KEGG   PATHWAY: eai04510
Entry
eai04510                    Pathway                                
Name
Focal adhesion - Equus asinus (ass)
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Class
Cellular Processes; Cellular community - eukaryotes
Pathway map
eai04510  Focal adhesion
eai04510

Other DBs
GO: 0005925
Organism
Equus asinus (ass) [GN:eai]
Gene
106822010  CRK; adapter molecule crk isoform X1 [KO:K04438]
106822593  [KO:K02649]
106822903  [KO:K12757]
106822905  [KO:K12757]
106822920  MYL7; myosin regulatory light chain 2, atrial isoform isoform X2 [KO:K12754]
106822923  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
106823110  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
106823207  PAK5; serine/threonine-protein kinase PAK 5 isoform X1 [KO:K05736] [EC:2.7.11.1]
106823583  DOCK1; dedicator of cytokinesis protein 1 isoform X1 [KO:K13708]
106823711  MYLK; myosin light chain kinase, smooth muscle isoform X3 [KO:K00907] [EC:2.7.11.18]
106823831  PRKCB; protein kinase C beta type isoform X1 [KO:K19662] [EC:2.7.11.13]
106824133  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
106824209  TNC; LOW QUALITY PROTEIN: tenascin [KO:K06252]
106824352  ITGB8; integrin beta-8 [KO:K06591]
106824516  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
106824973  HRAS; GTPase HRas isoform X1 [KO:K02833]
106824993  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
106825193  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
106825228  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
106825243  LAMB4; laminin subunit beta-4 [KO:K06245]
106825418  MYL5; LOW QUALITY PROTEIN: myosin light chain 5 [KO:K12753]
106825616  FLNA; filamin-A isoform X1 [KO:K04437]
106825844  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
106826000  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X6 [KO:K06276] [EC:2.7.11.1]
106826321  COL1A1; collagen alpha-1(I) chain precursor [KO:K06236]
106826341  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
106826351  CHAD; chondroadherin [KO:K06248]
106826435  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
106826601  ITGA4; integrin alpha-4 [KO:K06483]
106826726  EMP1; epithelial membrane protein 1 [KO:K26255]
106827171  LAMB3; laminin subunit beta-3 isoform X2 [KO:K06244]
106827264  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
106827323  ACTB; actin, cytoplasmic 1 [KO:K05692]
106827371  VAV3; guanine nucleotide exchange factor VAV3 [KO:K05730]
106827445  ITGAV; integrin alpha-V [KO:K06487]
106827733  PGF; placenta growth factor isoform X1 [KO:K16859]
106827857  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
106827859  COL4A3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237]
106828260  ITGA5; integrin alpha-5 [KO:K06484]
106828390  CTNNB1; catenin beta-1 [KO:K02105]
106828497  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
106828516  SHC1; SHC-transforming protein 1 isoform X3 [KO:K06279]
106828599  RAP1A; ras-related protein Rap-1A isoform X1 [KO:K04353]
106828747  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
106829188  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
106829266  CAV2; caveolin-2 [KO:K12958]
106829272  CAV1; caveolin-1 isoform X1 [KO:K06278]
106829287  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
106829313  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106829345  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
106829535  CAPN2; calpain-2 catalytic subunit [KO:K03853] [EC:3.4.22.53]
106829795  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
106829909  [KO:K04725] [EC:2.3.2.27]
106830292  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
106830304  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
106830680  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
106830690  RHOA; transforming protein RhoA [KO:K04513]
106830991  [KO:K04366] [EC:2.7.11.1]
106831007  TNXB; tenascin-X isoform X1 [KO:K06252]
106831384  MAPK8; mitogen-activated protein kinase 8 isoform X1 [KO:K04440] [EC:2.7.11.24]
106831485  VWF; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
106831500  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
106831522  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270]
106831831  COL9A1; collagen alpha-1(IX) chain isoform X2 [KO:K08131]
106831924  MYLPF; myosin regulatory light chain 2, skeletal muscle isoform [KO:K12758]
106831950  [KO:K06253]
106831951  SPP1; osteopontin [KO:K06250]
106832180  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
106832317  PIP5K1C; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1 [KO:K00889] [EC:2.7.1.68]
