KEGG   PATHWAY: tst04810
Entry
tst04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Trachemys scripta elegans (red-eared slider)
Class
Cellular Processes; Cell motility
Pathway map
tst04810  Regulation of actin cytoskeleton
tst04810

Other DBs
GO: 0030036
Organism
Trachemys scripta elegans (red-eared slider) [GN:tst]
Gene
117867668  lysophosphatidic acid receptor 3-like [KO:K04289]
117888807  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
117882872  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
117885920  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
117880105  CXCL12; stromal cell-derived factor 1 [KO:K10031]
117885175  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
117876933  F2; prothrombin isoform X1 [KO:K01313] [EC:3.4.21.5]
117879447  F2R; proteinase-activated receptor 1 [KO:K03914]
117876752  INS; insulin [KO:K04526]
117877887  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
117881750  FGF1; fibroblast growth factor 1 [KO:K18496]
117880942  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
117868913  FGF22; fibroblast growth factor 22 [KO:K04358]
117882261  FGF18; fibroblast growth factor 18 [KO:K04358]
117876951  FGF3; fibroblast growth factor 3 [KO:K04358]
117876981  FGF4; fibroblast growth factor 4 [KO:K04358]
117882928  FGF16; fibroblast growth factor 16 [KO:K04358]
117870827  FGF6; fibroblast growth factor 6 [KO:K04358]
117871110  FGF9; fibroblast growth factor 9 [KO:K04358]
117871601  FGF17; fibroblast growth factor 17 [KO:K04358]
117884072  FGF7; fibroblast growth factor 7 [KO:K04358]
117878329  FGF5; fibroblast growth factor 5 [KO:K04358]
117878330  FGF20; fibroblast growth factor 20 [KO:K04358]
117879538  FGF10; fibroblast growth factor 10 [KO:K04358]
117877429  FGF19; fibroblast growth factor 19 [KO:K22603]
117888433  FGF21; fibroblast growth factor 21 [KO:K22429]
117884568  FGF23; fibroblast growth factor 23 [KO:K22428]
117883612  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
117880268  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
117871165  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
117877938  PDGFC; platelet-derived growth factor C isoform X1 [KO:K05450]
117872619  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
117873025  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
117879776  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
117878458  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
117878037  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
117884854  FN1; fibronectin [KO:K05717]
117879320  ITGA1; integrin alpha-1 isoform X1 [KO:K06480]
117879230  ITGA2; integrin alpha-2 [KO:K06481]
117869417  ITGA2B; integrin alpha-IIb [KO:K06476]
117869234  ITGA3; integrin alpha-3 [KO:K06482]
117884870  ITGA4; LOW QUALITY PROTEIN: integrin alpha-4 [KO:K06483]
117888563  ITGA5; integrin alpha-5 isoform X1 [KO:K06484]
117884648  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
117888730  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
117872172  ITGA8; integrin alpha-8 [KO:K06584]
117871717  ITGA9; integrin alpha-9 [KO:K06585]
117869771  ITGA10; integrin alpha-10 [KO:K06586]
117884238  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
117884657  ITGAV; integrin alpha-V [KO:K06487]
117876238  LOW QUALITY PROTEIN: integrin alpha-D-like [KO:K06461]
117876233  integrin alpha-D-like [KO:K06594]
117867545  ITGAE; integrin alpha-E [KO:K06524]
117872076  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
117884829  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
117869313  ITGB3; integrin beta-3 [KO:K06493]
117887358  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
117884782  ITGB5; integrin beta-5 [KO:K06588]
117884810  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
117888384  ITGB7; integrin beta-7 [KO:K06590]
117872287  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
117882638  KNG1; kininogen-1 [KO:K03898]
117876113  BDKRB1; LOW QUALITY PROTEIN: B1 bradykinin receptor [KO:K03915]
117877243  BDKRB2; B2 bradykinin receptor [KO:K03916]
117880961  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
117881928  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
117874678  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
117877220  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
117876693  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
117889373  C5; complement C5 isoform X1 [KO:K03994]
117879170  C6; complement component C6 [KO:K03995]
117879140  C7; complement component C7 isoform X1 [KO:K03996]
117881403  C8A; complement component C8 alpha chain isoform X1 [KO:K03997]
117881530  C8B; complement component C8 beta chain [KO:K03998]
117867138  C8G; complement component C8 gamma chain [KO:K03999]
117879494  C9; complement component C9 [KO:K04000]
