KEGG   PATHWAY: npr05132
Entry
npr05132                    Pathway                                
Name
Salmonella infection - Nanorana parkeri (Xizang Plateau frog)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious disease: bacterial
Pathway map
npr05132  Salmonella infection
npr05132

Disease
H00111  Typhoid fever
Organism
Nanorana parkeri (Xizang Plateau frog) [GN:npr]
Gene
108783680  [KO:K18441]
108783893  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
108784101  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
108784114  RELA; transcription factor p65 [KO:K04735]
108784209  FHOD1; FH1/FH2 domain-containing protein 1 [KO:K23938]
108784413  GAPDH; glyceraldehyde-3-phosphate dehydrogenase [KO:K00134] [EC:1.2.1.12]
108784575  ACTR1A; alpha-centractin [KO:K16575]
108784626  MYD88; myeloid differentiation primary response protein MyD88 [KO:K04729]
108784646  DYNLT3; dynein light chain Tctex-type 3 [KO:K10420]
108784823  TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721]
108784895  [KO:K12757]
108784960  [KO:K07888]
108784979  RAB7A; ras-related protein Rab-7a [KO:K07897]
108785005  KPNA4; importin subunit alpha-3 [KO:K23583]
108785250  [KO:K10168]
108785415  LEF1; lymphoid enhancer-binding factor 1 [KO:K04492]
108785454  FADD; FAS-associated death domain protein [KO:K02373]
108785556  ANXA2; annexin A2 isoform X1 [KO:K17092]
108785569  SNX33; sorting nexin-33 [KO:K17923]
108785587  [KO:K04519]
108785600  [KO:K04519]
108785765  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
108785785  [KO:K07374]
108786073  EXOC7; exocyst complex component 7 isoform X1 [KO:K07195]
108786166  DYNLRB2; dynein light chain roadblock-type 2 [KO:K10419]
108786312  DCTN4; dynactin subunit 4 isoform X1 [KO:K10426]
108786547  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
108786689  HRAS; GTPase HRas [KO:K02833]
108786727  AHNAK2; protein AHNAK2 [KO:K23934]
108786774  RHOJ; rho-related GTP-binding protein RhoJ [KO:K07864]
108786806  DYNLRB1; dynein light chain roadblock-type 1 isoform X1 [KO:K10419]
108786933  [KO:K16060]
108787059  KLC1; kinesin light chain 1 isoform X1 [KO:K10407]
108787157  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108787259  TRAF2; TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
108787278  BAK1; bcl-2 homologous antagonist/killer isoform X1 [KO:K14021]
108787331  TUBB6; tubulin beta-6 chain isoform X1 [KO:K07375]
108787359  DYNLL2; dynein light chain 2, cytoplasmic [KO:K10418]
108787374  [KO:K07374]
108787378  [KO:K04441] [EC:2.7.11.24]
108787466  VPS33A; vacuolar protein sorting-associated protein 33A [KO:K20182]
108787573  [KO:K04366] [EC:2.7.11.1]
108787622  [KO:K03671]
108787648  [KO:K07955]
108787760  DYNLL1; dynein light chain 1, cytoplasmic [KO:K10418]
108787821  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
108787984  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
108788034  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
108788037  [KO:K07955]
108788164  JUN; transcription factor AP-1 [KO:K04448]
108788197  TLR2; toll-like receptor 2 isoform X1 [KO:K10159]
108788240  [KO:K04441] [EC:2.7.11.24]
108788466  [KO:K12807]
108788467  [KO:K12807]
108788529  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
108788538  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
108788599  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
108788628  DYNC1H1; cytoplasmic dynein 1 heavy chain 1 [KO:K10413]
108788633  [KO:K04079]
108788800  ARF1; ADP-ribosylation factor 1 [KO:K07937]
108788881  VPS41; vacuolar protein sorting-associated protein 41 homolog isoform X1 [KO:K20184]
108788937  RAB5C; ras-related protein Rab-5C [KO:K07889]
108788942  [KO:K23934]
108788968  MYC; myc proto-oncogene protein [KO:K04377]
108788997  MYO6; unconventional myosin-VI [KO:K10358]
108789021  HSP90B1; endoplasmin [KO:K09487]
108789059  NFKB1; nuclear factor NF-kappa-B p105 subunit [KO:K02580]
108789229  [KO:K04513]
108789292  VPS39; vam6/Vps39-like protein [KO:K20183]
108789369  [KO:K07375]
108789370  [KO:K07375]
