KEGG   PATHWAY: mleu05014
Entry
mleu05014                   Pathway                                
Name
Amyotrophic lateral sclerosis - Mandrillus leucophaeus (drill)
Description
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by a progressive degeneration of motor neurons in the brain and spinal cord. In 90% of patients, ALS is sporadic, with no clear genetic linkage. On the other hand, the remaining 10% of cases show familial inheritance, with mutations in SOD1, TDP43(TARDBP), FUS, or C9orf72 genes being the most frequent causes. In spite of such difference, familial ALS and sporadic ALS have similarities in their pathological features. Proposed disease mechanisms contributing to motor neuron degeneration in ALS are: impaired proteostasis, aberrant RNA processing, mitochondrial disfunction and oxidative stress, microglia activation, and axonal dysfunction.
Class
Human Diseases; Neurodegenerative disease
Pathway map
mleu05014  Amyotrophic lateral sclerosis
mleu05014

Organism
Mandrillus leucophaeus (drill) [GN:mleu]
Gene
105549866  TP53; cellular tumor antigen p53 isoform X1 [KO:K04451]
105534146  caspase-1-like [KO:K01370] [EC:3.4.22.36]
105534147  CASP1; caspase-1 isoform X1 [KO:K01370] [EC:3.4.22.36]
105534152  LOW QUALITY PROTEIN: caspase-1-like [KO:K01370] [EC:3.4.22.36]
105542917  BID; BH3-interacting domain death agonist isoform X1 [KO:K04726]
105535165  BCL2; apoptosis regulator Bcl-2 isoform X1 [KO:K02161]
105539496  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
105539167  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
105549098  BAD; bcl2-associated agonist of cell death [KO:K02158]
105548296  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
105533249  cytochrome c-like [KO:K08738]
105553485  cytochrome c [KO:K08738]
105553918  cytochrome c-like [KO:K08738]
105549520  cytochrome c-like [KO:K08738]
105549432  CASP9; caspase-9 isoform X1 [KO:K04399] [EC:3.4.22.62]
105552669  caspase-3-like [KO:K02187] [EC:3.4.22.56]
105553959  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
105545988  SOD1; superoxide dismutase [Cu-Zn] [KO:K04565] [EC:1.15.1.1]
105537633  LOW QUALITY PROTEIN: superoxide dismutase [Cu-Zn]-like [KO:K04565] [EC:1.15.1.1]
105544481  NDUFV1; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial isoform X1 [KO:K03942] [EC:7.1.1.2]
105542372  NDUFV2; NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial isoform X1 [KO:K03943] [EC:7.1.1.2]
105555594  NDUFV3; NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial [KO:K03944]
105537526  NDUFA1; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [KO:K03945]
105528352  NDUFA2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 isoform X1 [KO:K03946]
105539213  NDUFA3; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
105552516  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 [KO:K03947]
105545563  NDUFA4L2; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 [KO:K03948]
105553667  cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105547320  NDUFA4; cytochrome c oxidase subunit NDUFA4 [KO:K03948]
105539723  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5-like isoform X1 [KO:K03949]
105550883  NDUFA5; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 isoform X1 [KO:K03949]
105538803  NDUFA6; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 [KO:K03950]
105529172  NDUFA7; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [KO:K03951]
105546320  NDUFA8; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 isoform X1 [KO:K03952]
105551123  NDUFA9; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [KO:K03953]
105531588  NDUFA10; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [KO:K03954]
105531888  acyl carrier protein, mitochondrial [KO:K03955]
105545140  NDUFAB1; acyl carrier protein, mitochondrial [KO:K03955]
