KEGG   PATHWAY: oro04062
Entry
oro04062                    Pathway                                
Name
Chemokine signaling pathway - Odobenus rosmarus divergens (Pacific walrus)
Description
Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival.
The chemokine signal is transduced by chemokine receptors (G-protein coupled receptors) expressed on the immune cells. After receptor activation, the alpha- and beta-gamma-subunits of G protein dissociate to activate diverse downstream pathways resulting in cellular polarization and actin reorganization. Various members of small GTPases are involved in this process. Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production.
Class
Organismal Systems; Immune system
Pathway map
oro04062  Chemokine signaling pathway
oro04062

Other DBs
GO: 0070098
Organism
Odobenus rosmarus divergens (Pacific walrus) [GN:oro]
Gene
101365347  growth-regulated protein homolog beta-like [KO:K05505]
101377249  growth-regulated protein homolog gamma-like [KO:K05505]
101376379  C-X-C motif chemokine 6 [KO:K05506]
101376670  platelet basic protein-like [KO:K10029]
101365039  CXCL8; interleukin-8 [KO:K10030]
101380226  CXCL9; C-X-C motif chemokine 9 [KO:K05416]
101379926  CXCL10; C-X-C motif chemokine 10 [KO:K12671]
101379640  CXCL11; C-X-C motif chemokine 11 [KO:K12672]
101378047  CXCL12; stromal cell-derived factor 1 isoform X1 [KO:K10031]
101374515  CXCL13; C-X-C motif chemokine 13 [KO:K10032]
101373903  CXCL16; C-X-C motif chemokine 16 [KO:K10035]
101376961  uncharacterized protein LOC101376961 [KO:K05407]
101362344  CXCL14; C-X-C motif chemokine 14 [KO:K10033]
101383122  XCL1; lymphotactin [KO:K05507]
101369990  CX3CL1; fractalkine [KO:K05508]
101381829  CCL1; C-C motif chemokine 1 [KO:K05514]
101377584  CCL2; C-C motif chemokine 2 [KO:K14624]
101370944  C-C motif chemokine 3 [KO:K05408]
101371244  C-C motif chemokine 3-like [KO:K05408]
101371529  regakine-1-like [KO:K05408]
105758121  C-C motif chemokine 3-like [KO:K05408]
101370656  CCL4; C-C motif chemokine 4 isoform X1 [KO:K12964]
101381338  CCL5; LOW QUALITY PROTEIN: C-C motif chemokine 5 [KO:K12499]
101378149  C-C motif chemokine 7-like [KO:K05509]
101380961  CCL8; C-C motif chemokine 8 [KO:K16596]
101381254  LOW QUALITY PROTEIN: C-C motif chemokine 13 [KO:K16595]
101381629  CCL14; C-C motif chemokine 14 [KO:K21092]
105758123  C-C motif chemokine 15-like [KO:K05511]
101383063  CCL16; C-C motif chemokine 16 [KO:K21093]
101369692  CCL17; C-C motif chemokine 17 [KO:K21083]
101374344  CCL19; C-C motif chemokine 19 [KO:K05512]
101376905  CCL20; C-C motif chemokine 20 isoform X2 [KO:K14625]
101374634  CCL21; C-C motif chemokine 21 [KO:K16062]
101382391  CCL22; C-C motif chemokine 22 [KO:K21095]
101366957  CCL24; C-C motif chemokine 24 [KO:K21097]
101380044  CCL25; C-C motif chemokine 25 [KO:K13072]
101381737  CCL26; C-C motif chemokine 26 [KO:K21096]
101373757  CCL27; C-C motif chemokine 27 [KO:K16598]
101369601  CCL28; C-C motif chemokine 28 [KO:K05513]
101368927  CXCR2; C-X-C chemokine receptor type 2 [KO:K05050]
101386791  CXCR1; C-X-C chemokine receptor type 1 [KO:K04175]
101384395  CXCR3; C-X-C chemokine receptor type 3 [KO:K04188]
101372091  CXCR4; C-X-C chemokine receptor type 4 isoform X1 [KO:K04189]
101383908  CXCR5; C-X-C chemokine receptor type 5 [KO:K04190]
101384894  CXCR6; C-X-C chemokine receptor type 6 [KO:K04191]
101385189  XCR1; chemokine XC receptor 1 [KO:K04193]
101363570  CX3CR1; CX3C chemokine receptor 1 [KO:K04192]
101363857  CCR8; C-C chemokine receptor type 8 [KO:K04183]
101375856  CCR6; C-C chemokine receptor type 6 [KO:K04181]
101384611  CCR9; C-C chemokine receptor type 9 [KO:K04184]
101365020  CCR4; C-C chemokine receptor type 4 [KO:K04179]
101379863  CCR7; C-C chemokine receptor type 7 [KO:K04182]
101386073  CCR2; C-C chemokine receptor type 2 [KO:K04177]
101386361  CCR5; C-C chemokine receptor type 5 [KO:K04180]
101385489  CCR1; C-C chemokine receptor type 1 [KO:K04176]
101385778  CCR3; C-C chemokine receptor type 3 [KO:K04178]
101378967  CCR10; C-C chemokine receptor type 10 [KO:K04185]
101375007  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
101369142  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
101378785  STAT1; signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101368050  STAT2; signal transducer and activator of transcription 2 isoform X1 [KO:K11221]
101373587  STAT3; signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
101372217  STAT5B; signal transducer and activator of transcription 5B isoform X2 [KO:K11224]
101376186  GNAI1; guanine nucleotide-binding protein G(i) subunit alpha-1 isoform X1 [KO:K04630]
101367568  GNAI3; guanine nucleotide-binding protein G(k) subunit alpha [KO:K04630]
101367936  GNAI2; guanine nucleotide-binding protein G(i) subunit alpha-2 isoform X1 [KO:K04630]
101379158  ADCY1; adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
101365382  ADCY2; adenylate cyclase type 2 [KO:K08042] [EC:4.6.1.1]
