KEGG   PATHWAY: tup04140
Entry
tup04140                    Pathway                                
Name
Autophagy - animal - Tupaia chinensis (Chinese tree shrew)
Description
Autophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily conserved among eukaryotes and exquisitely regulated. This progress initiates with production of the autophagosome, a double-membrane intracellular structure of reticular origin that engulfs cytoplasmic contents and ultimately fuses with lysosomes for cargo degradation. Autophagy is regulated in response to extra- or intracellular stress and signals such as starvation, growth factor deprivation and ER stress. Constitutive level of autophagy plays an important role in cellular homeostasis and maintains quality control of essential cellular components.
Class
Cellular Processes; Transport and catabolism
Pathway map
tup04140  Autophagy - animal
tup04140

Other DBs
GO: 0006914
Organism
Tupaia chinensis (Chinese tree shrew) [GN:tup]
Gene
102467810  MAP1LC3C; microtubule associated protein 1 light chain 3 gamma [KO:K10435]
102467826  VPS41; VPS41, HOPS complex subunit [KO:K20184]
102468234  MRAS; muscle RAS oncogene homolog [KO:K07831]
102468736  EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3 [KO:K08860] [EC:2.7.11.1]
102469301  RRAGA; ras-related GTP-binding protein A [KO:K16185]
102469401  PIK3R2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
102469605  [KO:K21347]
102470222  VPS39; VPS39, HOPS complex subunit [KO:K20183]
102470650  EIF2S1; eukaryotic translation initiation factor 2 subunit alpha [KO:K03237]
102470795  RPTOR; regulatory associated protein of MTOR complex 1 [KO:K07204]
102470897  RB1CC1; RB1 inducible coiled-coil 1 [KO:K17589]
102471073  ATG10; autophagy related 10 [KO:K17888]
102471546  ATG2A; autophagy related 2A [KO:K17906]
102472094  VPS33A; VPS33A, CORVET/HOPS core subunit [KO:K20182]
102472172  AKT2; AKT serine/threonine kinase 2 [KO:K04456] [EC:2.7.11.1]
102472233  MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
102472641  SMCR8; Smith-Magenis syndrome chromosome region, candidate 8 [KO:K23611]
102472744  ATG16L1; autophagy related 16 like 1 [KO:K17890]
102473351  PIK3C3; phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]
102473456  ATG5; autophagy related 5 [KO:K08339]
102473463  GORASP2; golgi reassembly stacking protein 2 [KO:K26797]
102473496  IGF1R; insulin like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
102473622  ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO:K04958]
102473678  LAMP2; lysosomal associated membrane protein 2 [KO:K06528]
102473705  BIRC6; baculoviral IAP repeat containing 6 [KO:K10586] [EC:2.3.2.23]
102474161  [KO:K02977]
102474297  AKT3; AKT serine/threonine kinase 3 [KO:K04456] [EC:2.7.11.1]
102474582  CTSD; cathepsin D [KO:K01379] [EC:3.4.23.5]
102474592  BCL2; BCL2, apoptosis regulator [KO:K02161]
102474758  ATG4D; autophagy related 4D cysteine peptidase [KO:K08342] [EC:3.4.22.-]
102475031  ATG7; autophagy related 7 [KO:K08337]
102475214  ATG9B; autophagy related 9B [KO:K17907]
102475393  RAB1A; RAB1A, member RAS oncogene family [KO:K07874]
102475394  MAP1LC3B; microtubule associated protein 1 light chain 3 beta [KO:K10435]
102475423  RPS6KB2; ribosomal protein S6 kinase B2 [KO:K04688] [EC:2.7.11.1]
102475532  [KO:K01365] [EC:3.4.22.15]
102475730  MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
102475854  ATG2B; autophagy related 2B [KO:K17906]
102476361  MTMR4; myotubularin related protein 4 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
