KEGG   PATHWAY: tmu05167
Entry
tmu05167                    Pathway                                
Name
Kaposi sarcoma-associated herpesvirus infection - Trichechus manatus latirostris (Florida manatee)
Description
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV-8), is the most recently identified human tumor virus, and is associated with the pathogenesis of Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and Multicentric Castleman's disease (MCD). Like all other herpesviruses, KSHV displays two modes of life cycle, latency and lytic replication, which are characterized by the patterns of viral gene expression. Genes expressed in latency (LANA, v-cyclin, v-FLIP, Kaposins A, B and C and viral miRNAs) are mainly thought to facilitate the establishment of life long latency in its host and survival against the host innate, and adaptive immune surveillance mechanisms. Among the viral proteins shown to be expressed during lytic replication are potent signaling molecules such as vGPCR, vIL6, vIRFs, vCCLs, K1 and K15, which have been implicated experimentally in the angiogenic and inflammatory phenotype observed in KS lesions. Several of these latent viral and lytic proteins are known to transform host cells, linking KSHV with the development of severe human malignancies.
Class
Human Diseases; Infectious disease: viral
Pathway map
tmu05167  Kaposi sarcoma-associated herpesvirus infection
tmu05167

Organism
Trichechus manatus latirostris (Florida manatee) [GN:tmu]
Gene
101350977  complement C3 [KO:K03990]
101357653  toll-like receptor 3 isoform X1 [KO:K05401]
101358234  TIR domain-containing adapter molecule 1 [KO:K05842]
101347503  TNF receptor-associated factor 3 isoform X1 [KO:K03174]
101344779  inhibitor of nuclear factor kappa-B kinase subunit epsilon [KO:K07211] [EC:2.7.11.10]
101345902  serine/threonine-protein kinase TBK1 isoform X3 [KO:K05410] [EC:2.7.11.10]
101352078  interferon regulatory factor 7 [KO:K09447]
101341058  interferon alpha-5-like [KO:K05414]
101341314  interferon alpha-5-like [KO:K05414]
101341564  interferon alpha-5-like [KO:K05414]
101343075  interferon alpha-5-like [KO:K05414]
101342581  interferon alpha-5-like [KO:K05414]
101342828  interferon alpha-5-like [KO:K05414]
101350125  interferon alpha-5-like [KO:K05414]
101344616  interferon alpha-5-like [KO:K05414]
101343586  interferon alpha-5-like [KO:K05414]
101345099  interferon alpha-5-like [KO:K05414]
101348880  interferon regulatory factor 3 [KO:K05411]
101344282  CREB-binding protein [KO:K04498] [EC:2.3.1.48]
101349614  histone acetyltransferase p300 [KO:K04498] [EC:2.3.1.48]
101349610  interferon beta [KO:K05415]
101361715  interferon alpha/beta receptor 1 isoform X1 [KO:K05130]
101354122  interferon alpha/beta receptor 2 [KO:K05131]
101346613  tyrosine-protein kinase JAK1 [KO:K11217] [EC:2.7.10.2]
101357635  non-receptor tyrosine-protein kinase TYK2 [KO:K11219] [EC:2.7.10.2]
101357916  signal transducer and activator of transcription 1-alpha/beta [KO:K11220]
101348948  signal transducer and activator of transcription 2 [KO:K11221]
101354811  interferon regulatory factor 9 [KO:K04693]
101359071  interferon-induced, double-stranded RNA-activated protein kinase isoform X2 [KO:K16195] [EC:2.7.11.1]
101352466  mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
101347350  mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
101361614  mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
101361872  mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
101342996  MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
101344286  dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
101361138  mRNA decay activator protein ZFP36 [KO:K15308]
101351590  interleukin-6 [KO:K05405]
101357995  granulocyte-macrophage colony-stimulating factor [KO:K05427]
101358798  C-C chemokine receptor type 3 [KO:K04178]
101341365  C-C chemokine receptor type 5 [KO:K04180]
101358538  C-C chemokine receptor type 1 isoform X2 [KO:K04176]
101351151  C-C chemokine receptor type 4 [KO:K04179]
101342927  C-C chemokine receptor type 8 isoform X1 [KO:K04183]
101346704  tumor necrosis factor receptor superfamily member 6 isoform X1 [KO:K04390]
101352734  FAS-associated death domain protein [KO:K02373]
101344302  caspase-8 isoform X1 [KO:K04398] [EC:3.4.22.61]
101356396  BH3-interacting domain death agonist [KO:K04726]
101356564  apoptosis regulator BAX [KO:K02159]
101341201  bcl-2 homologous antagonist/killer [KO:K14021]
101355182  LOW QUALITY PROTEIN: cytochrome c, testis-specific-like [KO:K08738]
101354940  LOW QUALITY PROTEIN: cytochrome c-like [KO:K08738]
101340375  cytochrome c [KO:K08738]
101351271  cytochrome c-like [KO:K08738]
101355103  caspase-9 [KO:K04399] [EC:3.4.22.62]
101354307  caspase-3 isoform X1 [KO:K02187] [EC:3.4.22.56]
