KEGG   PATHWAY: mdo05167
Entry
mdo05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Monodelphis domestica (gray short-tailed opossum)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
mdo05167  Kaposi sarcoma-associated herpesvirus infection
mdo05167

Organism
Monodelphis domestica (gray short-tailed opossum) [GN:mdo]
Gene
100020034  C3; complement C3 [KO:K03990]
100014223  TLR3; toll like receptor 3 [KO:K05401]
100023610  TICAM1; toll like receptor adaptor molecule 1 [KO:K05842]
100017361  TRAF3; TNF receptor associated factor 3 [KO:K03174]
100019578  IKBKE; inhibitor of nuclear factor kappa B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
100021311  IFN7; type I interferon 7 [KO:K05414]
100021419  interferon tau-2-like [KO:K05414]
100021467  interferon alpha-16-like [KO:K05414]
100021290  IFN3; type I interferon 3 [KO:K05414]
100021340  IFN4; type I interferon 4 [KO:K05414]
100021368  interferon tau-2-like [KO:K05414]
100021487  IFN2; type I interferon 2 [KO:K05414]
100030239  IRF3; interferon regulatory factor 3 [KO:K05411]
100028102  EP300; E1A binding protein p300 [KO:K04498] [EC:2.3.1.48]
100013876  CREBBP; CREB binding protein [KO:K04498] [EC:2.3.1.48]
100021258  IFNB1; interferon beta [KO:K05415]
103092556  IFNAR2; interferon alpha and beta receptor subunit 2 [KO:K05131]
100031307  JAK1; Janus kinase 1 [KO:K11217] [EC:2.7.10.2]
100012931  TYK2; tyrosine kinase 2 [KO:K11219] [EC:2.7.10.2]
100028917  STAT1; signal transducer and activator of transcription 1 [KO:K11220]
100030758  IRF9; interferon regulatory factor 9 [KO:K04693]
103106286  EIF2AK2; eukaryotic translation initiation factor 2 alpha kinase 2 [KO:K16195] [EC:2.7.11.1]
100010279  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
100010891  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
100026324  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
100028821  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
100014871  MAPKAPK2; mitogen-activated protein kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
100029049  MAP2K6; mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
100014361  ZFP36; ZFP36 ring finger protein [KO:K15308]
103104339  IL6; interleukin 6 [KO:K05405]
103094208  CSF2; colony stimulating factor 2 [KO:K05427]
100029988  CCR3; C-C chemokine receptor type 3 [KO:K04178]
100030002  C-C chemokine receptor type 5-like [KO:K04180]
100023438  C-C chemokine receptor type 5-like [KO:K04180]
100029731  C-C chemokine receptor type 5-like [KO:K04180]
100029967  CCR1; C-C chemokine receptor type 1 [KO:K04176]
100028636  CCR4; C-C motif chemokine receptor 4 [KO:K04179]
100028671  C-C chemokine receptor type 8-like [KO:K04183]
100028687  C-C chemokine receptor type 8-like [KO:K04183]
100031941  FADD; Fas associated via death domain [KO:K02373]
100017025  CASP18; caspase-18 [KO:K04398] [EC:3.4.22.61]
100617599  CASP8; caspase-8 [KO:K04398] [EC:3.4.22.61]
100021895  BID; BH3 interacting domain death agonist [KO:K04726]
100030412  BAX; BCL2 associated X, apoptosis regulator [KO:K02159]
100027503  BAK1; BCL2 antagonist/killer 1 [KO:K14021]
100010620  cytochrome c [KO:K08738]
100026811  cytochrome c, testis-specific-like [KO:K08738]
100027338  CASP9; caspase 9 [KO:K04399] [EC:3.4.22.62]
654273  CASP3; caspase 3 [KO:K02187] [EC:3.4.22.56]
654275  caspase-3-like protein 2 [KO:K02187] [EC:3.4.22.56]
103104450  TNFRSF1A; TNF receptor superfamily member 1A [KO:K03158]
100019832  TRADD; TNFRSF1A associated via death domain [KO:K03171]
100017243  TRAF2; TNF receptor associated factor 2 [KO:K03173] [EC:2.3.2.27]
100027952  CHUK; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
100033031  IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
100022918  IKBKG; inhibitor of nuclear factor kappa B kinase subunit gamma [KO:K07210]
100011769  NFKBIA; NFKB inhibitor alpha [KO:K04734]
100014446  NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
100030053  RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
497248  TP53; tumor protein p53 [KO:K04451]
100029103  CDKN1A; cyclin dependent kinase inhibitor 1A [KO:K06625]
100021675  CDK6; cyclin dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
100022630  RB1; RB transcriptional corepressor 1 [KO:K06618]
100032280  E2F1; E2F transcription factor 1 [KO:K17454]
100009746  E2F2; E2F transcription factor 2 [KO:K09389]
100017977  E2F3; E2F transcription factor 3 [KO:K06620]
790902  MODO-UB; MHC class I antigen [KO:K06751]
100026156  MODO-UM; MHC class I antigen [KO:K06751]
100026178  MODO-UE; MHC class I antigen [KO:K06751]
100026665  MODO-UJ; MHC class I antigen [KO:K06751]
100026781  MODO-UI; MHC class I antigen [KO:K06751]
100026802  Modo-UA; patr class I histocompatibility antigen, A-5 alpha chain [KO:K06751]
100026822  MODO-UK; HLA class I histocompatibility antigen, A-69 alpha chain-like [KO:K06751]
790903  MODO-UC; MHC class I antigen [KO:K06751]
100009719  MHC-I; BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751]