108789386  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
108789468  IRAK4; LOW QUALITY PROTEIN: interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
108789478  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
108789599  RALA; ras-related protein Ral-A [KO:K07834]
108789977  KPNA3; importin subunit alpha-4 [KO:K23583]
108790400  TUBB; tubulin beta chain [KO:K07375]
108790442  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
108790450  FLNA; filamin-A isoform X1 [KO:K04437]
108790460  [KO:K07897]
108790504  DYNC1I1; cytoplasmic dynein 1 intermediate chain 1 isoform X1 [KO:K10415]
108790530  RAB5B; ras-related protein Rab-5B [KO:K07888]
108790540  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
108790560  [KO:K04513]
108790727  WASF3; wiskott-Aldrich syndrome protein family member 3 [KO:K06083]
108790738  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
108790756  [KO:K04079]
108790769  TAB3; TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 isoform X1 [KO:K12793]
108790873  [KO:K01370] [EC:3.4.22.36]
108790988  DCTN5; dynactin subunit 5 [KO:K10427]
108791216  [KO:K08738]
108791352  IKBKG; NF-kappa-B essential modulator [KO:K07210]
108791406  [KO:K07374]
108791424  [KO:K10159]
108791446  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [KO:K07209] [EC:2.7.11.10]
108791497  [KO:K20180]
108791579  TUBA8; tubulin alpha-8 chain [KO:K07374]
108791731  ACTR10; actin-related protein 10 [KO:K16576]
108791752  EXOC5; exocyst complex component 5 [KO:K19984]
108791810  PIK3C2G; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [KO:K00923] [EC:2.7.1.154]
108791882  DYNC2LI1; cytoplasmic dynein 2 light intermediate chain 1 [KO:K10417]
108791906  [KO:K06083]
108791918  ARL8B; ADP-ribosylation factor-like protein 8B [KO:K07955]
108792063  NOD1; nucleotide-binding oligomerization domain-containing protein 1 [KO:K08727]
108792113  CYFIP1; cytoplasmic FMR1-interacting protein 1 isoform X1 [KO:K05749]
108792126  TCF7; transcription factor 7 [KO:K02620]
108792127  SKP1; S-phase kinase-associated protein 1 [KO:K03094]
108792222  ELMO1; engulfment and cell motility protein 1 isoform X1 [KO:K12366]
108792270  [KO:K13744]
108792464  KIF5B; kinesin-1 heavy chain [KO:K10396] [EC:5.6.1.3]
108792468  [KO:K04397] [EC:3.4.22.60]
108792469  [KO:K04490]
108792529  SNX18; sorting nexin-18 isoform X1 [KO:K17923]
108793191  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
108793385  ELMO2; engulfment and cell motility protein 2 isoform X1 [KO:K18985]
108793401  RIPK1; receptor-interacting serine/threonine-protein kinase 1 [KO:K02861] [EC:2.7.11.1]
108793408  [KO:K07375]
108793410  EXOC2; exocyst complex component 2 [KO:K17637]
108793482  DYNLT1; dynein light chain Tctex-type 1 isoform X1 [KO:K10420]
108793512  TCF7L2; transcription factor 7-like 2 [KO:K04491]
108793513  CASP7; caspase-7 isoform X1 [KO:K04397] [EC:3.4.22.60]
108793666  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
108793697  TXN2; thioredoxin, mitochondrial [KO:K03671]
108793707  RHOH; rho-related GTP-binding protein RhoH [KO:K07873]
108793742  [KO:K03156]
108793888  AHNAK; neuroblast differentiation-associated protein AHNAK [KO:K23934]
108793910  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
108794095  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
108794200  RAB9A; ras-related protein Rab-9A [KO:K07899]
108794344  VPS18; vacuolar protein sorting-associated protein 18 homolog [KO:K20181]
108794418  BRK1; protein BRICK1 [KO:K05752]
108794473  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
108794544  PTPRC; receptor-type tyrosine-protein phosphatase C [KO:K06478] [EC:3.1.3.48]
108794589  [KO:K02187] [EC:3.4.22.56]
108794597  [KO:K02187] [EC:3.4.22.56]
108794619  TUBB4A; tubulin beta-4A chain isoform X1 [KO:K07375]
108794648  [KO:K04440] [EC:2.7.11.24]
108794768  [KO:K10160]
108794863  [KO:K10030]
108794864  [KO:K10030]
108794889  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
108794967  [KO:K07374]
108794980  STX10; syntaxin-10 isoform X1 [KO:K23937]
