KEGG   PATHWAY: eai04151
Entry
eai04151                    Pathway                                
Name
PI3K-Akt signaling pathway - Equus asinus (ass)
Description
The phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, translation, proliferation, growth, and survival. The binding of growth factors to their receptor tyrosine kinase (RTK) or G protein-coupled receptors (GPCR) stimulates class Ia and Ib PI3K isoforms, respectively. PI3K catalyzes the production of phosphatidylinositol-3,4,5-triphosphate (PIP3) at the cell membrane. PIP3 in turn serves as a second messenger that helps to activate Akt. Once active, Akt can control key cellular processes by phosphorylating substrates involved in apoptosis, protein synthesis, metabolism, and cell cycle.
Class
Environmental Information Processing; Signal transduction
Pathway map
eai04151  PI3K-Akt signaling pathway
eai04151

Other DBs
GO: 0043491
Organism
Equus asinus (ass) [GN:eai]
Gene
106821799  TLR2; toll-like receptor 2 [KO:K10159]
106821933  EIF4E1B; eukaryotic translation initiation factor 4E type 1B isoform X2 [KO:K03259]
106822015  YWHAE; 14-3-3 protein epsilon isoform X1 [KO:K06630]
106822031  NTRK2; BDNF/NT-3 growth factors receptor isoform X3 [KO:K04360] [EC:2.7.10.1]
106822085  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
106822536  RBL2; retinoblastoma-like protein 2 isoform X1 [KO:K16332]
106822593  [KO:K02649]
106822667  PPP2R1A; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [KO:K03456]
106822923  LAMA3; laminin subunit alpha-3 isoform X1 [KO:K06240]
106823110  COL9A2; collagen alpha-2(IX) chain [KO:K08131]
106823181  PPP2R3A; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha isoform X2 [KO:K11583]
106823355  RHEB; GTP-binding protein Rheb isoform X1 [KO:K07208]
106823361  NOS3; nitric oxide synthase, endothelial isoform X2 [KO:K13242] [EC:1.14.13.39]
106824013  GNG5; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 [KO:K04542]
106824041  F2R; proteinase-activated receptor 1 [KO:K03914]
106824051  LPAR3; lysophosphatidic acid receptor 3 [KO:K04294]
106824098  [KO:K13769]
106824133  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
106824209  TNC; LOW QUALITY PROTEIN: tenascin [KO:K06252]
106824214  TLR4; toll-like receptor 4 isoform X1 [KO:K10160]
106824352  ITGB8; integrin beta-8 [KO:K06591]
106824372  IL6; interleukin-6 [KO:K05405]
106824437  PPP2CB; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [KO:K04382] [EC:3.1.3.16]
106824516  CCND3; G1/S-specific cyclin-D3 isoform X1 [KO:K10152]
106824579  CDKN1A; cyclin-dependent kinase inhibitor 1 [KO:K06625]
106824659  FGFR1; fibroblast growth factor receptor 1 isoform X6 [KO:K04362] [EC:2.7.10.1]
106824699  [KO:K05414]
106824700  [KO:K05414]
106824701  [KO:K05414]
106824733  OSMR; oncostatin-M-specific receptor subunit beta isoform X3 [KO:K05057]
106824748  PRLR; prolactin receptor isoform X2 [KO:K05081]
106824750  PRKAA1; LOW QUALITY PROTEIN: 5'-AMP-activated protein kinase catalytic subunit alpha-1 [KO:K07198] [EC:2.7.11.31]
106824753  IL7R; interleukin-7 receptor subunit alpha [KO:K05072]
106824784  [KO:K05414]
106824785  [KO:K05414]
106824786  [KO:K05414]
106824793  GDNF; glial cell line-derived neurotrophic factor isoform X1 [KO:K05452]
106824829  MYC; myc proto-oncogene protein isoform X3 [KO:K04377]
106824927  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
106824930  FGF10; fibroblast growth factor 10 [KO:K04358]
106824973  HRAS; GTPase HRas isoform X1 [KO:K02833]
106824993  PIK3R2; LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
106825068  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
106825193  LAMB1; laminin subunit beta-1 isoform X1 [KO:K05636]
106825228  RELN; LOW QUALITY PROTEIN: reelin [KO:K06249] [EC:3.4.21.-]
