferred that the apoptotic signal derived from ROS that was produced by NOX, is mainly transduced through the JNK and p38 MAPK pathways.
Class
Human Diseases; Endocrine and metabolic disease
Pathway map
llv04936  Alcoholic liver disease
llv04936

Organism
Lutra lutra (Eurasian river otter) [GN:llv]
Gene
125099089  complement C1q subcomponent subunit A-like [KO:K03986]
125098971  complement C1q subcomponent subunit B-like [KO:K03987]
125099038  complement C1q subcomponent subunit C-like [KO:K03988]
125101523  LOW QUALITY PROTEIN: complement C2-like [KO:K01332] [EC:3.4.21.43]
125101520  complement C4-A-like [KO:K03989]
125086252  complement C3-like isoform X1 [KO:K03990]
125106704  C3a anaphylatoxin chemotactic receptor-like [KO:K04009]
125083237  LOW QUALITY PROTEIN: complement C5-like [KO:K03994]
125089890  C5a anaphylatoxin chemotactic receptor 1-like [KO:K04010]
125109251  lipopolysaccharide-binding protein-like [KO:K05399]
125109713  lipopolysaccharide-binding protein-like [KO:K05399]
125100878  monocyte differentiation antigen CD14-like [KO:K04391]
125098985  lymphocyte antigen 96-like isoform X1 [KO:K05400]
125083203  toll-like receptor 4 [KO:K10160]
125080065  toll/interleukin-1 receptor domain-containing adapter protein-like isoform X1 [KO:K05403]
125106441  myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
125106124  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
125091300  interleukin-1 receptor-associated kinase 1-like isoform X1 [KO:K04730] [EC:2.7.11.1]
125078866  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
125106336  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
125101867  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
125102400  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
125084339  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
125094028  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
125091312  NF-kappa-B essential modulator isoform X1 [KO:K07210]
125105211  NF-kappa-B inhibitor alpha [KO:K04734]
125078405  transcription factor p65 isoform X1 [KO:K04735]
125093224  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125103142  tumor necrosis factor isoform X1 [KO:K03156]
125109148  interleukin-1 beta [KO:K04519]
125081177  interleukin-6 [KO:K05405]
125099687  interleukin-12 subunit alpha [KO:K05406]
125101014  interleukin-12 subunit beta [KO:K05425]
125094403  interleukin-8 [KO:K10030]
125088060  TIR domain-containing adapter molecule 1-like [KO:K05842]
125103668  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
125085960  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
125106807  serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
125088511  interferon regulatory factor 3-like isoform X1 [KO:K05411]
125083482  interferon alpha-1/2-like [KO:K05414]
125083790  interferon alpha-2-like [KO:K05414]
125084017  interferon alpha-like [KO:K05414]
125084018  interferon alpha-1/2-like [KO:K05414]
125082970  interferon alpha-1/2-like [KO:K05414]
125083068  interferon alpha-1/2-like [KO:K05414]
125083069  interferon alpha-1/2-like [KO:K05414]
125083072  interferon alpha-1/2-like [KO:K05414]
125083073  interferon alpha-1/2-like [KO:K05414]
125083074  interferon alpha-1/2-like [KO:K05414]
125083075  interferon alpha-1/2-like [KO:K05414]
125083077  interferon alpha-1/2-like [KO:K05414]
125083078  interferon alpha-1/2-like [KO:K05414]
125083082  interferon alpha-1/2-like [KO:K05414]
125083083  interferon alpha-1/2-like [KO:K05414]
125083084  interferon alpha-1/2-like [KO:K05414]
125083789  interferon beta-like [KO:K05415]
125103110  interleukin-17A-like [KO:K05489]
125106674  interleukin-17 receptor A-like isoform X1 [KO:K05164]
125108766  interleukin-17 receptor C-like isoform X1 [KO:K05166]
125093820  growth-regulated protein homolog gamma-like isoform X1 [KO:K05505]
125093821  LOW QUALITY PROTEIN: growth-regulated alpha protein-like [KO:K05505]
125093822  growth-regulated alpha protein-like [KO:K05505]
