KEGG   PATHWAY: puc05207
Entry
puc05207                    Pathway                                
Name
Chemical carcinogenesis - receptor activation - Panthera uncia (snow leopard)
Description
Carcinogenesis is a multistage process that consists of initiation, promotion, and progression stages. Chemicals or environmental factors may act at any of these stages to induce and/or enhance the carcinogenic process. Based on their mode-of-action, carcinogens can be classified as genotoxic or non-genotoxic. Genotoxic agent begins their action at the deoxyribonucleic acid (DNA) level, causing DNA damage through several mechanisms. Non-genotoxic carcinogens are chemicals that cause the development of tumors through multiple non-genotoxic events and epigenetic alterations without direct interaction with DNA. One non-genotoxic mechanism involves receptor activation. Biological mechanisms involving receptor activation fall into two broad categories: (i) those that involve cell surface receptors and some intracellular receptors that activate signal transduction pathways, resulting in biological responses, including gene transcription, and (ii) those that involve intracellular receptors that translocate into the nucleus and act as transcription factors regulating gene expression. Both classes of receptors can be involved in mechanisms of carcinogenesis.
Class
Human Diseases; Cancer: overview
Pathway map
puc05207  Chemical carcinogenesis - receptor activation
puc05207

Organism
Panthera uncia (snow leopard) [GN:puc]
Gene
125910412  CHRNA7-FAM7A fusion protein [KO:K04809]
125937611  beta-arrestin-1 isoform X1 [KO:K04439]
125927085  beta-arrestin-2 isoform X1 [KO:K04439]
125936631  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
125930728  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
125933773  retinoblastoma-associated protein isoform X1 [KO:K06618]
125936106  transcription factor E2F1 [KO:K17454]
125926304  baculoviral IAP repeat-containing protein 5 [KO:K08731]
125932285  E3 ubiquitin-protein ligase XIAP [KO:K04725] [EC:2.3.2.27]
125926499  cell division control protein 6 homolog [KO:K02213]
125930666  M-phase inducer phosphatase 1 isoform X1 [KO:K06645] [EC:3.1.3.48]
125931060  tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
125926571  signal transducer and activator of transcription 3 isoform X1 [KO:K04692]
125925487  inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1 [KO:K07211] [EC:2.7.11.10]
125930010  G1/S-specific cyclin-D1 [KO:K04503]
125936413  neuronal acetylcholine receptor subunit alpha-4 [KO:K04806]
125925845  neuronal acetylcholine receptor subunit beta-2 [KO:K04813]
125910862  neuronal acetylcholine receptor subunit alpha-3 [KO:K04805]
125920056  voltage-dependent L-type calcium channel subunit alpha-1C isoform X1 [KO:K04850]
125931680  voltage-dependent L-type calcium channel subunit alpha-1F isoform X1 [KO:K04853]
125925380  voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
125928736  LOW QUALITY PROTEIN: voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
125921850  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
125913143  LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
125921289  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
125913493  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
125935698  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
125929237  phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
125915806  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125909102  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
125925091  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
125913121  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
125923687  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
125912163  transcription factor p65 [KO:K04735]
125937753  GTPase HRas isoform X1 [KO:K02833]
125918906  GTPase KRas isoform X1 [KO:K07827]
125912218  GTPase NRas [KO:K07828]
125910082  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
