KEGG   PATHWAY: phas04010
Entry
phas04010                   Pathway                                
Name
MAPK signaling pathway - Phyllostomus hastatus (greater spear-nosed bat)
Description
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
Class
Environmental Information Processing; Signal transduction
Pathway map
phas04010  MAPK signaling pathway
phas04010

Disease
H02157  Short-rib thoracic dysplasia
Other DBs
GO: 0000165
Organism
Phyllostomus hastatus (greater spear-nosed bat) [GN:phas]
Gene
123804414  NRAS; GTPase NRas [KO:K07828]
123804470  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
123804521  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
123804599  MAP3K21; mitogen-activated protein kinase kinase kinase 21 [KO:K17534] [EC:2.7.11.25]
123804625  NGF; beta-nerve growth factor [KO:K02582]
123804635  RAP1A; ras-related protein Rap-1A [KO:K04353]
123804682  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
123804735  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
123804847  EFNA1; ephrin-A1 [KO:K05462]
123804941  TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376]
123805290  ARRB1; beta-arrestin-1 isoform X1 [KO:K04439]
123805429  PTPN7; tyrosine-protein phosphatase non-receptor type 7 isoform X1 [KO:K18019] [EC:3.1.3.48]
123805461  DUSP10; dual specificity protein phosphatase 10 [KO:K20216] [EC:3.1.3.16 3.1.3.48]
123805534  PAK1; serine/threonine-protein kinase PAK 1 [KO:K04409] [EC:2.7.11.1]
123805628  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
123805975  NFATC3; nuclear factor of activated T-cells, cytoplasmic 3 isoform X1 [KO:K17333]
123806080  TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein [KO:K03171]
123806417  HSPB1; heat shock protein beta-1 [KO:K04455]
123806569  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
123806597  CRKL; crk-like protein isoform X1 [KO:K04438]
123806766  PPP3CA; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123806785  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
123806865  EGF; pro-epidermal growth factor isoform X1 [KO:K04357]
123806902  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
123806965  LAMTOR3; ragulator complex protein LAMTOR3 [KO:K04370]
123807082  MAPK8IP3; C-Jun-amino-terminal kinase-interacting protein 3 isoform X1 [KO:K04436]
123807193  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
123807317  HRAS; GTPase HRas isoform X1 [KO:K02833]
123807352  IGF2; insulin-like growth factor II [KO:K13769]
123807354  INS; insulin isoform X1 [KO:K04526]
123807361  DUSP8; dual specificity protein phosphatase 8 isoform X1 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123807416  CASP3; caspase-3 [KO:K02187] [EC:3.4.22.56]
123807471  FGFR1; fibroblast growth factor receptor 1 isoform X1 [KO:K04362] [EC:2.7.10.1]
123807479  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
123807508  VEGFC; vascular endothelial growth factor C isoform X1 [KO:K05449]
123807517  PDGFRB; platelet-derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
123807522  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
123807622  CACNB4; voltage-dependent L-type calcium channel subunit beta-4 isoform X1 [KO:K04865]
123807626  DUSP4; dual specificity protein phosphatase 4 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123807646  FGF20; fibroblast growth factor 20 [KO:K04358]
123807983  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
123808019  RASGRP1; RAS guanyl-releasing protein 1 isoform X1 [KO:K04350]
123808057  PLA2G4B; cytosolic phospholipase A2 beta isoform X1 [KO:K16342] [EC:3.1.1.4]
123808069  FGF7; fibroblast growth factor 7 [KO:K04358]
123808110  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
123808150  MAP3K9; mitogen-activated protein kinase kinase kinase 9 isoform X1 [KO:K04417] [EC:2.7.11.25]
123808226  FOS; proto-oncogene c-Fos [KO:K04379]
123808460  PGF; placenta growth factor isoform X1 [KO:K16859]
123808550  RPS6KA5; ribosomal protein S6 kinase alpha-5 [KO:K04445] [EC:2.7.11.1]
123808565  MAX; protein max isoform X1 [KO:K04453]
123808570  PLA2G4E; cytosolic phospholipase A2 epsilon [KO:K16342] [EC:3.1.1.4]
123808571  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
123808572  PLA2G4D; cytosolic phospholipase A2 delta [KO:K16342] [EC:3.1.1.4]
123808608  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123808666  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X1 [KO:K04450]
123808725  MAP2K5; dual specificity mitogen-activated protein kinase kinase 5 isoform X1 [KO:K04463] [EC:2.7.12.2]