101341867  tumor necrosis factor receptor superfamily member 1A [KO:K03158]
101341635  tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
101354911  TNF receptor-associated factor 2 [KO:K03173] [EC:2.3.2.27]
101341290  inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
101351256  inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
101347574  NF-kappa-B essential modulator isoform X1 [KO:K07210]
101355353  NF-kappa-B inhibitor alpha [KO:K04734]
101351866  nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101361706  transcription factor p65 [KO:K04735]
101351852  cellular tumor antigen p53 [KO:K04451]
101342008  cyclin-dependent kinase inhibitor 1 isoform X2 [KO:K06625]
101355276  cyclin-dependent kinase 4 isoform X1 [KO:K02089] [EC:2.7.11.22]
101355952  retinoblastoma-associated protein isoform X3 [KO:K06618]
101357348  transcription factor E2F1 [KO:K17454]
101357556  transcription factor E2F2 [KO:K09389]
101346679  transcription factor E2F3 isoform X1 [KO:K06620]
101359320  HLA class I histocompatibility antigen, A-80 alpha chain-like [KO:K06751]
101345748  H-2 class I histocompatibility antigen, Q10 alpha chain-like isoform X3 [KO:K06751]
101346884  HLA class I histocompatibility antigen, A-80 alpha chain-like [KO:K06751]
101347138  HLA class I histocompatibility antigen, B-40 alpha chain-like isoform X1 [KO:K06751]
101345854  class I histocompatibility antigen, Gogo-B*0101 alpha chain-like isoform X1 [KO:K06751]
101350180  patr class I histocompatibility antigen, B-1 alpha chain-like isoform X1 [KO:K06751]
101346109  class I histocompatibility antigen, Gogo-B*0102 alpha chain-like isoform X1 [KO:K06751]
101346365  class I histocompatibility antigen, Gogo-B*0103 alpha chain-like [KO:K06751]
101340887  saoe class I histocompatibility antigen, A alpha chain-like [KO:K06751]
101349740  HLA class I histocompatibility antigen, Cw-12 alpha chain-like [KO:K06751]
101345582  interferon gamma receptor 1 isoform X1 [KO:K05132]
101343257  intercellular adhesion molecule 1 [KO:K06490]
101347585  T-lymphocyte activation antigen CD86 isoform X1 [KO:K05413]
101349427  MHC class I polypeptide-related sequence A-like isoform X1 [KO:K07985]
101352061  C-type lectin domain family 2 member B [KO:K10071]
111822114  polyubiquitin-C [KO:K02927]
101361963  ubiquitin-60S ribosomal protein L40 [KO:K02927]
101361983  ubiquitin-40S ribosomal protein S27a [KO:K02977]
101359690  beclin-1 isoform X1 [KO:K08334]
101349952  LOW QUALITY PROTEIN: beclin-2 [KO:K08334]
101359341  beclin 1-associated autophagy-related key regulator [KO:K17889]
101345298  phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
101357622  ubiquitin-like-conjugating enzyme ATG3 isoform X2 [KO:K08343]
101356277  microtubule-associated proteins 1A/1B light chain 3A [KO:K10435]
101351409  microtubule-associated proteins 1A/1B light chain 3C-like [KO:K10435]
101353236  microtubule-associated proteins 1A/1B light chain 3B [KO:K10435]
101351672  microtubule-associated proteins 1A/1B light chain 3C [KO:K10435]
101350742  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
101345319  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
101355136  guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 [KO:K07825]
101348280  guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
101341327  guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
101352593  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X1 [KO:K07826]
101342107  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
101357541  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
101345326  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
101347845  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X2 [KO:K04543]
111821467  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
111819711  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
101341777  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
101351188  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
111819060  putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
101351136  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 [KO:K04547]
101342034  guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
101360148  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 [KO:K04549]
101342804  GTPase HRas isoform X2 [KO:K02833]
101347525  GTPase KRas isoform X3 [KO:K07827]
101344230  GTPase NRas isoform X1 [KO:K07828]
101357840  RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
101343332  dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101341078  dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101340589  mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101358526  mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101347136  hypoxia-inducible factor 1-alpha isoform X1 [KO:K08268]
101361653  transcription factor AP-1 [KO:K04448]