117884213  GNA12; guanine nucleotide-binding protein subunit alpha-12 isoform X1 [KO:K04346]
117887642  GNA13; guanine nucleotide-binding protein subunit alpha-13 isoform X1 [KO:K04639]
117881648  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
117880350  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
117873845  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
117867301  CRK; adapter molecule crk isoform X1 [KO:K04438]
117888021  CRKL; crk-like protein [KO:K04438]
117880556  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
117885642  SRC; proto-oncogene tyrosine-protein kinase Src isoform X1 [KO:K05704] [EC:2.7.10.2]
117874155  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
117876099  SOS2; son of sevenless homolog 2 [KO:K03099]
117877347  HRAS; GTPase HRas [KO:K02833]
117883516  KRAS; GTPase KRas isoform X1 [KO:K07827]
117875723  NRAS; GTPase NRas [KO:K07828]
117877223  RRAS2; ras-related protein R-Ras2 [KO:K07830]
117884867  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
117882703  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
117867910  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117882413  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
117882483  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
117881251  phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1 [KO:K02649]
117868848  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta isoform X1 [KO:K02649]
117879552  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
117867195  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
117881456  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
117889021  VAV1; proto-oncogene vav [KO:K05730]
117889410  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1 isoform X1 [KO:K05731]
117881799  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
117879804  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
117871650  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
117883780  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
117868754  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
117887996  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
117874665  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
117888624  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117876213  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
117870930  RGCC; regulator of cell cycle RGCC [KO:K26108]
117883332  regulator of cell cycle RGCC-like [KO:K26108]
117868667  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
117889132  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
117880295  RHOA; transforming protein RhoA [KO:K04513]
117888631  transforming protein RhoA-like [KO:K04513]
117883776  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
117880762  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
117867802  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
117871281  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
117882800  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
117882429  PAK3; serine/threonine-protein kinase PAK 3 isoform X1 [KO:K05733] [EC:2.7.11.1]
117888558  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
117874221  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
117876713  PAK6; serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
117870794  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X1 [KO:K13710]
117867442  GIT1; ARF GTPase-activating protein GIT1 isoform X1 [KO:K05737]
117873395  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
117875524  ROCK2; rho-associated protein kinase 2 [KO:K17388] [EC:2.7.11.1]
117886754  MYLK3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
117885275  MYLK; myosin light chain kinase, smooth muscle [KO:K00907] [EC:2.7.11.18]
117873146  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
117886013  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
117869384  myosin light chain kinase, smooth muscle-like isoform X1 [KO:K00907] [EC:2.7.11.18]
117874543  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
117888092  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
117876562  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
117889275  serine/threonine-protein phosphatase PP1-alpha catalytic subunit-like isoform X1 [KO:K06269] [EC:3.1.3.16]
117878110  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X1 [KO:K06270]
117875973  PPP1R12B; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12B [KO:K12329]
117888780  PPP1R12C; protein phosphatase 1 regulatory subunit 12C isoform X1 [KO:K17457]
117888105  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
117878737  MYL5; myosin light chain 5 isoform X1 [KO:K12753]
117872866  MYL7; myosin regulatory light chain 2, atrial isoform isoform X1 [KO:K12754]
117885774  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
