KEGG   PATHWAY: llv04010
Entry
llv04010                    Pathway                                
Name
MAPK signaling pathway - Lutra lutra (Eurasian river otter)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
llv04010  MAPK signaling pathway
llv04010

Other DBs
GO: 0000165
Organism
Lutra lutra (Eurasian river otter) [GN:llv]
Gene
125083811  voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
125083483  voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
125107204  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
125078710  LOW QUALITY PROTEIN: voltage-dependent L-type calcium channel subunit alpha-1D-like [KO:K04851]
125086015  voltage-dependent R-type calcium channel subunit alpha-1E isoform X1 [KO:K04852]
125091668  voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
125087666  voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
125090211  voltage-dependent T-type calcium channel subunit alpha-1H-like isoform X1 [KO:K04855]
125107501  voltage-dependent T-type calcium channel subunit alpha-1I-like isoform X1 [KO:K04856]
125086002  voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
125080441  voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
125079576  voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
125078684  voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
125107606  voltage-dependent calcium channel subunit alpha-2/delta-4 [KO:K04861]
125087304  voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
125107988  voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
125106493  voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
125095828  voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
125087691  voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
125107510  voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
125090859  voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
125087690  voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
125088144  voltage-dependent calcium channel gamma-5 subunit isoform X1 [KO:K04870]
125089771  voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
125089960  voltage-dependent calcium channel gamma-7 subunit [KO:K04872]
125089993  voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
125083608  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
125097539  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
125087644  protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
125090366  protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
125089171  protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
125090604  guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
125100232  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
125084299  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
125102718  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
125098222  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12-like [KO:K04347]
125084662  LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2B catalytic subunit beta isoform-like [KO:K04348] [EC:3.1.3.16]
125092859  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125093220  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
125083501  calcineurin subunit B type 2 [KO:K06268]
125105434  ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
125100102  ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
125104027  RAS guanyl-releasing protein 1 [KO:K04350]
125078503  RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
125108393  ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
125089719  RAS guanyl-releasing protein 4 [KO:K12363]
125093089  rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
125086608  neurofibromin isoform X1 [KO:K08052]
125100932  ras GTPase-activating protein 1 [KO:K04352]
125098087  ras GTPase-activating protein 2 isoform X1 [KO:K08053]
125096746  ras-related protein Rap-1A isoform X1 [KO:K04353]
125107556  ras-related protein Rap-1b [KO:K07836]
125106325  ras-related protein Rap-1b-like protein [KO:K07836]
125093282  pro-epidermal growth factor isoform X1 [KO:K04357]
125093827  proepiregulin [KO:K09784]
125093829  amphiregulin-like [KO:K09782]
125100276  fibroblast growth factor 1 isoform X1 [KO:K18496]
125093355  fibroblast growth factor 2 [KO:K18497]
125107865  fibroblast growth factor 6 [KO:K04358]
125092033  fibroblast growth factor 16 [KO:K04358]
125100815  fibroblast growth factor 10 [KO:K04358]
125084892  fibroblast growth factor 8 isoform X1 [KO:K04358]
125092847  fibroblast growth factor 17 [KO:K04358]
125100891  fibroblast growth factor 18 isoform X1 [KO:K04358]
125093906  fibroblast growth factor 5 isoform X1 [KO:K04358]
125094273  fibroblast growth factor 20 [KO:K04358]
125079901  fibroblast growth factor 3-like [KO:K04358]
125080009  fibroblast growth factor 4 [KO:K04358]
125087595  uncharacterized protein LOC125087595 isoform X1 [KO:K04358]
125096172  fibroblast growth factor 9 [KO:K04358]
125105389  fibroblast growth factor 7 isoform X1 [KO:K04358]
125079900  fibroblast growth factor 19-like [KO:K22603]
125088958  fibroblast growth factor 21-like [KO:K22429]
125107879  fibroblast growth factor 23-like [KO:K22428]
125099036  beta-nerve growth factor [KO:K02582]
125079596  brain-derived neurotrophic factor isoform X1 [KO:K04355]
125107864  neurotrophin-3 isoform X1 [KO:K04356]
125089665  neurotrophin-4 [KO:K12457]
125079072  insulin [KO:K04526]
125106739  insulin-like growth factor I isoform X1 [KO:K05459]
125079069  insulin-like growth factor II isoform X1 [KO:K13769]
125090848  platelet-derived growth factor subunit A isoform X1 [KO:K04359]
125107099  platelet-derived growth factor subunit B isoform X1 [KO:K17386]
125093106  platelet-derived growth factor C isoform X1 [KO:K05450]
125079346  platelet-derived growth factor D isoform X1 [KO:K05450]
125098134  macrophage colony-stimulating factor 1-like isoform X1 [KO:K05453]