108794992  [KO:K07374]
108794998  [KO:K07937]
108795003  VPS11; vacuolar protein sorting-associated protein 11 homolog isoform X1 [KO:K20179]
108795015  [KO:K10159]
108795075  ARF6; ADP-ribosylation factor 6 [KO:K07941]
108795080  [KO:K04398] [EC:3.4.22.61]
108795169  [KO:K08846] [EC:2.7.11.1]
108795228  EXOC4; exocyst complex component 4 [KO:K06111]
108795244  DYNC1LI2; cytoplasmic dynein 1 light intermediate chain 2 [KO:K10416]
108795276  TUBB3; tubulin beta-3 chain isoform X1 [KO:K07375]
108795508  KIF5C; kinesin heavy chain isoform X1 [KO:K10396] [EC:5.6.1.3]
108795673  DYNC1LI1; cytoplasmic dynein 1 light intermediate chain 1 isoform X1 [KO:K10416]
108795750  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
108795877  SNX9; sorting nexin-9 isoform X1 [KO:K17923]
108795963  DYNC2H1; cytoplasmic dynein 2 heavy chain 1 [KO:K10414]
108795999  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158]
108796046  RPS3; 40S ribosomal protein S3 [KO:K02985]
108796054  BAX; apoptosis regulator BAX [KO:K02159]
108796071  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
108796106  ABI1; abl interactor 1 isoform X1 [KO:K23649]
108796352  PIK3C2B; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta [KO:K00923] [EC:2.7.1.154]
108796407  DCTN6; dynactin subunit 6 [KO:K10428]
108796462  KLC4; kinesin light chain 4 isoform X1 [KO:K10407]
108796598  FBXO22; F-box only protein 22 [KO:K10302]
108796670  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
108796694  GCC2; GRIP and coiled-coil domain-containing protein 2 [KO:K20282]
108796718  ACTG1; actin, cytoplasmic 2 [KO:K05692]
108796830  ACBD3; Golgi resident protein GCP60 isoform X1 [KO:K23935]
108796837  PFN2; profilin-2 [KO:K05759]
108796951  DCTN1; dynactin subunit 1 [KO:K04648]
108796965  [KO:K05733] [EC:2.7.11.1]
108797066  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
108797103  NCKAP1L; nck-associated protein 1-like [KO:K05750]
108797293  [KO:K05405]
108797397  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
108797418  [KO:K07937]
108797632  RAB5A; ras-related protein Rab-5A [KO:K07887]
108797654  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
108797708  S100A10; protein S100-A10 [KO:K17274]
108797721  [KO:K12800]
108797733  [KO:K12799]
108797846  DNM2; dynamin-2 isoform X1 [KO:K23484]
108797989  DCTN2; dynactin subunit 2 isoform X1 [KO:K10424]
108798020  KIF5A; kinesin heavy chain [KO:K10396] [EC:5.6.1.3]
108798164  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
108798203  [KO:K07375]
108798322  [KO:K18441]
108798423  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
108798525  [KO:K07374]
108798526  [KO:K07374]
108799449  M6PR; cation-dependent mannose-6-phosphate receptor [KO:K10089]
108799491  [KO:K18441]
108799640  [KO:K07374]
108799641  [KO:K07374]
108799643  [KO:K07374]
108799665  NLRC4; NLR family CARD domain-containing protein 4 [KO:K12805]
108799763  VPS16; vacuolar protein sorting-associated protein 16 homolog [KO:K20180]
108799803  [KO:K05692]
108799889  CYTH3; cytohesin-3 [KO:K18441]
108799905  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
108799910  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
108800020  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
108800110  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
108800165  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
108800285  [KO:K06071] [EC:2.7.11.13]
108800485  DYNC1I2; cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]
108800535  RHOB; rho-related GTP-binding protein RhoB isoform X1 [KO:K07856]
108800545  [KO:K12799]
108800546  [KO:K12799]
108800547  [KO:K12799]
108800795  PIK3C2A; LOW QUALITY PROTEIN: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [KO:K00923] [EC:2.7.1.154]
108801297  [KO:K13744]
108801303  TLR5; toll-like receptor 5 [KO:K10168]
108801499  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
108801508  MLKL; mixed lineage kinase domain-like protein [KO:K08849] [EC:2.7.11.1]
108801733  RILP; rab-interacting lysosomal protein [KO:K13883]
