Entry
Name
Cytokine-cytokine receptor interaction - Pteropus vampyrus (large flying fox)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
pvp04060 Cytokine-cytokine receptor interaction
Ortholog table
Organism
Pteropus vampyrus (large flying fox) [GN:
pvp ]
Gene
105292342 growth-regulated protein homolog gamma-like isoform X1 [KO:K05505 ]
105293539 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
105303985 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
105303983 IL36RN; LOW QUALITY PROTEIN: interleukin-36 receptor antagonist protein [KO:K05483 ]
105297143 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
105301084 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
105299797 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
105292647 TNFSF15; tumor necrosis factor ligand superfamily member 15 isoform X1 [KO:K05478 ]
105305707 TNFSF10; tumor necrosis factor ligand superfamily member 10 [KO:K04721 ]
105298465 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
105291216 tumor necrosis factor ligand superfamily member 12 isoform X2 [KO:K05474 ]
105292648 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
105301107 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
105299794 TNFSF4; tumor necrosis factor ligand superfamily member 4 isoform X1 [KO:K05469 ]
105299795 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
105291217 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X1 [KO:K05475 ]
105301326 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
105311245 LOW QUALITY PROTEIN: bone morphogenetic protein 8B-like [KO:K16622 ]
105311493 IL2RB; interleukin-2 receptor subunit beta isoform X1 [KO:K05069 ]
105308006 granulocyte-macrophage colony-stimulating factor receptor subunit alpha-like [KO:K05066 ]
105290707 CSF3R; granulocyte colony-stimulating factor receptor [KO:K05061 ]
105299364 IL6ST; interleukin-6 receptor subunit beta isoform X1 [KO:K05060 ]
105306439 IL11RA; interleukin-11 receptor subunit alpha isoform X4 [KO:K05056 ]
105296672 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
105308496 IL27RA; interleukin-27 receptor subunit alpha isoform X1 [KO:K19598 ]
105306433 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
105300827 IL20RB; interleukin-20 receptor subunit beta isoform X5 [KO:K05137 ]
105306481 IL1RAP; interleukin-1 receptor accessory protein isoform X1 [KO:K04723 ]
105295979 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A [KO:K03158 ]
105294424 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B [KO:K05141 ]
105295976 LTBR; tumor necrosis factor receptor superfamily member 3 isoform X3 [KO:K03159 ]
105311736 tumor necrosis factor receptor superfamily member 14-like [KO:K05152 ]
105301465 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
105293104 FAS; tumor necrosis factor receptor superfamily member 6 isoform X5 [KO:K04390 ]
105297674 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X3 [KO:K05160 ]
105296657 TNFRSF10B; tumor necrosis factor receptor superfamily member 10B [KO:K04722 ]
105288521 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
105302315 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
105299649 EDA2R; tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
105295432 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
105292242 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
105292754 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A [KO:K05147 ]
105303124 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
105294356 TNFRSF8; tumor necrosis factor receptor superfamily member 8 [KO:K05145 ]
105298191 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
105297664 TNFRSF9; tumor necrosis factor receptor superfamily member 9 [KO:K05146 ]
105303568 TNFRSF4; tumor necrosis factor receptor superfamily member 4 [KO:K05142 ]
105303592 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
105290933 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
105304160 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
105298032 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C [KO:K05151 ]
105293304 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
105303643 RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway
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