105530057  NDUFA11; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 [KO:K03956]
105546990  NDUFA12; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 isoform X1 [KO:K11352]
105547363  NDUFA13; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 [KO:K11353]
105547955  NDUFB1; LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 [KO:K03957]
105550513  NDUFB2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial isoform X1 [KO:K03958]
105535428  NDUFB3; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 [KO:K03959]
105533216  NDUFB4; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 [KO:K03960]
105539929  NDUFB5; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform X1 [KO:K03961]
105539631  NDUFB6; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 isoform X1 [KO:K03962]
105540981  NDUFB7; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 [KO:K03963]
105533683  NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial-like [KO:K03964]
105537752  NDUFB8; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform X1 [KO:K03964]
105554617  NDUFB9; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 isoform X1 [KO:K03965]
105529740  NDUFB10; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [KO:K03966]
105541684  NDUFB11; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial isoform X1 [KO:K11351]
105549398  NDUFS1; LOW QUALITY PROTEIN: NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial [KO:K03934] [EC:7.1.1.2]
105536733  NDUFS2; NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial isoform X1 [KO:K03935] [EC:7.1.1.2]
105554828  NDUFS3; NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [KO:K03936] [EC:7.1.1.2]
105553460  NDUFS4; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial [KO:K03937]
105537917  LOW QUALITY PROTEIN: NADH dehydrogenase [ubiquinone] iron-sulfur protein 5-like [KO:K03938]
105531487  NDUFS6; NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [KO:K03939]
105551946  NDUFS7; NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial isoform X1 [KO:K03940] [EC:7.1.1.2]
105544487  NDUFS8; NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X1 [KO:K03941] [EC:7.1.1.2]
105543644  NDUFC1; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial [KO:K03967]
105546505  NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform X1 [KO:K03968]
105528135  SDHA; succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial [KO:K00234] [EC:1.3.5.1]
105537465  succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [KO:K00234] [EC:1.3.5.1]
105552727  SDHB; succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [KO:K00235] [EC:1.3.5.1]
105540160  succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial-like isoform X1 [KO:K00235] [EC:1.3.5.1]
105548772  LOW QUALITY PROTEIN: succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like [KO:K00236]
105536578  SDHC; succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X1 [KO:K00236]
105529588  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
105550790  succinate dehydrogenase cytochrome b560 subunit, mitochondrial-like isoform X1 [KO:K00236]
105551506  LOW QUALITY PROTEIN: succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial-like [KO:K00237]
105537410  SDHD; succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial [KO:K00237]
105550366  cytochrome b-c1 complex subunit Rieske, mitochondrial [KO:K00411] [EC:7.1.1.8]
105536314  cytochrome c1, heme protein, mitochondrial isoform X1 [KO:K00413]
105540380  cytochrome b-c1 complex subunit 1, mitochondrial [KO:K00414]
105545124  cytochrome b-c1 complex subunit 2, mitochondrial [KO:K00415]
105531777  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
105532363  cytochrome b-c1 complex subunit 6, mitochondrial [KO:K00416]