101368682  ADCY3; adenylate cyclase type 3 [KO:K08043] [EC:4.6.1.1]
101374313  ADCY4; adenylate cyclase type 4 [KO:K08044] [EC:4.6.1.1]
101380824  ADCY5; adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
101373816  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
101377421  ADCY7; adenylate cyclase type 7 [KO:K08047] [EC:4.6.1.1]
101370350  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101364108  ADCY9; adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
101367408  PRKACB; cAMP-dependent protein kinase catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
101383001  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101383639  LYN; tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
101383723  HCK; tyrosine-protein kinase HCK isoform X2 [KO:K08893] [EC:2.7.10.2]
101366929  FGR; tyrosine-protein kinase Fgr [KO:K08891] [EC:2.7.10.2]
101368668  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
101373821  SHC1; SHC-transforming protein 1 isoform X2 [KO:K06279]
101384118  SHC2; SHC-transforming protein 2 [KO:K17447]
101375500  SHC3; SHC-transforming protein 3 [KO:K17448]
101375729  SHC4; SHC-transforming protein 4 [KO:K17449]
101362094  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
101385114  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
101369947  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
101367134  GTPase HRas-like [KO:K02833]
101372786  HRAS; GTPase HRas isoform X1 [KO:K02833]
101370458  KRAS; GTPase KRas isoform X2 [KO:K07827]
101363525  NRAS; GTPase NRas [KO:K07828]
101372149  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X2 [KO:K04366] [EC:2.7.11.1]
101377465  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
101365373  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
101372573  MAPK1; mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
101382213  MAPK3; mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
101370689  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101385241  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101385267  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
101374787  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101370100  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101371800  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101362272  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
101374579  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
101375062  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
101380706  PRKCZ; protein kinase C zeta type [KO:K18952] [EC:2.7.11.13]
101383166  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101382320  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101374757  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101376741  forkhead box protein O3 [KO:K09408]
101364103  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha [KO:K04467] [EC:2.7.11.10]
101375346  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101384959  IKBKG; NF-kappa-B essential modulator isoform X2 [KO:K07210]
101384149  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101386560  NFKBIB; NF-kappa-B inhibitor beta isoform X2 [KO:K02581]
101371488  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101381225  RELA; transcription factor p65 [KO:K04735]
101375422  BAD; bcl2-associated agonist of cell death [KO:K02158]
101374811  GSK3A; glycogen synthase kinase-3 alpha [KO:K08822] [EC:2.7.11.26]
101365718  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101378358  ITK; tyrosine-protein kinase ITK/TSK [KO:K07363] [EC:2.7.10.2]
101363849  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
101366888  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101383637  VAV1; proto-oncogene vav isoform X2 [KO:K05730]
101378519  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
101366544  LOW QUALITY PROTEIN: ras-related C3 botulinum toxin substrate 1-like [KO:K04392]
101385830  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
101374128  RAC3; ras-related C3 botulinum toxin substrate 3 [KO:K07861]
101365642  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
101364638  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
101380859  WAS; wiskott-Aldrich syndrome protein [KO:K05747]
101383468  RHOA; transforming protein RhoA isoform X1 [KO:K04513]
101386230  ROCK1; rho-associated protein kinase 1 isoform X2 [KO:K04514] [EC:2.7.11.1]
101372971  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
101381482  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [KO:K04536]
101378633  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 isoform X1 [KO:K04537]
101371845  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101369300  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101362117  GNB5; guanine nucleotide-binding protein subunit beta-5 isoform X1 [KO:K04539]
101366315  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 [KO:K07826]
