KEGG   PATHWAY: vpc04722
Entry
vpc04722                    Pathway                                
Name
Neurotrophin signaling pathway - Vicugna pacos (alpaca)
Description
Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory.
Class
Organismal Systems; Nervous system
Pathway map
vpc04722  Neurotrophin signaling pathway
vpc04722

Organism
Vicugna pacos (alpaca) [GN:vpc]
Gene
102536531  NGF; beta-nerve growth factor isoform X1 [KO:K02582]
102532564  BDNF; LOW QUALITY PROTEIN: brain-derived neurotrophic factor [KO:K04355]
102528888  NTF4; neurotrophin-4 [KO:K12457]
102545739  NTF3; neurotrophin-3 isoform X4 [KO:K04356]
102543920  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
102536840  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
102530056  NTRK3; NT-3 growth factor receptor isoform X2 [KO:K05101] [EC:2.7.10.1]
102526001  SH2B2; SH2B adapter protein 2 [KO:K07193]
102531377  SH2B3; SH2B adapter protein 3 [KO:K12459]
102533238  SH2B1; LOW QUALITY PROTEIN: SH2B adapter protein 1 [KO:K12459]
102532895  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
102541429  SOS2; son of sevenless homolog 2 [KO:K03099]
102543818  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
102525363  HRAS; GTPase HRas isoform X1 [KO:K02833]
102529990  KRAS; GTPase KRas isoform X2 [KO:K07827]
102534785  NRAS; GTPase NRas [KO:K07828]
102543308  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
102528789  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
102530118  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102534668  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102536713  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102528720  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102534939  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
102534734  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X3 [KO:K04373] [EC:2.7.11.1]
102527685  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X2 [KO:K04373] [EC:2.7.11.1]
102541583  RPS6KA2; ribosomal protein S6 kinase alpha-2 [KO:K04373] [EC:2.7.11.1]
102539832  RPS6KA5; ribosomal protein S6 kinase alpha-5 isoform X1 [KO:K04445] [EC:2.7.11.1]
102531881  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
102538080  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
102541336  KIDINS220; kinase D-interacting substrate of 220 kDa [KO:K12460]
102530311  FRS2; fibroblast growth factor receptor substrate 2 [KO:K12461]
102533491  CRKL; crk-like protein [KO:K04438]
102539935  CRK; adapter molecule crk isoform X1 [KO:K04438]
102526154  RAPGEF1; LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 1 [KO:K06277]
102544212  RAP1A; ras-related protein Rap-1A [KO:K04353]
102535500  RAP1B; ras-related protein Rap-1b [KO:K07836]
102540602  MAP3K3; mitogen-activated protein kinase kinase kinase 3 [KO:K04421] [EC:2.7.11.25]
102532036  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
102541255  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
102525219  MAPK12; mitogen-activated protein kinase 12 isoform X7 [KO:K04441] [EC:2.7.11.24]
102531650  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
102540698  MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
102541290  MAPK13; mitogen-activated protein kinase 13 isoform X1 [KO:K04441] [EC:2.7.11.24]
102537860  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
102526482  SHC1; SHC-transforming protein 1 isoform X1 [KO:K06279]
102526634  SHC2; SHC-transforming protein 2 isoform X1 [KO:K17447]
102541852  SHC3; SHC-transforming protein 3 [KO:K17448]
102528702  SHC4; SHC-transforming protein 4 [KO:K17449]
102529162  GAB1; LOW QUALITY PROTEIN: GRB2-associated-binding protein 1 [KO:K09593]
102532395  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
102536302  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
102536225  phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
102540289  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
102524821  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
102543068  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102526860  AKT1; RAC-alpha serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102546009  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102542031  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
102531744  NFKBIB; LOW QUALITY PROTEIN: NF-kappa-B inhibitor beta [KO:K02581]
102524630  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
102533893  NFKBIE; NF-kappa-B inhibitor epsilon [KO:K05872]
