KEGG   PATHWAY: mni05160
Entry
mni05160                    Pathway                                
Name
Hepatitis C - Macaca nemestrina (pig-tailed macaque)
Description
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
Class
Human Diseases; Infectious disease: viral
Pathway map
mni05160  Hepatitis C
mni05160

Organism
Macaca nemestrina (pig-tailed macaque) [GN:mni]
Gene
105486920  LDLR; low-density lipoprotein receptor [KO:K12473]
105493629  SCARB1; scavenger receptor class B member 1 isoform X2 [KO:K13885]
105469774  CD81; CD81 molecule [KO:K06508]
105475472  CLDN12; claudin-12 [KO:K06087]
105473315  CLDN7; claudin-7 [KO:K06087]
105477374  CLDN10; claudin-10 isoform X1 [KO:K06087]
105465815  CLDN11; claudin-11 [KO:K06087]
105466374  CLDN4; claudin-4 [KO:K06087]
105466376  CLDN3; claudin-3 [KO:K06087]
105478110  CLDN34; claudin-34 [KO:K06087]
105466604  putative claudin-24 [KO:K06087]
105478720  CLDN20; claudin-20 [KO:K06087]
105467893  CLDN6; claudin-6 [KO:K06087]
105467894  CLDN9; claudin-9 [KO:K06087]
105490437  CLDN2; claudin-2 isoform X1 [KO:K06087]
105480727  CLDN5; LOW QUALITY PROTEIN: claudin-5 [KO:K06087]
105491138  CLDN23; claudin-23 [KO:K06087]
105469931  CLDN18; claudin-18 isoform X1 [KO:K06087]
105492740  CLDN15; claudin-15 [KO:K06087]
105470860  CLDN1; claudin-1 [KO:K06087]
105470861  CLDN16; claudin-16 [KO:K06087]
105493581  CLDN25; putative claudin-25 [KO:K06087]
105494850  CLDN19; claudin-19 isoform X1 [KO:K06087]
105472660  CLDN14; claudin-14 isoform X1 [KO:K06087]
105472757  CLDN17; claudin-17 [KO:K06087]
105472758  CLDN8; claudin-8 isoform X1 [KO:K06087]
105475186  OCLN; occludin [KO:K06088]
105493729  OAS3; LOW QUALITY PROTEIN: 2'-5'-oligoadenylate synthase 3 [KO:K14216] [EC:2.7.7.84]
105493381  OAS2; 2'-5'-oligoadenylate synthase 2 [KO:K14216] [EC:2.7.7.84]
105493382  OAS1; 2'-5'-oligoadenylate synthase 1 [KO:K14216] [EC:2.7.7.84]
105484553  RNASEL; 2-5A-dependent ribonuclease isoform X1 [KO:K01165]
105485638  DDX58; probable ATP-dependent RNA helicase DDX58 isoform X1 [KO:K12646] [EC:5.6.2.6]
105481575  MAVS; mitochondrial antiviral-signaling protein isoform X1 [KO:K12648]
105467377  TRAF3; TNF receptor-associated factor 3 isoform X1 [KO:K03174]
105473459  TBK1; serine/threonine-protein kinase TBK1 [KO:K05410] [EC:2.7.11.10]
105484842  IKBKE; inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
105497189  IRF3; interferon regulatory factor 3 isoform X1 [KO:K05411]
105494145  IRF7; interferon regulatory factor 7 isoform X1 [KO:K09447]
105465888  IFNA21; LOW QUALITY PROTEIN: interferon alpha-21 [KO:K05414]
105498418  interferon alpha-1/13-like [KO:K05414]
105498422  IFNA8; interferon alpha-8 [KO:K05414]
105498424  interferon alpha-6 [KO:K05414]
105498425  interferon alpha-1/13 [KO:K05414]
105498426  interferon alpha-2 [KO:K05414]
105498430  interferon alpha-4 [KO:K05414]
105465886  IFNB1; interferon beta [KO:K05415]
105473416  IFNG; interferon gamma isoform X1 [KO:K04687]
105466557  TLR3; toll-like receptor 3 isoform X1 [KO:K05401]
105485089  TICAM1; TIR domain-containing adapter molecule 1 [KO:K05842]
105471571  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
105487318  RIPK1; receptor-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K02861] [EC:2.7.11.1]
105478402  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
105476527  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
105471007  LOW QUALITY PROTEIN: NF-kappa-B essential modulator-like [KO:K07210]
105477978  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
105486337  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X3 [KO:K02580]
105469585  RELA; transcription factor p65 isoform X1 [KO:K04735]
105497642  TNF; tumor necrosis factor isoform X2 [KO:K03156]
105477263  CXCL10; C-X-C motif chemokine 10 precursor [KO:K12671]
105498124  EIF2AK1; eukaryotic translation initiation factor 2-alpha kinase 1 [KO:K16194] [EC:2.7.11.1]