101357016  proto-oncogene c-Fos [KO:K04379]
101354532  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform isoform X1 [KO:K21289] [EC:2.7.1.153]
101352786  phosphoinositide 3-kinase regulatory subunit 6 [KO:K21290]
101343689  phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
101358678  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101346849  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101359658  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101351035  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
101343804  phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101347746  phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
101360493  RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101356099  RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101350197  RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101343808  serine/threonine-protein kinase mTOR [KO:K07203] [EC:2.7.11.1]
101346362  phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein [KO:K12365]
101356054  ras-related C3 botulinum toxin substrate 1 [KO:K04392]
101351734  mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101351967  mitogen-activated protein kinase 9 isoform X2 [KO:K04440] [EC:2.7.11.24]
101343546  mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
101351405  cell surface glycoprotein CD200 receptor 1 [KO:K21668]
101351667  LOW QUALITY PROTEIN: cell surface glycoprotein CD200 receptor 1 [KO:K21668]
101351806  tyrosine-protein kinase SYK isoform X2 [KO:K05855] [EC:2.7.10.2]
101342555  proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
101344005  tyrosine-protein kinase HCK isoform X1 [KO:K08893] [EC:2.7.10.2]
101353037  tyrosine-protein kinase Lyn isoform X1 [KO:K05854] [EC:2.7.10.2]
101349700  dual specificity mitogen-activated protein kinase kinase 4 [KO:K04430] [EC:2.7.12.2]
101346746  dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
101346393  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
101359597  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [KO:K01116] [EC:3.1.4.11]
101346534  inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
101356404  inositol 1,4,5-trisphosphate receptor type 2 [KO:K04959]
101354392  inositol 1,4,5-trisphosphate receptor type 3 [KO:K04960]
101347126  calmodulin-2 isoform X2 [KO:K02183]
101361121  LOW QUALITY PROTEIN: calmodulin-like protein 6 [KO:K02183]
101358846  LOW QUALITY PROTEIN: calmodulin-like protein 3 [KO:K02183]
101346240  calmodulin-3 [KO:K02183]
101358487  calmodulin [KO:K02183]
101346473  calmodulin-like protein 4 [KO:K02183]
101359111  calmodulin-like [KO:K02183]
101353424  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2 [KO:K04348] [EC:3.1.3.16]
101357894  serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
101347440  serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform [KO:K04348] [EC:3.1.3.16]
101343394  calcineurin subunit B type 1 isoform X2 [KO:K06268]
101355330  calcineurin subunit B type 2 [KO:K06268]
101359059  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101355751  nuclear factor of activated T-cells, cytoplasmic 2 isoform X2 [KO:K17332]
101352434  nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
101350695  nuclear factor of activated T-cells, cytoplasmic 4 isoform X1 [KO:K17334]
101358515  interleukin-8 [KO:K10030]
101345018  prostaglandin G/H synthase 2 [KO:K11987] [EC:1.14.99.1]
101357988  growth-regulated protein homolog gamma-like [KO:K05505]
101346678  growth-regulated alpha protein-like [KO:K05505]
101341433  calcipressin-1 isoform X3 [KO:K17901]
101342442  LOW QUALITY PROTEIN: fibroblast growth factor 2 [KO:K18497]
101341920  vascular endothelial growth factor A [KO:K05448]
101344115  platelet-derived growth factor subunit B [KO:K17386]
101341636  angiopoietin-2 [KO:K05466]
101353064  interleukin-6 receptor subunit beta isoform X1 [KO:K05060]
101354918  tyrosine-protein kinase JAK2 [KO:K04447] [EC:2.7.10.2]
101342651  signal transducer and activator of transcription 3 isoform X3 [KO:K04692]
101349186  glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
101351897  catenin beta-1 [KO:K02105]
101350837  LOW QUALITY PROTEIN: transcription factor 7 [KO:K02620]
101341696  transcription factor 7-like 1 [KO:K04490]
101345532  transcription factor 7-like 2 isoform X1 [KO:K04491]
101345125  lymphoid enhancer-binding factor 1 isoform X2 [KO:K04492]
101356881  cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
101359745  G1/S-specific cyclin-D1 [KO:K04503]
101349786  myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00350  Phosphatidylethanolamine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:22403573
  Authors
Lee HR, Brulois K, Wong L, Jung JU
  Title
Modulation of Immune System by Kaposi's Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies.
