KEGG   PATHWAY: ggo04024
Entry
ggo04024                    Pathway                                
Name
cAMP signaling pathway - Gorilla gorilla gorilla (western lowland gorilla)
Description
cAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands including hormones, neurotransmitters, and other signaling molecules. cAMP regulates pivotal physiologic processes including metabolism, secretion, calcium homeostasis, muscle contraction, cell fate, and gene transcription. cAMP acts directly on three main targets: protein kinase A (PKA), the exchange protein activated by cAMP (Epac), and cyclic nucleotide-gated ion channels (CNGCs). PKA modulates, via phosphorylation, a number of cellular substrates, including transcription factors, ion channels, transporters, exchangers, intracellular Ca2+ -handling proteins, and the contractile machinery. Epac proteins function as guanine nucleotide exchange factors (GEFs) for both Rap1 and Rap2. Various effector proteins, including adaptor proteins implicated in modulation of the actin cytoskeleton, regulators of G proteins of the Rho family, and phospholipases, relay signaling downstream from Rap.
Class
Environmental Information Processing; Signal transduction
Pathway map
ggo04024  cAMP signaling pathway
ggo04024

Other DBs
GO: 0019933
Organism
Gorilla gorilla gorilla (western lowland gorilla) [GN:ggo]
Gene
101145217  VIP; VIP peptides isoform X1 [KO:K05264]
101129323  CRH; corticoliberin [KO:K05256]
101123865  CGA; glycoprotein hormones alpha chain isoform X1 [KO:K08522]
109024066  LHB; lutropin subunit beta precursor [KO:K08521]
101130927  GPHA2; glycoprotein hormone alpha-2 [KO:K25483]
101138178  GPHB5; glycoprotein hormone beta-5 [KO:K25484]
101149441  TSHB; thyrotropin subunit beta [KO:K05251]
101147771  POMC; pro-opiomelanocortin [KO:K05228]
101141703  GCG; pro-glucagon [KO:K05259]
101132288  GIP; gastric inhibitory polypeptide [KO:K05258]
101143526  FSHB; follitropin subunit beta [KO:K05250]
101133810  NPPA; natriuretic peptides A [KO:K12334]
101149139  ADCYAP1; pituitary adenylate cyclase-activating polypeptide isoform X1 [KO:K05262]
101149664  ADRB1; beta-1 adrenergic receptor [KO:K04141]
101142746  ADRB2; beta-2 adrenergic receptor [KO:K04142]
101134223  DRD1; D(1A) dopamine receptor [KO:K04144]
101128678  DRD5; D(1B) dopamine receptor [KO:K05840]
101153142  ADORA2A; LOW QUALITY PROTEIN: adenosine receptor A2a [KO:K04266]
101142127  HTR4; 5-hydroxytryptamine receptor 4 [KO:K04160]
101147748  HTR6; 5-hydroxytryptamine receptor 6 [KO:K04162]
101150673  PTGER2; prostaglandin E2 receptor EP2 subtype [KO:K04259]
101145323  ADCYAP1R1; pituitary adenylate cyclase-activating polypeptide type I receptor isoform X5 [KO:K04587]
101130270  VIPR2; vasoactive intestinal polypeptide receptor 2 isoform X2 [KO:K04590]
101136616  CRHR1; corticotropin-releasing factor receptor 1 isoform X1 [KO:K04578]
101140511  CRHR2; corticotropin-releasing factor receptor 2 isoform X2 [KO:K04579]
101152947  LHCGR; lutropin-choriogonadotropic hormone receptor isoform X1 [KO:K04248]
101125784  TSHR; thyrotropin receptor [KO:K04249]
101143835  MC2R; adrenocorticotropic hormone receptor [KO:K04200]
101145081  GLP1R; glucagon-like peptide 1 receptor [KO:K04581]
101130760  GIPR; gastric inhibitory polypeptide receptor [KO:K04580]
101145346  GPR119; glucose-dependent insulinotropic receptor [KO:K08424]