105464848  EIF2AK2; LOW QUALITY PROTEIN: interferon-induced, double-stranded RNA-activated protein kinase [KO:K16195] [EC:2.7.11.1]
105496025  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
105492461  EIF2AK4; eIF-2-alpha kinase GCN2 isoform X1 [KO:K16196] [EC:2.7.11.1]
105480652  IFIT1; interferon-induced protein with tetratricopeptide repeats 1 [KO:K14217]
105481199  IFIT1B; interferon-induced protein with tetratricopeptide repeats 1B [KO:K14217]
105475984  EIF3E; eukaryotic translation initiation factor 3 subunit E isoform X1 [KO:K03250]
105472858  EIF2S1; eukaryotic translation initiation factor 2 subunit 1 [KO:K03237]
105472413  STAT3; signal transducer and activator of transcription 3 [KO:K04692]
105469243  SOCS3; suppressor of cytokine signaling 3 [KO:K04696]
105472707  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
105498461  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
105475871  TYK2; non-receptor tyrosine-protein kinase TYK2 isoform X1 [KO:K11219] [EC:2.7.10.2]
105468204  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
105474140  STAT2; signal transducer and activator of transcription 2 [KO:K11221]
105477854  IRF9; interferon regulatory factor 9 [KO:K04693]
105472602  MX1; interferon-induced GTP-binding protein Mx1 [KO:K14754]
105472607  MX2; interferon-induced GTP-binding protein Mx2 [KO:K14754]
105486547  RSAD2; radical S-adenosyl methionine domain-containing protein 2 isoform X1 [KO:K15045]
105497074  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
105493624  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X1 [KO:K03456]
105466919  PPP2R2B; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform isoform X1 [KO:K04354]
105482032  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
105470886  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
105483910  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
105467143  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
105481960  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform isoform X1 [KO:K04382] [EC:3.1.3.16]
105488018  PIAS1; E3 SUMO-protein ligase PIAS1 [KO:K04706] [EC:2.3.2.-]
105486254  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
105493061  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
105469160  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
105465416  SOS1; son of sevenless homolog 1 [KO:K03099]
105481847  SOS2; LOW QUALITY PROTEIN: son of sevenless homolog 2 [KO:K03099]
105494134  HRAS; GTPase HRas isoform X1 [KO:K02833]
105492133  KRAS; GTPase KRas isoform X1 [KO:K07827]
105479146  NRAS; GTPase NRas [KO:K07828]
105471274  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
105477727  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
105463916  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
105476048  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
105486509  YWHAQ; 14-3-3 protein theta [KO:K16197]
105496419  YWHAB; 14-3-3 protein beta/alpha [KO:K16197]
105498986  LOW QUALITY PROTEIN: 14-3-3 protein beta/alpha [KO:K16197]
105471598  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
105487193  YWHAH; 14-3-3 protein eta [KO:K16198]
105492763  YWHAG; 14-3-3 protein gamma [KO:K16198]
105488275  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
105485357  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 isoform X1 [KO:K04369] [EC:2.7.12.2]
105480656  MAPK1; LOW QUALITY PROTEIN: mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
105482882  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
105475205  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
105488082  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
105494953  PIK3R3; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
105478978  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105489973  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
105469947  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