105538730  cytochrome b-c1 complex subunit 7 isoform X1 [KO:K00417]
105531338  cytochrome b-c1 complex subunit 8 [KO:K00418]
105550714  cytochrome b-c1 complex subunit 9 [KO:K00419]
105551955  cytochrome b-c1 complex subunit 10 [KO:K00420]
105539498  cytochrome c oxidase subunit 4 isoform 2, mitochondrial [KO:K02263]
105533155  uncharacterized protein LOC105533155 isoform X1 [KO:K02263]
105528615  cytochrome c oxidase subunit 4 isoform 1, mitochondrial-like [KO:K02263]
105553641  LOW QUALITY PROTEIN: cytochrome c oxidase subunit 5A, mitochondrial-like [KO:K02264]
105554110  cytochrome c oxidase subunit 5A, mitochondrial [KO:K02264]
105531657  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
105543464  cytochrome c oxidase subunit 5B, mitochondrial [KO:K02265]
105541474  cytochrome c oxidase subunit 6A2, mitochondrial isoform X1 [KO:K02266]
105527930  cytochrome c oxidase subunit 6A1, mitochondrial [KO:K02266]
105551631  cytochrome c oxidase subunit 6B2 [KO:K02267]
105543089  cytochrome c oxidase subunit 6B1 isoform X1 [KO:K02267]
105529563  cytochrome c oxidase subunit 6C [KO:K02268]
105528871  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
105543058  cytochrome c oxidase subunit 7A1, mitochondrial [KO:K02270]
105537923  cytochrome c oxidase subunit 7A2, mitochondrial [KO:K02270]
105538345  cytochrome c oxidase subunit 7A-related protein, mitochondrial [KO:K02270]
105530782  cytochrome c oxidase subunit 7B, mitochondrial isoform X1 [KO:K02271]
105538264  cytochrome c oxidase subunit 7B2, mitochondrial [KO:K02271]
105550036  cytochrome c oxidase subunit 7C, mitochondrial [KO:K02272]
105547937  cytochrome c oxidase subunit 8C, mitochondrial [KO:K02273]
105549087  cytochrome c oxidase subunit 8A, mitochondrial [KO:K02273]
105532785  LOW QUALITY PROTEIN: ATP synthase subunit alpha, mitochondrial-like [KO:K02132]
105538285  ATP5A1; ATP synthase subunit alpha, mitochondrial [KO:K02132]
105545548  ATP5B; ATP synthase subunit beta, mitochondrial [KO:K02133] [EC:7.1.2.2]
105535712  ATP5C1; ATP synthase subunit gamma, mitochondrial isoform X1 [KO:K02136]
105551985  ATP5D; ATP synthase subunit delta, mitochondrial [KO:K02134]
105548343  ATP5E; ATP synthase subunit epsilon, mitochondrial [KO:K02135]
105554307  ATP5F1; ATP synthase F(0) complex subunit B1, mitochondrial [KO:K02127]
105553294  ATP5G1; ATP synthase F(0) complex subunit C1, mitochondrial isoform X1 [KO:K02128]
105548040  ATP5G3; ATP synthase F(0) complex subunit C3, mitochondrial isoform X1 [KO:K02128]
105548527  ATP5G2; ATP synthase F(0) complex subunit C2, mitochondrial isoform X1 [KO:K02128]
105549301  ATP synthase F(0) complex subunit C2, mitochondrial [KO:K02128]
105531850  ATP synthase subunit d, mitochondrial [KO:K02138]
105536822  ATP5H; ATP synthase subunit d, mitochondrial isoform X1 [KO:K02138]
105533182  ATP synthase subunit O, mitochondrial [KO:K02137]
105553154  ATP5O; ATP synthase subunit O, mitochondrial isoform X1 [KO:K02137]
105545476  ATP5J; ATP synthase-coupling factor 6, mitochondrial isoform X1 [KO:K02131]
105544969  ATP synthase-coupling factor 6, mitochondrial-like [KO:K02131]
105531327  VDAC1; voltage-dependent anion-selective channel protein 1 isoform X1 [KO:K05862]
105535839  TOMM40; mitochondrial import receptor subunit TOM40 homolog [KO:K11518]
105536633  TOMM40L; mitochondrial import receptor subunit TOM40B isoform X1 [KO:K11518]
105547485  MCU; calcium uniporter protein, mitochondrial [KO:K20858]
105532247  PINK1; serine/threonine-protein kinase PINK1, mitochondrial [KO:K05688] [EC:2.7.11.1]
105553540  PARK2; E3 ubiquitin-protein ligase parkin [KO:K04556] [EC:2.3.2.31]
105530551  OPTN; optineurin [KO:K19946]
105537279  SQSTM1; sequestosome-1 [KO:K14381]
105533812  MAP1LC3B; microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