123808763  PPM1A; protein phosphatase 1A [KO:K04457] [EC:3.1.3.16]
123808879  TGFB3; transforming growth factor beta-3 proprotein [KO:K13377]
123809193  ARRB2; beta-arrestin-2 [KO:K04439]
123809287  MAPK7; mitogen-activated protein kinase 7 [KO:K04464] [EC:2.7.11.24]
123809359  MAP2K4; dual specificity mitogen-activated protein kinase kinase 4 isoform X1 [KO:K04430] [EC:2.7.12.2]
123809430  MAP2K3; dual specificity mitogen-activated protein kinase kinase 3 isoform X1 [KO:K04432] [EC:2.7.12.2]
123809443  TP53; cellular tumor antigen p53 [KO:K04451]
123809602  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
123809769  IGF1R; insulin-like growth factor 1 receptor isoform X1 [KO:K05087] [EC:2.7.10.1]
123809804  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
123809979  TRAF6; TNF receptor-associated factor 6 [KO:K03175] [EC:2.3.2.27]
123810054  BDNF; brain-derived neurotrophic factor isoform X1 [KO:K04355]
123810182  MAPK8IP1; C-Jun-amino-terminal kinase-interacting protein 1 isoform X1 [KO:K04434]
123810187  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
123810216  PTPN5; tyrosine-protein phosphatase non-receptor type 5 isoform X1 [KO:K18018] [EC:3.1.3.48]
123810283  MAP3K2; mitogen-activated protein kinase kinase kinase 2 [KO:K04420] [EC:2.7.11.25]
123810362  [KO:K03283]
123810433  TNF; tumor necrosis factor isoform X1 [KO:K03156]
123810462  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
123810504  [KO:K03283]
123810596  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
123810612  TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158]
123810671  NTF3; neurotrophin-3 [KO:K04356]
123810721  PDGFA; platelet-derived growth factor subunit A isoform X1 [KO:K04359]
123810790  FGF1; fibroblast growth factor 1 [KO:K18496]
123810976  FGF18; fibroblast growth factor 18 [KO:K04358]
123811120  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
123811124  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
123811159  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
123811176  PPM1B; protein phosphatase 1B isoform X1 [KO:K04461] [EC:3.1.3.16]
123811181  INSR; insulin receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
123811367  CACNA2D1; voltage-dependent calcium channel subunit alpha-2/delta-1 isoform X1 [KO:K04858]
123811378  PPP3R1; calcineurin subunit B type 1 [KO:K06268]
123811389  MAP4K3; mitogen-activated protein kinase kinase kinase kinase 3 isoform X1 [KO:K04406] [EC:2.7.11.1]
123811430  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
123811490  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
123811574  RASGRP3; ras guanyl-releasing protein 3 isoform X1 [KO:K12362]
123811592  MAP4K4; mitogen-activated protein kinase kinase kinase kinase 4 isoform X1 [KO:K04407] [EC:2.7.11.1]
123811594  IL1R1; interleukin-1 receptor type 1 isoform X1 [KO:K04386]
123811703  DUSP2; dual specificity protein phosphatase 2 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123811854  IL1B; interleukin-1 beta [KO:K04519]
123811865  IL1A; interleukin-1 alpha [KO:K04383]
123811931  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
123812406  KRAS; GTPase KRas isoform X1 [KO:K07827]
123812533  PTPRR; receptor-type tyrosine-protein phosphatase R isoform X1 [KO:K04458] [EC:3.1.3.48]
123812630  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
123812651  DUSP16; dual specificity protein phosphatase 16 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123812719  RAP1B; ras-related protein Rap-1b [KO:K07836]
123812775  DDIT3; DNA damage-inducible transcript 3 protein [KO:K04452]
123812800  IRAK4; interleukin-1 receptor-associated kinase 4 isoform X1 [KO:K04733] [EC:2.7.11.1]
123812915  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
123812925  CACNB3; voltage-dependent L-type calcium channel subunit beta-3 isoform X1 [KO:K04864]
123813008  MAP3K12; mitogen-activated protein kinase kinase kinase 12 isoform X1 [KO:K04423] [EC:2.7.11.25]
123813204  DUSP1; dual specificity protein phosphatase 1 [KO:K21278] [EC:3.1.3.16 3.1.3.48]
123813215  CD14; monocyte differentiation antigen CD14 [KO:K04391]
123813249  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X1 [KO:K05090] [EC:2.7.10.1]
123813423  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C [KO:K04850]
123813509  FGF23; fibroblast growth factor 23 [KO:K22428]
123813510  FGF6; fibroblast growth factor 6 [KO:K04358]
123813523  KITLG; kit ligand isoform X1 [KO:K05461]
123813527  DUSP6; dual specificity protein phosphatase 6 [KO:K21946] [EC:3.1.3.16 3.1.3.48]