101154387  FSHR; follicle-stimulating hormone receptor isoform X1 [KO:K04247]
101131617  NPR1; atrial natriuretic peptide receptor 1 isoform X1 [KO:K12323] [EC:4.6.1.2]
101132215  neuroendocrine secretory protein 55 [KO:K04632]
109023045  GNAS; guanine nucleotide-binding protein G(s) subunit alpha isoform X2 [KO:K04632]
101142752  EDN1; endothelin-1 [KO:K16366]
101133461  EDN2; endothelin-2 [KO:K16367]
101137470  EDN3; endothelin-3 isoform X2 [KO:K05227]
101147085  SST; somatostatin [KO:K05237]
101132802  NPY; pro-neuropeptide Y [KO:K05232]
101154276  GHRL; appetite-regulating hormone isoform X2 [KO:K05254]
101151686  OXT; oxytocin-neurophysin 1 [KO:K05243]
101141600  HTR1F; 5-hydroxytryptamine receptor 1F [KO:K04153]
101145070  HTR1A; 5-hydroxytryptamine receptor 1A [KO:K04153]
101124222  HTR1B; 5-hydroxytryptamine receptor 1B [KO:K04153]
101154204  HTR1E; 5-hydroxytryptamine receptor 1E [KO:K04153]
101145469  HTR1D; 5-hydroxytryptamine receptor 1D [KO:K04153]
101131622  CHRM1; muscarinic acetylcholine receptor M1 [KO:K04129]
101124976  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
101152577  DRD2; D(2) dopamine receptor isoform X1 [KO:K04145]
101126330  GABBR2; gamma-aminobutyric acid type B receptor subunit 2 isoform X1 [KO:K04615]
101136130  GABBR1; gamma-aminobutyric acid type B receptor subunit 1 isoform X1 [KO:K04615]
101140567  ADORA1; adenosine receptor A1 isoform X1 [KO:K04265]
101134554  EDNRA; endothelin-1 receptor isoform X1 [KO:K04197]
101127227  NPY1R; neuropeptide Y receptor type 1 [KO:K04204]
101139649  SSTR1; somatostatin receptor type 1 [KO:K04217]
109025532  SSTR2; somatostatin receptor type 2 isoform X2 [KO:K04218]
129527494  SSTR5; somatostatin receptor type 5 [KO:K04221]
101130464  HCAR1; hydroxycarboxylic acid receptor 1 [KO:K08401]
101130090  hydroxycarboxylic acid receptor 2 [KO:K08402]
115930167  hydroxycarboxylic acid receptor 3 [KO:K08402]
101144467  FFAR2; free fatty acid receptor 2 [KO:K04328]
101154411  SUCNR1; succinate receptor 1 [KO:K10042]
101130056  PTGER3; prostaglandin E2 receptor EP3 subtype isoform X2 [KO:K04260]
101127687  OXTR; oxytocin receptor [KO:K04229]
101129513  GHSR; growth hormone secretagogue receptor type 1 [KO:K04284]
101125616  GNAI3; guanine nucleotide-binding protein G(I) subunit alpha-3 [KO:K04630]
101154597  GNAI1; guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1 [KO:K04630]
101150178  GNAI2; guanine nucleotide-binding protein G(I) subunit alpha-2 isoform X1 [KO:K04630]
101125943  ADCY1; adenylate cyclase type 1 isoform X1 [KO:K08041] [EC:4.6.1.1]
101141389  ADCY2; adenylate cyclase type 2 isoform X2 [KO:K08042] [EC:4.6.1.1]
101144031  ADCY3; adenylate cyclase type 3 isoform X4 [KO:K08043] [EC:4.6.1.1]
101125890  ADCY4; adenylate cyclase type 4 isoform X6 [KO:K08044] [EC:4.6.1.1]
101150181  ADCY5; adenylate cyclase type 5 isoform X1 [KO:K08045] [EC:4.6.1.1]
101139873  ADCY6; adenylate cyclase type 6 isoform X1 [KO:K08046] [EC:4.6.1.1]
101126268  ADCY7; adenylate cyclase type 7 isoform X1 [KO:K08047] [EC:4.6.1.1]
101142672  ADCY8; adenylate cyclase type 8 isoform X1 [KO:K08048] [EC:4.6.1.1]
101145410  ADCY9; adenylate cyclase type 9 isoform X1 [KO:K08049] [EC:4.6.1.1]
101137507  ADCY10; adenylate cyclase type 10 isoform X2 [KO:K11265] [EC:4.6.1.1]
101135869  CNGA1; cGMP-gated cation channel alpha-1 [KO:K04948]
101133683  CNGA2; cyclic nucleotide-gated olfactory channel [KO:K04949]