125086282  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125084890  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
125079328  FAS-associated death domain protein-like [KO:K02373]
125107758  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
125088780  tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171]
125094998  caspase-8-like isoform X1 [KO:K04398] [EC:3.4.22.61]
125091274  caspase-3 [KO:K02187] [EC:3.4.22.56]
125103136  receptor-interacting serine/threonine-protein kinase 1-like [KO:K02861] [EC:2.7.11.1]
125091696  TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
125087485  sterol regulatory element-binding protein 1 isoform X1 [KO:K07197]
125087726  fatty acid synthase-like isoform X1 [KO:K00665] [EC:2.3.1.85]
125087711  acetyl-CoA carboxylase 1 isoform X1 [KO:K11262] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
125085172  stearoyl-CoA desaturase [KO:K00507] [EC:1.14.19.1]
125094210  stearoyl-CoA desaturase 5-like [KO:K00507] [EC:1.14.19.1]
125108234  phosphatidate phosphatase LPIN1 isoform X1 [KO:K15728] [EC:3.1.3.4]
125109929  phosphatidate phosphatase LPIN3-like isoform X1 [KO:K15728] [EC:3.1.3.4]
125081683  phosphatidate phosphatase LPIN2 isoform X1 [KO:K15728] [EC:3.1.3.4]
125084753  NAD-dependent protein deacetylase sirtuin-1 isoform X1 [KO:K11411] [EC:2.3.1.286]
125091282  transformer-2 protein homolog alpha-like [KO:K12897]
125101799  transformer-2 protein homolog beta isoform X1 [KO:K12897]
125080628  transformer-2 protein homolog alpha isoform X1 [KO:K12897]
125101922  adiponectin [KO:K07296]
125085711  adiponectin receptor protein 1 [KO:K07297]
125106411  adiponectin receptor protein 2 isoform X1 [KO:K07297]
125081965  calcium/calmodulin-dependent protein kinase kinase 2 isoform X1 [KO:K07359] [EC:2.7.11.17]
125100268  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1 [KO:K07198] [EC:2.7.11.31]
125096749  5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
125097369  5'-AMP-activated protein kinase subunit beta-2 [KO:K07199]
125081898  5'-AMP-activated protein kinase subunit beta-1 [KO:K07199]
125096032  5'-AMP-activated protein kinase subunit gamma-3-like isoform X1 [KO:K07200]
125080474  5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [KO:K07200]
125107078  5'-AMP-activated protein kinase subunit gamma-1 isoform X1 [KO:K07200]
125096352  forkhead box protein O1 isoform X1 [KO:K07201]
125101725  LOW QUALITY PROTEIN: forkhead box protein O3-like [KO:K09408]
125093590  peroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X1 [KO:K07202]
125106785  peroxisome proliferator-activated receptor alpha [KO:K07294]
125078256  carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [KO:K08765] [EC:2.3.1.21]
125087809  very long-chain specific acyl-CoA dehydrogenase, mitochondrial [KO:K09479] [EC:1.3.8.9]
125105476  LOW QUALITY PROTEIN: medium-chain specific acyl-CoA dehydrogenase, mitochondrial-like [KO:K00249] [EC:1.3.8.7]
125098234  medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X1 [KO:K00249] [EC:1.3.8.7]
125093501  peroxisomal acyl-coenzyme A oxidase 3-like [KO:K00232] [EC:1.3.3.6]
125086641  peroxisomal acyl-coenzyme A oxidase 1 isoform X1 [KO:K00232] [EC:1.3.3.6]
125109185  fatty acid-binding protein, liver [KO:K08750]
125093203  alcohol dehydrogenase E chain isoform X1 [KO:K13951] [EC:1.1.1.1]
125093201  LOW QUALITY PROTEIN: all-trans-retinol dehydrogenase [NAD(+)] ADH4-like [KO:K13980] [EC:1.1.1.1]
125093200  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
125105545  alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
125093205  alcohol dehydrogenase 6-like [KO:K13952] [EC:1.1.1.1]
125084014  aldehyde dehydrogenase X, mitochondrial [KO:K00128] [EC:1.2.1.3]
125084045  LOW QUALITY PROTEIN: aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
125086830  aldehyde dehydrogenase family 3 member A2 isoform X1 [KO:K00128] [EC:1.2.1.3]
125088409  LOW QUALITY PROTEIN: aldehyde dehydrogenase, mitochondrial-like [KO:K00128] [EC:1.2.1.3]
125082575  aldehyde dehydrogenase, mitochondrial [KO:K00128] [EC:1.2.1.3]
