KEGG   ORTHOLOGY: K05856Help
Entry
K05856                      KO                                     

Name
LCK
Definition
lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
Pathway
ko04064  NF-kappa B signaling pathway
ko04380  Osteoclast differentiation
ko04650  Natural killer cell mediated cytotoxicity
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko05135  Yersinia infection
ko05166  Human T-cell leukemia virus 1 infection
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05340  Primary immunodeficiency
Disease
H00093  Combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04660 T cell receptor signaling pathway
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04658 Th1 and Th2 cell differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04659 Th17 cell differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09163 Immune disease
   05340 Primary immunodeficiency
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
BRITE hierarchy
Other DBs
GO: 0004715
Genes
HSA: 3932(LCK)
PTR: 456715(LCK)
PPS: 100979670(LCK)
GGO: 101151112(LCK)
PON: 100436326(LCK)
NLE: 100585201(LCK)
MCC: 717704(LCK)
MCF: 102140916(LCK)
CSAB: 103225952(LCK)
RRO: 104654761(LCK)
RBB: 108518588(LCK)
SBQ: 101041579(LCK)
MMU: 16818(Lck)
MCAL: 110292164(Lck)
MPAH: 110322849(Lck)
RNO: 313050(Lck)
MUN: 110548547(Lck)
CGE: 100759316(Lck)
NGI: 103745927(Lck)
HGL: 101714396(Lck)
CCAN: 109692973(Lck)
OCU: 100349102(LCK)
TUP: 102468526(LCK)
CFA: 478151(LCK)
VVP: 112931744(LCK)
AML: 100477981(LCK)
UMR: 103666444(LCK)
UAH: 113268359(LCK)
ORO: 101383028(LCK)
ELK: 111142990
FCA: 101098805(LCK)
PTG: 102967826(LCK)
PPAD: 109255318(LCK)
AJU: 106982436(LCK)
BTA: 508890(LCK)
BOM: 102264903(LCK)
BIU: 109572368(LCK)
BBUB: 102406784(LCK)
CHX: 102171746(LCK)
OAS: 100216439(LCK)
SSC: 100233188(LCK)
CFR: 102507741(LCK)
CDK: 105085793(LCK)
BACU: 102998192(LCK)
LVE: 103069516(LCK)
OOR: 101271418(LCK)
DLE: 111175513(LCK)
PCAD: 102992010(LCK)
ECB: 100146139(LCK)
EPZ: 103552084(LCK)
EAI: 106829050(LCK)
MYB: 102242493(LCK)
MYD: 102764895(LCK)
MNA: 107542423(LCK)
HAI: 109390746(LCK) 109390751
DRO: 112299317(LCK)
PALE: 102891182(LCK)
RAY: 107513587(LCK)
MJV: 108407415(LCK)
LAV: 100666557(LCK)
TMU: 101358037
MDO: 100025680(LCK)
SHR: 100922118(LCK)
PCW: 110206265(LCK)
OAA: 100078190(LCK)
GGA: 396460(LCK)
MGP: 100547084(LCK)
CJO: 107323874(LCK)
NMEL: 110387471(LCK)
ACYG: 106037891(LCK)
TGU: 115498263(LCK)
LSR: 110475352(LCK)
SCAN: 103823477(LCK)
GFR: 102044922(LCK)
FAB: 101820768(LCK)
PHI: 102102392(LCK)
PMAJ: 107214075(LCK)
CCAE: 111945885
CCW: 104694772(LCK)
ETL: 114073234
FPG: 101919897(LCK)
FCH: 102055232(LCK)
CLV: 102085229(LCK)
EGZ: 104134930(LCK)
NNI: 104017767(LCK)
ACUN: 113488171(LCK)
PADL: 103923795(LCK)
AAM: 106493274(LCK)
ASN: 102374716(LCK)
AMJ: 102562977(LCK)
PSS: 102450693(LCK)
CMY: 102938279
CPIC: 101942842(LCK)
ACS: 100556474(lck)
PVT: 110082790(LCK)
PBI: 103065569(LCK)
PMUR: 107285506(LCK)
PMUA: 114601668(LCK)
GJA: 107107743(LCK)
XLA: 100036955(lck.L) 108708930(lck.S)
XTR: 100497656(lck)
NPR: 108795316(LCK)
DRE: 414333(lck)
SGH: 107582994(lck) 107583665
IPU: 108270195(LCK)
PHYP: 113545028
AMEX: 103032401(lck)
EEE: 113576333
TRU: 101064341(blk) 101075948(lck)
LCO: 104919312(lck)
NCC: 104946729(lck)
MZE: 101474633(lck)
ONL: 100712193(lck)
OLA: 100170631(lck) 101163706(blk)
XMA: 102224821(lck) 102225667(blk)
XCO: 114134400(lck) 114158151(blk)
PRET: 103458632(lck)
CVG: 107082827 107096412(lck)
NFU: 107392534(lck)
KMR: 108232471(lck) 108242452(blk)
ALIM: 106518262(lck) 106525299
AOCE: 111578479(lck)
CSEM: 103382672(lck)
POV: 109627923(lck)
LCF: 108898014
SDU: 111225420(lck)
SLAL: 111650089(lck)
HCQ: 109520801(lck)
BPEC: 110155252(lck) 110155529
MALB: 109964987(lck)
SASA: 100194878(lck) 106578585(lck)
SALP: 111963179 111968811(lck)
ELS: 105015810(lck)
SFM: 108931279(lck)
PKI: 111833034(lck)
LCM: 102361989(LCK)
CMK: 103184977 103185670(lck)
RTP: 109923406
EGL: EGR_10002
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3493153
  Authors
Koga Y, Caccia N, Toyonaga B, Spolski R, Yanagi Y, Yoshikai Y, Mak TW
  Title
A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases.