101376879  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101369684  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101365462  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101363588  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
101371482  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
101370001  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101375712  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101379027  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101374080  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
101368814  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7-like [KO:K04347]
101382152  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101375999  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 isoform X1 [KO:K04548]
101386155  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101384753  PREX1; phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
101376981  ELMO1; engulfment and cell motility protein 1 isoform X2 [KO:K12366]
101383042  DOCK2; dedicator of cytokinesis protein 2 [KO:K12367]
101371010  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
101369700  PXN; paxillin [KO:K05760]
101364349  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
101369015  CRKL; crk-like protein [KO:K04438]
101384062  CRK; adapter molecule crk isoform X1 [KO:K04438]
101373391  PTK2B; protein-tyrosine kinase 2-beta isoform X1 [KO:K05871] [EC:2.7.10.2]
101384596  GNAQ; guanine nucleotide-binding protein G(q) subunit alpha [KO:K04634]
101379806  PLCB2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 [KO:K05858] [EC:3.1.4.11]
101375710  PLCB3; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1 [KO:K05858] [EC:3.1.4.11]
101386162  PLCB4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2 [KO:K05858] [EC:3.1.4.11]
101386750  PLCB1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 isoform X1 [KO:K05858] [EC:3.1.4.11]
101380728  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
101378505  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 [KO:K05859] [EC:3.1.4.11]
101369676  RASGRP2; RAS guanyl-releasing protein 2 [KO:K12361]
101375466  RAP1A; ras-related protein Rap-1A [KO:K04353]
101383971  RAP1B; ras-related protein Rap-1b isoform X1 [KO:K07836]
101375042  PARD3; partitioning defective 3 homolog isoform X2 [KO:K04237]
101365424  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
101380879  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
101385728  PRKCD; protein kinase C delta type isoform X2 [KO:K06068] [EC:2.7.11.13]
101376795  NCF1; neutrophil cytosol factor 1 [KO:K08011]
101369670  GRK1; rhodopsin kinase [KO:K00909] [EC:2.7.11.14]
101367921  GRK7; G protein-coupled receptor kinase 7 [KO:K00909] [EC:2.7.11.14]
101384757  ADRBK1; beta-adrenergic receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
101385645  ADRBK2; beta-adrenergic receptor kinase 2 [KO:K00910] [EC:2.7.11.15]
101385208  GRK5; G protein-coupled receptor kinase 5 [KO:K08291] [EC:2.7.11.16]
101366445  GRK4; G protein-coupled receptor kinase 4 [KO:K08291] [EC:2.7.11.16]
101377206  GRK6; G protein-coupled receptor kinase 6 isoform X1 [KO:K08291] [EC:2.7.11.16]
101382651  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
101380767  ARRB2; beta-arrestin-2 isoform X1 [KO:K04439]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12495636
  Authors
Wong MM, Fish EN
  Title
Chemokines: attractive mediators of the immune response.
  Journal
Semin Immunol 15:5-14 (2003)
DOI:10.1016/S1044-5323(02)00123-9
Reference
PMID:11872087
  Authors
Curnock AP, Logan MK, Ward SG
  Title
Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.
  Journal
Immunology 105:125-36 (2002)
DOI:10.1046/j.1365-2567.2002.01345.x
Reference
PMID:12069927
  Authors
Olson TS, Ley K
  Title
Chemokines and chemokine receptors in leukocyte trafficking.
  Journal
Am J Physiol Regul Integr Comp Physiol 283:R7-28 (2002)
DOI:10.1152/ajpregu.00738.2001
Reference
PMID:17169327
  Authors
Busillo JM, Benovic JL
  Title
Regulation of CXCR4 signaling.
  Journal
Biochim Biophys Acta 1768:952-63 (2007)
DOI:10.1016/j.bbamem.2006.11.002
Reference
PMID:11244042
  Authors
Mellado M, Rodriguez-Frade JM, Manes S, Martinez-A C
  Title
Chemokine signaling and functional responses: the role of receptor dimerization and TK pathway activation.
  Journal
Annu Rev Immunol 19:397-421 (2001)
DOI:10.1146/annurev.immunol.19.1.397
Reference
PMID:8576262
  Authors
Knall C, Young S, Nick JA, Buhl AM, Worthen GS, Johnson GL
  Title
Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
  Journal
J Biol Chem 271:2832-8 (1996)
DOI:10.1074/jbc.271.5.2832
Reference
PMID:17537990
  Authors
Patrussi L, Ulivieri C, Lucherini OM, Paccani SR, Gamberucci A, Lanfrancone L, Pelicci PG, Baldari CT
  Title
p52Shc is required for CXCR4-dependent signaling and chemotaxis in T cells.
  Journal
Blood 110:1730-8 (2007)
DOI:10.1182/blood-2007-01-068411
Reference
PMID:18662984
  Authors
Sai J, Raman D, Liu Y, Wikswo J, Richmond A
  Title
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis.