125918032  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125918034  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
125914884  mitogen-activated protein kinase 1 isoform X1 [KO:K04371] [EC:2.7.11.24]
125928028  mitogen-activated protein kinase 3 isoform X1 [KO:K04371] [EC:2.7.11.24]
125909334  protein c-Fos [KO:K04379]
125912547  transcription factor Jun [KO:K04448]
125924410  myc proto-oncogene protein [KO:K04377]
125914709  apoptosis regulator Bcl-2 [KO:K02161]
125927372  protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
125927972  protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
125915497  protein kinase C gamma type isoform X1 [KO:K19663] [EC:2.7.11.13]
125938202  vascular endothelial growth factor A [KO:K05448]
125923095  fibroblast growth factor 2 [KO:K18497]
125933165  beta-1 adrenergic receptor [KO:K04141]
125934571  beta-2 adrenergic receptor [KO:K04142]
125924003  beta-3 adrenergic receptor [KO:K04143]
125917302  neuroendocrine secretory protein 55 [KO:K04632]
125918189  neuroendocrine secretory protein 55 [KO:K04632]
125936451  guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas isoform X1 [KO:K04632]
125930396  adenylate cyclase type 1 [KO:K08041] [EC:4.6.1.1]
125934726  adenylate cyclase type 2 isoform X1 [KO:K08042] [EC:4.6.1.1]
125937626  adenylate cyclase type 3 isoform X1 [KO:K08043] [EC:4.6.1.1]
125909634  adenylate cyclase type 4 isoform X1 [KO:K08044] [EC:4.6.1.1]
125921018  adenylate cyclase type 5 [KO:K08045] [EC:4.6.1.1]
125919005  adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
125915408  adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
125924401  adenylate cyclase type 8 [KO:K08048] [EC:4.6.1.1]
125926198  adenylate cyclase type 9 [KO:K08049] [EC:4.6.1.1]
125912461  cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
125929088  cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
125911260  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
125911819  cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
125919632  cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
125930188  cyclic AMP-responsive element-binding protein 3-like protein 2 [KO:K09048]
125925743  cyclic AMP-responsive element-binding protein 3-like protein 4 [KO:K09048]
125934155  cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
125919439  cyclic AMP-responsive element-binding protein 3 isoform X1 [KO:K09048]
125928859  cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
125930855  cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
125938414  cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
125929389  guanine nucleotide-binding protein G(i) subunit alpha-2 [KO:K04630]
125929845  guanine nucleotide-binding protein G(i) subunit alpha-1 [KO:K04630]
125912291  guanine nucleotide-binding protein G(i) subunit alpha-3 [KO:K04630]
125931741  bcl2-associated agonist of cell death [KO:K02158]
125923579  neuronal acetylcholine receptor subunit alpha-9 [KO:K04810]
125931535  ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
125939048  ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
125931793  ribosomal protein S6 kinase alpha-6 [KO:K04373] [EC:2.7.11.1]
125912889  ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
125908725  estrogen receptor beta [KO:K08551]
125920196  vitamin D3 receptor [KO:K08539]
125938244  G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
125929783  epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
125926370  growth factor receptor-bound protein 2 [KO:K04364]
125909520  son of sevenless homolog 2 isoform X1 [KO:K03099]
125917913  son of sevenless homolog 1 [KO:K03099]
125917917  son of sevenless homolog 1 [KO:K03099]
125923271  eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
125930574  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
125926762  ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
125912927  membrane progestin receptor alpha [KO:K25039]
125938565  membrane progestin receptor beta [KO:K25040]
125908920  membrane progestin receptor gamma isoform X1 [KO:K25041]
