KEGG   PATHWAY: pruf04510
Entry
pruf04510                   Pathway                                
Name
Focal adhesion - Pyrgilauda ruficollis (rufous-necked snowfinch)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
pruf04510  Focal adhesion
pruf04510

Other DBs
GO: 0005925
Organism
Pyrgilauda ruficollis (rufous-necked snowfinch) [GN:pruf]
Gene
121352898  COL1A2; collagen alpha-2(I) chain isoform X1 [KO:K06236]
121352454  COL1A1; collagen alpha-1(I) chain isoform X1 [KO:K06236]
121356096  COL2A1; collagen alpha-1(II) chain [KO:K19719]
121356170  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
121356172  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
121363152  COL4A6; collagen alpha-6(IV) chain isoform X1 [KO:K06237]
121363153  COL4A5; collagen alpha-5(IV) chain isoform X1 [KO:K06237]
121357939  COL4A4; collagen alpha-4(IV) chain [KO:K06237]
121357949  COL4A3; collagen alpha-3(IV) chain [KO:K06237]
121349614  COL6A3; collagen alpha-3(VI) chain [KO:K06238]
121355890  COL6A2; collagen alpha-2(VI) chain isoform X1 [KO:K06238]
121355894  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
121358902  COL9A1; collagen alpha-1(IX) chain [KO:K08131]
121359481  COL9A3; LOW QUALITY PROTEIN: collagen alpha-3(IX) chain [KO:K08131]
121359880  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
121358986  LAMA1; LOW QUALITY PROTEIN: laminin subunit alpha-1 [KO:K05637]
121354794  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
121359083  LAMA3; laminin subunit alpha-3 [KO:K06240]
121359452  LAMA5; LOW QUALITY PROTEIN: laminin subunit alpha-5 [KO:K06240]
121359279  LAMA4; laminin subunit alpha-4 [KO:K06241]
121357376  LAMB1; laminin subunit beta-1 [KO:K05636]
121349524  LAMB2; laminin subunit beta-2 [KO:K06243]
121350693  laminin subunit beta-2-like [KO:K06243]
121353934  LAMB3; laminin subunit beta-3 [KO:K06244]
121357377  LAMB4; laminin subunit beta-4 [KO:K06245]
121360076  LAMC1; laminin subunit gamma-1 [KO:K05635]
121360077  LAMC2; laminin subunit gamma-2 [KO:K06246]
121357573  LAMC3; laminin subunit gamma-3 [KO:K06247]
121363867  CHAD; chondroadherin [KO:K06248]
121357403  RELN; reelin [KO:K06249] [EC:3.4.21.-]
121349463  THBS1; thrombospondin-1 [KO:K16857]
121352697  cartilage oligomeric matrix protein isoform X1 [KO:K04659]
121354412  THBS2; thrombospondin-2 [KO:K04659]
121355364  THBS4; thrombospondin-4 isoform X1 [KO:K04659]
121352160  THBS3; thrombospondin-3 [KO:K04659]
121349601  FN1; fibronectin isoform X1 [KO:K05717]
121360406  SPP1; osteopontin [KO:K06250]
121361672  VTN; vitronectin [KO:K06251]
121358349  tenascin-X-like [KO:K06252]
121359806  TNR; tenascin-R isoform X1 [KO:K06252]
121357155  tenascin-X-like [KO:K06252]
121357484  TNC; tenascin isoform X1 [KO:K06252]
121349677  VWF; von Willebrand factor [KO:K03900]
121360255  bone sialoprotein 2 [KO:K06253]
121365275  ITGA1; integrin alpha-1 [KO:K06480]
121355334  ITGA2; integrin alpha-2 [KO:K06481]
121350552  ITGA2B; integrin alpha-IIb [KO:K06476]
121352441  ITGA3; integrin alpha-3 [KO:K06482]
121356718  ITGA4; integrin alpha-4 [KO:K06483]
121356550  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
121361497  integrin alpha-7-like [KO:K06583]
121365688  ITGA8; integrin alpha-8 [KO:K06584]
121353949  integrin alpha-9-like [KO:K06585]
121354578  LOW QUALITY PROTEIN: integrin alpha-10-like [KO:K06586]
121354332  ITGA11; integrin alpha-11 [KO:K06587]
121364364  ITGAV; integrin alpha-V [KO:K06487]
121364220  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
121350505  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
121363891  ITGB4; integrin beta-4 [KO:K06525]
121356607  ITGB5; integrin beta-5 [KO:K06588]
121356711  ITGB6; integrin beta-6 [KO:K06589]
121353126  ITGB8; integrin beta-8 [KO:K06591]
121350873  EMP2; epithelial membrane protein 2 [KO:K26256]
121350738  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
121361210  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
121364229  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
121360372  PDGFC; platelet-derived growth factor C [KO:K05450]
121360365  EGF; pro-epidermal growth factor [KO:K04357]
121363553  IGF1; insulin-like growth factor I [KO:K05459]
121358564  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
121356054  PGF; placenta growth factor isoform X1 [KO:K16859]
121360382  VEGFC; vascular endothelial growth factor C [KO:K05449]
121356236  VEGFD; vascular endothelial growth factor D [KO:K05449]
121357407  HGF; hepatocyte growth factor [KO:K05460]
121349389  PDGFRA; platelet-derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
121361297  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
121354271  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
121356907  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
121352949  EGFR; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
121364149  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
121362872  vascular endothelial growth factor receptor kdr-like isoform X1 [KO:K05096] [EC:2.7.10.1]
121361337  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
121355793  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
121351120  ERBB2; receptor tyrosine-protein kinase erbB-2 isoform X1 [KO:K05083] [EC:2.7.10.1]
121361226  EMP1; epithelial membrane protein 1 [KO:K26255]
121359688  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
121365350  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
121362524  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
121349586  RHOA; transforming protein RhoA [KO:K04513]
121359005  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
121359156  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
121365012  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform isoform X1 [KO:K10351]
121365900  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
121361676  MYL10; myosin regulatory light chain 10 [KO:K12756]
121359001  myosin regulatory light chain 2, smooth muscle minor isoform isoform X1 [KO:K12757]