117867556  MYL10; myosin regulatory light chain 10 [KO:K12756]
117873376  MYL12B; myosin regulatory light chain 12B [KO:K12757]
117880971  MYH9; myosin-9 [KO:K10352]
117887422  MYH10; myosin-10 isoform X1 [KO:K10352]
117883705  MYH11; myosin-11 isoform X1 [KO:K10352]
117881761  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
117882639  DIAPH2; protein diaphanous homolog 2 isoform X1 [KO:K05741]
117868272  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
117868783  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
117869549  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
117878957  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
117869412  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta isoform X1 [KO:K00920] [EC:2.7.1.149]
117870585  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma [KO:K00920] [EC:2.7.1.149]
117872132  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha isoform X1 [KO:K00920] [EC:2.7.1.149]
117885001  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]
117888082  LIMK2; LIM domain kinase 2 [KO:K05744] [EC:2.7.11.1]
117870909  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
117887237  BAIAP2; brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1 [KO:K05627]
117888761  LOW QUALITY PROTEIN: brain-specific angiogenesis inhibitor 1-associated protein 2-like [KO:K05627]
117874506  ENAH; protein enabled homolog isoform X1 [KO:K05746]
117876137  WASL; neural Wiskott-Aldrich syndrome protein isoform X1 [KO:K23612]
117868162  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
117881441  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
117870673  CYFIP1; cytoplasmic FMR1-interacting protein 1 [KO:K05749]
117889017  NCKAP1L; nck-associated protein 1-like [KO:K05750]
117884591  NCKAP1; nck-associated protein 1 isoform X1 [KO:K05750]
117884640  ABI2; abl interactor 2 isoform X1 [KO:K05751]
117880322  probable protein BRICK1 [KO:K05752]
117879752  probable protein BRICK1-B [KO:K05752]
117875035  WASF1; wiskott-Aldrich syndrome protein family member 1 [KO:K05753]
117874276  ACTR2; actin-related protein 2 isoform X1 [KO:K17260]
117880761  actin-related protein 2-B-like [KO:K17260]
117872027  ACTR3B; actin-related protein 3B isoform X1 [KO:K18584]
117884880  ACTR3; actin-related protein 3 [KO:K18584]
117884422  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
117884423  ARPC1B; actin-related protein 2/3 complex subunit 1B [KO:K05757]
117884830  ARPC2; actin-related protein 2/3 complex subunit 2 [KO:K05758]
117888311  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
117879959  ARPC4; actin-related protein 2/3 complex subunit 4 [KO:K05755]
117881876  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
117889376  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
117867995  ACTL8; actin-like protein 8 [KO:K05692]
117887319  ACTG1; actin, cytoplasmic 2 [KO:K05692]
117883668  actin, cytoplasmic type 5-like [KO:K05692]
117883704  ACTB; actin, cytoplasmic 1 [KO:K05692]
117884503  actin, cytoplasmic type 5 [KO:K05692]
117879462  ACTBL2; LOW QUALITY PROTEIN: beta-actin-like protein 2 [KO:K05692]
117874079  PFN3; profilin-3 [KO:K05759]
117875357  PFN4; profilin-4 [KO:K05759]
117882344  PFN2; profilin-2 isoform X1 [KO:K05759]
117871772  profilin-2-like [KO:K05759]
117878471  PFN1; profilin-1 [KO:K05759]
117888235  PXN; LOW QUALITY PROTEIN: paxillin [KO:K05760]
117874802  EZR; ezrin [KO:K08007]
117871140  RDX; radixin isoform X1 [KO:K05762]
117882591  MSN; moesin [KO:K05763]
117869846  TMSB4X; thymosin beta-4 [KO:K05764]
117876446  CFL2; cofilin-2 isoform X1 [KO:K05765]
117879899  CFL1; cofilin-1 [KO:K05765]
117867404  SSH2; protein phosphatase Slingshot homolog 2 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
117887908  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
117876031  SSH3; protein phosphatase Slingshot homolog 3 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
117880962  VCL; vinculin isoform X1 [KO:K05700]
117883548  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
117869675  IQGAP3; ras GTPase-activating-like protein IQGAP3 [KO:K05767]
117879446  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X1 [KO:K05767]
117889469  GSN; gelsolin isoform X1 [KO:K05768]
117872262  SCIN; adseverin [KO:K05768]
117876144  ACTN1; alpha-actinin-1 [KO:K05699]
117888413  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
117868794  APC2; adenomatous polyposis coli protein 2 [KO:K02085]
117879169  APC; adenomatous polyposis coli protein [KO:K02085]
117882592  LOW QUALITY PROTEIN: uncharacterized protein LOC117882592 [KO:K05769]
117871102  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
tst04010  MAPK signaling pathway
tst04510  Focal adhesion
tst04520  Adherens junction
KO pathway
ko04810   
LinkDB

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