KEGG   PATHWAY: mcoc04360
Entry
mcoc04360                   Pathway                                
Name
Axon guidance - Mastomys coucha (southern multimammate mouse)
Description
Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn.
Class
Organismal Systems; Development and regeneration
Pathway map
mcoc04360  Axon guidance
mcoc04360

Other DBs
GO: 0007411
Organism
Mastomys coucha (southern multimammate mouse) [GN:mcoc]
Gene
116093655  Ntng1; netrin-G1 isoform X1 [KO:K07522]
116089916  Ntng2; netrin-G2 isoform X1 [KO:K16359]
116090538  Lrrc4c; leucine-rich repeat-containing protein 4C [KO:K07523]
116098652  Lrrc4; leucine-rich repeat-containing protein 4 [KO:K16351]
116076876  Ntn1; netrin-1 [KO:K06843]
116079114  Ntn3; netrin-3 [KO:K06844]
116075778  Ntn4; netrin-4 [KO:K06845]
116087326  Dcc; netrin receptor DCC isoform X1 [KO:K06765]
116091317  Plcg1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
116070251  Plcg2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
116072568  Trpc1; short transient receptor potential channel 1 isoform X1 [KO:K04964]
116095106  Trpc3; short transient receptor potential channel 3 isoform X1 [KO:K04966]
116092867  Trpc4; short transient receptor potential channel 4 isoform X1 [KO:K04967]
116089333  Trpc5; short transient receptor potential channel 5 [KO:K04968]
116073047  Trpc6; short transient receptor potential channel 6 isoform X1 [KO:K04969]
116093830  Ppp3ca; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116084124  Ppp3cc; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116084832  Ppp3cb; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
116096012  Ppp3r2; calcineurin subunit B type 2 [KO:K06268]
116071362  Ppp3r1; calcineurin subunit B type 1 isoform X1 [KO:K06268]
116091445  Nfatc2; nuclear factor of activated T-cells, cytoplasmic 2 isoform X1 [KO:K17332]
116070090  Nfatc3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
116084618  Nfatc4; nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
116073569  Ptk2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
116074574  Fyn; tyrosine-protein kinase Fyn [KO:K05703] [EC:2.7.10.2]
116091289  Src; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
116068714  Rac1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
116075508  Rac2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
116077969  Rac3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
116096877  Cdc42; cell division control protein 42 homolog isoform X1 [KO:K04393]
116104034  Ablim1; actin-binding LIM protein 1 isoform X1 [KO:K07520]
116087244  Ablim3; actin-binding LIM protein 3 isoform X1 [KO:K07520]
116070393  Ablim2; actin-binding LIM protein 2 isoform X1 [KO:K07520]
116072030  Nck1; cytoplasmic protein NCK1 isoform X1 [KO:K07365]
116102599  Pak1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
116085808  Pak2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
116089228  Pak3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
116101918  Pak4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
116091004  Pak5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
116090694  Pak6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
116073981  Rhoa; transforming protein RhoA [KO:K04513]
116076329  LOW QUALITY PROTEIN: transforming protein RhoA-like [KO:K04513]
116086826  Rock1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
116080601  Rock2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
116074584  Unc5b; netrin receptor UNC5B isoform X1 [KO:K07521]
116093863  Unc5c; netrin receptor UNC5C isoform X1 [KO:K07521]
116069098  Unc5d; netrin receptor UNC5D isoform X1 [KO:K07521]
116081620  Unc5a; netrin receptor UNC5A isoform X1 [KO:K07521]
116068338  Ptpn11; tyrosine-protein phosphatase non-receptor type 11 isoform X1 [KO:K07293] [EC:3.1.3.48]
116102394  Rgma; repulsive guidance molecule A [KO:K23096]
116072890  Neo1; neogenin isoform X1 [KO:K06766]
116091273  Myl9; myosin regulatory light polypeptide 9 [KO:K12755]
116088889  Myl12b; myosin regulatory light chain 12B [KO:K12757]
116088890  myosin regulatory light chain RLC-A [KO:K12757]