102476496  MAP2K1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
102476949  PIK3R4; phosphoinositide-3-kinase regulatory subunit 4 [KO:K08333] [EC:2.7.11.1]
102477255  ULK1; unc-51 like autophagy activating kinase 1 [KO:K21357] [EC:2.7.11.1]
102477331  MAP3K7; mitogen-activated protein kinase kinase kinase 7 [KO:K04427] [EC:2.7.11.25]
102477411  UBA52; ubiquitin A-52 residue ribosomal protein fusion product 1 [KO:K02927]
102477807  RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
102477819  WIPI2; WD repeat domain, phosphoinositide interacting 2 [KO:K17908]
102477877  OPTN; optineurin [KO:K19946]
102478525  PRKACA; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
102479161  PPP2CA; protein phosphatase 2 catalytic subunit alpha [KO:K04382] [EC:3.1.3.16]
102479222  RRAGC; Ras related GTP binding C [KO:K16186]
102480078  RAB33B; RAB33B, member RAS oncogene family [KO:K07920]
102480117  VAMP8; vesicle associated membrane protein 8 [KO:K08512]
102480476  DAPK2; death associated protein kinase 2 [KO:K08803] [EC:2.7.11.1]
102480495  MAP1LC3A; microtubule associated protein 1 light chain 3 alpha [KO:K10435]
102480638  EPG5; ectopic P-granules autophagy protein 5 homolog [KO:K23883]
102480731  NRBF2; nuclear receptor binding factor 2 [KO:K21246]
102481191  INS; insulin [KO:K04526]
102481334  VPS18; VPS18, CORVET/HOPS core subunit [KO:K20181]
102481347  TANK; TRAF family member associated NFKB activator [KO:K12650]
102481748  ATG12; autophagy related 12 [KO:K08336]
102481788  RAB8A; RAB8A, member RAS oncogene family [KO:K07901]
102482055  BNIP3; BCL2 interacting protein 3 [KO:K15464]
102482652  TRAF6; TNF receptor associated factor 6 [KO:K03175] [EC:2.3.2.27]
102482992  [KO:K02977]
102483057  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
102483282  SNAP29; synaptosome associated protein 29 [KO:K08509]
102483329  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
102483442  STX7; syntaxin 7 [KO:K08488]
102483474  TSC1; tuberous sclerosis 1 [KO:K07206]
102483527  RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
102483590  CTSB; cathepsin B [KO:K01363] [EC:3.4.22.1]
102483700  MAP2K2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
102483724  LAMP1; lysosomal associated membrane protein 1 [KO:K06528]
102484078  TBK1; TANK binding kinase 1 [KO:K05410] [EC:2.7.11.10]
102484276  TSC2; tuberous sclerosis 2 [KO:K07207]
102484444  PIK3R3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
102484500  PIK3R1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
102484915  UBB; ubiquitin B [KO:K04551]
102485172  GABARAP; GABA type A receptor-associated protein [KO:K08341]
102485262  MTOR; mechanistic target of rapamycin [KO:K07203] [EC:2.7.11.1]
102485293  VPS16; VPS16, CORVET/HOPS core subunit [KO:K20180]
102485377  GABARAPL1; GABA type A receptor associated protein like 1 [KO:K08341]
102485528  AKT1S1; AKT1 substrate 1 [KO:K16184]
102485662  ATG4A; autophagy related 4A cysteine peptidase [KO:K08342] [EC:3.4.22.-]
102485941  [KO:K17606]
102486143  WDR45; WD repeat domain 45 [KO:K22991]
102486437  STX17; syntaxin 17 [KO:K08491]
102486626  BCL2L1; BCL2 like 1 [KO:K04570]
102486807  ATG14; autophagy related 14 [KO:K17889]
102486959  HIF1A; hypoxia inducible factor 1 alpha subunit [KO:K08268]
102487574  PRKCD; protein kinase C delta [KO:K06068] [EC:2.7.11.13]
102487892  [KO:K02927]
102487950  [KO:K04382] [EC:3.1.3.16]
102488020  ATG16L2; autophagy related 16 like 2 [KO:K20868]