  Journal
Eur J Immunol 16:1643-6 (1986)
DOI:10.1002/eji.1830161229
  Sequence
[hsa:3932]
Reference
PMID:8293463
  Authors
Weiss A, Littman DR
  Title
Signal transduction by lymphocyte antigen receptors.
  Journal
Cell 76:263-74 (1994)
DOI:10.1016/0092-8674(94)90334-4
Reference
  Authors
Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM
  Title
Centrosome docking at the immunological synapse is controlled by Lck signaling.
  Journal
J Cell Biol 192:663-74 (2011)
DOI:10.1083/jcb.201008140
LinkDB All DBs

KEGG   ORTHOLOGY: K05703Help
Entry
K05703                      KO                                     

Name
FYN
Definition
tyrosine-protein kinase Fyn [EC:2.7.10.2]
Pathway
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04360  Axon guidance
ko04380  Osteoclast differentiation
ko04510  Focal adhesion
ko04520  Adherens junction
ko04611  Platelet activation
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04725  Cholinergic synapse
ko05020  Prion diseases
ko05130  Pathogenic Escherichia coli infection
ko05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    K05703  FYN; tyrosine-protein kinase Fyn
   04071 Sphingolipid signaling pathway
    K05703  FYN; tyrosine-protein kinase Fyn
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05703  FYN; tyrosine-protein kinase Fyn
   04520 Adherens junction
    K05703  FYN; tyrosine-protein kinase Fyn
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K05703  FYN; tyrosine-protein kinase Fyn
   04650 Natural killer cell mediated cytotoxicity
    K05703  FYN; tyrosine-protein kinase Fyn
   04660 T cell receptor signaling pathway
    K05703  FYN; tyrosine-protein kinase Fyn
   04664 Fc epsilon RI signaling pathway
    K05703  FYN; tyrosine-protein kinase Fyn
  09156 Nervous system
   04725 Cholinergic synapse
    K05703  FYN; tyrosine-protein kinase Fyn
  09158 Development and regeneration
   04360 Axon guidance
    K05703  FYN; tyrosine-protein kinase Fyn
   04380 Osteoclast differentiation
    K05703  FYN; tyrosine-protein kinase Fyn
 09160 Human Diseases
  09164 Neurodegenerative disease
   05020 Prion diseases
    K05703  FYN; tyrosine-protein kinase Fyn
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K05703  FYN; tyrosine-protein kinase Fyn
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K05703  FYN; tyrosine-protein kinase Fyn
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05703  FYN; tyrosine-protein kinase Fyn
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05703  FYN; tyrosine-protein kinase Fyn
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05703  FYN; tyrosine-protein kinase Fyn
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K05703  FYN; tyrosine-protein kinase Fyn
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K05703  FYN; tyrosine-protein kinase Fyn
 Endocytosis
  Lipid raft mediated endocytosis
   Flotillin-dependent endocytosis
    K05703  FYN; tyrosine-protein kinase Fyn
BRITE hierarchy
Other DBs
GO: 0004715
Genes
HSA: 2534(FYN)
PTR: 462944(FYN)
PPS: 100971932(FYN)
GGO: 101143006(FYN)
PON: 100439712(FYN)
NLE: 100585303(FYN)
MCC: 574214(FYN)
MCF: 102126878(FYN)
CSAB: 103240563(FYN)