125089050  aldehyde dehydrogenase family 16 member A1 [KO:K00128] [EC:1.2.1.3]
125100356  alpha-aminoadipic semialdehyde dehydrogenase [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
125086052  4-trimethylaminobutyraldehyde dehydrogenase [KO:K00149] [EC:1.2.1.47 1.2.1.3]
125085126  cytochrome P450 2E1 [KO:K07415] [EC:1.14.14.-]
125081691  acetyl-CoA carboxylase 2 isoform X1 [KO:K01946] [EC:6.4.1.2 6.3.4.14 2.1.3.15]
125088712  malonyl-CoA decarboxylase, mitochondrial [KO:K01578] [EC:4.1.1.9]
125106776  carnitine O-palmitoyltransferase 1, muscle isoform isoform X1 [KO:K19523] [EC:2.3.1.21]
125089298  LOW QUALITY PROTEIN: carnitine O-palmitoyltransferase 1, brain isoform-like [KO:K19524] [EC:2.3.1.21]
125079264  NADPH oxidase 4 [KO:K21423] [EC:1.6.3.-]
125086439  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125104283  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125089561  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125097853  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
125106092  catenin beta-1 [KO:K02105]
125099902  transcription factor 7 isoform X1 [KO:K02620]
125108462  transcription factor 7-like 1 isoform X1 [KO:K04490]
125084325  transcription factor 7-like 2 isoform X1 [KO:K04491]
125093264  lymphoid enhancer-binding factor 1 isoform X1 [KO:K04492]
125078419  G1/S-specific cyclin-D1 [KO:K04503]
125103005  mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
125087109  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
125085818  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
125099732  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125084526  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125093137  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
125087473  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
125087142  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
125101777  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
125103018  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
125096321  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
125106184  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
125106185  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
125086838  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
Compound
C00003  NAD+
C00005  NADPH
C00006  NADP+
C00024  Acetyl-CoA
C00033  Acetate
C00040  Acyl-CoA
C00076  Calcium cation
C00083  Malonyl-CoA
C00084  Acetaldehyde
C00469  Ethanol
C22381  Reactive oxygen species
Reference
PMID:25782093
  Authors
Louvet A, Mathurin P
  Title
Alcoholic liver disease: mechanisms of injury and targeted treatment.
  Journal
Nat Rev Gastroenterol Hepatol 12:231-42 (2015)
DOI:10.1038/nrgastro.2015.35
Reference
PMID:21920463
  Authors
Gao B, Bataller R
  Title
Alcoholic liver disease: pathogenesis and new therapeutic targets.
  Journal
Gastroenterology 141:1572-85 (2011)
DOI:10.1053/j.gastro.2011.09.002
Reference
PMID:28134813
  Authors
Magdaleno F, Blajszczak CC, Nieto N
  Title
Key Events Participating in the Pathogenesis of Alcoholic Liver Disease.
  Journal
Biomolecules 7:E9 (2017)
DOI:10.3390/biom7010009
Reference
PMID:19553649
  Authors
Lucey MR, Mathurin P, Morgan TR
  Title
Alcoholic hepatitis.
  Journal
N Engl J Med 360:2758-69 (2009)
DOI:10.1056/NEJMra0805786
Reference
PMID:26919968
  Authors
Nagy LE, Ding WX, Cresci G, Saikia P, Shah VH
  Title
Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.
  Journal
Gastroenterology 150:1756-68 (2016)
DOI:10.1053/j.gastro.2016.02.035
Reference
PMID:25009376
  Authors
Fujii H, Kawada N
  Title
Fibrogenesis in alcoholic liver disease.
  Journal
World J Gastroenterol 20:8048-54 (2014)
DOI:10.3748/wjg.v20.i25.8048
Reference
PMID:26755857
  Authors
Kim MS, Ong M, Qu X
  Title
Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?
  Journal
World J Gastroenterol 22:8-23 (2016)
DOI:10.3748/wjg.v22.i1.8
Reference
PMID:15194557
  Authors
You M, Crabb DW
  Title
Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver.