102488403  MTMR14; myotubularin related protein 14 [KO:K18086] [EC:3.1.3.64 3.1.3.95]
102488530  CALCOCO2; calcium binding and coiled-coil domain 2 [KO:K21348]
102488975  BECN1; beclin 1 [KO:K08334]
102489114  PTEN; phosphatase and tensin homolog [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
102489199  [KO:K02927]
102489416  IRS4; insulin receptor substrate 4 [KO:K17446]
102490430  [KO:K01365] [EC:3.4.22.15]
102490992  WDR45B; WD repeat domain 45B [KO:K22991]
102491119  PRKAA2; protein kinase AMP-activated catalytic subunit alpha 2 [KO:K07198] [EC:2.7.11.31]
102491255  [KO:K01365] [EC:3.4.22.15]
102491258  PRAP1; proline rich acidic protein 1 [KO:K21250]
102491329  SH3GLB1; SH3 domain containing GRB2 like endophilin B1 [KO:K11248]
102491386  RRAS; related RAS viral (r-ras) oncogene homolog [KO:K07829]
102491552  WIPI1; WD repeat domain, phosphoinositide interacting 1 [KO:K17908]
102491681  MLST8; MTOR associated protein, LST8 homolog [KO:K08266]
102491780  AMBRA1; autophagy and beclin 1 regulator 1 [KO:K17985]
102491971  ERN1; endoplasmic reticulum to nucleus signaling 1 [KO:K08852] [EC:2.7.11.1 3.1.26.-]
102492554  YKT6; YKT6 v-SNARE homolog (S. cerevisiae) [KO:K08516]
102492771  AKT1; AKT serine/threonine kinase 1 [KO:K04456] [EC:2.7.11.1]
102492798  ATG101; autophagy related 101 [KO:K19730]
102493011  DDIT4; DNA damage inducible transcript 4 [KO:K08270]
102493152  RPS6KB1; ribosomal protein S6 kinase B1 [KO:K04688] [EC:2.7.11.1]
102493230  HRAS; HRas proto-oncogene, GTPase [KO:K02833]
102493235  CAMKK2; calcium/calmodulin dependent protein kinase kinase 2 [KO:K07359] [EC:2.7.11.17]
102493273  ZFYVE1; zinc finger FYVE-type containing 1 [KO:K17603]
102493447  UVRAG; UV radiation resistance associated [KO:K21249]
102493543  VPS11; VPS11, CORVET/HOPS core subunit [KO:K20179]
102493891  TP53INP2; tumor protein p53 inducible nuclear protein 2 [KO:K21247]
102494248  SUPT20H; SPT20 homolog, SAGA complex component [KO:K21245]
102494501  CFLAR; CASP8 and FADD like apoptosis regulator [KO:K04724]
102495112  WDR41; WD repeat domain 41 [KO:K23610]
102495340  NBR1; NBR1, autophagy cargo receptor [KO:K17987]
102495486  TAX1BP1; Tax1 binding protein 1 [KO:K21347]
102495513  EIF2AK4; eukaryotic translation initiation factor 2 alpha kinase 4 [KO:K16196] [EC:2.7.11.1]
102495892  RRAGD; Ras related GTP binding D [KO:K16186]
102495895  DAPK1; death associated protein kinase 1 [KO:K08803] [EC:2.7.11.1]
102496235  MTMR3; myotubularin related protein 3 [KO:K18082] [EC:3.1.3.48 3.1.3.64 3.1.3.95]
102496329  RRAS2; ras-related protein R-Ras2 [KO:K07830]
102496453  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
102496534  NRAS; neuroblastoma RAS viral oncogene homolog [KO:K07828]
102496620  IRS1; insulin receptor substrate 1 [KO:K16172]
102496661  RRAGB; Ras related GTP binding B [KO:K16185]
102497095  MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
102497244  ATG4B; autophagy related 4B cysteine peptidase [KO:K08342] [EC:3.4.22.-]
102497488  RAF1; Raf-1 proto-oncogene, serine/threonine kinase [KO:K04366] [EC:2.7.11.1]
102497633  PDPK1; 3-phosphoinositide dependent protein kinase 1 [KO:K06276] [EC:2.7.11.1]
102498069  BAD; BCL2 associated agonist of cell death [KO:K02158]
102498598  SQSTM1; sequestosome 1 [KO:K14381]
102498896  PRKCQ; protein kinase C theta [KO:K18052] [EC:2.7.11.13]
102498991  GORASP1; golgi reassembly stacking protein 1 [KO:K26797]
102499437  ATG4C; autophagy related 4C cysteine peptidase [KO:K08342] [EC:3.4.22.-]
102499783  RUBCN; RUN and cysteine rich domain containing beclin 1 interacting protein [KO:K19330]