RRO: 104668854(FYN)
RBB: 108512073(FYN)
CJC: 100391434(FYN)
SBQ: 101051746(FYN)
MMU: 14360(Fyn)
MCAL: 110302997(Fyn)
MPAH: 110326389(Fyn)
RNO: 25150(Fyn)
MUN: 110561016(Fyn)
CGE: 100772355(Fyn)
NGI: 103749533(Fyn)
HGL: 101721279(Fyn)
CCAN: 109695356(Fyn)
OCU: 100339741(FYN)
TUP: 102498676(FYN)
CFA: 475032(FYN)
VVP: 112925186(FYN)
AML: 100470931(FYN)
UMR: 103676988(FYN)
UAH: 113264721(FYN)
ORO: 101362244(FYN)
ELK: 111158275
FCA: 101085720(FYN)
PTG: 102956260(FYN)
PPAD: 109263555(FYN)
AJU: 106968910(FYN)
BTA: 527263(FYN)
BOM: 102284015(FYN)
BIU: 109563811(FYN)
BBUB: 102416287(FYN)
CHX: 102179673(FYN)
OAS: 101109363(FYN)
SSC: 791125(FYN)
CFR: 102506492(FYN)
CDK: 105099211(FYN)
BACU: 103012275(FYN)
LVE: 103071829(FYN)
OOR: 101279266(FYN)
DLE: 111164732(FYN)
PCAD: 102974010(FYN)
ECB: 102149085(FYN)
EPZ: 103547543(FYN)
EAI: 106847048(FYN)
MYB: 102242533(FYN)
MYD: 102751410(FYN)
MNA: 107540684(FYN)
HAI: 109384758(FYN)
DRO: 112297021(FYN)
PALE: 102896849(FYN)
RAY: 107506307(FYN)
MJV: 108396080(FYN)
LAV: 100675535(FYN)
TMU: 101340362
MDO: 100022459(FYN)
SHR: 100923088(FYN)
PCW: 110222880(FYN)
OAA: 100073798(FYN)
GGA: 396294(FYN)
MGP: 100543914
CJO: 107311849(FYN)
NMEL: 110397033(FYN)
APLA: 101799525(FYN)
ACYG: 106032576(FYN)
TGU: 100228220(FYN)
LSR: 110484642(FYN)
SCAN: 103818548(FYN)
GFR: 102037765(FYN)
FAB: 101807629(FYN)
PHI: 102103534(FYN)
PMAJ: 107202142(FYN)
CCAE: 111927157(FYN)
CCW: 104691303(FYN)
ETL: 114062026(FYN)
FPG: 101924310(FYN)
FCH: 102057542(FYN)
CLV: 102095466(FYN)
EGZ: 104131981(FYN)
NNI: 104011133(FYN)
ACUN: 113477834(FYN)
PADL: 103918980(FYN)
AAM: 106489691(FYN)
ASN: 102384418(FYN)
AMJ: 102574913(FYN)
PSS: 102464071(FYN)
CMY: 102935370(FYN)
CPIC: 101949716(FYN)
ACS: 100559709(fyn)
PVT: 110085313(FYN)
PBI: 103062202(FYN)
PMUR: 107287161(FYN)
TSR: 106540113(FYN)
PMUA: 114594054(FYN)
GJA: 107118444(FYN)
XLA: 373609(fyn.L) 379812(fyn.S)
XTR: 100488004(fyn)
NPR: 108790091(FYN)
DRE: 373872(fyna) 574422(fynb)
IPU: 108255503 108270342(fyna)
PHYP: 113525201(fyn) 113533722
AMEX: 103026055(fyn) 103043249
TRU: 101063191 101070253(fyn)
LCO: 104922928(fyn) 104931606
NCC: 104960495(fyn)
MZE: 101474799 101479859(fyn)
ONL: 100690757(fyn) 100691175
CVG: 107092365(fyn) 107096191
NFU: 107392150 107396024(fyn)
KMR: 108236545 108248899(fyn)
AOCE: 111563357(fyn) 111573260
CSEM: 103378673 103380632(fyn)
POV: 109632533(fyn) 109636463
LCF: 108875026 108899306(fyn)
SDU: 111225278 111235770(fyn)
SLAL: 111651009 111672913(fyn)
BPEC: 110153632
MALB: 109968046 109968087(fyn)
SASA: 100306819(fyn) 106571317
ELS: 105017971(fyn)
SFM: 108921798 108929301(fyn)
PKI: 111843036(fyn) 111857866
LCM: 102354666(FYN)
CMK: 103178951(fyn)
RTP: 109912754
NVL: 108561389
PCAN: 112556135
OBI: 106875007
LAK: 106171164
SHX: MS3_05835
EGL: EGR_09507
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7822789
  Authors
Rigley K, Slocombe P, Proudfoot K, Wahid S, Mandair K, Bebbington C
  Title
Human p59fyn(T) regulates OKT3-induced calcium influx by a mechanism distinct from PIP2 hydrolysis in Jurkat T cells.
  Journal
J Immunol 154:1136-45 (1995)
  Sequence
[hsa:2534]
LinkDB All DBs

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