  Journal
Front Microbiol 3:44 (2012)
DOI:10.3389/fmicb.2012.00044
Reference
PMID:18948197
  Authors
Liang C, Lee JS, Jung JU
  Title
Immune evasion in Kaposi's sarcoma-associated herpes virus associated oncogenesis.
  Journal
Semin Cancer Biol 18:423-36 (2008)
DOI:10.1016/j.semcancer.2008.09.003
Reference
PMID:21040832
  Authors
Cai Q, Verma SC, Lu J, Robertson ES
  Title
Molecular biology of Kaposi's sarcoma-associated herpesvirus and related oncogenesis.
  Journal
Adv Virus Res 78:87-142 (2010)
DOI:10.1016/B978-0-12-385032-4.00003-3
Reference
PMID:16760382
  Authors
Rezaee SA, Cunningham C, Davison AJ, Blackbourn DJ
  Title
Kaposi's sarcoma-associated herpesvirus immune modulation: an overview.
  Journal
J Gen Virol 87:1781-804 (2006)
DOI:10.1099/vir.0.81919-0
Reference
PMID:19230674
  Authors
Areste C, Blackbourn DJ
  Title
Modulation of the immune system by Kaposi's sarcoma-associated herpesvirus.
  Journal
Trends Microbiol 17:119-29 (2009)
DOI:10.1016/j.tim.2008.12.001
Reference
PMID:16905191
  Authors
Mark L, Spiller OB, Villoutreix BO, Blom AM
  Title
Kaposi's sarcoma-associated herpes virus complement control protein: KCP--complement inhibition and more.
  Journal
Mol Immunol 44:11-22 (2007)
DOI:10.1016/j.molimm.2006.06.018
Reference
PMID:11500830
  Authors
Weber KS, Grone HJ, Rocken M, Klier C, Gu S, Wank R, Proudfoot AE, Nelson PJ, Weber C
  Title
Selective recruitment of Th2-type cells and evasion from a cytotoxic immune response mediated by viral macrophage inhibitory protein-II.
  Journal
Eur J Immunol 31:2458-66 (2001)
DOI:10.1002/1521-4141(200108)31:8<2458::AID-IMMU2458>3.0.CO;2-L
Reference
PMID:10666184
  Authors
Stine JT, Wood C, Hill M, Epp A, Raport CJ, Schweickart VL, Endo Y, Sasaki T, Simmons G, Boshoff C, Clapham P, Chang Y, Moore P, Gray PW, Chantry D
  Title
KSHV-encoded CC chemokine vMIP-III is a CCR4 agonist, stimulates angiogenesis, and selectively chemoattracts TH2 cells.
  Journal
Blood 95:1151-7 (2000)
Reference
PMID:26431609
  Authors
Schulz TF, Cesarman E
  Title
Kaposi Sarcoma-associated Herpesvirus: mechanisms of oncogenesis.
  Journal
Curr Opin Virol 14:116-28 (2015)
DOI:10.1016/j.coviro.2015.08.016
Reference
PMID:10377196
  Authors
Endres MJ, Garlisi CG, Xiao H, Shan L, Hedrick JA
  Title
The Kaposi's sarcoma-related herpesvirus (KSHV)-encoded chemokine vMIP-I is a specific agonist for the CC chemokine receptor (CCR)8.
  Journal
J Exp Med 189:1993-8 (1999)
DOI:10.1084/jem.189.12.1993
Reference
PMID:18434408
  Authors
Choi YB, Nicholas J
  Title
Autocrine and paracrine promotion of cell survival and virus replication by human herpesvirus 8 chemokines.
  Journal
J Virol 82:6501-13 (2008)
DOI:10.1128/JVI.02396-07
Reference
PMID:15692053
  Authors
McCormick C, Ganem D
  Title
The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs.
  Journal
Science 307:739-41 (2005)
DOI:10.1126/science.1105779
Reference
PMID:15967719
  Authors
Wang HW, Boshoff C
  Title
Linking Kaposi virus to cancer-associated cytokines.
  Journal
Trends Mol Med 11:309-12 (2005)
DOI:10.1016/j.molmed.2005.06.002
Reference
PMID:16828973
  Authors
Jarviluoma A, Ojala PM
  Title
Cell signaling pathways engaged by KSHV.