106832715  FN1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
106832766  VAV1; proto-oncogene vav [KO:K05730]
106832883  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
106832910  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
106833032  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
106833089  PARVA; alpha-parvin [KO:K06275]
106833477  JUN; LOW QUALITY PROTEIN: transcription factor AP-1 [KO:K04448]
106833503  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
106833626  BAD; bcl2-associated agonist of cell death [KO:K02158]
106833635  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
106833720  MYLK2; myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
106833952  TNR; tenascin-R isoform X1 [KO:K06252]
106833955  TNN; tenascin-N isoform X2 [KO:K06252]
106834253  SHC2; LOW QUALITY PROTEIN: SHC-transforming protein 2 [KO:K17447]
106834287  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
106834716  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
106834748  PDGFA; platelet-derived growth factor subunit A isoform X3 [KO:K04359]
106834849  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1 [KO:K00889] [EC:2.7.1.68]
106835045  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
106835088  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
106835162  THBS1; thrombospondin-1 [KO:K16857]
106835170  PAK6; serine/threonine-protein kinase PAK 6 [KO:K05735] [EC:2.7.11.1]
106835324  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
106835371  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
106835457  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
106835567  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
106835653  ITGA11; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
106835699  BCAR1; breast cancer anti-estrogen resistance protein 1 isoform X2 [KO:K05726]
106836069  ACTN4; alpha-actinin-4 isoform X1 [KO:K05699]
106836087  PAK4; serine/threonine-protein kinase PAK 4 [KO:K05734] [EC:2.7.11.1]
106836329  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
106836404  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
106836459  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
106836515  [KO:K12755]
106836604  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
106836617  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
106836695  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106836760  EMP2; epithelial membrane protein 2 [KO:K26256]
106836837  COL2A1; collagen alpha-1(II) chain [KO:K19719]
106836855  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
106836923  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
106836960  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
106836991  LAMC2; LOW QUALITY PROTEIN: laminin subunit gamma-2 [KO:K06246]
106837014  LAMC1; laminin subunit gamma-1 [KO:K05635]
106837055  [KO:K12757]
106837075  [KO:K06269] [EC:3.1.3.16]
106837404  TLN2; LOW QUALITY PROTEIN: talin-2 [KO:K06271]
106837585  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
106838023  LAMA1; laminin subunit alpha-1 isoform X2 [KO:K05637]
106838100  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
106838181  ILK; integrin-linked protein kinase isoform X1 [KO:K06272] [EC:2.7.11.1]
106838202  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
106838209  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
106838493  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
106838625  SHC4; SHC-transforming protein 4 [KO:K17449]
106838933  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
106839051  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
106839173  PAK3; serine/threonine-protein kinase PAK 3 isoform X2 [KO:K05733] [EC:2.7.11.1]
106839338  MYL10; myosin regulatory light chain 10 [KO:K12756]
106839421  MAPK10; mitogen-activated protein kinase 10 isoform X2 [KO:K04440] [EC:2.7.11.24]
106839506  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
106839597  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106839712  COL4A5; collagen alpha-5(IV) chain isoform X5 [KO:K06237]
106839714  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
106840004  CDC42; cell division control protein 42 homolog isoform X1 [KO:K04393]
106840141  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
106840178  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
106840263  PPP1R12B; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12B [KO:K12329]
106840465  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
106840518  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