116072951  Arhgef12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
116093551  Lrig2; leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X1 [KO:K24609]
116093165  Efna1; ephrin-A1 isoform X1 [KO:K05462]
116093166  Efna3; ephrin-A3 isoform X1 [KO:K05462]
116093175  Efna4; ephrin-A4 [KO:K05462]
116076345  Efna2; ephrin-A2 [KO:K05462]
116088835  Efna5; ephrin-A5 isoform X1 [KO:K05462]
116087064  Efnb1; ephrin-B1 [KO:K05463]
116068877  Efnb2; ephrin-B2 [KO:K05463]
116078273  Efnb3; ephrin-B3 [KO:K05463]
116098808  Epha1; ephrin type-A receptor 1 [KO:K05102] [EC:2.7.10.1]
116096958  Epha2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
116086043  Epha3; ephrin type-A receptor 3 isoform X1 [KO:K05104] [EC:2.7.10.1]
116088622  Epha4; ephrin type-A receptor 4 isoform X1 [KO:K05105] [EC:2.7.10.1]
116071402  Epha5; ephrin type-A receptor 5 isoform X1 [KO:K05106] [EC:2.7.10.1]
116086034  Epha6; ephrin type-A receptor 6 isoform X1 [KO:K05107] [EC:2.7.10.1]
116088005  Epha7; ephrin type-A receptor 7 isoform X1 [KO:K05108] [EC:2.7.10.1]
116096872  Epha8; ephrin type-A receptor 8 [KO:K05109] [EC:2.7.10.1]
116072126  Ephb1; ephrin type-B receptor 1 isoform X1 [KO:K05110] [EC:2.7.10.1]
116096871  Ephb2; ephrin type-B receptor 2 isoform X1 [KO:K05111] [EC:2.7.10.1]
116085737  Ephb3; ephrin type-B receptor 3 isoform X1 [KO:K05112] [EC:2.7.10.1]
116068594  Ephb4; ephrin type-B receptor 4 isoform X1 [KO:K05113] [EC:2.7.10.1]
116098804  Ephb6; ephrin type-B receptor 6 isoform X1 [KO:K05114] [EC:2.7.10.1]
116089976  Abl1; tyrosine-protein kinase ABL1 isoform X1 [KO:K06619] [EC:2.7.10.2]
116067948  Enah; protein enabled homolog isoform X1 [KO:K05746]
116083408  Rasa1; ras GTPase-activating protein 1 isoform X1 [KO:K04352]
116088721  Ngef; ephexin-1 isoform X1 [KO:K07525]
116099791  Kras; GTPase KRas isoform X1 [KO:K07827]
116093530  Nras; GTPase NRas [KO:K07828]
116102969  Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
116073648  Mapk6; mitogen-activated protein kinase 6 [KO:K04371] [EC:2.7.11.24]
116085641  Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
116088369  Nck2; cytoplasmic protein NCK2 [KO:K19862]
116096115  Rgs3; regulator of G-protein signaling 3 isoform X1 [KO:K07524]
116099458  Cxcl12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
116098629  Cxcr4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
116097497  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
116093617  Gnai3; guanine nucleotide-binding protein G(i) subunit alpha [KO:K04630]
116072321  Gnai2; guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
116103831  Slit1; slit homolog 1 protein [KO:K06838]
116070780  Slit2; slit homolog 2 protein isoform X1 [KO:K06839]
116077885  Slit3; slit homolog 3 protein [KO:K06850]
116086057  Robo1; roundabout homolog 1 isoform X1 [KO:K06753]
116086059  Robo2; roundabout homolog 2 isoform X1 [KO:K06754]
116073369  Robo3; roundabout homolog 3 isoform X1 [KO:K06755]
116098838  Srgap2; SLIT-ROBO Rho GTPase-activating protein 2 isoform X1 [KO:K07526]
116099380  Srgap3; SLIT-ROBO Rho GTPase-activating protein 3 isoform X1 [KO:K07526]
116075709  Srgap1; SLIT-ROBO Rho GTPase-activating protein 1 isoform X1 [KO:K07526]
116097481  Sema3d; semaphorin-3D [KO:K06840]
116097482  Sema3a; semaphorin-3A [KO:K06840]
116097483  Sema3e; semaphorin-3E isoform X1 [KO:K06840]
116097491  Sema3c; semaphorin-3C [KO:K06840]
116084930  Sema3g; semaphorin-3G [KO:K06840]
116072066  Sema3b; semaphorin-3B [KO:K06840]
116072086  Sema3f; semaphorin-3F isoform X1 [KO:K06840]
116098694  Plxna4; plexin-A4 [KO:K06820]
116099236  Plxna1; plexin-A1 [KO:K06820]
116076703  Plxna3; plexin-A3 [KO:K06820]
116069229  Plxna2; plexin-A2 [KO:K06820]
116070456  Nrp1; neuropilin-1 isoform X1 [KO:K06724]
116086035  L1cam; neural cell adhesion molecule L1 isoform X1 [KO:K06550]
116068512  Limk1; LIM domain kinase 1 isoform X1 [KO:K05743] [EC:2.7.11.1]
116069764  Limk2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
116098022  cofilin-1 [KO:K05765]
116101393  Cfl1; cofilin-1 [KO:K05765]
116081147  Cfl2; cofilin-2 isoform X1 [KO:K05765]