123813532  CACNA2D4; voltage-dependent calcium channel subunit alpha-2/delta-4 isoform X1 [KO:K04861]
123813640  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
123813667  FGF2; fibroblast growth factor 2 [KO:K18497]
123813684  RAPGEF2; rap guanine nucleotide exchange factor 2 isoform X1 [KO:K08018]
123813874  GADD45B; growth arrest and DNA damage-inducible protein GADD45 beta [KO:K04402]
123813920  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
123813990  MKNK2; MAP kinase-interacting serine/threonine-protein kinase 2 [KO:K04372] [EC:2.7.11.1]
123814141  PDGFC; platelet-derived growth factor C [KO:K05450]
123814187  NRTN; neurturin [KO:K25414]
123814197  PSPN; persephin [KO:K25416]
123814206  EFNA2; ephrin-A2 isoform X1 [KO:K05462]
123814364  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
123814395  RASA2; ras GTPase-activating protein 2 isoform X1 [KO:K08053]
123814505  CACNA2D3; voltage-dependent calcium channel subunit alpha-2/delta-3 isoform X1 [KO:K04860]
123814577  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
123814659  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
123814838  STK4; serine/threonine-protein kinase 4 [KO:K04411]
123815209  CDC25B; M-phase inducer phosphatase 2 [KO:K05866] [EC:3.1.3.48]
123815560  GADD45G; growth arrest and DNA damage-inducible protein GADD45 gamma [KO:K04402]
123815579  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
123815667  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
123815784  KDR; vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
123815790  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
123816012  TAB1; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 [KO:K04403]
123816126  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
123816152  CACNA1I; voltage-dependent T-type calcium channel subunit alpha-1I isoform X1 [KO:K04856]
123816191  CACNG2; voltage-dependent calcium channel gamma-2 subunit [KO:K04867]
123816206  MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
123816209  PDGFB; platelet-derived growth factor subunit B [KO:K17386]
123816243  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
123816247  MAPK11; mitogen-activated protein kinase 11 isoform X1 [KO:K04441] [EC:2.7.11.24]
123816280  MAPK8IP2; C-Jun-amino-terminal kinase-interacting protein 2 isoform X1 [KO:K04435]
123816440  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
123816445  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
123816474  GADD45A; growth arrest and DNA damage-inducible protein GADD45 alpha [KO:K04402]
123816481  DAXX; death domain-associated protein 6 [KO:K02308]
123816659  CACNG4; voltage-dependent calcium channel gamma-4 subunit [KO:K04869]
123816809  MAP3K3; mitogen-activated protein kinase kinase kinase 3 isoform X1 [KO:K04421] [EC:2.7.11.25]
123816832  MAPT; microtubule-associated protein tau isoform X1 [KO:K04380]
123816854  NF1; neurofibromin isoform X1 [KO:K08052]
123816955  CACNA1G; voltage-dependent T-type calcium channel subunit alpha-1G isoform X1 [KO:K04854]
123816974  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
123817083  MAP3K14; mitogen-activated protein kinase kinase kinase 14 [KO:K04466] [EC:2.7.11.25]
123817154  MAP2K6; dual specificity mitogen-activated protein kinase kinase 6 isoform X1 [KO:K04433] [EC:2.7.12.2]
123817160  DUSP3; dual specificity protein phosphatase 3 [KO:K17614] [EC:3.1.3.16 3.1.3.48]
123817259  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
123817318  CACNG5; voltage-dependent calcium channel gamma-5 subunit [KO:K04870]
123817321  CRK; adapter molecule crk isoform X1 [KO:K04438]
123817344  TAOK1; serine/threonine-protein kinase TAO1 isoform X1 [KO:K04429] [EC:2.7.11.1]
123817350  GRB2; growth factor receptor-bound protein 2 [KO:K04364]
123817374  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
123817421  NLK; serine/threonine-protein kinase NLK isoform X1 [KO:K04468] [EC:2.7.11.24]
123817430  CACNG1; voltage-dependent calcium channel gamma-1 subunit [KO:K04866]
123817470  CACNB1; voltage-dependent L-type calcium channel subunit beta-1 isoform X1 [KO:K04862]
123817558  PRKCA; protein kinase C alpha type [KO:K02677] [EC:2.7.11.13]
123818097  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
123818320  CACNA1E; voltage-dependent R-type calcium channel subunit alpha-1E [KO:K04852]
123818381  PLA2G4A; cytosolic phospholipase A2 isoform X1 [KO:K16342] [EC:3.1.1.4]
123818449  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
123819501  MAP3K1; mitogen-activated protein kinase kinase kinase 1 [KO:K04416] [EC:2.7.11.25]