105474669  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105489842  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
105495343  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
105470323  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
105480261  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
105469512  BAD; bcl2-associated agonist of cell death [KO:K02158]
105474528  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
105473688  TP53; cellular tumor antigen p53 [KO:K04451]
105474169  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
105474081  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
105475503  CDK6; cyclin-dependent kinase 6 isoform X1 [KO:K02091] [EC:2.7.11.22]
105490695  RB1; retinoblastoma-associated protein isoform X1 [KO:K06618]
105496223  E2F1; transcription factor E2F1 [KO:K17454]
105494424  E2F2; LOW QUALITY PROTEIN: transcription factor E2F2 [KO:K09389]
105482518  E2F3; transcription factor E2F3 isoform X1 [KO:K06620]
105484176  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
105491441  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein isoform X2 [KO:K03171]
105471953  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
105484428  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
105480710  FAS; tumor necrosis factor receptor superfamily member 6 precursor [KO:K04390]
105469733  FADD; FAS-associated death domain protein [KO:K02373]
105468105  CASP8; caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
105466747  CASP3; LOW QUALITY PROTEIN: caspase-3 [KO:K02187] [EC:3.4.22.56]
105492342  caspase-3-like isoform X1 [KO:K02187] [EC:3.4.22.56]
105468108  CFLAR; CASP8 and FADD-like apoptosis regulator isoform X1 [KO:K04724]
105480751  BH3-interacting domain death agonist [KO:K04726]
105478665  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
105474465  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
105475711  cytochrome c [KO:K08738]
105495842  cytochrome c-like [KO:K08738]
105477037  cytochrome c-like [KO:K08738]
105486922  cytochrome c-like [KO:K08738]
105477715  cytochrome c-like [KO:K08738]
105487609  cytochrome c-like [KO:K08738]
105497820  cytochrome c-like [KO:K08738]
105491771  cytochrome c-like [KO:K08738]
112428088  cytochrome c-like [KO:K08738]
105485043  cytochrome c-like [KO:K08738]
105495023  cytochrome c-like [KO:K08738]
105463369  APAF1; apoptotic protease-activating factor 1 isoform X1 [KO:K02084]
105473212  CASP9; caspase-9 [KO:K04399] [EC:3.4.22.62]
105472090  PSME3; proteasome activator complex subunit 3 isoform X1 [KO:K06698]
105471885  RXRA; retinoic acid receptor RXR-alpha isoform X1 [KO:K08524]
105489798  PPARA; peroxisome proliferator-activated receptor alpha [KO:K07294]
105471680  NR1H3; oxysterols receptor LXR-alpha isoform X1 [KO:K08536]
105469727  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
105492792  MYC; myc proto-oncogene protein isoform X1 [KO:K04377]
Compound
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C20935  2-5A
Reference
PMID:24520529
  Authors
Hassan M, Selimovic D, El-Khattouti A, Ghozlan H, Haikel Y, Abdelkader O
  Title
Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.
  Journal
World J Exp Med 2:7-25 (2012)
DOI:10.5493/wjem.v2.i2.7
Reference
PMID:23641066
  Authors
Yamauchi Y, Helenius A
  Title
Virus entry at a glance.
  Journal
J Cell Sci 126:1289-95 (2013)
DOI:10.1242/jcs.119685
Reference
PMID:24509809
  Authors
Feneant L, Levy S, Cocquerel L
  Title
CD81 and hepatitis C virus (HCV) infection.
  Journal
Viruses 6:535-72 (2014)
DOI:10.3390/v6020535
Reference
PMID:18081727
  Authors
Dubuisson J, Helle F, Cocquerel L
  Title
Early steps of the hepatitis C virus life cycle.
  Journal
Cell Microbiol 10:821-7 (2008)
DOI:10.1111/j.1462-5822.2007.01107.x
Reference
PMID:23675659
  Authors
Liang TJ, Ghany MG
  Title
Current and future therapies for hepatitis C virus infection.