102500069  KRAS; KRAS proto-oncogene, GTPase [KO:K07827]
102500173  PPP2CB; protein phosphatase 2 catalytic subunit beta [KO:K04382] [EC:3.1.3.16]
102500211  DEPTOR; DEP domain containing MTOR interacting protein [KO:K20402]
102500530  PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
102500757  ATG13; autophagy related 13 [KO:K08331]
102500813  [KO:K01365] [EC:3.4.22.15]
102500868  ATG9A; autophagy related 9A [KO:K17907]
102500922  [KO:K23609]
102501152  RAB39B; RAB39B, member RAS oncogene family [KO:K07925]
102501335  WDFY3; WD repeat and FYVE domain containing 3 [KO:K22262]
102501394  [KO:K08341]
102501428  PLEKHM1; pleckstrin homology and RUN domain containing M1 [KO:K23282]
102501463  RPS27A; ribosomal protein S27a [KO:K02977]
102501859  IGBP1; immunoglobulin binding protein 1 [KO:K17606]
102501936  [KO:K01365] [EC:3.4.22.15]
102502163  PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
102502422  STK11; serine/threonine kinase 11 [KO:K07298] [EC:2.7.11.1]
102502506  PRKACB; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
102502516  RHEB; Ras homolog enriched in brain [KO:K07208]
102502678  GABARAPL2; GABA type A receptor associated protein like 2 [KO:K08341]
102502826  ULK2; unc-51 like autophagy activating kinase 2 [KO:K08269] [EC:2.7.11.1]
102502864  BECN2; beclin 2 [KO:K08334]
102502989  ATG3; autophagy related 3 [KO:K08343]
106733777  [KO:K10802]
106734036  [KO:K07830]
106734235  DAPK3; death associated protein kinase 3 [KO:K08803] [EC:2.7.11.1]
106735435  [KO:K10802]
106735628  [KO:K17445]
106735707  PRKAA1; protein kinase AMP-activated catalytic subunit alpha 1 [KO:K07198] [EC:2.7.11.31]
106736149  [KO:K02977]
106736453  [KO:K00922] [EC:2.7.1.153]
Compound
C00035  GDP
C00044  GTP
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:15325584
  Authors
Meijer AJ, Codogno P.
  Title
Regulation and role of autophagy in mammalian cells.
  Journal
Int J Biochem Cell Biol 36:2445-62 (2004)
DOI:10.1016/j.biocel.2004.02.002
Reference
PMID:16099218
  Authors
Deretic V.
  Title
Autophagy in innate and adaptive immunity.
  Journal
Trends Immunol 26:523-8 (2005)
DOI:10.1016/j.it.2005.08.003
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:15325588
  Authors
Tanida I, Ueno T, Kominami E.
  Title
LC3 conjugation system in mammalian autophagy.
  Journal
Int J Biochem Cell Biol 36:2503-18 (2004)
DOI:10.1016/j.biocel.2004.05.009
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:16125113
  Authors
Bechet D, Tassa A, Taillandier D, Combaret L, Attaix D.
  Title
Lysosomal proteolysis in skeletal muscle.
  Journal
Int J Biochem Cell Biol 37:2098-114 (2005)
DOI:10.1016/j.biocel.2005.02.029
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:20034776
  Authors
Yang Z, Klionsky DJ
  Title
Mammalian autophagy: core molecular machinery and signaling regulation.
  Journal
Curr Opin Cell Biol 22:124-31 (2010)
DOI:10.1016/j.ceb.2009.11.014
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:24343578
  Authors
Russell RC, Yuan HX, Guan KL
  Title
Autophagy regulation by nutrient signaling.
  Journal
Cell Res 24:42-57 (2014)
DOI:10.1038/cr.2013.166
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
Related
pathway
tup04010  MAPK signaling pathway
tup04141  Protein processing in endoplasmic reticulum
tup04142  Lysosome
tup04150  mTOR signaling pathway
tup04152  AMPK signaling pathway
tup04910  Insulin signaling pathway
KO pathway
ko04140   

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