123819554  FGF10; fibroblast growth factor 10 [KO:K04358]
123819748  TGFBR1; TGF-beta receptor type-1 [KO:K04674] [EC:2.7.11.30]
123820012  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
123820198  PPP3R2; calcineurin subunit B type 2 [KO:K06268]
123820257  NTRK2; BDNF/NT-3 growth factors receptor isoform X1 [KO:K04360] [EC:2.7.10.1]
123820551  ELK4; ETS domain-containing protein Elk-4 isoform X1 [KO:K04376]
123820667  MAPKAPK2; MAP kinase-activated protein kinase 2 [KO:K04443] [EC:2.7.11.1]
123820880  PPP3CB; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123820887  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
123821068  RET; proto-oncogene tyrosine-protein kinase receptor Ret isoform X1 [KO:K05126] [EC:2.7.10.1]
123821417  VEGFA; vascular endothelial growth factor A [KO:K05448]
123821447  RPS6KA2; ribosomal protein S6 kinase alpha-2 isoform X1 [KO:K04373] [EC:2.7.11.1]
123821518  TAOK3; serine/threonine-protein kinase TAO3 isoform X1 [KO:K04429] [EC:2.7.11.1]
123821571  MAP3K4; mitogen-activated protein kinase kinase kinase 4 isoform X1 [KO:K04428] [EC:2.7.11.25]
123821582  MAP3K5; mitogen-activated protein kinase kinase kinase 5 [KO:K04426] [EC:2.7.11.25]
123821688  TAB2; TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1 [KO:K04404]
123821751  MAP3K7; mitogen-activated protein kinase kinase kinase 7 isoform X1 [KO:K04427] [EC:2.7.11.25]
123821864  MAPKAPK5; MAP kinase-activated protein kinase 5 isoform X1 [KO:K04442] [EC:2.7.11.1]
123821969  SRF; serum response factor [KO:K04378]
123822258  MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
123822259  MAPK14; mitogen-activated protein kinase 14 isoform X1 [KO:K04441] [EC:2.7.11.24]
123822657  FLT1; vascular endothelial growth factor receptor 1 [KO:K05096] [EC:2.7.10.1]
123822727  FLT3; receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
123822789  FGF9; fibroblast growth factor 9 [KO:K04358]
123822966  RELB; transcription factor RelB [KO:K09253]
123823033  PPP5C; serine/threonine-protein phosphatase 5 [KO:K04460] [EC:3.1.3.16]
123823081  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
123823090  IRAK1; interleukin-1 receptor-associated kinase 1 isoform X1 [KO:K04730] [EC:2.7.11.1]
123823112  DUSP9; dual specificity protein phosphatase 9 [KO:K18498] [EC:3.1.3.16 3.1.3.48]
123823135  FLNA; filamin-A isoform X1 [KO:K04437]
123823376  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
123823598  TRAF2; TNF receptor-associated factor 2 isoform X1 [KO:K03173] [EC:2.3.2.27]
123823713  TGFB1; transforming growth factor beta-1 proprotein [KO:K13375]
123823743  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123823790  MAP3K10; mitogen-activated protein kinase kinase kinase 10 isoform X1 [KO:K04418] [EC:2.7.11.25]
123823849  RASGRP4; RAS guanyl-releasing protein 4 isoform X1 [KO:K12363]
123823883  MAP4K1; mitogen-activated protein kinase kinase kinase kinase 1 [KO:K04408] [EC:2.7.11.1]
123824140  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
123824143  CACNG6; voltage-dependent calcium channel gamma-6 subunit [KO:K04871]
123824144  CACNG7; voltage-dependent calcium channel gamma-7 subunit isoform X1 [KO:K04872]
123824150  CACNG8; voltage-dependent calcium channel gamma-8 subunit [KO:K04873]
123824309  RPS6KA6; ribosomal protein S6 kinase alpha-6 isoform X1 [KO:K04373] [EC:2.7.11.1]
123824352  FGF16; fibroblast growth factor 16 [KO:K04358]
123824375  MET; hepatocyte growth factor receptor isoform X1 [KO:K05099] [EC:2.7.10.1]
123824549  MEF2C; myocyte-specific enhancer factor 2C isoform X1 [KO:K04454]
123824628  RASGRF2; ras-specific guanine nucleotide-releasing factor 2 isoform X1 [KO:K12326]
123824736  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
123824870  RASA1; ras GTPase-activating protein 1 [KO:K04352]
123825489  TAOK2; serine/threonine-protein kinase TAO2 isoform X1 [KO:K04429] [EC:2.7.11.1]
123825494  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
123825515  CACNA1H; voltage-dependent T-type calcium channel subunit alpha-1H isoform X1 [KO:K04855]
123825523  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
123825593  CACNG3; voltage-dependent calcium channel gamma-3 subunit [KO:K04868]
123825630  [KO:K04409] [EC:2.7.11.1]
123826011  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
123826609  MAP2K7; dual specificity mitogen-activated protein kinase kinase 7 isoform X1 [KO:K04431] [EC:2.7.12.2]
123826822  MECOM; histone-lysine N-methyltransferase MECOM isoform X1 [KO:K04462] [EC:2.1.1.367]