  Journal
N Engl J Med 368:1907-17 (2013)
DOI:10.1056/NEJMra1213651
Reference
PMID:23836234
  Authors
Scheel TK, Rice CM
  Title
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.
  Journal
Nat Med 19:837-49 (2013)
DOI:10.1038/nm.3248
Reference
PMID:26586968
  Authors
Holmes JA, Thompson AJ
  Title
Interferon-free combination therapies for the treatment of hepatitis C: current insights.
  Journal
Hepat Med 7:51-70 (2015)
DOI:10.2147/HMER.S55864
Reference
PMID:15039538
  Authors
Taguchi T, Nagano-Fujii M, Akutsu M, Kadoya H, Ohgimoto S, Ishido S, Hotta H
  Title
Hepatitis C virus NS5A protein interacts with 2',5'-oligoadenylate synthetase and inhibits antiviral activity of IFN in an IFN sensitivity-determining region-independent manner.
  Journal
J Gen Virol 85:959-69 (2004)
DOI:10.1099/vir.0.19513-0
Reference
PMID:19708811
  Authors
Horner SM, Gale M Jr
  Title
Intracellular innate immune cascades and interferon defenses that control hepatitis C virus.
  Journal
J Interferon Cytokine Res 29:489-98 (2009)
DOI:10.1089/jir.2009.0063
Reference
PMID:20457596
  Authors
Lemon SM
  Title
Induction and evasion of innate antiviral responses by hepatitis C virus.
  Journal
J Biol Chem 285:22741-7 (2010)
DOI:10.1074/jbc.R109.099556
Reference
PMID:23836238
  Authors
Horner SM, Gale M Jr
  Title
Regulation of hepatic innate immunity by hepatitis C virus.
  Journal
Nat Med 19:879-88 (2013)
DOI:10.1038/nm.3253
Reference
PMID:28862649
  Authors
Ortega-Prieto AM, Dorner M
  Title
Immune Evasion Strategies during Chronic Hepatitis B and C Virus Infection.
  Journal
Vaccines (Basel) 5:E24 (2017)
DOI:10.3390/vaccines5030024
Reference
PMID:25852264
  Authors
Yang DR, Zhu HZ
  Title
Hepatitis C virus and antiviral innate immunity: who wins at tug-of-war?
  Journal
World J Gastroenterol 21:3786-800 (2015)
DOI:10.3748/wjg.v21.i13.3786
Reference
PMID:16107833
  Authors
Gale M Jr, Foy EM
  Title
Evasion of intracellular host defence by hepatitis C virus.
  Journal
Nature 436:939-45 (2005)
DOI:10.1038/nature04078
Reference
PMID:17467654
  Authors
Bode JG, Brenndorfer ED, Haussinger D
  Title
Subversion of innate host antiviral strategies by the hepatitis C virus.
  Journal
Arch Biochem Biophys 462:254-65 (2007)
DOI:10.1016/j.abb.2007.03.033
Reference
PMID:12686421
  Authors
Panteva M, Korkaya H, Jameel S
  Title
Hepatitis viruses and the MAPK pathway: is this a survival strategy?
  Journal
Virus Res 92:131-40 (2003)
DOI:10.1016/S0168-1702(02)00356-8
Reference
PMID:16239065
  Authors
Pang R, Tse E, Poon RT
  Title
Molecular pathways in hepatocellular carcinoma.
  Journal
Cancer Lett 240:157-69 (2006)
DOI:10.1016/j.canlet.2005.08.031
Reference
PMID:15302943
  Authors
Macdonald A, Harris M
  Title
Hepatitis C virus NS5A: tales of a promiscuous protein.