116103334  Rhod; rho-related GTP-binding protein RhoD [KO:K07530]
116079156  Rnd1; rho-related GTP-binding protein Rho6 [KO:K07531]
116102463  Fes; tyrosine-protein kinase Fes/Fps [KO:K07527] [EC:2.7.10.2]
116079613  Dpysl5; dihydropyrimidinase-related protein 5 [KO:K07529]
116085236  Dpysl2; dihydropyrimidinase-related protein 2 isoform X1 [KO:K07528]
116097551  Cdk5; cyclin-dependent-like kinase 5 [KO:K02090] [EC:2.7.11.22]
116085894  Gsk3b; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
116102451  Sema4b; semaphorin-4B [KO:K06521]
116103907  Sema4g; semaphorin-4G [KO:K06521]
116099118  Sema4f; semaphorin-4F isoform X1 [KO:K06521]
116082678  Sema4d; semaphorin-4D isoform X1 [KO:K06521]
116093128  Sema4a; semaphorin-4A isoform X1 [KO:K06521]
116088303  Sema4c; semaphorin-4C isoform X1 [KO:K06521]
116083127  Sema5a; semaphorin-5A [KO:K06841]
116085860  Sema5b; semaphorin-5B isoform X1 [KO:K06841]
116093397  Sema6c; semaphorin-6C isoform X1 [KO:K06842]
116075481  Sema6b; semaphorin-6B isoform X1 [KO:K06842]
116087142  Sema6a; semaphorin-6A isoform X1 [KO:K06842]
116090835  Sema6d; semaphorin-6D isoform X1 [KO:K06842]
116073750  Plxnb1; plexin-B1 isoform X1 [KO:K06821]
116077804  Plxnb2; plexin-B2 [KO:K06821]
116071928  Plxnb3; plexin-B3 [KO:K06821]
116098601  Met; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
116099433  Raf1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
116102164  Rras; ras-related protein R-Ras isoform X1 [KO:K07829]
116072880  Sema7a; semaphorin-7A isoform X1 [KO:K06529]
116094839  LOW QUALITY PROTEIN: plexin-C1-like [KO:K06572]
116076525  Plxnc1; plexin-C1 [KO:K06572]
116070458  Itgb1; integrin beta-1 [KO:K05719]
116097591  Shh; sonic hedgehog protein [KO:K11988]
116081424  Ptch1; protein patched homolog 1 isoform X1 [KO:K06225]
116098671  Smo; smoothened homolog isoform X1 [KO:K06226]
116076783  Prkca; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
116102736  Ilk; integrin-linked protein kinase [KO:K06272] [EC:2.7.11.1]
116085942  Boc; brother of CDO isoform X1 [KO:K20020]
116099495  Wnt5b; protein Wnt-5b [KO:K00444]
116084455  Wnt5a; protein Wnt-5a isoform X1 [KO:K00444]
116085420  Fzd3; frizzled-3 isoform X1 [KO:K02329]
116073889  Ryk; tyrosine-protein kinase RYK isoform X1 [KO:K05128] [EC:2.7.10.1]
116084777  Camk2g; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
116093748  Camk2d; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X1 [KO:K04515] [EC:2.7.11.17]
116087223  Camk2a; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
116069264  Camk2b; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
116096876  Wnt4; protein Wnt-4 [KO:K00408]
116095058  Pik3ca; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116097037  Pik3cd; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116073929  Pik3cb; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
116096465  Pik3r3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
116083721  Pik3r1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
116069491  Pik3r2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
116078189  Pdpk1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
116070446  Pard3; partitioning defective 3 homolog isoform X1 [KO:K04237]
116095810  Prkcz; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
116087400  Pard6g; partitioning defective 6 homolog gamma [KO:K06093]
116070066  Pard6a; partitioning defective 6 homolog alpha isoform X1 [KO:K06093]
116091834  Pard6b; partitioning defective 6 homolog beta [KO:K06093]
116103330  Ssh3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
116068211  Ssh1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
116076986  Ssh2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
116091480  Bmp7; bone morphogenetic protein 7 [KO:K16621]
116079977  Gdf7; growth/differentiation factor 7 [KO:K20013]
116088482  Bmpr2; bone morphogenetic protein receptor type-2 isoform X1 [KO:K04671] [EC:2.7.11.30]
116093866  Bmpr1b; bone morphogenetic protein receptor type-1B isoform X1 [KO:K13578] [EC:2.7.11.30]
Compound
C00076  Calcium cation
Reference
PMID:14682358
  Authors
Guan KL, Rao Y.