123826833  MAP3K13; LOW QUALITY PROTEIN: mitogen-activated protein kinase kinase kinase 13 [KO:K04422] [EC:2.7.11.25]
123826853  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
123827290  [KO:K04723]
123828079  ERBB4; receptor tyrosine-protein kinase erbB-4 isoform X1 [KO:K05085] [EC:2.7.10.1]
123828197  PPP3CC; serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform isoform X1 [KO:K04348] [EC:3.1.3.16]
123828203  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
123828215  ECSIT; evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial [KO:K04405]
123828245  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
123828441  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
123828462  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
123828464  JUND; transcription factor jun-D [KO:K04449]
123828668  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
123828689  NFKB2; nuclear factor NF-kappa-B p100 subunit [KO:K04469]
123828714  FGFR2; fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
123828974  FGF8; fibroblast growth factor 8 isoform X1 [KO:K04358]
123829116  DUSP5; dual specificity protein phosphatase 5 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123829139  FAS; tumor necrosis factor receptor superfamily member 6 [KO:K04390]
123829212  FGF3; fibroblast growth factor 3 [KO:K04358]
123829213  FGF19; fibroblast growth factor 19 [KO:K22603]
123829277  RASGRP2; RAS guanyl-releasing protein 2 isoform X1 [KO:K12361]
123829327  MAP3K11; mitogen-activated protein kinase kinase kinase 11 [KO:K04419] [EC:2.7.11.25]
123829410  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
123829479  RPS6KA4; ribosomal protein S6 kinase alpha-4 isoform X1 [KO:K16510] [EC:2.7.11.1]
123829498  MAP4K2; mitogen-activated protein kinase kinase kinase kinase 2 [KO:K04414] [EC:2.7.11.1]
123829518  RELA; transcription factor p65 [KO:K04735]
123829593  FGF4; fibroblast growth factor 4 [KO:K04358]
123829653  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
123829882  RPS6KA3; ribosomal protein S6 kinase alpha-3 isoform X1 [KO:K04373] [EC:2.7.11.1]
123830134  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
123830210  FGF21; fibroblast growth factor 21 isoform X1 [KO:K22429]
123830294  FLT3LG; fms-related tyrosine kinase 3 ligand isoform X1 [KO:K05454]
123830304  RRAS; ras-related protein R-Ras [KO:K07829]
123830318  NTF4; neurotrophin-4 [KO:K12457]
123830325  MAP3K20; mitogen-activated protein kinase kinase kinase 20 isoform X1 [KO:K04424] [EC:2.7.11.25]
123830471  TGFBR2; TGF-beta receptor type-2 isoform X1 [KO:K04388] [EC:2.7.11.30]
123830760  MRAS; ras-related protein M-Ras [KO:K07831]
123830783  CACNA2D2; voltage-dependent calcium channel subunit alpha-2/delta-2 isoform X1 [KO:K04859]
123830816  DUSP7; dual specificity protein phosphatase 7 [KO:K04459] [EC:3.1.3.16 3.1.3.48]
123830827  MAPKAPK3; MAP kinase-activated protein kinase 3 [KO:K04444] [EC:2.7.11.1]
123830839  MYD88; myeloid differentiation primary response protein MyD88 isoform X1 [KO:K04729]
123831013  CACNB2; voltage-dependent L-type calcium channel subunit beta-2 isoform X1 [KO:K04863]
123831167  EREG; proepiregulin [KO:K09784]
123831179  MAP3K8; mitogen-activated protein kinase kinase kinase 8 [KO:K04415] [EC:2.7.11.25]
123831258  AREG; amphiregulin [KO:K09782]
123831289  FGF5; fibroblast growth factor 5 [KO:K04358]
123831409  JUN; transcription factor AP-1 [KO:K04448]
123831625  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
123831786  RPS6KA1; ribosomal protein S6 kinase alpha-1 isoform X1 [KO:K04373] [EC:2.7.11.1]
123831810  MAP3K6; mitogen-activated protein kinase kinase kinase 6 isoform X1 [KO:K04425] [EC:2.7.11.25]
123831835  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
123831882  STMN1; stathmin [KO:K04381]
123832050  MKNK1; MAP kinase-interacting serine/threonine-protein kinase 1 isoform X1 [KO:K04372] [EC:2.7.11.1]
123832146  ARTN; artemin [KO:K25415]
123832297  AKT3; RAC-gamma serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
123832334  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S isoform X1 [KO:K04857]
123832579  HSPA8; heat shock cognate 71 kDa protein [KO:K03283]
123832643  ARAF; serine/threonine-protein kinase A-Raf isoform X1 [KO:K08845] [EC:2.7.11.1]
123832645  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
123832713  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
123833073  STK3; serine/threonine-protein kinase 3 [KO:K04412]
123833335  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