101141822  CNGA3; cyclic nucleotide-gated cation channel alpha-3 isoform X2 [KO:K04950]
101143655  CNGA4; cyclic nucleotide-gated cation channel alpha-4 isoform X1 [KO:K04951]
101150131  CNGB3; cyclic nucleotide-gated cation channel beta-3 [KO:K04953]
101151475  CALML3; calmodulin-like protein 3 [KO:K02183]
101151113  CALML5; calmodulin-like protein 5 [KO:K02183]
101139397  CALML4; calmodulin-like protein 4 isoform X1 [KO:K02183]
101140627  calmodulin-2-like [KO:K02183]
101139013  CALM2; calmodulin-2 isoform X1 [KO:K02183]
101149474  CALM1; calmodulin-1 isoform X1 [KO:K02183]
129528583  CALM3; calmodulin-3 [KO:K02183]
129532589  CALML6; calmodulin-like protein 6 isoform X1 [KO:K02183]
101134676  CAMK2D; calcium/calmodulin-dependent protein kinase type II subunit delta isoform X28 [KO:K04515] [EC:2.7.11.17]
101153594  CAMK2A; calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1 [KO:K04515] [EC:2.7.11.17]
101148194  CAMK2B; calcium/calmodulin-dependent protein kinase type II subunit beta isoform X8 [KO:K04515] [EC:2.7.11.17]
101136547  CAMK2G; calcium/calmodulin-dependent protein kinase type II subunit gamma isoform X1 [KO:K04515] [EC:2.7.11.17]
101140371  CAMK4; calcium/calmodulin-dependent protein kinase type IV isoform X2 [KO:K05869] [EC:2.7.11.17]
101139926  BVES; blood vessel epicardial substance isoform X2 [KO:K21108]
101152354  POPDC2; popeye domain-containing protein 2 isoform X2 [KO:K26206]
101139565  POPDC3; popeye domain-containing protein 3 [KO:K26207]
101149331  KCNK2; potassium channel subfamily K member 2 isoform X1 [KO:K04913]
101132298  HCN2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [KO:K04955]
101141482  HCN4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 [KO:K04957]
101142224  ABCC4; ATP-binding cassette sub-family C member 4 isoform X1 [KO:K05673]
101153785  RAPGEF3; rap guanine nucleotide exchange factor 3 isoform X4 [KO:K08014]
101151388  RAPGEF4; rap guanine nucleotide exchange factor 4 isoform X1 [KO:K04351]
109024246  RRAS; ras-related protein R-Ras [KO:K07829]
101147763  RRAS2; ras-related protein R-Ras2 isoform X2 [KO:K07830]
101135150  PLD1; phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
101135996  PLD2; phospholipase D2 isoform X1 [KO:K01115] [EC:3.1.4.4]
101125007  PLCE1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5 [KO:K05860] [EC:3.1.4.11]
101152026  MAPK9; mitogen-activated protein kinase 9 isoform X4 [KO:K04440] [EC:2.7.11.24]
101124033  MAPK8; mitogen-activated protein kinase 8 isoform X4 [KO:K04440] [EC:2.7.11.24]
101133141  MAPK10; mitogen-activated protein kinase 10 isoform X1 [KO:K04440] [EC:2.7.11.24]
101125618  RAP1A; ras-related protein Rap-1A isoform X2 [KO:K04353]
101125880  RAP1B; ras-related protein Rap-1b [KO:K07836]
101125464  TIAM1; rho guanine nucleotide exchange factor TIAM1 isoform X1 [KO:K05731]
101124128  VAV2; guanine nucleotide exchange factor VAV2 isoform X1 [KO:K05730]
101142265  VAV1; proto-oncogene vav isoform X1 [KO:K05730]
101139851  VAV3; guanine nucleotide exchange factor VAV3 isoform X1 [KO:K05730]
101135430  RAC1; ras-related C3 botulinum toxin substrate 1 isoform X3 [KO:K04392]
101141534  RAC2; ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K07860]
129533953  RAC3; ras-related C3 botulinum toxin substrate 3 isoform X1 [KO:K07861]
101138276  PAK1; serine/threonine-protein kinase PAK 1 isoform X1 [KO:K04409] [EC:2.7.11.1]