106825232  PIK3CG; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [KO:K21289] [EC:2.7.1.153]
106825233  PCK1; phosphoenolpyruvate carboxykinase, cytosolic [GTP] [KO:K01596] [EC:4.1.1.32]
106825243  LAMB4; laminin subunit beta-4 [KO:K06245]
106825461  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
106825548  KRAS; GTPase KRas isoform X2 [KO:K07827]
106825573  GYS2; glycogen [starch] synthase, liver [KO:K00693] [EC:2.4.1.11]
106825844  SOS1; son of sevenless homolog 1 isoform X1 [KO:K03099]
106825951  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
106826000  PDPK1; 3-phosphoinositide-dependent protein kinase 1 isoform X6 [KO:K06276] [EC:2.7.11.1]
106826321  COL1A1; collagen alpha-1(I) chain precursor [KO:K06236]
106826341  ERBB2; receptor tyrosine-protein kinase erbB-2 [KO:K05083] [EC:2.7.10.1]
106826351  CHAD; chondroadherin [KO:K06248]
106826352  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
106826390  CSF3; granulocyte colony-stimulating factor [KO:K05423]
106826435  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
106826447  GNGT2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2 isoform X2 [KO:K04549]
106826526  G6PC1; glucose-6-phosphatase catalytic subunit 1 isoform X1 [KO:K01084] [EC:3.1.3.9]
106826528  NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583]
106826601  ITGA4; integrin alpha-4 [KO:K06483]
106826717  YWHAH; 14-3-3 protein eta [KO:K16198]
106826745  CDKN1B; cyclin-dependent kinase inhibitor 1B [KO:K06624]
106826827  GNG3; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 [KO:K04540]
106826868  GNG10; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 [KO:K04545]
106826903  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
106826929  GNG14; putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 isoform X1 [KO:K04347]
106827140  PPP2R5A; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform [KO:K11584]
106827171  LAMB3; laminin subunit beta-3 isoform X2 [KO:K06244]
106827183  OSM; oncostatin-M [KO:K05418]
106827191  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
106827264  IGF1; insulin-like growth factor I isoform X1 [KO:K05459]
106827306  [KO:K06856]
106827389  CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453]
106827445  ITGAV; integrin alpha-V [KO:K06487]
106827637  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
106827733  PGF; placenta growth factor isoform X1 [KO:K16859]
106827854  IRS1; insulin receptor substrate 1 [KO:K16172]
106827857  COL4A4; collagen alpha-4(IV) chain isoform X1 [KO:K06237]
106827859  COL4A3; LOW QUALITY PROTEIN: collagen alpha-3(IV) chain [KO:K06237]
106827993  EPHA2; ephrin type-A receptor 2 [KO:K05103] [EC:2.7.10.1]
106828005  CASP9; caspase-9 isoform X2 [KO:K04399] [EC:3.4.22.62]
106828064  FGF5; fibroblast growth factor 5 isoform X1 [KO:K04358]
106828159  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X1 [KO:K05870]
106828260  ITGA5; integrin alpha-5 [KO:K06484]
106828264  FGF20; fibroblast growth factor 20 [KO:K04358]
106828271  [KO:K05414]
106828272  [KO:K05415]
106828311  TGFA; protransforming growth factor alpha isoform X1 [KO:K08774]
106828417  MTCP1; protein p13 MTCP-1 [KO:K16837]
106828447  NTRK1; high affinity nerve growth factor receptor [KO:K03176] [EC:2.7.10.1]
106828497  THBS3; thrombospondin-3 isoform X1 [KO:K04659]
106828504  EFNA1; ephrin-A1 [KO:K05462]
106828508  EFNA3; ephrin-A3 isoform X1 [KO:K05462]
106828509  EFNA4; ephrin-A4 isoform X1 [KO:K05462]
106828529  IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055]
106828556  FGF9; fibroblast growth factor 9 [KO:K04358]
106828716  PPP2R5D; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform [KO:K11584]
106828747  VEGFA; vascular endothelial growth factor A isoform X1 [KO:K05448]