123833339  MYC; myc proto-oncogene protein [KO:K04377]
Compound
C00076  Calcium cation
C00165  Diacylglycerol
C00338  Lipopolysaccharide
C00575  3',5'-Cyclic AMP
C01245  D-myo-Inositol 1,4,5-trisphosphate
Reference
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Chem Rev 101:2449-76 (2001)
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Pharmacol Ther 93:193-202 (2002)
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Reference
PMID:12947395
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Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S.
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Oncogene 22:5885-96 (2003)
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PMID:12676795
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Annu Rev Biochem 72:609-42 (2003)
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PMID:11369511
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Harper SJ, LoGrasso P.
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Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.
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Cell Signal 13:299-310 (2001)
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Reference
PMID:12390245
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Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.
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Reference
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Zhu X, Lee HG, Raina AK, Perry G, Smith MA.
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The role of mitogen-activated protein kinase pathways in Alzheimer's disease.
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Neurosignals 11:270-81 (2002)
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Reference
PMID:12849693
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Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y.
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Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.
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Toxicol Lett 143:323-30 (2003)
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PMID:20602996
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Lemmon MA, Schlessinger J
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Cell signaling by receptor tyrosine kinases.
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Cell 141:1117-34 (2010)
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Skaper SD
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The neurotrophin family of neurotrophic factors: an overview.
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Methods Mol Biol 846:1-12 (2012)
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Reference
PMID:23085193
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Chu WM
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Tumor necrosis factor.
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Cancer Lett 328:222-5 (2013)
DOI:10.1016/j.canlet.2012.10.014
Reference
PMID:22296764
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Newton K, Dixit VM
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Signaling in innate immunity and inflammation.
  Journal
Cold Spring Harb Perspect Biol 4:a006049 (2012)
DOI:10.1101/cshperspect.a006049
Reference
PMID:19483709
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Gaestel M, Kotlyarov A, Kracht M
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Targeting innate immunity protein kinase signalling in inflammation.
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Nat Rev Drug Discov 8:480-99 (2009)
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Reference
PMID:23664135
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Ajibade AA, Wang HY, Wang RF
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Cell type-specific function of TAK1 in innate immune signaling.
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Trends Immunol 34:307-16 (2013)
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Reference
PMID:24892271
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Turner MD, Nedjai B, Hurst T, Pennington DJ
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Biochim Biophys Acta 1843:2563-2582 (2014)
DOI:10.1016/j.bbamcr.2014.05.014
Related
pathway
phas04070  Phosphatidylinositol signaling system
phas04110  Cell cycle
phas04115  p53 signaling pathway
phas04210  Apoptosis
phas04310  Wnt signaling pathway
phas04668  TNF signaling pathway
KO pathway
ko04010   

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