125914903  progesterone receptor isoform X1 [KO:K08556]
125933815  tumor necrosis factor ligand superfamily member 11 [KO:K05473]
125926570  LOW QUALITY PROTEIN: signal transducer and activator of transcription 5A-like [KO:K11223]
125926542  signal transducer and activator of transcription 5B isoform X1 [KO:K11224]
125921820  B-cell lymphoma 6 protein [KO:K15618]
125933866  Krueppel-like factor 5 isoform X1 [KO:K09206]
125920350  Krueppel-like factor 4 isoform X1 [KO:K17846]
125920405  proto-oncogene Wnt-1 [KO:K03209]
125913263  neurogenic locus notch homolog protein 2 isoform X1 [KO:K20994]
125936815  protein jagged-1 [KO:K06052]
125932188  androgen receptor [KO:K08557]
125923024  pro-epidermal growth factor isoform X1 [KO:K04357]
125922856  fibroblast growth factor 5 [KO:K04358]
125923316  fibroblast growth factor 17 [KO:K04358]
125923425  fibroblast growth factor 20 [KO:K04358]
125915576  fibroblast growth factor 4 [KO:K04358]
125931780  fibroblast growth factor 16 [KO:K04358]
125908857  fibroblast growth factor 7 [KO:K04358]
125932896  fibroblast growth factor 8 [KO:K04358]
125911102  fibroblast growth factor 3 [KO:K04358]
125918741  fibroblast growth factor 6 [KO:K04358]
125934060  fibroblast growth factor 9 isoform X1 [KO:K04358]
125934607  fibroblast growth factor 10 [KO:K04358]
125928773  fibroblast growth factor 22 [KO:K04358]
125915207  delta-like protein 3 [KO:K06051]
125939075  delta-like protein 1 [KO:K06051]
125909877  delta-like protein 4 [KO:K06051]
125920266  prostaglandin E synthase 3 isoform X1 [KO:K15730] [EC:5.3.99.3]
125930510  AH receptor-interacting protein isoform X1 [KO:K17767]
125927127  aryl-hydrocarbon-interacting protein-like 1 [KO:K17767]
125929981  aryl hydrocarbon receptor [KO:K09093]
125920637  aryl hydrocarbon receptor-like [KO:K09093]
125937878  heat shock protein HSP 90-beta [KO:K04079]
125909153  heat shock protein HSP 90-alpha [KO:K04079]
125919493  endoplasmin isoform X1 [KO:K09487]
125920998  importin subunit alpha-5 isoform X1 [KO:K23940]
125927364  importin subunit alpha-1 [KO:K15043]
125928573  importin subunit alpha-8 [KO:K15043]
125933753  importin subunit alpha-4 [KO:K23583]
125921196  importin subunit alpha-3 isoform X1 [KO:K23583]
125938843  importin subunit alpha-6 [KO:K15042]
125912835  importin subunit alpha-7 isoform X1 [KO:K15042]
125927287  importin subunit beta-1 [KO:K14293]
125912122  aryl hydrocarbon receptor nuclear translocator isoform X1 [KO:K09097]
125910157  cytochrome P450 1A1 [KO:K07408] [EC:1.14.14.1]
125937522  cytochrome P450 1B1 [KO:K07410] [EC:1.14.14.1]
125917789  epoxide hydrolase 1-like [KO:K01253] [EC:3.3.2.9]
125917793  epoxide hydrolase 1-like [KO:K01253] [EC:3.3.2.9]
125923805  bifunctional epoxide hydrolase 2 isoform X1 [KO:K08726] [EC:3.3.2.10 3.1.3.76]
125929153  epoxide hydrolase 3 [KO:K22368] [EC:3.3.2.10]
125913368  epoxide hydrolase 4 [KO:K22369] [EC:3.3.-.-]
125914029  glutathione S-transferase theta-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
125914031  glutathione S-transferase theta-3-like [KO:K00799] [EC:2.5.1.18]
125914033  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
125914034  glutathione S-transferase theta-4-like [KO:K00799] [EC:2.5.1.18]
125914630  LOW QUALITY PROTEIN: glutathione S-transferase theta-2B-like [KO:K00799] [EC:2.5.1.18]
125938214  glutathione S-transferase-like [KO:K00799] [EC:2.5.1.18]
125938572  LOW QUALITY PROTEIN: glutathione S-transferase A4-like [KO:K00799] [EC:2.5.1.18]
125938573  glutathione S-transferase A2 [KO:K00799] [EC:2.5.1.18]
125938574  glutathione S-transferase A4 [KO:K00799] [EC:2.5.1.18]
125938576  glutathione S-transferase alpha M14-like [KO:K00799] [EC:2.5.1.18]
125923708  microsomal glutathione S-transferase 2 [KO:K00799] [EC:2.5.1.18]
125932940  glutathione S-transferase omega-1 isoform X1 [KO:K00799] [EC:2.5.1.18]
125932941  glutathione S-transferase omega-2 isoform X1 [KO:K00799] [EC:2.5.1.18]
125925943  microsomal glutathione S-transferase 3 [KO:K00799] [EC:2.5.1.18]
125918878  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