  Journal
Biochim Biophys Acta 1766:140-58 (2006)
DOI:10.1016/j.bbcan.2006.05.001
Reference
PMID:12032073
  Authors
Wang HW, Sharp TV, Koumi A, Koentges G, Boshoff C
  Title
Characterization of an anti-apoptotic glycoprotein encoded by Kaposi's sarcoma-associated herpesvirus which resembles a spliced variant of human survivin.
  Journal
EMBO J 21:2602-15 (2002)
DOI:10.1093/emboj/21.11.2602
Reference
PMID:10510092
  Authors
Djerbi M, Screpanti V, Catrina AI, Bogen B, Biberfeld P, Grandien A
  Title
The inhibitor of death receptor signaling, FLICE-inhibitory protein defines a new class of tumor progression factors.
  Journal
J Exp Med 190:1025-32 (1999)
DOI:10.1084/jem.190.7.1025
Reference
PMID:10523854
  Authors
Chaudhary PM, Jasmin A, Eby MT, Hood L
  Title
Modulation of the NF-kappa B pathway by virally encoded death effector domains-containing proteins.
  Journal
Oncogene 18:5738-46 (1999)
DOI:10.1038/sj.onc.1202976
Reference
PMID:12890756
  Authors
Field N, Low W, Daniels M, Howell S, Daviet L, Boshoff C, Collins M
  Title
KSHV vFLIP binds to IKK-gamma to activate IKK.
  Journal
J Cell Sci 116:3721-8 (2003)
DOI:10.1242/jcs.00691
Reference
PMID:20865011
  Authors
Mesri EA, Cesarman E, Boshoff C
  Title
Kaposi's sarcoma and its associated herpesvirus.
  Journal
Nat Rev Cancer 10:707-19 (2010)
DOI:10.1038/nrc2888
Reference
PMID:10799607
  Authors
Ishido S, Wang C, Lee BS, Cohen GB, Jung JU
  Title
Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.
  Journal
J Virol 74:5300-9 (2000)
DOI:10.1128/JVI.74.11.5300-5309.2000
Reference
PMID:17166914
  Authors
Li Q, Means R, Lang S, Jung JU
  Title
Downregulation of gamma interferon receptor 1 by Kaposi's sarcoma-associated herpesvirus K3 and K5.
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J Virol 81:2117-27 (2007)
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Thomas M, Boname JM, Field S, Nejentsev S, Salio M, Cerundolo V, Wills M, Lehner PJ
  Title
Down-regulation of NKG2D and NKp80 ligands by Kaposi's sarcoma-associated herpesvirus K5 protects against NK cell cytotoxicity.
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Proc Natl Acad Sci U S A 105:1656-61 (2008)
DOI:10.1073/pnas.0707883105
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PMID:11413168
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Coscoy L, Ganem D
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A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.
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J Clin Invest 107:1599-606 (2001)
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How human tumor viruses make use of autophagy.
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Cells 1:617-30 (2012)
DOI:10.3390/cells1030617
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PMID:10354594
  Authors
Schulz TF, Moore PS
  Title
Kaposi's sarcoma-associated herpesvirus: a new human tumor virus, but how?
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Trends Microbiol 7:196-200 (1999)
DOI:10.1016/S0966-842X(99)01495-X
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PMID:9594662
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Moore PS, Chang Y
  Title
Antiviral activity of tumor-suppressor pathways: clues from molecular piracy by KSHV.
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Trends Genet 14:144-50 (1998)
DOI:10.1016/S0168-9525(98)01408-5
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PMID:12770701
  Authors
Verma SC, Robertson ES
  Title
Molecular biology and pathogenesis of Kaposi sarcoma-associated herpesvirus.
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FEMS Microbiol Lett 222:155-63 (2003)
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PMID:11960692
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Jenner RG, Boshoff C
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The molecular pathology of Kaposi's sarcoma-associated herpesvirus.
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Biochim Biophys Acta 1602:1-22 (2002)
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PMID:15220441
  Authors
Foster-Cuevas M, Wright GJ, Puklavec MJ, Brown MH, Barclay AN
  Title
Human herpesvirus 8 K14 protein mimics CD200 in down-regulating macrophage activation through CD200 receptor.
