KEGG    Network variation - Epstein-Barr virus (EBV)
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ENTRYnt06165
NameEpstein-Barr virus (EBV)
CategoryDisease view; Viral infection
Pathwayhsa05169 Epstein-Barr virus infection
GenomeT40079
DiseaseH00367 Infectious mononucleosis
H00008 Burkitt lymphoma
Display drug-target relation   disease type
PI3K signaling
N00033    EGFEGFRPI3KPIP3AKTBAD
N00485    LMP1(TRAF3,TRAF5)PI3K
N00266    LMP2A(LYN,SYK)PI3K
 
JAK-STAT signaling
N00053    CytokineReceptorJAKSTATPIM1
N00486      LMP1JAK3(STAT3+STAT1)
 
Calcium signaling
N00487    IGH(LYN,SYK)(BTK,BLNK)PLCG2IP3Ca2+CALM=CNNFAT
N00488    (LMP2A+NEDD4)(LYN,SYK)
 
TLR signaling
N00435    (TLR1,TLR2,TLR4)(TIRAP+MYD88)(IRAK4+IRAK1)(TRAF6+TAK1+TAB2)IKKNFKBIANFKB(TNF,IL6,IL12A,IL1..
N00466        BPLF1(TRAF6+TAK1+(TAB1,..
N00467          BPLF1IKK
N00468            BPLF1NFKBIA
 
RLR signaling
N00469    RNARIGIMAVSTRAF3(TANK+NAP1+SINTBAD..(TBK1+IKBKE)(IRF7,IRF3)(IFNA,IFNB1)
N00470              BGLF4IRF3
 
IFN signaling
N00150    (IFNA,IFNB1)(IFNAR1+IFNAR2)(JAK1,TYK2)(STAT1+STAT2+IRF9)(IRF7,EIF2AK2)
N00471    (LMP2A,LMP2B)(IFNAR1+IFNAR2)
N00472      LMP1TYK2
N00473        BGLF4(STAT1+STAT2+IRF9)
 
TNF signaling
N00151      TNFTNFRSF1A(RIPK1+TRADD+TRAF2..(TAB1/2/3+TAK1)IKKNFKBIANFKB
N00265        LMP1(TRADD+TRAF6)(TAB1/2+TAK1)IKKNFKBIANFKB
 
MHC presentation
N00363      TAP1/2=TAPBP=(PDIA3+CALR)(MHCI+B2M)
N00479    BNLF2ATAP1/2
N00480          BILF1MHCI
 
Cell cycle
N00066    CDKN2AMDM2TP53CDKN1A(CCND+CDK4/6)RB1E2F
N00483          EBNA3C(CCND+CDK4/6)RB1E2F
N00484          EBNA3CSKP2RB1E2F
N00091        (SCF+SKP2)CDKN1B((CCNA,CCNE)+CDK2)RB1E2F
N00264      EBNA3CSKP2CDKN1B((CCNA,CCNE)+CDK2)RB1E2F
N00482          EBNA3C((CCNA,CCNE)+CDK2)RB1E2F
 
Apoptosis
N00146    (FASLG,TNFSF10)(FAS,TNFRSF10B)FADD(CASP8,CASP10)BID(BAX,BAK1)CYCS=APAF1CASP9(CASP3,CASP7)
N00477          BHRF1BID
N00098          (PMAIP1,BBC3,BAD,B..(BCL2,BCL2L1)(BAX,BAK1)CYCS=APAF1CASP9(CASP3,CASP7)
N00262        EBNA3CBCL2L11
N00474        BHRF1BCL2L11
N00475          BHRF1BCL2
N00478          BARF1BCL2(BAX,BAK1)CYCS=APAF1CASP9CASP3
N00476            BHRF1BAK1
 
Transcription
N00481      BZLF1TP53(CDKN1A,GADD45,BAX..
N00223    EBNA1USP7TP53(CDKN1A,GADD45,BAX..
N00225      EBNA2=SNW1RBPJ(LMP1,CR2,HES1,FCE..
N00224    EBNALPEBNA2=SNW1RBPJLMP1
N00226        (EBNA3A,EBNA3B,EBN..RBPJLMP1
N00263    EBNA3CMDM2TP53(CDKN1A,GADD45,BAX..