  Journal
J Biol Chem 283:26538-47 (2008)
DOI:10.1074/jbc.M805611200
Reference
PMID:10852130
  Authors
Hauck CR, Klingbeil CK, Schlaepfer DD
  Title
Focal adhesion kinase functions as a receptor-proximal signaling component required for directed cell migration.
  Journal
Immunol Res 21:293-303 (2000)
DOI:10.1385/IR:21:2-3:293
Reference
PMID:14625285
  Authors
Chandrasekar B, Bysani S, Mummidi S
  Title
CXCL16 signals via Gi, phosphatidylinositol 3-kinase, Akt, I kappa B kinase, and nuclear factor-kappa B and induces cell-cell adhesion and aortic smooth muscle cell proliferation.
  Journal
J Biol Chem 279:3188-96 (2004)
DOI:10.1074/jbc.M311660200
Reference
PMID:17371236
  Authors
Smith L, Webb A, Ward SG
  Title
T-lymphocyte navigation and migration: beyond the PI3K paradigm.
  Journal
Biochem Soc Trans 35:193-8 (2007)
DOI:10.1042/BST0350193
Reference
PMID:16144840
  Authors
Huttenrauch F, Pollok-Kopp B, Oppermann M
  Title
G protein-coupled receptor kinases promote phosphorylation and beta-arrestin-mediated internalization of CCR5 homo- and hetero-oligomers.
  Journal
J Biol Chem 280:37503-15 (2005)
DOI:10.1074/jbc.M500535200
Reference
PMID:18711432
  Authors
Thelen M, Stein JV
  Title
How chemokines invite leukocytes to dance.
  Journal
Nat Immunol 9:953-9 (2008)
DOI:10.1038/ni.f.207
Reference
PMID:19159344
  Authors
Ward SG, Marelli-Berg FM
  Title
Mechanisms of chemokine and antigen-dependent T-lymphocyte navigation.
  Journal
Biochem J 418:13-27 (2009)
DOI:10.1042/BJ20081969
Reference
PMID:15803148
  Authors
Schwartzberg PL, Finkelstein LD, Readinger JA
  Title
TEC-family kinases: regulators of T-helper-cell differentiation.
  Journal
Nat Rev Immunol 5:284-95 (2005)
DOI:10.1038/nri1591
Reference
PMID:15771581
  Authors
Berg LJ, Finkelstein LD, Lucas JA, Schwartzberg PL.
  Title
Tec family kinases in T lymphocyte development and function.
  Journal
Annu Rev Immunol 23:549-600 (2005)
DOI:10.1146/annurev.immunol.22.012703.104743
Reference
PMID:17496928
  Authors
Ticchioni M, Essafi M, Jeandel PY, Davi F, Cassuto JP, Deckert M, Bernard A
  Title
Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a.
  Journal
Oncogene 26:7081-91 (2007)
DOI:10.1038/sj.onc.1210519
Reference
PMID:9765254
  Authors
Korchak HM, Rossi MW, Kilpatrick LE
  Title
Selective role for beta-protein kinase C in signaling for O-2 generation but not degranulation or adherence in differentiated HL60 cells.
  Journal
J Biol Chem 273:27292-9 (1998)
DOI:10.1074/jbc.273.42.27292
Reference
PMID:15046611
  Authors
Johnson Z, Power CA, Weiss C, Rintelen F, Ji H, Ruckle T, Camps M, Wells TN, Schwarz MK, Proudfoot AE, Rommel C
  Title
Chemokine inhibition--why, when, where, which and how?
  Journal
Biochem Soc Trans 32:366-77 (2004)
DOI:10.1042/bst0320366
Reference
PMID:12051620
  Authors
Zhelev DV, Alteraifi A
  Title
Signaling in the motility responses of the human neutrophil.
  Journal
Ann Biomed Eng 30:356-70 (2002)
DOI:10.1114/1.1477446
Reference
PMID:17675482
  Authors
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS
  Title
Phospholipase cbeta is critical for T cell chemotaxis.
  Journal
J Immunol 179:2223-7 (2007)
DOI:10.4049/jimmunol.179.4.2223
Reference
PMID:14607270
  Authors
Hornstein I, Alcover A, Katzav S
  Title
Vav proteins, masters of the world of cytoskeleton organization.
  Journal
Cell Signal 16:1-11 (2004)
DOI:10.1016/S0898-6568(03)00110-4
Related
pathway
oro04010  MAPK signaling pathway
oro04060  Cytokine-cytokine receptor interaction
oro04120  Ubiquitin mediated proteolysis
oro04630  JAK-STAT signaling pathway
oro04670  Leukocyte transendothelial migration
oro04810  Regulation of actin cytoskeleton
KO pathway
ko04062   
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