125106353  kit ligand isoform X1 [KO:K05461]
125089051  fms-related tyrosine kinase 3 ligand-like isoform X1 [KO:K05454]
125101605  uncharacterized protein LOC125101605 [KO:K05448]
125105448  placenta growth factor-like isoform X1 [KO:K16859]
125090950  vascular endothelial growth factor C [KO:K05449]
125091711  vascular endothelial growth factor D-like [KO:K05449]
125081138  hepatocyte growth factor isoform X1 [KO:K05460]
125098553  angiopoietin-1 isoform X1 [KO:K05465]
125090759  angiopoietin-2 isoform X1 [KO:K05466]
125108708  angiopoietin-4 isoform X1 [KO:K05467]
125099837  ephrin-A5 isoform X1 [KO:K05462]
125085734  ephrin-A1 isoform X1 [KO:K05462]
125086008  ephrin-A4-like [KO:K05462]
125086009  ephrin-A3 [KO:K05462]
125089172  ephrin-A2 [KO:K05462]
125100984  glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
125088418  neurturin isoform X1 [KO:K25414]
125088424  neurturin [KO:K25414]
125098479  artemin-like [KO:K25415]
125088443  persephin-like [KO:K25416]
125080419  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
125087205  receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
125106206  receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
125095556  receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
125092758  fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
125084713  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
125093458  fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
125100667  fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
125087886  tumor necrosis factor receptor superfamily member 16 [KO:K02583]
125085737  high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
125083535  BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
125085453  insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
125105350  insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
125093724  platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
125100170  platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
125100440  macrophage colony-stimulating factor 1 receptor [KO:K05090] [EC:2.7.10.1]
125093731  mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
125096240  receptor-type tyrosine-protein kinase FLT3 isoform X1 [KO:K05092] [EC:2.7.10.1]
125096245  vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
125100265  vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
125093732  vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
125080939  hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
125083337  angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
125098359  ephrin type-A receptor 2 isoform X1 [KO:K05103] [EC:2.7.10.1]
125085127  proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
125087106  growth factor receptor-bound protein 2 [KO:K04364]
125109653  LOW QUALITY PROTEIN: son of sevenless homolog 1-like [KO:K03099]
125104149  son of sevenless homolog 2 isoform X1 [KO:K03099]
125078621  GTPase HRas isoform X1 [KO:K02833]
125106241  GTPase KRas isoform X1 [KO:K07827]
125098043  GTPase NRas [KO:K07828]
125088514  ras-related protein R-Ras [KO:K07829]
125080162  ras-related protein R-Ras2 [KO:K07830]
125103936  ras-related protein M-Ras [KO:K07831]
125091395  serine/threonine-protein kinase A-Raf [KO:K08845] [EC:2.7.11.1]
125080584  serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
125108469  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125105594  dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
125086704  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125093213  ragulator complex protein LAMTOR3 [KO:K04370]
125081690  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
125090203  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
125088979  MAP kinase-interacting serine/threonine-protein kinase 2 isoform X1 [KO:K04372] [EC:2.7.11.1]
125098010  MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
125091422  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
125102292  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
125097938  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
125106338  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
125091401  ETS domain-containing protein Elk-1 [KO:K04375]
125085812  ETS domain-containing protein Elk-4-like [KO:K04376]
125098611  myc proto-oncogene protein [KO:K04377]
125102376  serum response factor [KO:K04378]
125105343  protein c-Fos [KO:K04379]
125086936  microtubule-associated protein tau isoform X1 [KO:K04380]
125091022  stathmin-like [KO:K04381]
125095566  LOW QUALITY PROTEIN: stathmin-like [KO:K04381]
125098789  stathmin [KO:K04381]
125086218  cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
125104288  cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
125104913  cytosolic phospholipase A2 delta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
125104914  cytosolic phospholipase A2 epsilon isoform X1 [KO:K16342] [EC:3.1.1.4]
125105491  cytosolic phospholipase A2 zeta-like [KO:K16342] [EC:3.1.1.4]
125103142  tumor necrosis factor isoform X1 [KO:K03156]
125109147  interleukin-1 alpha [KO:K04383]
125109148  interleukin-1 beta [KO:K04519]
125089683  transforming growth factor beta-1 proprotein isoform X1 [KO:K13375]
125085760  LOW QUALITY PROTEIN: transforming growth factor beta-2 proprotein-like [KO:K13376]
125103650  transforming growth factor beta-3 proprotein [KO:K13377]
125107758  tumor necrosis factor receptor superfamily member 1A-like isoform X1 [KO:K03158]
125108912  interleukin-1 receptor type 1-like isoform X1 [KO:K04386]
125102154  interleukin-1 receptor accessory protein [KO:K04723]
125083498  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
125105441  TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
125086282  tumor necrosis factor ligand superfamily member 6 [KO:K04389]
125084890  tumor necrosis factor receptor superfamily member 6-like [KO:K04390]