106840602  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
106840813  RASGRF1; ras-specific guanine nucleotide-releasing factor 1 isoform X1 [KO:K04349]
106840859  PRKCG; protein kinase C gamma type [KO:K19663] [EC:2.7.11.13]
106840918  PPP1R12C; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
106841151  THBS4; thrombospondin-4 [KO:K04659]
106841279  ARHGAP5; rho GTPase-activating protein 5 isoform X1 [KO:K13709]
106841313  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
106841578  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
106841633  SHC3; LOW QUALITY PROTEIN: SHC-transforming protein 3 [KO:K17448]
106841765  CAV3; caveolin-3 [KO:K12959]
106842019  ZYX; zyxin [KO:K06273]
106842058  [KO:K05692]
106842216  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
106842271  MYL2; myosin regulatory light chain 2, ventricular/cardiac muscle isoform [KO:K10351]
106842618  BRAF; serine/threonine-protein kinase B-raf isoform X8 [KO:K04365] [EC:2.7.11.1]
106842751  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
106842753  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
106842755  [KO:K06238]
106842841  MYLK4; myosin light chain kinase family member 4 isoform X1 [KO:K00907] [EC:2.7.11.18]
106842897  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
106842982  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
106842984  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
106843040  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
106843123  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
106843289  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106843321  ACTN1; alpha-actinin-1 isoform X1 [KO:K05699]
106843329  ITGA1; integrin alpha-1 [KO:K06480]
106843345  ITGA2; integrin alpha-2 [KO:K06481]
106843404  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
106843547  VCL; vinculin isoform X1 [KO:K05700]
106843564  VEGFC; vascular endothelial growth factor C [KO:K05449]
106843586  RAP1B; ras-related protein Rap-1b [KO:K07836]
106843729  MAPK9; mitogen-activated protein kinase 9 isoform X1 [KO:K04440] [EC:2.7.11.24]
106843734  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
106843740  [KO:K06274]
106843793  ITGB3; integrin beta-3 [KO:K06493]
106844248  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
106844588  VTN; vitronectin [KO:K06251]
106844784  PXN; paxillin isoform X1 [KO:K05760]
106845164  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
106845291  VAV2; LOW QUALITY PROTEIN: guanine nucleotide exchange factor VAV2 [KO:K05730]
106845299  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
106845379  RAPGEF1; rap guanine nucleotide exchange factor 1 isoform X4 [KO:K06277]
106845632  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
106845778  ACTG1; actin, cytoplasmic 2 [KO:K05692]
106845876  BIRC3; baculoviral IAP repeat-containing protein 3 [KO:K16060]
106845877  BIRC2; baculoviral IAP repeat-containing protein 2 [KO:K16060]
106845897  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106845953  PARVB; beta-parvin [KO:K06275]
106845955  PARVG; gamma-parvin isoform X6 [KO:K06275]
106846040  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
106846070  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
106846305  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
106846480  [KO:K04659]
106846511  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1 [KO:K00889] [EC:2.7.1.68]
106846766  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
106846978  TLN1; talin-1 isoform X1 [KO:K06271]
106847044  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
106847048  FYN; tyrosine-protein kinase Fyn isoform X1 [KO:K05703] [EC:2.7.10.2]
106847529  ITGB5; integrin beta-5 [KO:K06588]
106847657  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
106847985  ELK1; ETS domain-containing protein Elk-1 [KO:K04375]
106848229  MYLK3; myosin light chain kinase 3 isoform X1 [KO:K00907] [EC:2.7.11.18]
106848262  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106848274  CRKL; crk-like protein [KO:K04438]
106848316  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
106848649  FLNB; filamin-B isoform X1 [KO:K27392]
Compound
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:14756624
  Authors
Berman AE, Kozlova NI, Morozevich GE.
  Title
Integrins: structure and signaling.
  Journal
Biochemistry (Mosc) 68:1284-99 (2003)
DOI:10.1023/b:biry.0000011649.03634.74
Reference
PMID:15179030
  Authors
Lee JW, Juliano R.
  Title
Mitogenic signal transduction by integrin- and growth factor receptor-mediated pathways.