105546751  MAP1LC3C; microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
105533867  MAP1LC3A; microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
105534224  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
105547719  TANK; TRAF family member-associated NF-kappa-B activator isoform X1 [KO:K12650]
105551118  WDR41; WD repeat-containing protein 41 isoform X1 [KO:K23610]
105536018  SMCR8; smith-Magenis syndrome chromosomal region candidate gene 8 protein [KO:K23611]
105549732  protein C9orf72 homolog [KO:K23609]
105540105  RAB8A; ras-related protein Rab-8A isoform X1 [KO:K07901]
105533487  RAB39B; ras-related protein Rab-39B [KO:K07925]
105543537  RAB1A; ras-related protein Rab-1A isoform X1 [KO:K07874]
105551388  MTOR; serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
105541289  ULK1; serine/threonine-protein kinase ULK1 [KO:K21357] [EC:2.7.11.1]
105552558  ULK2; serine/threonine-protein kinase ULK2 [KO:K08269] [EC:2.7.11.1]
105555380  ATG101; autophagy-related protein 101 [KO:K19730]
105554803  ATG13; autophagy-related protein 13 isoform X1 [KO:K08331]
105549822  RB1CC1; RB1-inducible coiled-coil protein 1 [KO:K17589]
105554801  AMBRA1; activating molecule in BECN1-regulated autophagy protein 1 [KO:K17985]
105552939  BECN1; beclin-1 [KO:K08334]
105546749  BECN2; beclin-2 [KO:K08334]
105538161  PIK3R4; phosphoinositide 3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
105553640  ATG14; beclin 1-associated autophagy-related key regulator [KO:K17889]
105527848  NRBF2; nuclear receptor-binding factor 2 isoform X1 [KO:K21246]
105528857  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
105547898  ATG2B; autophagy-related protein 2 homolog B [KO:K17906]
105549118  ATG2A; autophagy-related protein 2 homolog A [KO:K17906]
105551090  WIPI2; WD repeat domain phosphoinositide-interacting protein 2 isoform X1 [KO:K17908]
105533512  WIPI1; WD repeat domain phosphoinositide-interacting protein 1 isoform X1 [KO:K17908]
105535413  ALS2; alsin isoform X1 [KO:K04575]
105530773  RAB5A; ras-related protein Rab-5A isoform X1 [KO:K07887]
105551438  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
105546567  ras-related protein Rac1-like [KO:K04392]
105537161  CHMP2B; charged multivesicular body protein 2b isoform X1 [KO:K12192]
105536565  FIG4; polyphosphoinositide phosphatase [KO:K22913] [EC:3.1.3.-]
105548181  SPG11; spatacsin [KO:K19026]
105547498  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105529928  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105531014  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
105546762  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
105533495  UBQLN3; ubiquilin-3 [KO:K04523]
105534419  UBQLN2; ubiquilin-2 isoform X1 [KO:K04523]
105541641  UBQLN1; ubiquilin-1 isoform X1 [KO:K04523]
105548632  UBQLN4; ubiquilin-4 isoform X1 [KO:K04523]
105539693  VCP; transitional endoplasmic reticulum ATPase [KO:K13525]
105534306  DERL1; derlin-1 isoform X1 [KO:K11519]
105550159  PSMA6; proteasome subunit alpha type-6 isoform X1 [KO:K02730] [EC:3.4.25.1]
105550244  PSMA2; proteasome subunit alpha type-2 [KO:K02726] [EC:3.4.25.1]
105541609  PSMA4; proteasome subunit alpha type-4 isoform X1 [KO:K02728] [EC:3.4.25.1]
105545221  PSMA8; proteasome subunit alpha type-7-like isoform X1 [KO:K02731] [EC:3.4.25.1]
105548402  PSMA7; proteasome subunit alpha type-7 [KO:K02731] [EC:3.4.25.1]
105530954  PSMA5; proteasome subunit alpha type-5 isoform X1 [KO:K02729] [EC:3.4.25.1]
105553483  PSMA1; proteasome subunit alpha type-1 isoform X1 [KO:K02725] [EC:3.4.25.1]
105546399  PSMA3; proteasome subunit alpha type-3 isoform X1 [KO:K02727] [EC:3.4.25.1]
105539966  PSMB6; proteasome subunit beta type-6 isoform X1 [KO:K02738] [EC:3.4.25.1]