125100878  monocyte differentiation antigen CD14-like [KO:K04391]
125090900  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
125101158  ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
125107249  ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
125086620  ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
125107993  cell division control protein 42 homolog [KO:K04393]
125094750  cell division control protein 42 homolog [KO:K04393]
125097697  cell division control protein 42 homolog isoform X1 [KO:K04393]
125088780  tumor necrosis factor receptor type 1-associated DEATH domain protein-like [KO:K03171]
125091274  caspase-3 [KO:K02187] [EC:3.4.22.56]
125083298  TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
125102313  death domain-associated protein 6 isoform X1 [KO:K02308]
125106441  myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
125091300  interleukin-1 receptor-associated kinase 1-like isoform X1 [KO:K04730] [EC:2.7.11.1]
125106124  interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
125078866  TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
125084011  growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
125087160  growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
125098822  growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
125106336  TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 isoform X1 [KO:K04403]
125101867  TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 [KO:K04404]
125084384  evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial-like [KO:K04405]
125108251  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
125109578  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
125089927  mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
125080073  serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
125102224  serine/threonine-protein kinase PAK 2 isoform X1 [KO:K04410] [EC:2.7.11.1]
125102630  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 2-like [KO:K04410] [EC:2.7.11.1]
125108887  serine/threonine-protein kinase 4 [KO:K04411]
125097698  serine/threonine-protein kinase 3 isoform X1 [KO:K04412]
125078649  mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
125107123  mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
125101058  mitogen-activated protein kinase kinase kinase 1 isoform X1 [KO:K04416] [EC:2.7.11.25]
125078716  mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
125096067  mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
125087832  mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
125104197  mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
125089071  mitogen-activated protein kinase kinase kinase 10 [KO:K04418] [EC:2.7.11.25]
125084807  mitogen-activated protein kinase kinase kinase 21 isoform X1 [KO:K17534] [EC:2.7.11.25]
125106027  mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
125101721  mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
125095736  mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
125098229  mitogen-activated protein kinase kinase kinase 6 [KO:K04425] [EC:2.7.11.25]
125103005  mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
125102400  LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 7-like [KO:K04427] [EC:2.7.11.25]
125102269  mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
125087186  serine/threonine-protein kinase TAO1 [KO:K04429] [EC:2.7.11.1]
125082556  serine/threonine-protein kinase TAO3 [KO:K04429] [EC:2.7.11.1]
125090334  serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
125087109  LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 4-like [KO:K04430] [EC:2.7.12.2]
125085818  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
125087473  dual specificity mitogen-activated protein kinase kinase 3 [KO:K04432] [EC:2.7.12.2]
125087142  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
125078346  C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
125107644  C-Jun-amino-terminal kinase-interacting protein 2 [KO:K04435]
125090192  LOW QUALITY PROTEIN: C-Jun-amino-terminal kinase-interacting protein 3-like [KO:K04436]
125091339  LOW QUALITY PROTEIN: filamin-A-like [KO:K04437]
125087250  adapter molecule crk isoform X1 [KO:K04438]
125082002  crk-like protein [KO:K04438]
125078624  beta-arrestin-1 isoform X1 [KO:K04439]
125086632  beta-arrestin-2 [KO:K04439]
125099732  mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
125084526  mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
125093137  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
125101777  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
125103018  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
125096321  mitogen-activated protein kinase 13-like [KO:K04441] [EC:2.7.11.24]
125106184  mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
125106185  mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
125082576  MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
125085671  MAP kinase-activated protein kinase 2 isoform X1 [KO:K04443] [EC:2.7.11.1]
125079510  MAP kinase-activated protein kinase 3 isoform X1 [KO:K04444] [EC:2.7.11.1]
125104128  ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
125079379  ribosomal protein S6 kinase alpha-4 [KO:K16510] [EC:2.7.11.1]
125108201  M-phase inducer phosphatase 2 isoform X1 [KO:K05866] [EC:3.1.3.48]
125089105  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
125098159  transcription factor Jun [KO:K04448]
125082070  transcription factor JunD [KO:K04449]
125095761  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
125087037  cellular tumor antigen p53 isoform X1 [KO:K04451]
125106097  DNA damage-inducible transcript 3 protein [KO:K04452]
125104744  protein max isoform X1 [KO:K04453]
125100113  myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
125091098  heat shock protein beta-1 [KO:K04455]