  Journal
Mol Cells 17:188-202 (2004)
Reference
PMID:11573199
  Authors
Danen EH, Yamada KM.
  Title
Fibronectin, integrins, and growth control.
  Journal
J Cell Physiol 189:1-13 (2001)
DOI:10.1002/jcp.1137
Reference
PMID:15459662
  Authors
Guo W, Giancotti FG.
  Title
Integrin signalling during tumour progression.
  Journal
Nat Rev Mol Cell Biol 5:816-26 (2004)
DOI:10.1038/nrm1490
Reference
PMID:11229600
  Authors
Petit V, Thiery JP.
  Title
Focal adhesions: structure and dynamics.
  Journal
Biol Cell 92:477-94 (2000)
DOI:10.1016/S0248-4900(00)01101-1
Reference
PMID:12235283
  Authors
Stupack DG, Cheresh DA.
  Title
Get a ligand, get a life: integrins, signaling and cell survival.
  Journal
J Cell Sci 115:3729-38 (2002)
DOI:10.1242/jcs.00071
Reference
PMID:12640026
  Authors
Parsons JT.
  Title
Focal adhesion kinase: the first ten years.
  Journal
J Cell Sci 116:1409-16 (2003)
DOI:10.1242/jcs.00373
Reference
PMID:15688067
  Authors
Mitra SK, Hanson DA, Schlaepfer DD.
  Title
Focal adhesion kinase: in command and control of cell motility.
  Journal
Nat Rev Mol Cell Biol 6:56-68 (2005)
DOI:10.1038/nrm1549
Reference
PMID:14519391
  Authors
Comoglio PM, Boccaccio C, Trusolino L.
  Title
Interactions between growth factor receptors and adhesion molecules: breaking the rules.
  Journal
Curr Opin Cell Biol 15:565-71 (2003)
DOI:10.1016/S0955-0674(03)00096-6
Reference
PMID:15108811
  Authors
Schlaepfer DD, Mitra SK.
  Title
Multiple connections link FAK to cell motility and invasion.
  Journal
Curr Opin Genet Dev 14:92-101 (2004)
DOI:10.1016/j.gde.2003.12.002
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:10698680
  Authors
Vanhaesebroeck B, Alessi DR.
  Title
The PI3K-PDK1 connection: more than just a road to PKB.
  Journal
Biochem J 346 Pt 3:561-76 (2000)
DOI:10.1042/bj3460561
Reference
PMID:11882383
  Authors
Nicholson KM, Anderson NG.
  Title
The protein kinase B/Akt signalling pathway in human malignancy.
  Journal
Cell Signal 14:381-95 (2002)
DOI:10.1016/S0898-6568(01)00271-6
Reference
PMID:15053919
  Authors
Oloumi A, McPhee T, Dedhar S.
  Title
Regulation of E-cadherin expression and beta-catenin/Tcf transcriptional activity by the integrin-linked kinase.
  Journal
Biochim Biophys Acta 1691:1-15 (2004)
DOI:10.1016/j.bbamcr.2003.12.002
Reference
PMID:11146675
  Authors
Turner CE.
  Title
Paxillin and focal adhesion signalling.
  Journal
Nat Cell Biol 2:E231-6 (2000)
DOI:10.1038/35046659
Reference
PMID:15034601
  Authors
Hlobilkova A, Knillova J, Bartek J, Lukas J, Kolar Z.
  Title
The mechanism of action of the tumour suppressor gene PTEN.
  Journal
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 147:19-25 (2003)
Related
pathway
eai04010  MAPK signaling pathway
eai04060  Cytokine-cytokine receptor interaction
eai04070  Phosphatidylinositol signaling system
eai04110  Cell cycle
eai04151  PI3K-Akt signaling pathway
eai04310  Wnt signaling pathway
eai04512  ECM-receptor interaction
eai04810  Regulation of actin cytoskeleton
KO pathway
ko04510   

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