125912286  glutathione S-transferase Mu 3 [KO:K00799] [EC:2.5.1.18]
125912288  glutathione S-transferase Mu 4-like [KO:K00799] [EC:2.5.1.18]
125922780  UDP-glucuronosyltransferase 2C1-like [KO:K00699] [EC:2.4.1.17]
125922781  UDP-glucuronosyltransferase 2A2 isoform X1 [KO:K00699] [EC:2.4.1.17]
125911043  UDP-glucuronosyltransferase 1A1 [KO:K00699] [EC:2.4.1.17]
125911044  UDP-glucuronosyltransferase 1A3-like [KO:K00699] [EC:2.4.1.17]
125915742  cytochrome P450 2B11-like isoform X1 [KO:K07412] [EC:1.14.14.1]
125925579  nuclear receptor subfamily 1 group I member 3 isoform X1 [KO:K08541]
125922972  retinoic acid receptor RXR-alpha [KO:K08524]
125938378  retinoic acid receptor RXR-beta isoform X1 [KO:K08525]
125925934  retinoic acid receptor RXR-gamma isoform X1 [KO:K08526]
125928549  cytochrome P450 3A12 isoform X1 [KO:K07424] [EC:1.14.14.1]
125910173  cytochrome P450 1A2 [KO:K07409] [EC:1.14.14.1]
125919714  peroxisome proliferator-activated receptor alpha [KO:K07294]
Compound
C00076  Calcium cation
C00410  Progesterone
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00745  Nicotine
C00780  Serotonin
C00788  L-Adrenaline
C00951  Estradiol-17beta
C03690  Bis(2-ethylhexyl)phthalate
C04623  DDT
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C06697  Arsenite
C06790  Trichloroethene
C06916  Clofibrate
C07020  Gemfibrozil
C07434  Phenobarbital
C07535  Benzo[a]pyrene
C07557  2,3,7,8-Tetrachlorodibenzodioxin
C08150  Medroxyprogesterone acetate
C11042  Hexachlorobenzene
C11150  Trichloroacetate
C11371  Nafenopin
C11906  Sodium arsenite
C13624  Bisphenol A
C14240  Di(2-ethylhexyl) adipate
C14573  3,3',4,4',5-Pentachlorobiphenyl
C15995  Bombesin
C16452  N'-Nitrosonornicotine
C16453  4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone
Reference
PMID:15660110
  Authors
Luch A.
  Title
Nature and nurture - lessons from chemical carcinogenesis.
  Journal
Nat Rev Cancer 5:113-25 (2005)
DOI:10.1038/nrc1546
Reference
PMID:19631282
  Authors
Hernandez LG, van Steeg H, Luijten M, van Benthem J
  Title
Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach.
  Journal
Mutat Res 682:94-109 (2009)
DOI:10.1016/j.mrrev.2009.07.002
Reference
PMID:21444681
  Authors
Wu CH, Lee CH, Ho YS
  Title
Nicotinic acetylcholine receptor-based blockade: applications of molecular targets for cancer therapy.
  Journal
Clin Cancer Res 17:3533-41 (2011)
DOI:10.1158/1078-0432.CCR-10-2434
Reference
PMID:19194381
  Authors
Schuller HM
  Title
Is cancer triggered by altered signalling of nicotinic acetylcholine receptors?
  Journal
Nat Rev Cancer 9:195-205 (2009)
DOI:10.1038/nrc2590
Reference
PMID:21541211
  Authors
Singh S, Pillai S, Chellappan S
  Title
Nicotinic acetylcholine receptor signaling in tumor growth and metastasis.
  Journal
J Oncol 2011:456743 (2011)
DOI:10.1155/2011/456743
Reference
PMID:31956359
  Authors
Cheng WL, Chen KY, Lee KY, Feng PH, Wu SM
  Title
Nicotinic-nAChR signaling mediates drug resistance in lung cancer.
  Journal
J Cancer 11:1125-1140 (2020)
DOI:10.7150/jca.36359
Reference
PMID:24827506
  Authors
Grando SA
  Title
Connections of nicotine to cancer.
  Journal
Nat Rev Cancer 14:419-29 (2014)
DOI:10.1038/nrc3725
Reference
PMID:24398389
  Authors
Schaal C, Chellappan SP
  Title
Nicotine-mediated cell proliferation and tumor progression in smoking-related cancers.
  Journal
Mol Cancer Res 12:14-23 (2014)
DOI:10.1158/1541-7786.MCR-13-0541
Reference
PMID:21640716
  Authors
Improgo MR, Tapper AR, Gardner PD
  Title
Nicotinic acetylcholine receptor-mediated mechanisms in lung cancer.
  Journal
Biochem Pharmacol 82:1015-21 (2011)
DOI:10.1016/j.bcp.2011.05.020
Reference
PMID:18262664
  Authors
Egleton RD, Brown KC, Dasgupta P
  Title
Nicotinic acetylcholine receptors in cancer: multiple roles in proliferation and inhibition of apoptosis.
  Journal
Trends Pharmacol Sci 29:151-8 (2008)
DOI:10.1016/j.tips.2007.12.006
Reference
PMID:24830349
  Authors
Xue J, Yang S, Seng S
  Title
Mechanisms of Cancer Induction by Tobacco-Specific NNK and NNN.