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J Virol 78:7667-76 (2004)
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PMID:10987301
  Authors
Sodhi A, Montaner S, Patel V, Zohar M, Bais C, Mesri EA, Gutkind JS
  Title
The Kaposi's sarcoma-associated herpes virus G protein-coupled receptor up-regulates vascular endothelial growth factor expression and secretion through mitogen-activated protein kinase and p38 pathways acting on hypoxia-inducible factor 1alpha.
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Cancer Res 60:4873-80 (2000)
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Abere B, Schulz TF
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KSHV non-structural membrane proteins involved in the activation of intracellular signaling pathways and the pathogenesis of Kaposi's sarcoma.
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Curr Opin Virol 20:11-19 (2016)
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PMID:15573137
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Sodhi A, Montaner S, Gutkind JS
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Viral hijacking of G-protein-coupled-receptor signalling networks.
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Nat Rev Mol Cell Biol 5:998-1012 (2004)
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Montaner S
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Akt/TSC/mTOR activation by the KSHV G protein-coupled receptor: emerging insights into the molecular oncogenesis and treatment of Kaposi's sarcoma.
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Cell Cycle 6:438-43 (2007)
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PMID:23028325
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Bala K, Bosco R, Gramolelli S, Haas DA, Kati S, Pietrek M, Havemeier A, Yakushko Y, Singh VV, Dittrich-Breiholz O, Kracht M, Schulz TF
  Title
Kaposi's sarcoma herpesvirus K15 protein contributes to virus-induced angiogenesis by recruiting PLCgamma1 and activating NFAT1-dependent RCAN1 expression.
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PLoS Pathog 8:e1002927 (2012)
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PMID:10318948
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Lagunoff M, Majeti R, Weiss A, Ganem D
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Deregulated signal transduction by the K1 gene product of Kaposi's sarcoma-associated herpesvirus.
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Proc Natl Acad Sci U S A 96:5704-9 (1999)
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Sousa-Squiavinato AC, Silvestre RN, Elgui De Oliveira D
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Biology and oncogenicity of the Kaposi sarcoma herpesvirus K1 protein.
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Rev Med Virol 25:273-85 (2015)
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PMID:25187543
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Havemeier A, Gramolelli S, Pietrek M, Jochmann R, Sturzl M, Schulz TF
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Activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus K15 protein involves recruitment of the NF-kappaB-inducing kinase, IkappaB kinases, and phosphorylation of p65.
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J Virol 88:13161-72 (2014)
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PMID:17050609
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Brinkmann MM, Pietrek M, Dittrich-Breiholz O, Kracht M, Schulz TF
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Modulation of host gene expression by the K15 protein of Kaposi's sarcoma-associated herpesvirus.
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J Virol 81:42-58 (2007)
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PMID:16585191
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Wang L, Dittmer DP, Tomlinson CC, Fakhari FD, Damania B
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Immortalization of primary endothelial cells by the K1 protein of Kaposi's sarcoma-associated herpesvirus.
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Cancer Res 66:3658-66 (2006)
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PMID:22521915
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Morris VA, Punjabi AS, Wells RC, Wittkopp CJ, Vart R, Lagunoff M
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The KSHV viral IL-6 homolog is sufficient to induce blood to lymphatic endothelial cell differentiation.
  Journal
Virology 428:112-20 (2012)
DOI:10.1016/j.virol.2012.03.013
Reference
PMID:25594835
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Purushothaman P, Uppal T, Verma SC
  Title
Molecular biology of KSHV lytic reactivation.
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Viruses 7:116-53 (2015)
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PMID:14991150
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Fujimuro M, Hayward SD
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Manipulation of glycogen-synthase kinase-3 activity in KSHV-associated cancers.
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J Mol Med (Berl) 82:223-31 (2004)
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PMID:26870016
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Purushothaman P, Dabral P, Gupta N, Sarkar R, Verma SC
  Title
KSHV Genome Replication and Maintenance.
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Front Microbiol 7:54 (2016)
DOI:10.3389/fmicb.2016.00054
Related
pathway
tmu04010  MAPK signaling pathway
tmu04064  NF-kappa B signaling pathway
tmu04110  Cell cycle
tmu04115  p53 signaling pathway
tmu04140  Autophagy - animal
tmu04144  Endocytosis
tmu04151  PI3K-Akt signaling pathway
tmu04210  Apoptosis
tmu04310  Wnt signaling pathway
tmu04610  Complement and coagulation cascades
tmu04620  Toll-like receptor signaling pathway
tmu04630  JAK-STAT signaling pathway
tmu04650  Natural killer cell mediated cytotoxicity
tmu04668  TNF signaling pathway
KO pathway
ko05167   
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