  Title
Signalling mechanisms mediating neuronal responses to guidance cues.
  Journal
Nat Rev Neurosci 4:941-56 (2003)
DOI:10.1038/nrn1254
Reference
PMID:15630019
  Authors
Govek EE, Newey SE, Van Aelst L.
  Title
The role of the Rho GTPases in neuronal development.
  Journal
Genes Dev 19:1-49 (2005)
DOI:10.1101/gad.1256405
Reference
PMID:12677003
  Authors
Huber AB, Kolodkin AL, Ginty DD, Cloutier JF.
  Title
Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance.
  Journal
Annu Rev Neurosci 26:509-63 (2003)
DOI:10.1146/annurev.neuro.26.010302.081139
Reference
PMID:15818466
  Authors
Negishi M, Oinuma I, Katoh H.
  Title
Plexins: axon guidance and signal transduction.
  Journal
Cell Mol Life Sci 62:1363-71 (2005)
DOI:10.1007/s00018-005-5018-2
Reference
PMID:15363605
  Authors
Huot J.
  Title
Ephrin signaling in axon guidance.
  Journal
Prog Neuropsychopharmacol Biol Psychiatry 28:813-8 (2004)
DOI:10.1016/j.pnpbp.2004.05.025
Reference
PMID:11891122
  Authors
Patel BN, Van Vactor DL.
  Title
Axon guidance: the cytoplasmic tail.
  Journal
Curr Opin Cell Biol 14:221-9 (2002)
DOI:10.1016/S0955-0674(02)00308-3
Reference
PMID:11687826
  Authors
Yu TW, Bargmann CI.
  Title
Dynamic regulation of axon guidance.
  Journal
Nat Neurosci 4 Suppl:1169-76 (2001)
DOI:10.1038/nn748
Reference
PMID:12471249
  Authors
Dickson BJ.
  Title
Molecular mechanisms of axon guidance.
  Journal
Science 298:1959-64 (2002)
DOI:10.1126/science.1072165
Reference
PMID:15960985
  Authors
Barallobre MJ, Pascual M, Del Rio JA, Soriano E.
  Title
The Netrin family of guidance factors: emphasis on Netrin-1 signalling.
  Journal
Brain Res Brain Res Rev 49:22-47 (2005)
DOI:10.1016/j.brainresrev.2004.11.003
Reference
PMID:15084255
  Authors
Sabatier C, Plump AS, Le Ma, Brose K, Tamada A, Murakami F, Lee EY, Tessier-Lavigne M.
  Title
The divergent Robo family protein rig-1/Robo3 is a negative regulator of slit responsiveness required for midline crossing by commissural axons.
  Journal
Cell 117:157-69 (2004)
DOI:10.1016/S0092-8674(04)00303-4
Reference
PMID:25374504
  Authors
Fujita Y, Yamashita T
  Title
Axon growth inhibition by RhoA/ROCK in the central nervous system.
  Journal
Front Neurosci 8:338 (2014)
DOI:10.3389/fnins.2014.00338
Reference
PMID:17169551
  Authors
Yamashita T, Mueller BK, Hata K
  Title
Neogenin and repulsive guidance molecule signaling in the central nervous system.
  Journal
Curr Opin Neurobiol 17:29-34 (2007)
DOI:10.1016/j.conb.2006.12.001
Reference
PMID:26651291
  Authors
van Erp S, van den Heuvel DMA, Fujita Y, Robinson RA, Hellemons AJCGM, Adolfs Y, Van Battum EY, Blokhuis AM, Kuijpers M, Demmers JAA, Hedman H, Hoogenraad CC, Siebold C, Yamashita T, Pasterkamp RJ
  Title
Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases.
  Journal
Dev Cell 35:537-552 (2015)
DOI:10.1016/j.devcel.2015.11.008
Related
pathway
mcoc04010  MAPK signaling pathway
mcoc04060  Cytokine-cytokine receptor interaction
mcoc04310  Wnt signaling pathway
mcoc04810  Regulation of actin cytoskeleton
KO pathway
ko04360   
LinkDB

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