  Journal
Cancers (Basel) 6:1138-56 (2014)
DOI:10.3390/cancers6021138
Reference
PMID:21801603
  Authors
Wen J, Fu JH, Zhang W, Guo M
  Title
Lung carcinoma signaling pathways activated by smoking.
  Journal
Chin J Cancer 30:551-8 (2011)
DOI:10.5732/cjc.011.10059
Reference
PMID:28664511
  Authors
Gankhuyag N, Lee KH, Cho JY
  Title
The Role of Nitrosamine (NNK) in Breast Cancer Carcinogenesis.
  Journal
J Mammary Gland Biol Neoplasia 22:159-170 (2017)
DOI:10.1007/s10911-017-9381-z
Reference
PMID:22330135
  Authors
Guo J, Kim D, Gao J, Kurtyka C, Chen H, Yu C, Wu D, Mittal A, Beg AA, Chellappan SP, Haura EB, Cheng JQ
  Title
IKBKE is induced by STAT3 and tobacco carcinogen and determines chemosensitivity in non-small cell lung cancer.
  Journal
Oncogene 32:151-9 (2013)
DOI:10.1038/onc.2012.39
Reference
PMID:20106947
  Authors
Chen RJ, Ho YS, Guo HR, Wang YJ
  Title
Long-term nicotine exposure-induced chemoresistance is mediated by activation of Stat3 and downregulation of ERK1/2 via nAChR and beta-adrenoceptors in human bladder cancer cells.
  Journal
Toxicol Sci 115:118-30 (2010)
DOI:10.1093/toxsci/kfq028
Reference
PMID:20953833
  Authors
Lee CH, Chang YC, Chen CS, Tu SH, Wang YJ, Chen LC, Chang YJ, Wei PL, Chang HW, Chang CH, Huang CS, Wu CH, Ho YS
  Title
Crosstalk between nicotine and estrogen-induced estrogen receptor activation induces alpha9-nicotinic acetylcholine receptor expression in human breast cancer cells.
  Journal
Breast Cancer Res Treat 129:331-45 (2011)
DOI:10.1007/s10549-010-1209-0
Reference
PMID:16421368
  Authors
Yager JD, Davidson NE
  Title
Estrogen carcinogenesis in breast cancer.
  Journal
N Engl J Med 354:270-82 (2006)
DOI:10.1056/NEJMra050776
Reference
PMID:29229539
  Authors
Murata M, Kang JH
  Title
Bisphenol A (BPA) and cell signaling pathways.
  Journal
Biotechnol Adv 36:311-327 (2018)
DOI:10.1016/j.biotechadv.2017.12.002
Reference
PMID:28251049
  Authors
Wang Z, Liu H, Liu S
  Title
Low-Dose Bisphenol A Exposure: A Seemingly Instigating Carcinogenic Effect on Breast Cancer.
  Journal
Adv Sci (Weinh) 4:1600248 (2017)
DOI:10.1002/advs.201600248
Reference
PMID:28426875
  Authors
Sauer SJ, Tarpley M, Shah I, Save AV, Lyerly HK, Patierno SR, Williams KP, Devi GR
  Title
Bisphenol A activates EGFR and ERK promoting proliferation, tumor spheroid formation and resistance to EGFR pathway inhibition in estrogen receptor-negative inflammatory breast cancer cells.
  Journal
Carcinogenesis 38:252-260 (2017)
DOI:10.1093/carcin/bgx003
Reference
PMID:29769245
  Authors
Chen QY, Costa M
  Title
PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis.
  Journal
Mol Pharmacol 94:784-792 (2018)
DOI:10.1124/mol.118.112268
Reference
PMID:32867363
  Authors
Pedroza DA, Subramani R, Lakshmanaswamy R
  Title
Classical and Non-Classical Progesterone Signaling in Breast Cancers.
  Journal
Cancers (Basel) 12:E2440 (2020)
DOI:10.3390/cancers12092440
Reference
PMID:26265122
  Authors
Finlay-Schultz J, Sartorius CA
  Title
Steroid hormones, steroid receptors, and breast cancer stem cells.
  Journal
J Mammary Gland Biol Neoplasia 20:39-50 (2015)
DOI:10.1007/s10911-015-9340-5
Reference
PMID:27368976
  Authors
Valadez-Cosmes P, Vazquez-Martinez ER, Cerbon M, Camacho-Arroyo I
  Title
Membrane progesterone receptors in reproduction and cancer.