101137714  ARAP3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 isoform X1 [KO:K12490]
101134778  RHOA; transforming protein RhoA [KO:K04513]
101145438  AFDN; afadin isoform X17 [KO:K05702]
101143811  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
101146434  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform isoform X2 [KO:K00922] [EC:2.7.1.153]
101152123  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
101130978  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X2 [KO:K02649]
101135298  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
101129336  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2 [KO:K02649]
101137723  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
101138019  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
129526696  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
101145098  BRAF; serine/threonine-protein kinase B-raf isoform X1 [KO:K04365] [EC:2.7.11.1]
101136454  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X3 [KO:K04366] [EC:2.7.11.1]
101132391  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
101126885  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
101140164  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
101135988  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
101151469  PRKACG; cAMP-dependent protein kinase catalytic subunit gamma [KO:K04345] [EC:2.7.11.11]
101134260  PRKACB; cAMP-dependent protein kinase catalytic subunit beta isoform X1 [KO:K04345] [EC:2.7.11.11]
129528907  PRKACA; cAMP-dependent protein kinase catalytic subunit alpha isoform X1 [KO:K04345] [EC:2.7.11.11]
101139296  PPP1R1B; protein phosphatase 1 regulatory subunit 1B [KO:K15494]
101143438  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
101129953  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
129525268  PPP1CA; serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
101144410  CREB1; cyclic AMP-responsive element-binding protein 1 isoform X3 [KO:K05870]
101128609  CREB3L2; cyclic AMP-responsive element-binding protein 3-like protein 2 isoform X1 [KO:K09048]
101144135  CREB3; cyclic AMP-responsive element-binding protein 3 [KO:K09048]
101144628  CREB3L1; cyclic AMP-responsive element-binding protein 3-like protein 1 isoform X1 [KO:K09048]
101152081  CREB3L4; cyclic AMP-responsive element-binding protein 3-like protein 4 isoform X1 [KO:K09048]
129528837  CREB3L3; cyclic AMP-responsive element-binding protein 3-like protein 3 isoform X1 [KO:K09048]
101153965  CREB5; cyclic AMP-responsive element-binding protein 5 isoform X4 [KO:K09047]
101144808  CREBBP; CREB-binding protein isoform X2 [KO:K04498] [EC:2.3.1.48]
101153383  EP300; histone acetyltransferase p300 isoform X2 [KO:K04498] [EC:2.3.1.48]
101134399  BDNF; brain-derived neurotrophic factor isoform X2 [KO:K04355]
101127590  FOS; protein C-Fos [KO:K04379]
101145729  JUN; transcription factor Jun [KO:K04448]
101153250  GLI3; transcriptional activator GLI3 isoform X2 [KO:K06230]
101139020  GLI1; zinc finger protein GLI1 isoform X1 [KO:K16797]
101138988  PTCH1; protein patched homolog 1 isoform X1 [KO:K06225]
101152009  HHIP; hedgehog-interacting protein isoform X1 [KO:K06231]
101128204  NFKBIA; NF-kappa-B inhibitor alpha [KO:K04734]
101153465  NFKB1; nuclear factor NF-kappa-B p105 subunit isoform X1 [KO:K02580]
101150285  RELA; transcription factor p65 isoform X1 [KO:K04735]