106828754  HSP90AB1; heat shock protein HSP 90-beta [KO:K04079]
106828814  IKBKG; NF-kappa-B essential modulator isoform X1 [KO:K07210]
106828880  IL2RG; cytokine receptor common subunit gamma [KO:K05070]
106828887  FGF8; fibroblast growth factor 8 [KO:K04358]
106828957  IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1 [KO:K07209] [EC:2.7.11.10]
106829083  IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071]
106829099  CD19; B-lymphocyte antigen CD19 [KO:K06465]
106829188  GSK3B; glycogen synthase kinase-3 beta isoform X1 [KO:K03083] [EC:2.7.11.26]
106829287  MET; hepatocyte growth factor receptor [KO:K05099] [EC:2.7.10.1]
106829312  GNB4; guanine nucleotide-binding protein subunit beta-4 [KO:K04538]
106829313  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106829345  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
106829397  [KO:K07827]
106829408  SGK3; serine/threonine-protein kinase Sgk3 isoform X2 [KO:K13304] [EC:2.7.11.1]
106829683  LPAR6; lysophosphatidic acid receptor 6 [KO:K04273]
106829766  FOXO3; forkhead box protein O3 [KO:K09408]
106829795  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
106829982  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
106829990  CHRM2; muscarinic acetylcholine receptor M2 isoform X2 [KO:K04130]
106830292  GRB2; growth factor receptor-bound protein 2 isoform X1 [KO:K04364]
106830304  ITGB4; integrin beta-4 isoform X1 [KO:K06525]
106830549  CSF3R; LOW QUALITY PROTEIN: granulocyte colony-stimulating factor receptor [KO:K05061]
106830606  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
106830622  DDIT4; DNA damage-inducible transcript 4 protein [KO:K08270]
106830680  LAMB2; laminin subunit beta-2 isoform X1 [KO:K06243]
106830858  JAK3; tyrosine-protein kinase JAK3 [KO:K11218] [EC:2.7.10.2]
106830903  PHLPP2; PH domain leucine-rich repeat-containing protein phosphatase 2 isoform X1 [KO:K16340] [EC:3.1.3.16]
106830991  [KO:K04366] [EC:2.7.11.1]
106831007  TNXB; tenascin-X isoform X1 [KO:K06252]
106831009  ATF6B; cyclic AMP-dependent transcription factor ATF-6 beta isoform X1 [KO:K09049]
106831046  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X1 [KO:K09047]
106831339  RET; proto-oncogene tyrosine-protein kinase receptor Ret [KO:K05126] [EC:2.7.10.1]
106831440  FGF23; LOW QUALITY PROTEIN: fibroblast growth factor 23 [KO:K22428]
106831458  CCNE2; G1/S-specific cyclin-E2 isoform X1 [KO:K06626]
106831485  VWF; LOW QUALITY PROTEIN: von Willebrand factor [KO:K03900]
106831487  NTF3; neurotrophin-3 isoform X1 [KO:K04356]
106831500  CCND2; G1/S-specific cyclin-D2 [KO:K10151]
106831535  FGF6; fibroblast growth factor 6 [KO:K04358]
106831585  PKN2; serine/threonine-protein kinase N2 [KO:K23691]
106831831  COL9A1; collagen alpha-1(IX) chain isoform X2 [KO:K08131]
106831950  [KO:K06253]
106831951  SPP1; osteopontin [KO:K06250]
106832180  COL6A3; collagen alpha-3(VI) chain isoform X1 [KO:K06238]
106832259  CDK6; cyclin-dependent kinase 6 [KO:K02091] [EC:2.7.11.22]
106832322  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
106832323  CREB3L3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3-like protein 3 [KO:K09048]
106832401  CCNE1; G1/S-specific cyclin-E1 isoform X1 [KO:K06626]
106832616  TCL1A; T-cell leukemia/lymphoma protein 1A [KO:K10167]
106832715  FN1; LOW QUALITY PROTEIN: fibronectin [KO:K05717]
106832783  PSPN; persephin [KO:K25416]
106832840  IFNAR1; interferon alpha/beta receptor 1 [KO:K05130]
106832843  IFNAR2; interferon alpha/beta receptor 2 isoform X1 [KO:K05131]
106832858  PHLPP1; LOW QUALITY PROTEIN: PH domain leucine-rich repeat-containing protein phosphatase 1 [KO:K16340] [EC:3.1.3.16]
106832883  BCL2; apoptosis regulator Bcl-2 [KO:K02161]