102532161  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
102540197  RELA; transcription factor p65 isoform X1 [KO:K04735]
102530369  FOXO3; LOW QUALITY PROTEIN: forkhead box protein O3 [KO:K09408]
102536116  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
102538813  BAD; bcl2-associated agonist of cell death isoform X2 [KO:K02158]
102539918  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
102528174  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X1 [KO:K06276] [EC:2.7.11.1]
102533840  IRS1; insulin receptor substrate 1 [KO:K16172]
102542680  PLCG1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X1 [KO:K01116] [EC:3.1.4.11]
102540897  PLCG2; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1 [KO:K05859] [EC:3.1.4.11]
102537750  PRKCD; protein kinase C delta type [KO:K06068] [EC:2.7.11.13]
102531096  CALM2; calmodulin-2 [KO:K02183]
102539425  CALM1; calmodulin-1 [KO:K02183]
102544854  CALML4; LOW QUALITY PROTEIN: calmodulin-like protein 4 [KO:K02183]
102532310  calmodulin-like [KO:K02183]
102533842  CALM3; calmodulin-3 [KO:K02183]
102542241  CALML5; calmodulin-like protein 5 [KO:K02183]
102543778  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X3 [KO:K04515] [EC:2.7.11.17]
102536144  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X1 [KO:K04515] [EC:2.7.11.17]
102541361  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma [KO:K04515] [EC:2.7.11.17]
102544405  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
102539084  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X2 [KO:K05869] [EC:2.7.11.17]
102528583  ABL1; tyrosine-protein kinase ABL1 isoform X2 [KO:K06619] [EC:2.7.10.2]
102529754  PTPN11; tyrosine-protein phosphatase non-receptor type 11 isoform X3 [KO:K07293] [EC:3.1.3.48]
102539029  tyrosine-protein phosphatase non-receptor type 11-like [KO:K07293] [EC:3.1.3.48]
102537641  MATK; megakaryocyte-associated tyrosine-protein kinase [KO:K08888] [EC:2.7.10.2]
102525766  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
102543769  ARHGDIA; rho GDP-dissociation inhibitor 1 [KO:K12462]
102539709  ARHGDIB; rho GDP-dissociation inhibitor 2 [KO:K12462]
102532072  rho GDP-dissociation inhibitor 1-like [KO:K12462]
102527210  ARHGDIG; rho GDP-dissociation inhibitor 3 [KO:K12462]
102534196  RHOA; transforming protein RhoA [KO:K04513]
102530757  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
102543993  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
102530799  MAP3K1; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
102544996  MAP3K5; mitogen-activated protein kinase kinase kinase 5 isoform X1 [KO:K04426] [EC:2.7.11.25]
102525041  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
102528221  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
102543430  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
102539859  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102541687  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
102530959  TP53; cellular tumor antigen p53 [KO:K04451]
102543566  BAX; apoptosis regulator BAX isoform X1 [KO:K02159]
102538948  TP73; tumor protein p73 isoform X1 [KO:K10148]
102540938  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
102543109  ZNF274; neurotrophin receptor-interacting factor homolog isoform X1 [KO:K12458]
102540324  PRDM4; PR domain zinc finger protein 4 [KO:K12463] [EC:2.1.1.-]
102538240  MAGED1; melanoma-associated antigen D1 [KO:K12464]
102543180  protein BEX3 isoform X1 [KO:K12465]
102539697  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
102529559  RIPK2; receptor-interacting serine/threonine-protein kinase 2 [KO:K08846] [EC:2.7.11.1]
102529835  IRAK1; interleukin-1 receptor-associated kinase 1 [KO:K04730] [EC:2.7.11.1]
102526122  IRAK2; interleukin-1 receptor-associated kinase-like 2 isoform X1 [KO:K04731] [EC:2.7.11.1]
102532531  IRAK3; interleukin-1 receptor-associated kinase 3 isoform X1 [KO:K04732] [EC:2.7.11.1]
102544486  IRAK4; interleukin-1 receptor-associated kinase 4 [KO:K04733] [EC:2.7.11.1]
102528824  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
102544276  SORT1; sortilin isoform X3 [KO:K12388]
102531879  PSEN1; presenilin-1 isoform X1 [KO:K04505] [EC:3.4.23.-]
102524839  PSEN2; presenilin-2 isoform X4 [KO:K04522] [EC:3.4.23.-]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00195  N-Acylsphingosine
C01245  D-myo-Inositol 1,4,5-trisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:12676795
  Authors
Huang EJ, Reichardt LF.