108801744  [KO:K05482]
108801753  MYL10; myosin regulatory light chain 10 [KO:K12756]
108801973  [KO:K04492]
108802029  [KO:K08738]
108802395  [KO:K12807]
108802396  [KO:K12807]
108802481  FOS; proto-oncogene c-Fos [KO:K04379]
108802707  [KO:K23940]
108802729  TUBB1; tubulin beta-1 chain isoform X1 [KO:K07375]
108803301  ARPC5; actin-related protein 2/3 complex subunit 5 isoform X1 [KO:K05754]
108803381  CSE1L; LOW QUALITY PROTEIN: exportin-2 [KO:K18423]
108803445  [KO:K07863]
108803587  PLEKHM2; LOW QUALITY PROTEIN: pleckstrin homology domain-containing family M member 2 [KO:K15348]
108803688  PFN4; profilin-4 [KO:K05759]
108803788  [KO:K07863]
108803794  PLEKHM1; pleckstrin homology domain-containing family M member 1 [KO:K23282]
108803796  [KO:K12758]
108804255  [KO:K07937]
108804267  [KO:K07937]
108804280  [KO:K07937]
108804344  [KO:K07937]
108804404  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
108804436  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1 [KO:K00914] [EC:2.7.1.137]
108804455  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
108804489  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
108804653  [KO:K10169]
108804838  MAPK12; mitogen-activated protein kinase 12 isoform X1 [KO:K04441] [EC:2.7.11.24]
108804839  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
108804992  [KO:K07941]
Compound
C00338  Lipopolysaccharide
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:28875943
  Authors
Bernal-Bayard J, Ramos-Morales F
  Title
Molecular Mechanisms Used by Salmonella to Evade the Immune System.
  Journal
Curr Issues Mol Biol 25:133-168 (2018)
DOI:10.21775/cimb.025.133
Reference
PMID:28848711
  Authors
Hume PJ, Singh V, Davidson AC, Koronakis V
  Title
Swiss Army Pathogen: The Salmonella Entry Toolkit.
  Journal
Front Cell Infect Microbiol 7:348 (2017)
DOI:10.3389/fcimb.2017.00348
Reference
PMID:31402916
  Authors
Wemyss MA, Pearson JS
  Title
Host Cell Death Responses to Non-typhoidal Salmonella Infection.
  Journal
Front Immunol 10:1758 (2019)
DOI:10.3389/fimmu.2019.01758
Reference
PMID:27974148
  Authors
Bierschenk D, Boucher D, Schroder K
  Title
Salmonella-induced inflammasome activation in humans.
  Journal
Mol Immunol 86:38-43 (2017)
DOI:10.1016/j.molimm.2016.11.009
Reference
PMID:29477730
  Authors
Pinaud L, Sansonetti PJ, Phalipon A
  Title
Host Cell Targeting by Enteropathogenic Bacteria T3SS Effectors.
  Journal
Trends Microbiol 26:266-283 (2018)
DOI:10.1016/j.tim.2018.01.010
Reference
PMID:25749450
  Authors
LaRock DL, Chaudhary A, Miller SI
  Title
Salmonellae interactions with host processes.
  Journal
Nat Rev Microbiol 13:191-205 (2015)
DOI:10.1038/nrmicro3420
Reference
PMID:17983751
  Authors
Ramsden AE, Holden DW, Mota LJ
  Title
Membrane dynamics and spatial distribution of Salmonella-containing vacuoles.
  Journal
Trends Microbiol 15:516-24 (2007)
DOI:10.1016/j.tim.2007.10.002
Reference
PMID:22702524
  Authors
van der Heijden J, Finlay BB
  Title
Type III effector-mediated processes in Salmonella infection.
  Journal
Future Microbiol 7:685-703 (2012)
DOI:10.2217/fmb.12.49
Reference
PMID:27222578
  Authors
Galan JE
  Title
Typhoid toxin provides a window into typhoid fever and the biology of Salmonella Typhi.
  Journal
Proc Natl Acad Sci U S A 113:6338-44 (2016)
DOI:10.1073/pnas.1606335113
Reference
PMID:19157959
  Authors
McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V
  Title
Salmonella takes control: effector-driven manipulation of the host.
  Journal
Curr Opin Microbiol 12:117-24 (2009)
DOI:10.1016/j.mib.2008.12.001
Reference
PMID:12675800
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
PMID:17074883
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
PMID:18411289
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
PMID:10499590
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Related
pathway
npr04010  MAPK signaling pathway
npr04210  Apoptosis
npr04217  Necroptosis
npr04621  NOD-like receptor signaling pathway
KO pathway
ko05132   

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