105545655  PSMB7; proteasome subunit beta type-7 [KO:K02739] [EC:3.4.25.1]
105542985  PSMB3; proteasome subunit beta type-3 [KO:K02735] [EC:3.4.25.1]
105550661  PSMB2; proteasome subunit beta type-2 isoform X1 [KO:K02734] [EC:3.4.25.1]
105547177  PSMB5; proteasome subunit beta type-5 isoform X1 [KO:K02737] [EC:3.4.25.1]
105542029  PSMB1; proteasome subunit beta type-1 isoform X1 [KO:K02732] [EC:3.4.25.1]
105534724  PSMB4; proteasome subunit beta type-4 isoform X1 [KO:K02736] [EC:3.4.25.1]
105543319  PSMC2; 26S protease regulatory subunit 7 [KO:K03061]
105535289  PSMC1; 26S protease regulatory subunit 4 isoform X1 [KO:K03062]
105542428  PSMC4; 26S protease regulatory subunit 6B isoform X1 [KO:K03063]
105553601  PSMC6; 26S protease regulatory subunit 10B [KO:K03064]
105554823  PSMC3; 26S protease regulatory subunit 6A isoform X1 [KO:K03065]
105551722  PSMC5; 26S protease regulatory subunit 8 isoform X1 [KO:K03066]
105541024  PSMD2; 26S proteasome non-ATPase regulatory subunit 2 [KO:K03028]
105552414  PSMD1; 26S proteasome non-ATPase regulatory subunit 1 isoform X1 [KO:K03032]
105553052  PSMD3; 26S proteasome non-ATPase regulatory subunit 3 [KO:K03033]
105527964  PSMD9; 26S proteasome non-ATPase regulatory subunit 9 isoform X1 [KO:K06693]
105553193  PSMD12; 26S proteasome non-ATPase regulatory subunit 12 isoform X1 [KO:K03035]
105548703  PSMD11; 26S proteasome non-ATPase regulatory subunit 11 [KO:K03036]
105539886  PSMD6; LOW QUALITY PROTEIN: 26S proteasome non-ATPase regulatory subunit 6 [KO:K03037]
105537186  PSMD7; 26S proteasome non-ATPase regulatory subunit 7 [KO:K03038]
105530811  PSMD13; 26S proteasome non-ATPase regulatory subunit 13 [KO:K03039]
105534732  PSMD4; 26S proteasome non-ATPase regulatory subunit 4 [KO:K03029]
105547714  PSMD14; 26S proteasome non-ATPase regulatory subunit 14 [KO:K03030]
105534582  PSMD8; 26S proteasome non-ATPase regulatory subunit 8 isoform X1 [KO:K03031]
105548358  ADRM1; proteasomal ubiquitin receptor ADRM1 isoform X1 [KO:K06691]
105535576  SHFM1; 26S proteasome complex subunit DSS1 isoform X1 [KO:K10881]
105547721  HDAC6; histone deacetylase 6 isoform X1 [KO:K11407] [EC:3.5.1.98]
105551393  TARDBP; TAR DNA-binding protein 43 [KO:K23600]
105541469  FUS; RNA-binding protein FUS isoform X1 [KO:K13098]
105545735  HNRNPA1L2; LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like 2 [KO:K12741]
105533523  heterogeneous nuclear ribonucleoprotein A3 isoform X1 [KO:K12741]
105533791  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
105534955  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
105554897  LOW QUALITY PROTEIN: heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
105548249  heterogeneous nuclear ribonucleoprotein A1-like isoform X1 [KO:K12741]
105548549  HNRNPA1; heterogeneous nuclear ribonucleoprotein A1 [KO:K12741]
105549235  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
105537516  heterogeneous nuclear ribonucleoprotein A1-like [KO:K12741]
105533746  HNRNPA2B1; heterogeneous nuclear ribonucleoproteins A2/B1 isoform X1 [KO:K13158]
105552267  ATXN2; ataxin-2 [KO:K23625]
105541385  ATXN2L; ataxin-2-like protein [KO:K23625]
105551830  MATR3; matrin-3 isoform X1 [KO:K13213]
105536732  ANG; angiogenin [KO:K16631] [EC:3.1.27.-]
105549279  NCBP1; nuclear cap-binding protein subunit 1 [KO:K12882]
105531114  ALYREF; THO complex subunit 4 [KO:K12881]
105544230  SRSF3; serine/arginine-rich splicing factor 3 isoform X1 [KO:K12892]
105551902  SRSF7; serine/arginine-rich splicing factor 7 isoform X1 [KO:K12896]
105535476  nuclear RNA export factor 2-like [KO:K14284]
105549057  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
105530262  NXF3; nuclear RNA export factor 3 isoform X1 [KO:K14284]
105530281  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