  Title
Trk receptors: roles in neuronal signal transduction.
  Journal
Annu Rev Biochem 72:609-42 (2003)
DOI:10.1146/annurev.biochem.72.121801.161629
Reference
PMID:11399424
  Authors
Patapoutian A, Reichardt LF
  Title
Trk receptors: mediators of neurotrophin action.
  Journal
Curr Opin Neurobiol 11:272-80 (2001)
DOI:10.1016/S0959-4388(00)00208-7
Reference
PMID:16699811
  Authors
Arevalo JC, Wu SH
  Title
Neurotrophin signaling: many exciting surprises!
  Journal
Cell Mol Life Sci 63:1523-37 (2006)
DOI:10.1007/s00018-006-6010-1
Reference
PMID:14704852
  Authors
Teng KK, Hempstead BL
  Title
Neurotrophins and their receptors: signaling trios in complex biological systems.
  Journal
Cell Mol Life Sci 61:35-48 (2004)
DOI:10.1007/s00018-003-3099-3
Reference
PMID:11529497
  Authors
Miller FD, Kaplan DR
  Title
Neurotrophin signalling pathways regulating neuronal apoptosis.
  Journal
Cell Mol Life Sci 58:1045-53 (2001)
DOI:10.1007/PL00000919
Reference
PMID:10851172
  Authors
Kaplan DR, Miller FD
  Title
Neurotrophin signal transduction in the nervous system.
  Journal
Curr Opin Neurobiol 10:381-91 (2000)
DOI:10.1016/S0959-4388(00)00092-1
Reference
PMID:16939974
  Authors
Reichardt LF
  Title
Neurotrophin-regulated signalling pathways.
  Journal
Philos Trans R Soc Lond B Biol Sci 361:1545-64 (2006)
DOI:10.1098/rstb.2006.1894
Reference
PMID:16856873
  Authors
Zampieri N, Chao MV
  Title
Mechanisms of neurotrophin receptor signalling.
  Journal
Biochem Soc Trans 34:607-11 (2006)
DOI:10.1042/BST0340607
Reference
PMID:15499580
  Authors
Rose CR, Blum R, Kafitz KW, Kovalchuk Y, Konnerth A
  Title
From modulator to mediator: rapid effects of BDNF on ion channels.
  Journal
Bioessays 26:1185-94 (2004)
DOI:10.1002/bies.20118
Reference
PMID:10812966
  Authors
Yano H, Chao MV
  Title
Neurotrophin receptor structure and interactions.
  Journal
Pharm Acta Helv 74:253-60 (2000)
DOI:10.1016/s0031-6865(99)00036-9
Reference
PMID:10764727
  Authors
Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA
  Title
NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR.
  Journal
J Biol Chem 275:17566-70 (2000)
DOI:10.1074/jbc.C000140200
Reference
PMID:10985348
  Authors
Salehi AH, Roux PP, Kubu CJ, Zeindler C, Bhakar A, Tannis LL, Verdi JM, Barker PA
  Title
NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor-dependent apoptosis.
  Journal
Neuron 27:279-88 (2000)
DOI:10.1016/S0896-6273(00)00036-2
Related
pathway
vpc04010  MAPK signaling pathway
vpc04120  Ubiquitin mediated proteolysis
vpc04210  Apoptosis
vpc04720  Long-term potentiation
vpc04810  Regulation of actin cytoskeleton
KO pathway
ko04722   
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