  Journal
Am J Physiol Gastrointest Liver Physiol 287:G1-6 (2004)
DOI:10.1152/ajpgi.00056.2004
Reference
PMID:26695748
  Authors
Nagy LE
  Title
The Role of Innate Immunity in Alcoholic Liver Disease.
  Journal
Alcohol Res 37:237-50 (2015)
Reference
PMID:21252049
  Authors
Gao B, Seki E, Brenner DA, Friedman S, Cohen JI, Nagy L, Szabo G, Zakhari S
  Title
Innate immunity in alcoholic liver disease.
  Journal
Am J Physiol Gastrointest Liver Physiol 300:G516-25 (2011)
DOI:10.1152/ajpgi.00537.2010
Reference
PMID:22524187
  Authors
Wang HJ, Gao B, Zakhari S, Nagy LE
  Title
Inflammation in alcoholic liver disease.
  Journal
Annu Rev Nutr 32:343-68 (2012)
DOI:10.1146/annurev-nutr-072610-145138
Reference
PMID:29597356
  Authors
McCullough RL, McMullen MR, Sheehan MM, Poulsen KL, Roychowdhury S, Chiang DJ, Pritchard MT, Caballeria J, Nagy LE
  Title
Complement Factor D protects mice from ethanol-induced inflammation and liver injury.
  Journal
Am J Physiol Gastrointest Liver Physiol 315:G66-G79 (2018)
DOI:10.1152/ajpgi.00334.2017
Reference
PMID:24385684
  Authors
Kawaratani H, Tsujimoto T, Douhara A, Takaya H, Moriya K, Namisaki T, Noguchi R, Yoshiji H, Fujimoto M, Fukui H
  Title
The effect of inflammatory cytokines in alcoholic liver disease.
  Journal
Mediators Inflamm 2013:495156 (2013)
DOI:10.1155/2013/495156
Reference
PMID:20238398
  Authors
Szabo G, Bala S
  Title
Alcoholic liver disease and the gut-liver axis.
  Journal
World J Gastroenterol 16:1321-9 (2010)
DOI:10.3748/wjg.v16.i11.1321
Reference
PMID:28627645
  Authors
Kawaratani H, Moriya K, Namisaki T, Uejima M, Kitade M, Takeda K, Okura Y, Kaji K, Takaya H, Nishimura N, Sato S, Sawada Y, Seki K, Kubo T, Mitoro A, Yamao J, Yoshiji H
  Title
Therapeutic strategies for alcoholic liver disease: Focusing on inflammation and fibrosis (Review).
  Journal
Int J Mol Med 40:263-270 (2017)
DOI:10.3892/ijmm.2017.3015
Reference
PMID:23855294
  Authors
Roh YS, Seki E
  Title
Toll-like receptors in alcoholic liver disease, non-alcoholic steatohepatitis and carcinogenesis.
  Journal
J Gastroenterol Hepatol 28 Suppl 1:38-42 (2013)
DOI:10.1111/jgh.12019
Reference
PMID:18709650
  Authors
Rogers CQ, Ajmo JM, You M
  Title
Adiponectin and alcoholic fatty liver disease.
  Journal
IUBMB Life 60:790-7 (2008)
DOI:10.1002/iub.124
Reference
PMID:26278388
  Authors
You M, Jogasuria A, Lee K, Wu J, Zhang Y, Lee YK, Sadana P
  Title
Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
  Journal
Curr Mol Pharmacol 10:226-236 (2017)
DOI:10.2174/1874467208666150817112109
Reference
PMID:26005675
  Authors
You M, Jogasuria A, Taylor C, Wu J
  Title
Sirtuin 1 signaling and alcoholic fatty liver disease.
  Journal
Hepatobiliary Surg Nutr 4:88-100 (2015)
DOI:10.3978/j.issn.2304-3881.2014.12.06
Reference
PMID:33162823
  Authors
Ren R, Wang Z, Wu M, Wang H
  Title
Emerging Roles of SIRT1 in Alcoholic Liver Disease.
  Journal
Int J Biol Sci 16:3174-3183 (2020)
DOI:10.7150/ijbs.49535
Reference
PMID:19032584
  Authors
Purohit V, Gao B, Song BJ
  Title
Molecular mechanisms of alcoholic fatty liver.