125086439  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125104283  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125089561  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125103921  protein phosphatase 1A isoform X1 [KO:K04457] [EC:3.1.3.16]
125107438  receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
125079969  tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
125085794  tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
125100671  dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
125091728  dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125085003  dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125109919  dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125078924  dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125079236  dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125107092  dual specificity protein phosphatase 16-like [KO:K04459] [EC:3.1.3.16 3.1.3.48]
125107286  dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
125092414  dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
125086088  dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
125087270  dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
125089069  serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
125108401  protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
125107574  heat shock cognate 71 kDa protein-like [KO:K03283]
125100538  heat shock cognate 71 kDa protein [KO:K03283]
125100679  heat shock cognate 71 kDa protein-like [KO:K03283]
125108856  heat shock cognate 71 kDa protein-like [KO:K03283]
125092981  heat shock cognate 71 kDa protein-like [KO:K03283]
125093086  heat shock cognate 71 kDa protein-like [KO:K03283]
125078422  heat shock cognate 71 kDa protein [KO:K03283]
125102166  heat shock 70 kDa protein 1 [KO:K03283]
125102167  heat shock 70 kDa protein 1-like [KO:K03283]
125094337  heat shock cognate 71 kDa protein-like [KO:K03283]
125078931  heat shock cognate 71 kDa protein-like [KO:K03283]
125102986  heat shock cognate 71 kDa protein-like [KO:K03283]
125100039  histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
125103769  dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
125088025  mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
125107277  nuclear receptor subfamily 4 group A member 1 [KO:K04465]
125086838  mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
125084339  LOW QUALITY PROTEIN: inhibitor of nuclear factor kappa-B kinase subunit alpha-like [KO:K04467] [EC:2.7.11.10]
125094028  inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
125091312  NF-kappa-B essential modulator isoform X1 [KO:K07210]
125087256  serine/threonine-protein kinase NLK [KO:K04468] [EC:2.7.11.24]
125093224  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125084865  nuclear factor NF-kappa-B p100 subunit isoform X1 [KO:K04469]
125078405  transcription factor p65 isoform X1 [KO:K04735]
125088662  transcription factor RelB isoform X1 [KO:K09253]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
PMID:11749383
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Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH.
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MAP kinases.
  Journal
Chem Rev 101:2449-76 (2001)
DOI:10.1021/cr000241p
Reference
PMID:12191611
  Authors
Tanoue T, Nishida E.
  Title
Docking interactions in the mitogen-activated protein kinase cascades.
  Journal
Pharmacol Ther 93:193-202 (2002)
DOI:10.1016/S0163-7258(02)00188-2
Reference
PMID:12947395
  Authors
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
  Title
MAPK pathways in radiation responses.
  Journal
Oncogene 22:5885-96 (2003)
DOI:10.1038/sj.onc.1206701
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11369511
  Authors
Harper SJ, LoGrasso P.
  Title
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
  Journal
Cell Signal 13:299-310 (2001)
DOI:10.1016/S0898-6568(01)00148-6
Reference
PMID:12390245
  Authors
Takeda K, Ichijo H
  Title
Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
  Journal
Genes Cells 7:1099-111 (2002)
DOI:10.1046/j.1365-2443.2002.00591.x
Reference
PMID:14597384
  Authors
Yang SH, Sharrocks AD, Whitmarsh AJ.
  Title
Transcriptional regulation by the MAP kinase signaling cascades.
  Journal
Gene 320:3-21 (2003)
DOI:10.1016/S0378-1119(03)00816-3
Reference
PMID:12566928
  Authors
Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
  Title
The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
  Journal
Neurosignals 11:270-81 (2002)
DOI:10.1159/000067426
Reference
PMID:12849693
  Authors
Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
  Title
Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
  Journal
Toxicol Lett 143:323-30 (2003)
DOI:10.1016/S0378-4274(03)00193-0
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Reference
PMID:23085193
  Authors
Chu WM
  Title
Tumor necrosis factor.
  Journal
Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
  Authors
Newton K, Dixit VM
  Title
Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
  Authors
Gaestel M, Kotlyarov A, Kracht M
  Title
Targeting innate immunity protein kinase signalling in inflammation.
  Journal
Nat Rev Drug Discov 8:480-99 (2009)
DOI:10.1038/nrd2829
Reference
PMID:23664135
  Authors
Ajibade AA, Wang HY, Wang RF
  Title
Cell type-specific function of TAK1 in innate immune signaling.
  Journal
Trends Immunol 34:307-16 (2013)
DOI:10.1016/j.it.2013.03.007
Reference
PMID:24892271
  Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
  Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
  Journal
Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
llv04070  Phosphatidylinositol signaling system
llv04110  Cell cycle
llv04115  p53 signaling pathway
llv04210  Apoptosis
llv04310  Wnt signaling pathway
llv04668  TNF signaling pathway
KO pathway
ko04010   
LinkDB

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