106832906  FLT3; LOW QUALITY PROTEIN: receptor-type tyrosine-protein kinase FLT3 [KO:K05092] [EC:2.7.10.1]
106832910  FLT1; vascular endothelial growth factor receptor 1 isoform X1 [KO:K05096] [EC:2.7.10.1]
106832936  ERBB3; receptor tyrosine-protein kinase erbB-3 [KO:K05084] [EC:2.7.10.1]
106833016  CDK4; cyclin-dependent kinase 4 [KO:K02089] [EC:2.7.11.22]
106833032  PDGFC; platelet-derived growth factor C isoform X2 [KO:K05450]
106833475  PRKAA2; 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1 [KO:K07198] [EC:2.7.11.31]
106833496  RPS6KB2; ribosomal protein S6 kinase beta-2 [KO:K04688] [EC:2.7.11.1]
106833569  RELA; transcription factor p65 isoform X1 [KO:K04735]
106833607  PPP2R5B; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X2 [KO:K11584]
106833626  BAD; bcl2-associated agonist of cell death [KO:K02158]
106833635  VEGFB; vascular endothelial growth factor B isoform X1 [KO:K16858]
106833695  ANGPT4; angiopoietin-4 isoform X1 [KO:K05467]
106833712  BCL2L1; bcl-2-like protein 1 isoform X1 [KO:K04570]
106833795  IL2RA; interleukin-2 receptor subunit alpha isoform X1 [KO:K05068]
106833890  [KO:K05414]
106833952  TNR; tenascin-R isoform X1 [KO:K06252]
106833955  TNN; tenascin-N isoform X2 [KO:K06252]
106834013  PPP2R2A; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [KO:K04354]
106834045  RPS6; 40S ribosomal protein S6 [KO:K02991]
106834088  IL2; interleukin-2 [KO:K05429]
106834157  GNG7; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 [KO:K04543]
106834164  [KO:K05415]
106834179  [KO:K05415]
106834191  STK11; serine/threonine-protein kinase STK11 isoform X2 [KO:K07298] [EC:2.7.11.1]
106834202  [KO:K05415]
106834223  EFNA2; ephrin-A2 [KO:K05462]
106834247  FGF22; fibroblast growth factor 22 isoform X2 [KO:K04358]
106834287  ITGA9; integrin alpha-9 isoform X1 [KO:K06585]
106834351  [KO:K13303] [EC:2.7.11.1]
106834655  PPP2CA; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform [KO:K04382] [EC:3.1.3.16]
106834701  GNG4; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 [KO:K04541]
106834716  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
106834748  PDGFA; platelet-derived growth factor subunit A isoform X3 [KO:K04359]
106835162  THBS1; thrombospondin-1 [KO:K16857]
106835239  NR4A1; nuclear receptor subfamily 4 group A member 1 [KO:K04465]
106835273  EIF4B; eukaryotic translation initiation factor 4B isoform X1 [KO:K03258]
106835324  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
106835371  LAMA2; laminin subunit alpha-2 isoform X1 [KO:K05637]
106835457  AKT3; RAC-gamma serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
106835535  [KO:K05438]
106835567  PRKCA; protein kinase C alpha type isoform X1 [KO:K02677] [EC:2.7.11.13]
106835653  ITGA11; LOW QUALITY PROTEIN: integrin alpha-11 [KO:K06587]
106835678  NRAS; GTPase NRas [KO:K07828]
106835685  NGF; beta-nerve growth factor [KO:K02582]
106836191  GNG13; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 isoform X2 [KO:K04547]
106836234  TSC2; tuberin [KO:K07207]
106836240  MLST8; target of rapamycin complex subunit LST8 isoform X1 [KO:K08266]
106836329  COL9A3; collagen alpha-3(IX) chain isoform X1 [KO:K08131]
106836404  LAMA5; laminin subunit alpha-5 isoform X1 [KO:K06240]
106836447  G6PC3; glucose-6-phosphatase 3 isoform X1 [KO:K01084] [EC:3.1.3.9]
106836459  ITGA2B; integrin alpha-IIb isoform X1 [KO:K06476]
106836514  KITLG; kit ligand isoform X1 [KO:K05461]
106836604  IGF1R; insulin-like growth factor 1 receptor [KO:K05087] [EC:2.7.10.1]
106836617  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
106836676  MTOR; serine/threonine-protein kinase mTOR isoform X3 [KO:K07203] [EC:2.7.11.1]
106836695  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