105533783  NXT1; NTF2-related export protein 1 [KO:K14285]
105542823  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
105545630  GLE1; nucleoporin GLE1 [KO:K18723]
105553179  TPR; nucleoprotein TPR isoform X1 [KO:K09291]
105542462  NUP50; nuclear pore complex protein Nup50 [KO:K14295]
105530179  NUP153; nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
105549250  NUP98; nuclear pore complex protein Nup98-Nup96 isoform X1 [KO:K14297]
105538318  RAE1; mRNA export factor isoform X1 [KO:K14298]
105549532  SEC13; protein SEC13 homolog isoform X1 [KO:K14004]
105543577  SEH1L; nucleoporin SEH1 [KO:K14299]
105553711  NUP133; nuclear pore complex protein Nup133 [KO:K14300]
105537111  NUP107; nuclear pore complex protein Nup107 [KO:K14301]
105534477  NUP37; nucleoporin Nup37 [KO:K14302]
105554845  NUP160; nuclear pore complex protein Nup160 [KO:K14303]
105528338  NUP85; nuclear pore complex protein Nup85 [KO:K14304]
105528768  NUP43; nucleoporin Nup43 [KO:K14305]
105528965  NUP62; nuclear pore glycoprotein p62 [KO:K14306]
105553795  NUPL1; nucleoporin p58/p45 isoform X1 [KO:K14307]
105529116  NUP54; nucleoporin p54 isoform X1 [KO:K14308]
105533409  NUP93; nuclear pore complex protein Nup93 isoform X1 [KO:K14309]
105553931  NUP205; nuclear pore complex protein Nup205 [KO:K14310]
105532874  NUP188; nucleoporin NUP188 homolog [KO:K14311]
105553347  NUP155; nuclear pore complex protein Nup155 isoform X1 [KO:K14312]
105553888  NUP35; nucleoporin NUP53 isoform X1 [KO:K14313]
105554066  NUP210L; nuclear pore membrane glycoprotein 210-like [KO:K14314]
105542183  NUP210; LOW QUALITY PROTEIN: nuclear pore membrane glycoprotein 210 [KO:K14314]
105534879  NDC1; nucleoporin NDC1 isoform X1 [KO:K14315]
105547562  POM121L2; POM121-like protein 2 [KO:K14316]
105536848  POM121C; nuclear envelope pore membrane protein POM 121C [KO:K14316]
105532837  NUP214; nuclear pore complex protein Nup214 isoform X1 [KO:K14317]
105549940  NUP88; nuclear pore complex protein Nup88 [KO:K14318]
105540048  RANBP2; LOW QUALITY PROTEIN: E3 SUMO-protein ligase RanBP2 [KO:K12172] [EC:2.3.2.-]
105554933  SETX; probable helicase senataxin [KO:K10706] [EC:5.6.2.5 5.6.2.3]
105530419  CHCHD10; coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial isoform X1 [KO:K22759]
105545670  HSPA5; 78 kDa glucose-regulated protein [KO:K09490] [EC:3.6.4.10]
105548395  vesicle-associated membrane protein-associated protein B/C-like [KO:K10707]
105551004  ATF6; cyclic AMP-dependent transcription factor ATF-6 alpha [KO:K09054]
105545576  DDIT3; DNA damage-inducible transcript 3 protein isoform X1 [KO:K04452]
105551753  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
105550732  XBP1; LOW QUALITY PROTEIN: X-box-binding protein 1 [KO:K09027]
105543266  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
105538551  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
105534151  CASP4; caspase-4 [KO:K04741] [EC:3.4.22.-]
105553689  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
105549624  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105538852  ATF4; cyclic AMP-dependent transcription factor ATF-4 isoform X1 [KO:K04374]
105544182  ITPR3; inositol 1,4,5-trisphosphate receptor type 3 isoform X1 [KO:K04960]
105539676  SIGMAR1; sigma non-opioid intracellular receptor 1 [KO:K20719]
105554159  TNF; tumor necrosis factor [KO:K03156]
105541778  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105551364  TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141]
105544171  DAXX; death domain-associated protein 6 [KO:K02308]
105554627  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
105544191  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 [KO:K04433] [EC:2.7.12.2]
105543603  MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
105543619  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
