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ENTRY	nt06165
Name	Epstein-Barr virus (EBV)
Category	Disease view; Viral infection
Pathway	hsa05169 Epstein-Barr virus infection
Genome	T40079
Disease	H00367 Infectious mononucleosis H00008 Burkitt lymphoma
Display	drug-target relation   disease type

PI3K signaling N00033    EGF → EGFR → PI3K → PIP3 → AKT ⊣ BAD N00485    LMP1 → (TRAF3,TRAF5) → PI3K N00266    LMP2A → (LYN,SYK) → PI3K   JAK-STAT signaling N00053    Cytokine → Receptor → JAK → STAT ⇒ PIM1 N00486        LMP1 → JAK3 → (STAT3+STAT1)   Calcium signaling N00487    IGH → (LYN,SYK) → (BTK,BLNK) → PLCG2 → IP3 → Ca2+ → CALM = CN → NFAT N00488    (LMP2A+NEDD4) ⊣ (LYN,SYK)   TLR signaling N00435    (TLR1,TLR2,TLR4) → (TIRAP+MYD88) → (IRAK4+IRAK1) → (TRAF6+TAK1+TAB2) → IKK → NFKBIA → NFKB ⇒ (TNF,IL6,IL12A,IL1.. N00466            BPLF1 ⊣ (TRAF6+TAK1+(TAB1,.. N00467                BPLF1 ⊣ IKK N00468                    BPLF1 ⊣ NFKBIA   RLR signaling N00469    RNA → RIGI → MAVS → TRAF3 → (TANK+NAP1+SINTBAD.. → (TBK1+IKBKE) → (IRF7,IRF3) ⇒ (IFNA,IFNB1) N00470                        BGLF4 ⊣ IRF3   IFN signaling N00150    (IFNA,IFNB1) → (IFNAR1+IFNAR2) → (JAK1,TYK2) → (STAT1+STAT2+IRF9) ⇒ (IRF7,EIF2AK2) N00471    (LMP2A,LMP2B) ⊣ (IFNAR1+IFNAR2) N00472        LMP1 ⊣ TYK2 N00473            BGLF4 ⊣ (STAT1+STAT2+IRF9)   TNF signaling N00151        TNF → TNFRSF1A → (RIPK1+TRADD+TRAF2.. → (TAB1/2/3+TAK1) → IKK → NFKBIA → NFKB N00265            LMP1 → (TRADD+TRAF6) → (TAB1/2+TAK1) → IKK → NFKBIA → NFKB   MHC presentation N00363        TAP1/2 = TAPBP = (PDIA3+CALR) → (MHCI+B2M) N00479    BNLF2A ⊣ TAP1/2 N00480                BILF1 ⊣ MHCI   Cell cycle N00066    CDKN2A ⊣ MDM2 ⊣ TP53 ⇒ CDKN1A ⊣ (CCND+CDK4/6) → RB1 ⌿ E2F N00483                EBNA3C → (CCND+CDK4/6) → RB1 ⌿ E2F N00484                EBNA3C → SKP2 → RB1 ⌿ E2F N00091            (SCF+SKP2) ⊣ CDKN1B ⊣ ((CCNA,CCNE)+CDK2) → RB1 ⌿ E2F N00264        EBNA3C → SKP2 ⊣ CDKN1B ⊣ ((CCNA,CCNE)+CDK2) → RB1 ⌿ E2F N00482                EBNA3C → ((CCNA,CCNE)+CDK2) → RB1 ⌿ E2F   Apoptosis N00146    (FASLG,TNFSF10) → (FAS,TNFRSF10B) → FADD → (CASP8,CASP10) → BID → (BAX,BAK1) → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00477                BHRF1 ⊣ BID N00098                (PMAIP1,BBC3,BAD,B.. ⊣ (BCL2,BCL2L1) ⊣ (BAX,BAK1) → CYCS = APAF1 → CASP9 → (CASP3,CASP7) N00262            EBNA3C ⊣ BCL2L11 N00474            BHRF1 ⊣ BCL2L11 N00475                BHRF1 → BCL2 N00478                BARF1 → BCL2 ⊣ (BAX,BAK1) → CYCS = APAF1 → CASP9 → CASP3 N00476                    BHRF1 ⊣ BAK1   Transcription N00481        BZLF1 ⊣ TP53 ⇒ (CDKN1A,GADD45,BAX.. N00223    EBNA1 ⊣ USP7 → TP53 ⇒ (CDKN1A,GADD45,BAX.. N00225        EBNA2 = SNW1 → RBPJ ⇒ (LMP1,CR2,HES1,FCE.. N00224    EBNALP → EBNA2 = SNW1 → RBPJ ⇒ LMP1 N00226            (EBNA3A,EBNA3B,EBN.. ⊣ RBPJ ⇒ LMP1 N00263    EBNA3C → MDM2 ⊣ TP53 ⇒ (CDKN1A,GADD45,BAX..