Entry
Name
Cytokine-cytokine receptor interaction - Equus przewalskii (Przewalski's horse)
Description
Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped.
Class
Environmental Information Processing; Signaling molecules and interaction
BRITE hierarchy
Pathway map
epz04060 Cytokine-cytokine receptor interaction
Organism
Equus przewalskii (Przewalski's horse) [GN:
epz ]
Gene
103540014 IL20RB; interleukin-20 receptor subunit beta isoform X1 [KO:K05137 ]
103540324 TNFSF13B; tumor necrosis factor ligand superfamily member 13B [KO:K05476 ]
103540728 TNFRSF13B; tumor necrosis factor receptor superfamily member 13B [KO:K05150 ]
103540970 CSF2RB; cytokine receptor common subunit beta isoform X1 [KO:K04738 ]
103542210 TNFSF9; tumor necrosis factor ligand superfamily member 9 [KO:K05472 ]
103542488 IL13RA2; interleukin-13 receptor subunit alpha-2 isoform X2 [KO:K05077 ]
103542631 GALT; galactose-1-phosphate uridylyltransferase isoform X3 [KO:K05056 ]
103543045 TGFB2; transforming growth factor beta-2 proprotein isoform X1 [KO:K13376 ]
103544207 TNFSF18; tumor necrosis factor ligand superfamily member 18 [KO:K05479 ]
103544216 TNFSF4; tumor necrosis factor ligand superfamily member 4 isoform X1 [KO:K05469 ]
103544677 EDA2R; LOW QUALITY PROTEIN: tumor necrosis factor receptor superfamily member 27 [KO:K05163 ]
103545274 CSF2RA; granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1 [KO:K05066 ]
103545416 IL7R; interleukin-7 receptor subunit alpha isoform X1 [KO:K05072 ]
103546356 TNFSF10; tumor necrosis factor ligand superfamily member 10 isoform X2 [KO:K04721 ]
103546683 IL10RA; interleukin-10 receptor subunit alpha isoform X1 [KO:K05134 ]
103546993 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A isoform X1 [KO:K03158 ]
103546995 LTBR; tumor necrosis factor receptor superfamily member 3 isoform X1 [KO:K03159 ]
103547498 TNFRSF11B; tumor necrosis factor receptor superfamily member 11B [KO:K05148 ]
103548203 IL31RA; interleukin-31 receptor subunit alpha isoform X1 [KO:K22630 ]
103548204 IL6ST; interleukin-6 receptor subunit beta isoform X3 [KO:K05060 ]
103548904 IL15RA; interleukin-15 receptor subunit alpha isoform X1 [KO:K05074 ]
103549042 IL20RA; LOW QUALITY PROTEIN: interleukin-20 receptor subunit alpha [KO:K05136 ]
103549278 CSF3R; granulocyte colony-stimulating factor receptor isoform X1 [KO:K05061 ]
103550169 CSF3; granulocyte colony-stimulating factor isoform X2 [KO:K05423 ]
103550188 IL5RA; interleukin-5 receptor subunit alpha isoform X1 [KO:K05067 ]
103551072 NGFR; tumor necrosis factor receptor superfamily member 16 [KO:K02583 ]
103551646 TNFRSF12A; tumor necrosis factor receptor superfamily member 12A [KO:K05149 ]
103551918 CD40; tumor necrosis factor receptor superfamily member 5 isoform X1 [KO:K03160 ]
103552189 TNFRSF1B; tumor necrosis factor receptor superfamily member 1B isoform X1 [KO:K05141 ]
103552190 TNFRSF8; tumor necrosis factor receptor superfamily member 8 isoform X1 [KO:K05145 ]
103554252 FASLG; tumor necrosis factor ligand superfamily member 6 [KO:K04389 ]
103555269 OSMR; oncostatin-M-specific receptor subunit beta isoform X3 [KO:K05057 ]
103555416 IL6R; interleukin-6 receptor subunit alpha isoform X1 [KO:K05055 ]
103556252 EDAR; tumor necrosis factor receptor superfamily member EDAR isoform X1 [KO:K05162 ]
103556347 IL4R; interleukin-4 receptor subunit alpha isoform X1 [KO:K05071 ]
103556360 IL1RN; interleukin-1 receptor antagonist protein isoform X1 [KO:K05481 ]
103556575 CSF2; granulocyte-macrophage colony-stimulating factor [KO:K05427 ]
103557150 TNFRSF17; tumor necrosis factor receptor superfamily member 17 [KO:K05153 ]
103557529 CSF1; macrophage colony-stimulating factor 1 isoform X1 [KO:K05453 ]
103557715 TNFSF12; tumor necrosis factor ligand superfamily member 12 isoform X2 [KO:K05474 ]
103557716 TNFSF13; tumor necrosis factor ligand superfamily member 13 isoform X2 [KO:K05475 ]
103558124 FAS; tumor necrosis factor receptor superfamily member 6 isoform X2 [KO:K04390 ]
103558557 TNFRSF18; tumor necrosis factor receptor superfamily member 18 [KO:K05154 ]
103558558 TNFRSF4; tumor necrosis factor receptor superfamily member 4 isoform X1 [KO:K05142 ]
103559649 TNFRSF19; tumor necrosis factor receptor superfamily member 19 [KO:K05155 ]