103093835  class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751]
107651418  mamu class I histocompatibility antigen, alpha chain F-like [KO:K06751]
103106169  uncharacterized LOC103106169 [KO:K06751]
103095253  zinc-alpha-2-glycoprotein-like [KO:K06751]
103094634  major histocompatibility complex class I-related gene protein-like [KO:K06751]
103096009  Modo-UT15; zinc-alpha-2-glycoprotein-like [KO:K06751]
103103471  BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
103094094  Modo-UT10; zinc-alpha-2-glycoprotein-like [KO:K06751]
107651120  RT1 class I histocompatibility antigen, AA alpha chain-like [KO:K06751]
780946  MODO-UG; MHC class I antigen [KO:K06751]
103092429  Modo-UT6; zinc-alpha-2-glycoprotein-like [KO:K06751]
103106351  Modo-UT3; H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751]
103093918  Modo-UT9; zinc-alpha-2-glycoprotein-like [KO:K06751]
103092123  Modo-UT5; class I histocompatibility antigen, F10 alpha chain-like [KO:K06751]
100024719  Mhc-1; BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751]
751097  MHC-1; major histocompatibility complex class I [KO:K06751]
100031565  IFNGR1; interferon gamma receptor 1 [KO:K05132]
100018203  CD86; CD86 molecule [KO:K05413]
100012532  UBA52; ubiquitin A-52 residue ribosomal protein fusion product 1 [KO:K02927]
100619355  ubiquitin [KO:K02927]
100032038  RPS27A; ribosomal protein S27a [KO:K02977]
100021198  polyubiquitin-C [KO:K08770]
100010612  BECN1; beclin 1 [KO:K08334]
100020665  ATG14; autophagy related 14 [KO:K17889]
100011397  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
100010740  ATG3; autophagy related 3 [KO:K08343]
100018370  MAP1LC3B; microtubule associated protein 1 light chain 3 beta [KO:K10435]
100027672  MAP1LC3C; microtubule associated protein 1 light chain 3 gamma [KO:K10435]
100028493  MAP1LC3A; microtubule associated protein 1 light chain 3 alpha [KO:K10435]
100010736  GNB1; G protein subunit beta 1 [KO:K04536]
100017392  GNB2; G protein subunit beta 2 [KO:K04537]
100013759  GNB3; G protein subunit beta 3 [KO:K07825]
100013546  GNB4; G protein subunit beta 4 [KO:K04538]
100031383  GNB5; G protein subunit beta 5 [KO:K04539]
100010452  GNG3; G protein subunit gamma 3 [KO:K04540]
100021132  GNG4; G protein subunit gamma 4 [KO:K04541]
100011015  GNG5; G protein subunit gamma 5 [KO:K04542]
100014687  GNG7; G protein subunit gamma 7 [KO:K04543]
100016961  GNG8; G protein subunit gamma 8 [KO:K04544]
100018189  GNG10; G protein subunit gamma 10 [KO:K04545]
100016914  GNG12; G protein subunit gamma 12 [KO:K04347]
100010184  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
100017439  GNG13; G protein subunit gamma 13 [KO:K04547]
100018838  GNGT2; G protein subunit gamma transducin 2 [KO:K04549]
100032921  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
554186  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
554197  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
100022523  GTPase NRas-like [KO:K07828]
100015410  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
100018410  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100018044  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100028096  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100012916  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100027212  HIF1A; hypoxia inducible factor 1 alpha subunit [KO:K08268]
100018774  JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
100018285  FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
100009879  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [KO:K21289] [EC:2.7.1.153]
100012464  PIK3R5; phosphoinositide-3-kinase regulatory subunit 5 [KO:K21290]
100010412  PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
100017332  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
100024769  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
100019317  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
100032726  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
100616957  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
100014564  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
100019947  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
100027373  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
100619675  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
100029404  PREX1; phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1 [KO:K12365]
100026992  RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
100028089  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
100618895  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
100012471  cell surface glycoprotein CD200 receptor 1-like [KO:K21668]
100012335  cell surface glycoprotein CD200 receptor 1-like [KO:K21668]
100012382  cell surface glycoprotein CD200 receptor 2-like [KO:K21668]
100012513  cell surface glycoprotein CD200 receptor 1-like [KO:K21668]