106836837  COL2A1; collagen alpha-1(II) chain [KO:K19719]
106836855  PDGFB; platelet-derived growth factor subunit B isoform X1 [KO:K17386]
106836923  KDR; LOW QUALITY PROTEIN: vascular endothelial growth factor receptor 2 [KO:K05098] [EC:2.7.10.1]
106836975  FGF1; fibroblast growth factor 1 isoform X1 [KO:K18496]
106836991  LAMC2; LOW QUALITY PROTEIN: laminin subunit gamma-2 [KO:K06246]
106837014  LAMC1; laminin subunit gamma-1 [KO:K05635]
106837135  MAGI2; LOW QUALITY PROTEIN: membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [KO:K05629]
106837154  GNB5; guanine nucleotide-binding protein subunit beta-5 [KO:K04539]
106837176  SGK1; serine/threonine-protein kinase Sgk1 isoform X2 [KO:K13302] [EC:2.7.11.1]
106837184  MYB; transcriptional activator Myb isoform X1 [KO:K09420]
106837360  FGF18; fibroblast growth factor 18 [KO:K04358]
106837581  IL2RB; interleukin-2 receptor subunit beta [KO:K05069]
106837675  ERBB4; LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-4 [KO:K05085] [EC:2.7.10.1]
106837686  EIF4EBP1; eukaryotic translation initiation factor 4E-binding protein 1 [KO:K07205]
106837905  ATF2; cyclic AMP-dependent transcription factor ATF-2 isoform X2 [KO:K04450]
106838023  LAMA1; laminin subunit alpha-1 isoform X2 [KO:K05637]
106838100  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform [KO:K00922] [EC:2.7.1.153]
106838202  COL4A2; collagen alpha-2(IV) chain [KO:K06237]
106838209  COL4A1; collagen alpha-1(IV) chain [KO:K06237]
106838258  FGF21; fibroblast growth factor 21 [KO:K22429]
106838266  GYS1; glycogen [starch] synthase, muscle [KO:K00693] [EC:2.4.1.11]
106838275  NTF4; neurotrophin-4 [KO:K12457]
106838490  CSF1R; macrophage colony-stimulating factor 1 receptor isoform X2 [KO:K05090] [EC:2.7.10.1]
106838493  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
106838539  BCL2L11; bcl-2-like protein 11 isoform X6 [KO:K16341]
106838575  FGF7; fibroblast growth factor 7 [KO:K04358]
106838669  FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389]
106838745  EFNA5; ephrin-A5 isoform X1 [KO:K05462]
106838751  JAK1; tyrosine-protein kinase JAK1 isoform X1 [KO:K11217] [EC:2.7.10.2]
106838801  PPP2R3C; serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1 [KO:K11583]
106838933  COL1A2; collagen alpha-2(I) chain precursor [KO:K06236]
106838935  GNG11; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 [KO:K04546]
106838940  GNGT1; guanine nucleotide-binding protein G(T) subunit gamma-T1 [KO:K04548]
106838956  TEK; angiopoietin-1 receptor isoform X1 [KO:K05121] [EC:2.7.10.1]
106839051  PDGFRA; platelet-derived growth factor receptor alpha isoform X2 [KO:K04363] [EC:2.7.10.1]
106839052  KIT; mast/stem cell growth factor receptor Kit isoform X1 [KO:K05091] [EC:2.7.10.1]
106839145  PPP2R5E; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform isoform X1 [KO:K11584]
106839170  IL7; interleukin-7 isoform X3 [KO:K05431]
106839278  YWHAG; 14-3-3 protein gamma [KO:K16198]
106839312  GNB2; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [KO:K04537]
106839355  EPO; erythropoietin [KO:K05437]
106839490  GNG2; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 isoform X2 [KO:K07826]
106839506  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
106839597  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106839639  HSP90AA1; heat shock protein HSP 90-alpha [KO:K04079]
106839642  PPP2R5C; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X4 [KO:K11584]
106839712  COL4A5; collagen alpha-5(IV) chain isoform X5 [KO:K06237]
106839714  COL4A6; collagen alpha-6(IV) chain [KO:K06237]
106839739  SYK; tyrosine-protein kinase SYK isoform X1 [KO:K05855] [EC:2.7.10.2]
106839823  PPP2R2B; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform [KO:K04354]