  Journal
Mol Cell Endocrinol 434:166-75 (2016)
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PMID:33014829
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Chen B, Ye P, Chen Y, Liu T, Cha JH, Yan X, Yang WH
  Title
Involvement of the Estrogen and Progesterone Axis in Cancer Stemness: Elucidating Molecular Mechanisms and Clinical Significance.
  Journal
Front Oncol 10:1657 (2020)
DOI:10.3389/fonc.2020.01657
Reference
PMID:25568920
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Murray IA, Patterson AD, Perdew GH
  Title
Aryl hydrocarbon receptor ligands in cancer: friend and foe.
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Nat Rev Cancer 14:801-14 (2014)
DOI:10.1038/nrc3846
Reference
PMID:30003042
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Larigot L, Juricek L, Dairou J, Coumoul X
  Title
AhR signaling pathways and regulatory functions.
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Biochim Open 7:1-9 (2018)
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PMID:27980293
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Kawajiri K, Fujii-Kuriyama Y
  Title
The aryl hydrocarbon receptor: a multifunctional chemical sensor for host defense and homeostatic maintenance.
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Exp Anim 66:75-89 (2017)
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PMID:31552251
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Hidaka T, Fujimura T, Aiba S
  Title
Aryl Hydrocarbon Receptor Modulates Carcinogenesis and Maintenance of Skin Cancers.
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Front Med (Lausanne) 6:194 (2019)
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PMID:15900503
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Mandal PK
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Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology.
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J Comp Physiol B 175:221-30 (2005)
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Impact of endocrine disruptor hexachlorobenzene on the mammary gland and breast cancer: The story thus far.
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Environ Res 173:330-341 (2019)
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Zarate LV, Pontillo CA, Espanol A, Miret NV, Chiappini F, Cocca C, Alvarez L, de Pisarev DK, Sales ME, Randi AS
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Angiogenesis signaling in breast cancer models is induced by hexachlorobenzene and chlorpyrifos, pesticide ligands of the aryl hydrocarbon receptor.
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Toxicol Appl Pharmacol 401:115093 (2020)
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Defining molecular sensors to assess long-term effects of pesticides on carcinogenesis.
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Int J Mol Sci 15:17148-61 (2014)
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Cigarette smoke as a trigger for the dioxin receptor-mediated signaling pathway.
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Cancer Lett 252:184-94 (2007)
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Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis.
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Environ Health Perspect 124:713-21 (2016)
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Yoshinari K
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Role of Nuclear Receptors PXR and CAR in Xenobiotic-Induced Hepatocyte Proliferation and Chemical Carcinogenesis.
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Biol Pharm Bull 42:1243-1252 (2019)
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Yoo HS, Cichocki JA, Kim S, Venkatratnam A, Iwata Y, Kosyk O, Bodnar W, Sweet S, Knap A, Wade T, Campbell J, Clewell HJ, Melnyk SB, Chiu WA, Rusyn I
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The Contribution of Peroxisome Proliferator-Activated Receptor Alpha to the Relationship Between Toxicokinetics and Toxicodynamics of Trichloroethylene.
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Toxicol Sci 147:339-49 (2015)
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PMID:20414453
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Pyper SR, Viswakarma N, Yu S, Reddy JK
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PPARalpha: energy combustion, hypolipidemia, inflammation and cancer.
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Nucl Recept Signal 8:e002 (2010)
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PMID:20049115
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Guyton KZ, Chiu WA, Bateson TF, Jinot J, Scott CS, Brown RC, Caldwell JC
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A reexamination of the PPAR-alpha activation mode of action as a basis for assessing human cancer risks of environmental contaminants.
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Environ Health Perspect 117:1664-72 (2009)
DOI:10.1289/ehp.0900758
Related
pathway
puc00980  Metabolism of xenobiotics by cytochrome P450
puc03320  PPAR signaling pathway
puc04010  MAPK signaling pathway
puc04024  cAMP signaling pathway
puc04150  mTOR signaling pathway
puc04151  PI3K-Akt signaling pathway
puc04370  VEGF signaling pathway
puc04915  Estrogen signaling pathway
puc05204  Chemical carcinogenesis - DNA adducts
puc05206  MicroRNAs in cancer
puc05208  Chemical carcinogenesis - reactive oxygen species
KO pathway
ko05207   
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