100028356  tyrosine-protein kinase SYK [KO:K05855] [EC:2.7.10.2]
100029391  SRC; SRC proto-oncogene, non-receptor tyrosine kinase [KO:K05704] [EC:2.7.10.2]
100010539  HCK; HCK proto-oncogene, Src family tyrosine kinase [KO:K08893] [EC:2.7.10.2]
100616821  LYN; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
100019828  MAP2K4; mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
100026752  MAP2K7; mitogen-activated protein kinase kinase 7 [KO:K04431] [EC:2.7.12.2]
100027579  PLCG2; phospholipase C gamma 2 [KO:K05859] [EC:3.1.4.11]
100032696  PLCG1; phospholipase C gamma 1 [KO:K01116] [EC:3.1.4.11]
100013305  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
100010212  ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
100025596  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
100021688  CALM3; calmodulin 3 [KO:K02183]
100018191  CALM1; calmodulin 1 [KO:K02183]
100032171  CALM2; calmodulin 2 [KO:K02183]
100025795  CALML4; calmodulin like 4 [KO:K02183]
100015722  calmodulin-alpha-like [KO:K02183]
100022649  calmodulin-alpha-like [KO:K02183]
100014900  PPP3CA; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
100011077  PPP3CB; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
100033104  PPP3CC; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
100033302  PPP3R1; protein phosphatase 3 regulatory subunit B, alpha [KO:K06268]
100023153  NFATC1; nuclear factor of activated T-cells 1 [KO:K04446]
100028435  NFATC2; nuclear factor of activated T-cells 2 [KO:K17332]
100021991  NFATC3; nuclear factor of activated T-cells 3 [KO:K17333]
100025432  NFATC4; nuclear factor of activated T-cells 4 [KO:K17334]
100023722  IL8; interleukin-8 [KO:K10030]
100024802  PTGS2; prostaglandin-endoperoxide synthase 2 [KO:K11987] [EC:1.14.99.1]
100023783  CXCL1; growth-regulated alpha protein [KO:K05505]
100025606  RCAN1; regulator of calcineurin 1 [KO:K17901]
619384  FGF2; fibroblast growth factor 2 [KO:K18497]
100012132  VEGFA; vascular endothelial growth factor A [KO:K05448]
100012899  PDGFB; platelet derived growth factor subunit B [KO:K17386]
100028850  ANGPT2; angiopoietin 2 [KO:K05466]
100017284  IL6ST; interleukin 6 signal transducer [KO:K05060]
100017930  JAK2; Janus kinase 2 [KO:K04447] [EC:2.7.10.2]
100011382  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
100012447  GSK3B; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
100022896  CTNNB1; catenin beta 1 [KO:K02105]
100017589  TCF7; transcription factor 7 (T-cell specific, HMG-box) [KO:K02620]
100030368  TCF7L1; transcription factor 7 like 1 [KO:K04490]
100021451  TCF7L2; transcription factor 7 like 2 [KO:K04491]
100011783  LEF1; lymphoid enhancer binding factor 1 [KO:K04492]
100014049  CREB1; cAMP responsive element binding protein 1 [KO:K05870]
100013257  CCND1; cyclin D1 [KO:K04503]
100032344  MYC; v-myc avian myelocytomatosis viral oncogene homolog [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
  Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
  Journal
J Exp Med 190:1025-32 (1999)
DOI:10.1084/jem.190.7.1025
Reference
PMID:10523854
  Authors
Chaudhary PM, Jasmin A, Eby MT, Hood L
  Title
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
  Journal
Oncogene 18:5738-46 (1999)
DOI:10.1038/sj.onc.1202976
Reference
PMID:12890756
  Authors
Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M
  Title
KSHV vFLIP binds to IKK-gamma to activate IKK.
  Journal
J Cell Sci 116:3721-8 (2003)
DOI:10.1242/jcs.00691
Reference
PMID:20865011
  Authors
Mesri EA, Cesarman E, Boshoff C
  Title
Kaposi's sarcoma and its associated herpesvirus.
  Journal
Nat Rev Cancer 10:707-19 (2010)
DOI:10.1038/nrc2888
Reference
PMID:10799607
  Authors
Ishido S, Wang C, Lee BS, Cohen GB, Jung JU
  Title
Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
  Journal
J Virol 74:5300-9 (2000)
DOI:10.1128/JVI.74.11.5300-5309.2000
Reference
PMID:17166914
  Authors
Li Q, Means R, Lang S, Jung JU
  Title
Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
  Journal
J Virol 81:2117-27 (2007)
DOI:10.1128/JVI.01961-06
Reference
PMID:18230726
  Authors
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Virology 428:112-20 (2012)
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Viruses 7:116-53 (2015)
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Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
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Front Microbiol 7:54 (2016)
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pathway
mdo04010  MAPK signaling pathway
mdo04064  NF-kappa B signaling pathway
mdo04110  Cell cycle
mdo04115  p53 signaling pathway
mdo04140  Autophagy - animal
mdo04144  Endocytosis
mdo04151  PI3K-Akt signaling pathway
mdo04210  Apoptosis
mdo04310  Wnt signaling pathway
mdo04610  Complement and coagulation cascades
mdo04620  Toll-like receptor signaling pathway
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KO pathway
ko05167   
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