106840032  GHR; growth hormone receptor isoform X2 [KO:K05080]
106840095  ANGPT1; angiopoietin-1 isoform X1 [KO:K05465]
106840141  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
106840178  HGF; hepatocyte growth factor isoform X1 [KO:K05460]
106840324  PPP2R1B; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X2 [KO:K03456]
106840465  ITGA8; integrin alpha-8 isoform X1 [KO:K06584]
106840518  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X1 [KO:K04392]
106840602  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [KO:K04368] [EC:2.7.12.2]
106841015  IL4; interleukin-4 isoform X2 [KO:K05430]
106841056  PPP2R2D; serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform isoform X1 [KO:K04354]
106841135  RPS6KB1; ribosomal protein S6 kinase beta-1 isoform X1 [KO:K04688] [EC:2.7.11.1]
106841151  THBS4; thrombospondin-4 [KO:K04659]
106841302  CDK2; cyclin-dependent kinase 2 isoform X1 [KO:K02206] [EC:2.7.11.22]
106841313  ITGA7; integrin alpha-7 isoform X1 [KO:K06583]
106841411  ANGPT2; angiopoietin-2 isoform X1 [KO:K05466]
106841578  VEGFD; vascular endothelial growth factor D isoform X1 [KO:K05449]
106842092  PIK3AP1; phosphoinositide 3-kinase adapter protein 1 isoform X1 [KO:K12230]
106842425  PPP2R3B; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta [KO:K11583]
106842437  ATF4; cyclic AMP-dependent transcription factor ATF-4 [KO:K04374]
106842655  MAGI1; membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 isoform X1 [KO:K05631]
106842751  COL6A6; collagen alpha-6(VI) chain [KO:K06238]
106842753  COL6A5; collagen alpha-5(VI) chain isoform X1 [KO:K06238]
106842755  [KO:K06238]
106842982  COL6A1; collagen alpha-1(VI) chain [KO:K06238]
106842984  COL6A2; collagen alpha-2(VI) chain [KO:K06238]
106843008  YWHAB; 14-3-3 protein beta/alpha isoform X1 [KO:K16197]
106843040  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
106843123  PDGFD; platelet-derived growth factor D isoform X1 [KO:K05450]
106843289  AKT2; RAC-beta serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
106843329  ITGA1; integrin alpha-1 [KO:K06480]
106843345  ITGA2; integrin alpha-2 [KO:K06481]
106843564  VEGFC; vascular endothelial growth factor C [KO:K05449]
106843578  MDM2; E3 ubiquitin-protein ligase Mdm2 isoform X1 [KO:K06643] [EC:2.3.2.27]
106843620  JAK2; tyrosine-protein kinase JAK2 isoform X1 [KO:K04447] [EC:2.7.10.2]
106843713  G6PC2; glucose-6-phosphatase 2 isoform X1 [KO:K01084] [EC:3.1.3.9]
106843734  FLT4; vascular endothelial growth factor receptor 3 isoform X1 [KO:K05097] [EC:2.7.10.1]
106843793  ITGB3; integrin beta-3 [KO:K06493]
106843990  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 [KO:K09048]
106844218  TP53; cellular tumor antigen p53 [KO:K04451]
106844246  FGF4; LOW QUALITY PROTEIN: fibroblast growth factor 4 [KO:K04358]
106844248  CCND1; G1/S-specific cyclin-D1 [KO:K04503]
106844254  FGF3; fibroblast growth factor 3 [KO:K04358]
106844255  FGF19; fibroblast growth factor 19 [KO:K22603]
106844309  PKN1; serine/threonine-protein kinase N1 isoform X1 [KO:K06071] [EC:2.7.11.13]
106844478  PPP2R2C; protein phosphatase 2, regulatory subunit B, gamma isoform X1 [KO:K04354]
106844524  INSR; insulin receptor isoform X2 [KO:K04527] [EC:2.7.10.1]
106844588  VTN; vitronectin [KO:K06251]
106844842  EIF4E2; eukaryotic translation initiation factor 4E type 2 isoform X1 [KO:K03259]
106845218  GNB1; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 [KO:K04536]
106845299  LAMC3; LOW QUALITY PROTEIN: laminin subunit gamma-3 [KO:K06247]
106845341  RXRA; retinoic acid receptor RXR-alpha isoform X2 [KO:K08524]
106845368  TSC1; hamartin isoform X1 [KO:K07206]
106845426  PKN3; serine/threonine-protein kinase N3 isoform X1 [KO:K23692]
106845632  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