105544221  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
105544400  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
105527995  NOS1; nitric oxide synthase, brain [KO:K13240] [EC:1.14.13.39]
105544443  CCS; copper chaperone for superoxide dismutase [KO:K04569]
105538447  GPX2; LOW QUALITY PROTEIN: glutathione peroxidase 2 [KO:K00432] [EC:1.11.1.9]
105551503  GPX8; probable glutathione peroxidase 8 isoform X1 [KO:K00432] [EC:1.11.1.9]
105540354  GPX1; LOW QUALITY PROTEIN: glutathione peroxidase 1 [KO:K00432] [EC:1.11.1.9]
105547609  GPX6; LOW QUALITY PROTEIN: glutathione peroxidase 6 [KO:K00432] [EC:1.11.1.9]
105547610  GPX5; epididymal secretory glutathione peroxidase isoform X1 [KO:K00432] [EC:1.11.1.9]
105534944  GPX7; glutathione peroxidase 7 [KO:K00432] [EC:1.11.1.9]
105543416  GPX3; LOW QUALITY PROTEIN: glutathione peroxidase 3 [KO:K00432] [EC:1.11.1.9]
105528698  CAT; catalase [KO:K03781] [EC:1.11.1.6]
105544899  PRPH; peripherin isoform X1 [KO:K07607]
105531042  NEFL; neurofilament light polypeptide [KO:K04572]
105531041  NEFM; neurofilament medium polypeptide isoform X1 [KO:K04573]
105550722  NEFH; neurofilament heavy polypeptide [KO:K04574]
105546707  PFN3; profilin-3 [KO:K05759]
105534037  PFN4; profilin-4 [KO:K05759]
105534133  PFN2; profilin-2 [KO:K05759]
105549954  PFN1; profilin-1 isoform X1 [KO:K05759]
105551087  ACTB; actin, cytoplasmic 1 isoform X1 [KO:K05692]
105549083  ACTG1; actin, cytoplasmic 2 [KO:K05692]
105547496  ANXA7; annexin A7 isoform X1 [KO:K17095]
105536281  ANXA11; annexin A11 isoform X1 [KO:K17095]
105545579  KIF5A; kinesin heavy chain isoform 5A isoform X1 [KO:K10396]
105533106  KIF5C; kinesin heavy chain isoform 5C [KO:K10396]
105537661  KIF5B; kinesin-1 heavy chain [KO:K10396]
105547973  kinesin light chain 1-like [KO:K10407]
105535854  KLC3; kinesin light chain 3 isoform X1 [KO:K10407]
105544322  KLC4; LOW QUALITY PROTEIN: kinesin light chain 4 [KO:K10407]
105544422  KLC2; kinesin light chain 2 isoform X1 [KO:K10407]
105551099  tubulin alpha-3 chain [KO:K07374]
105532182  tubulin alpha-3 chain-like [KO:K07374]
105528059  TUBA4A; tubulin alpha-4A chain isoform X1 [KO:K07374]
105535730  TUBAL3; tubulin alpha chain-like 3 [KO:K07374]
105542914  TUBA8; tubulin alpha-8 chain isoform X1 [KO:K07374]
105544900  TUBA1C; tubulin alpha-1C chain isoform X1 [KO:K07374]
105544901  tubulin alpha-1B chain isoform X1 [KO:K07374]
105544902  tubulin alpha-1B chain-like isoform X1 [KO:K07374]
105532706  tubulin beta chain-like [KO:K07375]
105532707  tubulin beta-8 chain-like [KO:K07375]
105553127  TUBB; tubulin beta chain isoform X1 [KO:K07375]
105548341  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
105542853  tubulin beta chain-like isoform X1 [KO:K07375]
105542854  tubulin beta-2A chain isoform X1 [KO:K07375]
105543294  tubulin beta-4B chain isoform X1 [KO:K07375]
105543301  tubulin beta-8 chain-like [KO:K07375]
105543556  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
105530075  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
105540189  DCTN1; dynactin subunit 1 isoform X1 [KO:K04648]
105545578  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
105539675  DCTN3; dynactin subunit 3 isoform X1 [KO:K10425]
105543419  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
105545141  DCTN5; dynactin subunit 5 isoform X1 [KO:K10427]
105538008  DCTN6; dynactin subunit 6 [KO:K10428]
105531701  ACTR1B; beta-centractin [KO:K16575]
105537788  ACTR1A; alpha-centractin isoform X1 [KO:K16575]
105546419  ACTR10; actin-related protein 10 [KO:K16576]
105553084  HAP1; LOW QUALITY PROTEIN: huntingtin-associated protein 1 [KO:K04647]
105545850  DNAH10; dynein heavy chain 10, axonemal [KO:K10408]
105551781  DNAH7; dynein heavy chain 7, axonemal isoform X1 [KO:K10408]