  Journal
Alcohol Clin Exp Res 33:191-205 (2009)
DOI:10.1111/j.1530-0277.2008.00827.x
Reference
PMID:34071962
  Authors
Hyun J, Han J, Lee C, Yoon M, Jung Y
  Title
Pathophysiological Aspects of Alcohol Metabolism in the Liver.
  Journal
Int J Mol Sci 22:5717 (2021)
DOI:10.3390/ijms22115717
Reference
PMID:24297186
  Authors
Combs TP, Marliss EB
  Title
Adiponectin signaling in the liver.
  Journal
Rev Endocr Metab Disord 15:137-47 (2014)
DOI:10.1007/s11154-013-9280-6
Reference
PMID:25548474
  Authors
Ceni E, Mello T, Galli A
  Title
Pathogenesis of alcoholic liver disease: role of oxidative metabolism.
  Journal
World J Gastroenterol 20:17756-72 (2014)
DOI:10.3748/wjg.v20.i47.17756
Reference
PMID:31159489
  Authors
Kong LZ, Chandimali N, Han YH, Lee DH, Kim JS, Kim SU, Kim TD, Jeong DK, Sun HN, Lee DS, Kwon T
  Title
Pathogenesis, Early Diagnosis, and Therapeutic Management of Alcoholic Liver Disease.
  Journal
Int J Mol Sci 20:E2712 (2019)
DOI:10.3390/ijms20112712
Reference
PMID:31214376
  Authors
Ohashi K, Pimienta M, Seki E
  Title
Alcoholic liver disease: A current molecular and clinical perspective.
  Journal
Liver Res 2:161-172 (2018)
DOI:10.1016/j.livres.2018.11.002
Reference
PMID:30658725
  Authors
You M, Arteel GE
  Title
Effect of ethanol on lipid metabolism.
  Journal
J Hepatol 70:237-248 (2019)
DOI:10.1016/j.jhep.2018.10.037
Reference
PMID:25595739
  Authors
Bi L, Jiang Z, Zhou J
  Title
The role of lipin-1 in the pathogenesis of alcoholic fatty liver.
  Journal
Alcohol Alcohol 50:146-51 (2015)
DOI:10.1093/alcalc/agu102
Reference
PMID:31263795
  Authors
Ali H, Assiri MA, Shearn CT, Fritz KS
  Title
Lipid peroxidation derived reactive aldehydes in alcoholic liver disease.
  Journal
Curr Opin Toxicol 13:110-117 (2019)
DOI:10.1016/j.cotox.2018.10.003
Reference
PMID:24262277
  Authors
Yin H, Hu M, Liang X, Ajmo JM, Li X, Bataller R, Odena G, Stevens SM Jr, You M
  Title
Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver.
  Journal
Gastroenterology 146:801-11 (2014)
DOI:10.1053/j.gastro.2013.11.008
Reference
PMID:22110053
  Authors
Stickel F, Hampe J
  Title
Genetic determinants of alcoholic liver disease.
  Journal
Gut 61:150-9 (2012)
DOI:10.1136/gutjnl-2011-301239
Reference
PMID:29336467
  Authors
Yang CF, Zhong YJ, Ma Z, Li L, Shi L, Chen L, Li C, Wu D, Chen Q, Li YW
  Title
NOX4/ROS mediate ethanolinduced apoptosis via MAPK signal pathway in L02 cells.
  Journal
Int J Mol Med 41:2306-2316 (2018)
DOI:10.3892/ijmm.2018.3390
Related
pathway
llv00061  Fatty acid biosynthesis
llv00071  Fatty acid degradation
llv01040  Biosynthesis of unsaturated fatty acids
llv03040  Spliceosome
llv04010  MAPK signaling pathway
llv04064  NF-kappa B signaling pathway
llv04152  AMPK signaling pathway
llv04210  Apoptosis
llv04310  Wnt signaling pathway
llv04610  Complement and coagulation cascades
llv04620  Toll-like receptor signaling pathway
llv04657  IL-17 signaling pathway
llv04668  TNF signaling pathway
llv04920  Adipocytokine signaling pathway
llv05034  Alcoholism
llv05225  Hepatocellular carcinoma
KO pathway
ko04936   
LinkDB

DBGET integrated database retrieval system