106845645  RPTOR; regulatory-associated protein of mTOR isoform X1 [KO:K07204]
106845727  PIK3R6; phosphoinositide 3-kinase regulatory subunit 6 isoform X1 [KO:K21290]
106845751  PIK3R5; phosphoinositide 3-kinase regulatory subunit 5 [KO:K21290]
106845897  PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1 [KO:K01110] [EC:3.1.3.16 3.1.3.48 3.1.3.67]
106846249  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X2 [KO:K09048]
106846251  CRTC2; CREB-regulated transcription coactivator 2 isoform X1 [KO:K16333]
106846305  PTK2; focal adhesion kinase 1 isoform X1 [KO:K05725] [EC:2.7.10.2]
106846353  EIF4E; eukaryotic translation initiation factor 4E isoform X1 [KO:K03259]
106846380  EREG; proepiregulin [KO:K09784]
106846382  AREG; amphiregulin [KO:K09782]
106846480  [KO:K04659]
106846539  MCL1; induced myeloid leukemia cell differentiation protein Mcl-1 [KO:K02539]
106846605  EPOR; erythropoietin receptor isoform X1 [KO:K05079]
106846626  CDC37; hsp90 co-chaperone Cdc37 [KO:K09554]
106846705  CHUK; inhibitor of nuclear factor kappa-B kinase subunit alpha isoform X1 [KO:K04467] [EC:2.7.11.10]
106846766  THBS2; thrombospondin-2 isoform X1 [KO:K04659]
106846786  HSP90B1; endoplasmin [KO:K09487]
106846929  FGF16; fibroblast growth factor 16 [KO:K04358]
106846935  FGFR2; fibroblast growth factor receptor 2 isoform X6 [KO:K05093] [EC:2.7.10.1]
106846981  CREB3; LOW QUALITY PROTEIN: cyclic AMP-responsive element-binding protein 3 [KO:K09048]
106847015  PRL; prolactin isoform X1 [KO:K05439]
106847044  LAMA4; laminin subunit alpha-4 isoform X1 [KO:K06241]
106847320  GNB3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform X1 [KO:K07825]
106847340  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
106847477  YWHAQ; 14-3-3 protein theta [KO:K16197]
106847529  ITGB5; integrin beta-5 [KO:K06588]
106847657  ITGA10; integrin alpha-10 isoform X1 [KO:K06586]
106847700  FGF17; fibroblast growth factor 17 isoform X3 [KO:K04358]
106847839  YWHAZ; 14-3-3 protein zeta/delta [KO:K16197]
106847895  ARTN; LOW QUALITY PROTEIN: artemin [KO:K25415]
106848262  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
106848358  THEM4; acyl-coenzyme A thioesterase THEM4 [KO:K16339] [EC:3.1.2.2]
106848606  PCK2; phosphoenolpyruvate carboxykinase [GTP], mitochondrial [KO:K01596] [EC:4.1.1.32]
123278991  NRTN; LOW QUALITY PROTEIN: neurturin [KO:K25414]
123280233  [KO:K05414]
123280237  [KO:K05414]
123280245  [KO:K05414]
123280255  [KO:K05415]
123280259  [KO:K05414]
123280293  [KO:K05415]
123281285  GNG8; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8 [KO:K04544]
Compound
C00020  AMP
C00533  Nitric oxide
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:16847462
  Authors
Engelman JA, Luo J, Cantley LC
  Title
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism.
  Journal
Nat Rev Genet 7:606-19 (2006)
DOI:10.1038/nrg1879
Reference
PMID:15784165
  Authors
Song G, Ouyang G, Bao S
  Title
The activation of Akt/PKB signaling pathway and cell survival.
  Journal
J Cell Mol Med 9:59-71 (2005)
DOI:10.1111/j.1582-4934.2005.tb00337.x
Reference
PMID:21620960
  Authors
Hers I, Vincent EE, Tavare JM
  Title
Akt signalling in health and disease.
  Journal
Cell Signal 23:1515-27 (2011)
DOI:10.1016/j.cellsig.2011.05.004
Reference
PMID:18842113
  Authors
Duronio V
  Title
The life of a cell: apoptosis regulation by the PI3K/PKB pathway.
  Journal
Biochem J 415:333-44 (2008)
DOI:10.1042/BJ20081056
Reference
PMID:16248975
  Authors
Kim D, Chung J.
  Title
Akt: versatile mediator of cell survival and beyond.
  Journal
J Biochem Mol Biol 35:106-15 (2002)
DOI:10.5483/bmbrep.2002.35.1.106
Reference
PMID:12660731
  Authors
Koyasu S
  Title
The role of PI3K in immune cells.