105552696  DNAH12; dynein heavy chain 12, axonemal [KO:K10408]
105535007  DNAH11; dynein heavy chain 11, axonemal [KO:K10408]
105535250  DNAH6; dynein heavy chain 6, axonemal [KO:K10408]
105528794  DNAH9; dynein heavy chain 9, axonemal [KO:K10408]
105529656  DNAH17; dynein heavy chain 17, axonemal [KO:K10408]
105536668  DNAH3; LOW QUALITY PROTEIN: dynein heavy chain 3, axonemal [KO:K10408]
105549581  DNAH5; LOW QUALITY PROTEIN: dynein heavy chain 5, axonemal [KO:K10408]
105544010  DNAH1; dynein heavy chain 1, axonemal [KO:K10408]
105549962  DNAH2; dynein heavy chain 2, axonemal [KO:K10408]
105544405  DNAH8; dynein heavy chain 8, axonemal [KO:K10408]
105531557  DNALI1; axonemal dynein light intermediate polypeptide 1 isoform X1 [KO:K10410]
105539669  DNAI1; dynein intermediate chain 1, axonemal isoform X1 [KO:K10409]
105533573  DNAI2; dynein intermediate chain 2, axonemal [KO:K11143]
105541878  DNAL1; dynein light chain 1, axonemal [KO:K10411]
105538866  DNAL4; dynein light chain 4, axonemal isoform X1 [KO:K10412]
105528691  SLC1A2; excitatory amino acid transporter 2 isoform X1 [KO:K05613]
105552048  NOS2; nitric oxide synthase, inducible [KO:K13241] [EC:1.14.13.39]
105540560  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
105532333  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
105543326  GRIN1; glutamate receptor ionotropic, NMDA 1 [KO:K05208]
105542605  GRIN2A; glutamate receptor ionotropic, NMDA 2A [KO:K05209]
105549192  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
105555518  GRIN2C; glutamate receptor ionotropic, NMDA 2C [KO:K05211]
105539212  GRIN2D; glutamate receptor ionotropic, NMDA 2D [KO:K05212]
105537989  NRG1; pro-neuregulin-1, membrane-bound isoform isoform X1 [KO:K05455]
105551844  NRG2; pro-neuregulin-2, membrane-bound isoform [KO:K05456]
105550326  NRG3; pro-neuregulin-3, membrane-bound isoform isoform X1 [KO:K05457]
105541578  NRG4; pro-neuregulin-4, membrane-bound isoform [KO:K05458]
105543943  ERBB4; receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
Compound
C00001  H2O
C00008  ADP
C00025  L-Glutamate
C00027  Hydrogen peroxide
C00039  DNA
C00046  RNA
C00062  L-Arginine
C00070  Copper
C00076  Calcium cation
C00533  Nitric oxide
C00704  Superoxide
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C16844  Hydroxyl radical
C16845  Peroxynitrite
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Front Mol Neurosci 7:63 (2014)
DOI:10.3389/fnmol.2014.00063
Reference
PMID:29299811
  Authors
Kim JM, Billington E, Reyes A, Notarianni T, Sage J, Agbas E, Taylor M, Monast I, Stanford JA, Agbas A
  Title
Impaired Cu-Zn Superoxide Dismutase (SOD1) and Calcineurin (Cn) Interaction in ALS: A Presumed Consequence for TDP-43 and Zinc Aggregation in Tg SOD1(G93A) Rodent Spinal Cord Tissue.
  Journal
Neurochem Res 44:228-233 (2019)
DOI:10.1007/s11064-017-2461-z
Reference
PMID:30242016
  Authors
Benarroch EE
  Title
Sigma-1 receptor and amyotrophic lateral sclerosis.
  Journal
Neurology 91:743-747 (2018)
DOI:10.1212/WNL.0000000000006347
Reference
PMID:23361386
  Authors
Millecamps S, Julien JP
  Title
Axonal transport deficits and neurodegenerative diseases.
  Journal
Nat Rev Neurosci 14:161-76 (2013)
DOI:10.1038/nrn3380
Related
pathway
mleu00190  Oxidative phosphorylation
mleu03013  Nucleocytoplasmic transport
mleu03050  Proteasome
mleu04010  MAPK signaling pathway
mleu04012  ErbB signaling pathway
mleu04020  Calcium signaling pathway
mleu04115  p53 signaling pathway
mleu04137  Mitophagy - animal
mleu04140  Autophagy - animal
mleu04141  Protein processing in endoplasmic reticulum
mleu04210  Apoptosis
mleu04724  Glutamatergic synapse
mleu04810  Regulation of actin cytoskeleton
KO pathway
ko05014   
LinkDB

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