  Journal
J Gen Virol 85:2485-502 (2004)
DOI:10.1099/vir.0.80204-0
Reference
PMID:21250384
  Authors
He Y, Staschke KA, Tan SL
  Title
HCV NS5A: A Multifunctional Regulator of Cellular Pathways and Virus Replication
  Journal
Hepatitis C Viruses: Genomes and Molecular Biology (2006)
Reference
PMID:12101418
  Authors
Lan KH, Sheu ML, Hwang SJ, Yen SH, Chen SY, Wu JC, Wang YJ, Kato N, Omata M, Chang FY, Lee SD
  Title
HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
  Journal
Oncogene 21:4801-11 (2002)
DOI:10.1038/sj.onc.1205589
Reference
PMID:11886269
  Authors
Majumder M, Ghosh AK, Steele R, Zhou XY, Phillips NJ, Ray R, Ray RB
  Title
Hepatitis C virus NS5A protein impairs TNF-mediated hepatic apoptosis, but not by an anti-FAS antibody, in transgenic mice.
  Journal
Virology 294:94-105 (2002)
DOI:10.1006/viro.2001.1309
Reference
PMID:15381253
  Authors
Hassan M, Ghozlan H, Abdel-Kader O
  Title
Activation of RB/E2F signaling pathway is required for the modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells.
  Journal
Cell Signal 16:1375-85 (2004)
DOI:10.1016/j.cellsig.2004.04.005
Reference
PMID:11514734
  Authors
Kwun HJ, Jung EY, Ahn JY, Lee MN, Jang KL
  Title
p53-dependent transcriptional repression of p21(waf1) by hepatitis C virus NS3.
  Journal
J Gen Virol 82:2235-41 (2001)
DOI:10.1099/0022-1317-82-9-2235
Reference
PMID:12056797
  Authors
Yamanaka T, Uchida M, Doi T
  Title
Innate form of HCV core protein plays an important role in the localization and the function of HCV core protein.
  Journal
Biochem Biophys Res Commun 294:521-7 (2002)
DOI:10.1016/S0006-291X(02)00507-7
Reference
PMID:22611309
  Authors
Lim EJ, Chin R, Angus PW, Torresi J
  Title
Enhanced apoptosis in post-liver transplant hepatitis C: effects of virus and immunosuppressants.
  Journal
World J Gastroenterol 18:2172-9 (2012)
DOI:10.3748/wjg.v18.i18.2172
Reference
PMID:17828818
  Authors
Fischer R, Baumert T, Blum HE
  Title
Hepatitis C virus infection and apoptosis.
  Journal
World J Gastroenterol 13:4865-72 (2007)
DOI:10.3748/wjg.v13.i36.4865
Reference
PMID:16611896
  Authors
Saito K, Meyer K, Warner R, Basu A, Ray RB, Ray R
  Title
Hepatitis C virus core protein inhibits tumor necrosis factor alpha-mediated apoptosis by a protective effect involving cellular FLICE inhibitory protein.
  Journal
J Virol 80:4372-9 (2006)
DOI:10.1128/JVI.80.9.4372-4379.2006
Reference
PMID:19148799
  Authors
Koike K
  Title
Steatosis, liver injury, and hepatocarcinogenesis in hepatitis C viral infection.
  Journal
J Gastroenterol 44 Suppl 19:82-8 (2009)
DOI:10.1007/s00535-008-2276-4
Reference
PMID:17764115
  Authors
Tanaka N, Moriya K, Kiyosawa K, Koike K, Aoyama T
  Title
Hepatitis C virus core protein induces spontaneous and persistent activation of peroxisome proliferator-activated receptor alpha in transgenic mice: implications for HCV-associated hepatocarcinogenesis.
  Journal
Int J Cancer 122:124-31 (2008)
DOI:10.1002/ijc.23056
Reference
PMID:18251977
  Authors
Tan A, Yeh SH, Liu CJ, Cheung C, Chen PJ
  Title
Viral hepatocarcinogenesis: from infection to cancer.
  Journal
Liver Int 28:175-88 (2008)
DOI:10.1111/j.1478-3231.2007.01652.x
Related
pathway
mni03320  PPAR signaling pathway
mni04010  MAPK signaling pathway
mni04144  Endocytosis
mni04210  Apoptosis
mni04514  Cell adhesion molecules
mni04620  Toll-like receptor signaling pathway
mni04622  RIG-I-like receptor signaling pathway
mni04630  JAK-STAT signaling pathway
mni04668  TNF signaling pathway
KO pathway
ko05160   
LinkDB

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