  Journal
Nat Immunol 4:313-9 (2003)
DOI:10.1038/ni0403-313
Reference
PMID:12669022
  Authors
Okkenhaug K, Vanhaesebroeck B.
  Title
PI3K in lymphocyte development, differentiation and activation.
  Journal
Nat Rev Immunol 3:317-30 (2003)
DOI:10.1038/nri1056
Reference
PMID:15209374
  Authors
Richardson CJ, Schalm SS, Blenis J
  Title
PI3-kinase and TOR: PIKTORing cell growth.
  Journal
Semin Cell Dev Biol 15:147-59 (2004)
DOI:10.1016/j.semcdb.2003.12.023
Reference
PMID:21440011
  Authors
Zhang X, Tang N, Hadden TJ, Rishi AK
  Title
Akt, FoxO and regulation of apoptosis.
  Journal
Biochim Biophys Acta 1813:1978-86 (2011)
DOI:10.1016/j.bbamcr.2011.03.010
Reference
PMID:21779440
  Authors
Georgescu MM
  Title
PTEN Tumor Suppressor Network in PI3K-Akt Pathway Control.
  Journal
Genes Cancer 1:1170-7 (2010)
DOI:10.1177/1947601911407325
Reference
PMID:12531180
  Authors
West KA, Castillo SS, Dennis PA
  Title
Activation of the PI3K/Akt pathway and chemotherapeutic resistance.
  Journal
Drug Resist Updat 5:234-48 (2002)
DOI:10.1016/S1368-7646(02)00120-6
Reference
PMID:9838078
  Authors
Wymann MP, Pirola L
  Title
Structure and function of phosphoinositide 3-kinases.
  Journal
Biochim Biophys Acta 1436:127-50 (1998)
DOI:10.1016/S0005-2760(98)00139-8
Reference
PMID:12048182
  Authors
Moelling K, Schad K, Bosse M, Zimmermann S, Schweneker M
  Title
Regulation of Raf-Akt Cross-talk.
  Journal
J Biol Chem 277:31099-106 (2002)
DOI:10.1074/jbc.M111974200
Reference
PMID:16187290
  Authors
Kikani CK, Dong LQ, Liu F
  Title
"New"-clear functions of PDK1: beyond a master kinase in the cytosol?
  Journal
J Cell Biochem 96:1157-62 (2005)
DOI:10.1002/jcb.20651
Reference
PMID:11357143
  Authors
Blume-Jensen P, Hunter T
  Title
Oncogenic kinase signalling.
  Journal
Nature 411:355-65 (2001)
DOI:10.1038/35077225
Reference
PMID:15505410
  Authors
Osaki M, Oshimura M, Ito H
  Title
PI3K-Akt pathway: its functions and alterations in human cancer.
  Journal
Apoptosis 9:667-76 (2004)
DOI:10.1023/B:APPT.0000045801.15585.dd
Reference
PMID:17360849
  Authors
Noguchi M, Ropars V, Roumestand C, Suizu F
  Title
Proto-oncogene TCL1: more than just a coactivator for Akt.
  Journal
FASEB J 21:2273-84 (2007)
DOI:10.1096/fj.06-7684com
Reference
PMID:20602996
  Authors
Lemmon MA, Schlessinger J
  Title
Cell signaling by receptor tyrosine kinases.
  Journal
Cell 141:1117-34 (2010)
DOI:10.1016/j.cell.2010.06.011
Reference
PMID:22367796
  Authors
Skaper SD
  Title
The neurotrophin family of neurotrophic factors: an overview.
  Journal
Methods Mol Biol 846:1-12 (2012)
DOI:10.1007/978-1-61779-536-7_1
Related
pathway
eai00010  Glycolysis / Gluconeogenesis
eai04010  MAPK signaling pathway
eai04012  ErbB signaling pathway
eai04062  Chemokine signaling pathway
eai04064  NF-kappa B signaling pathway
eai04068  FoxO signaling pathway
eai04110  Cell cycle
eai04115  p53 signaling pathway
eai04150  mTOR signaling pathway
eai04210  Apoptosis
eai04370  VEGF signaling pathway
eai04510  Focal adhesion
eai04620  Toll-like receptor signaling pathway
eai04630  JAK-STAT signaling pathway
eai04662  B cell receptor signaling pathway
eai04910  Insulin signaling pathway
KO pathway
ko04151   

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