103559875 CLCF1; cardiotrophin-like cytokine factor 1 isoform X1 [KO:K05421 ]
103560371 TNFSF11; tumor necrosis factor ligand superfamily member 11 [KO:K05473 ]
103560539 TNFRSF25; tumor necrosis factor receptor superfamily member 25 isoform X2 [KO:K05160 ]
103561087 RELT; tumor necrosis factor receptor superfamily member 19L [KO:K05156 ]
103561544 IL12RB1; interleukin-12 receptor subunit beta-1 isoform X1 [KO:K05063 ]
103561644 TNFSF15; tumor necrosis factor ligand superfamily member 15 [KO:K05478 ]
103561707 TNFRSF9; tumor necrosis factor receptor superfamily member 9 isoform X1 [KO:K05146 ]
103561711 TNFSF8; tumor necrosis factor ligand superfamily member 8 [KO:K05471 ]
103561906 IL12RB2; interleukin-12 receptor subunit beta-2 isoform X1 [KO:K05064 ]
103561912 TNFRSF21; tumor necrosis factor receptor superfamily member 21 [KO:K05157 ]
103562285 TNFRSF6B; tumor necrosis factor receptor superfamily member 6B [KO:K05143 ]
103562372 IL18RAP; interleukin-18 receptor accessory protein isoform X1 [KO:K05174 ]
103562543 TGFB1; transforming growth factor beta-1 proprotein isoform X2 [KO:K13375 ]
103562575 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A isoform X1 [KO:K05147 ]
103562703 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C isoform X1 [KO:K05151 ]
103564365 CNTFR; ciliary neurotrophic factor receptor subunit alpha [KO:K05059 ]
103564462 IL2RB; interleukin-2 receptor subunit beta isoform X2 [KO:K05069 ]
103564852 IL1RAP; interleukin-1 receptor accessory protein isoform X2 [KO:K04723 ]
103565543 TNFSF14; tumor necrosis factor ligand superfamily member 14 [KO:K05477 ]
Reference
Authors
Turner MD, Nedjai B, Hurst T, Pennington DJ
Title
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Journal
Reference
Authors
Brocker C, Thompson D, Matsumoto A, Nebert DW, Vasiliou V
Title
Evolutionary divergence and functions of the human interleukin (IL) gene family.
Journal
Reference
Authors
Akdis M, Aab A, Altunbulakli C, Azkur K, Costa RA, Crameri R, Duan S, Eiwegger T, Eljaszewicz A, Ferstl R, Frei R, Garbani M, Globinska A, Hess L, Huitema C, Kubo T, Komlosi Z, Konieczna P, Kovacs N, Kucuksezer UC, Meyer N, Morita H, Olzhausen J, O'Mahony L, Pezer M, Prati M, Rebane A, Rhyner C, Rinaldi A, Sokolowska M, Stanic B, Sugita K, Treis A, van de Veen W, Wanke K, Wawrzyniak M, Wawrzyniak P, Wirz OF, Zakzuk JS, Akdis CA
Title
Interleukins (from IL-1 to IL-38), interferons, transforming growth factor beta, and TNF-alpha: Receptors, functions, and roles in diseases.
Journal
Reference
Authors
Boulanger MJ, Garcia KC
Title
Shared cytokine signaling receptors: structural insights from the gp130 system.
Journal
Reference
Authors
Allan SM, Tyrrell PJ, Rothwell NJ
Title
Interleukin-1 and neuronal injury.
Journal
Reference
Authors
Lopetuso LR, Chowdhry S, Pizarro TT
Title
Opposing Functions of Classic and Novel IL-1 Family Members in Gut Health and Disease.
Journal
Reference
Authors
Iwakura Y, Ishigame H, Saijo S, Nakae S
Title
Functional specialization of interleukin-17 family members.
Journal
Reference
Authors
Fischer P, Hilfiker-Kleiner D
Title
Survival pathways in hypertrophy and heart failure: the gp130-STAT3 axis.
Journal
Reference
Authors
Richards CD
Title
The enigmatic cytokine oncostatin m and roles in disease.
Journal
Reference
Authors
Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W
Title
Structures and biological functions of IL-31 and IL-31 receptors.
Journal
Reference
Authors
Meenhuis A, Verwijmeren C, Roovers O, Touw IP
Title
The deubiquitinating enzyme DUB2A enhances CSF3 signalling by attenuating lysosomal routing of the CSF3 receptor.
Journal
Reference
Authors
de Weerd NA, Nguyen T
Title
The interferons and their receptors--distribution and regulation.
Journal
Reference
Authors
Aggarwal BB
Title
Signalling pathways of the TNF superfamily: a double-edged sword.
Journal
Reference
Authors
Ashkenazi A
Title
Targeting death and decoy receptors of the tumour-necrosis factor superfamily.
Journal
Reference
Authors
Seeger P, Musso T, Sozzani S
Title
The TGF-beta superfamily in dendritic cell biology.
Journal
Reference
Authors
Wakefield LM, Hill CS
Title
Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer.
Journal
Reference
Authors
Mueller TD, Nickel J
Title
Promiscuity and specificity in BMP receptor activation.
Journal
KO pathway