121359002  myosin regulatory light chain 2, smooth muscle minor isoform-like [KO:K12757]
121358769  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [KO:K06269] [EC:3.1.3.16]
121364966  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
121355156  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
121352505  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
121365385  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X1 [KO:K12329]
121348636  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
121348877  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
121356511  MYLK; myosin light chain kinase, smooth muscle isoform X1 [KO:K00907] [EC:2.7.11.18]
121357753  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
121359182  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
121363347  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
121352409  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
121365545  actin, cytoplasmic type 5 [KO:K05692]
121350746  ACTB; actin, cytoplasmic 1 [KO:K05692]
121363408  ACTG1; actin, cytoplasmic 2 [KO:K05692]
121352245  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 [KO:K04349]
121357014  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
121349449  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
121354296  TLN2; talin-2 isoform X1 [KO:K06271]
121355493  TLN1; talin-1 isoform X1 [KO:K06271]
121349476  FLNB; filamin-B isoform X1 [KO:K27392]
121364811  PXN; paxillin isoform X1 [KO:K05760]
121355145  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
121354697  ZYX; zyxin isoform X1 [KO:K06273]
121356739  VCL; vinculin isoform X1 [KO:K05700]
121351893  PARVB; beta-parvin isoform X1 [KO:K06275]
121351901  PARVG; gamma-parvin [KO:K06275]
121363374  PARVA; alpha-parvin isoform X1 [KO:K06275]
121365851  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
121358263  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121358719  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
121351746  GSK3B; glycogen synthase kinase-3 beta [KO:K03083] [EC:2.7.11.26]
121352885  CTNNB1; catenin beta-1 isoform X1 [KO:K02105]
121363372  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
121365824  PRKCB; protein kinase C beta type [KO:K19662] [EC:2.7.11.13]
121360033  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
121364047  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
121353797  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
121349627  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
121355311  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
121361353  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
121361937  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
121356527  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
121360115  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
121362393  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
121350603  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
121361104  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
121352797  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
121350522  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
121364029  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
121362845  serine/threonine-protein kinase PAK 3-like [KO:K05733] [EC:2.7.11.1]
121363208  serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
121360732  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
121357114  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
121354786  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
121365792  CDC42; cell division control protein 42 homolog [KO:K04393]
121348806  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X1 [KO:K05726]
121364856  CRKL; crk-like protein [KO:K04438]
121361767  CRK; adapter molecule crk isoform X1 [KO:K04438]
121350046  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
121357576  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X1 [KO:K06277]
121353155  RAP1A; ras-related protein Rap-1A [KO:K04353]
121352517  RAP1B; ras-related protein Rap-1b [KO:K07836]
121365224  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
121350038  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
121361485  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
121361966  JUN; transcription factor AP-1 [KO:K04448]
121364303  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
121355767  CAV1; caveolin-1 isoform X1 [KO:K06278]
121355783  CAV2; caveolin-2 [KO:K12958]
121352671  CAV3; caveolin-3 [KO:K12959]
121359270  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
121352206  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
121361768  SHC2; SHC-transforming protein 2 [KO:K17447]
121363937  SHC3; SHC-transforming protein 3 [KO:K17448]
121354436  SHC4; SHC-transforming protein 4 [KO:K17449]
121363830  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
121358630  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
121348679  SOS2; son of sevenless homolog 2 [KO:K03099]
121360994  HRAS; GTPase HRas [KO:K02833]
121349059  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
121354353  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
121365143  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
121349085  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
121364327  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
121354002  CCND3; G1/S-specific cyclin-D3 [KO:K10152]
121364160  inhibitor of apoptosis protein-like [KO:K16060]
121363028  E3 ubiquitin-protein ligase XIAP isoform X1 [KO:K04725] [EC:2.3.2.27]
121358052  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
pruf04010  MAPK signaling pathway
pruf04060  Cytokine-cytokine receptor interaction
pruf04070  Phosphatidylinositol signaling system
pruf04110  Cell cycle
pruf04310  Wnt signaling pathway
pruf04512  ECM-receptor interaction
pruf04810  Regulation of actin cytoskeleton
KO pathway
ko04510   
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