101135517  SOX9; transcription factor SOX-9 [KO:K18435]
101137456  AMH; muellerian-inhibiting factor [KO:K04665]
101146658  PPARA; peroxisome proliferator-activated receptor alpha isoform X1 [KO:K07294]
101152360  ACOX3; peroxisomal acyl-coenzyme A oxidase 3 [KO:K00232] [EC:1.3.3.6]
101145668  ACOX1; peroxisomal acyl-coenzyme A oxidase 1 isoform X2 [KO:K00232] [EC:1.3.3.6]
101147593  NFATC1; nuclear factor of activated T-cells, cytoplasmic 1 isoform X1 [KO:K04446]
101144448  F2R; proteinase-activated receptor 1 [KO:K03914]
101151128  BAD; bcl2-associated agonist of cell death [KO:K02158]
101145804  LIPE; hormone-sensitive lipase isoform X1 [KO:K07188] [EC:3.1.1.79]
101154194  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.39]
101134988  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.39]
101139376  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270]
101138103  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
101137001  TNNI3; troponin I, cardiac muscle [KO:K12044]
101139566  PLN; cardiac phospholamban [KO:K05852]
101140334  ATP2A2; sarcoplasmic/endoplasmic reticulum calcium ATPase 2 isoform X2 [KO:K05853] [EC:7.2.2.10]
115932652  LOW QUALITY PROTEIN: sarcoplasmic/endoplasmic reticulum calcium ATPase 3-like [KO:K05853] [EC:7.2.2.10]
101141624  ATP2A1; sarcoplasmic/endoplasmic reticulum calcium ATPase 1 isoform X1 [KO:K05853] [EC:7.2.2.10]
101124707  ATP2A3; sarcoplasmic/endoplasmic reticulum calcium ATPase 3 isoform X3 [KO:K05853] [EC:7.2.2.10]
101152456  RYR2; ryanodine receptor 2 isoform X1 [KO:K04962]
101146203  GRIN1; glutamate receptor ionotropic, NMDA 1 isoform X9 [KO:K05208]
101124569  GRIN2A; glutamate receptor ionotropic, NMDA 2A isoform X1 [KO:K05209]
101127573  GRIN2B; glutamate receptor ionotropic, NMDA 2B [KO:K05210]
101146970  GRIN2C; glutamate receptor ionotropic, NMDA 2C isoform X1 [KO:K05211]
101128942  GRIN2D; glutamate receptor ionotropic, NMDA 2D isoform X2 [KO:K05212]
101144498  GRIN3A; glutamate receptor ionotropic, NMDA 3A [KO:K05213]
101127983  GRIN3B; glutamate receptor ionotropic, NMDA 3B isoform X2 [KO:K05214]
101145558  GRIA1; glutamate receptor 1 isoform X1 [KO:K05197]
101146262  GRIA2; glutamate receptor 2 isoform X1 [KO:K05198]
101128020  GRIA3; glutamate receptor 3 isoform X4 [KO:K05199]
101140968  GRIA4; glutamate receptor 4 isoform X1 [KO:K05200]
101132066  CFTR; cystic fibrosis transmembrane conductance regulator [KO:K05031] [EC:5.6.1.6]
101154367  ATP1A1; sodium/potassium-transporting ATPase subunit alpha-1 isoform X2 [KO:K01539] [EC:7.2.2.13]
101132606  ATP1A2; sodium/potassium-transporting ATPase subunit alpha-2 [KO:K01539] [EC:7.2.2.13]
101136136  ATP1A3; sodium/potassium-transporting ATPase subunit alpha-3 isoform X2 [KO:K01539] [EC:7.2.2.13]
101133472  ATP1A4; sodium/potassium-transporting ATPase subunit alpha-4 [KO:K01539] [EC:7.2.2.13]
101133872  ATP1B2; sodium/potassium-transporting ATPase subunit beta-2 [KO:K01540]
101150859  ATP1B4; protein ATP1B4 isoform X1 [KO:K01540]
101145254  ATP1B1; sodium/potassium-transporting ATPase subunit beta-1 [KO:K01540]
101140721  ATP1B3; sodium/potassium-transporting ATPase subunit beta-3 isoform X1 [KO:K01540]
101143506  sodium/potassium-transporting ATPase subunit beta-3-like [KO:K01540]
109023060  FXYD2; sodium/potassium-transporting ATPase subunit gamma isoform X1 [KO:K01538]
101136262  FXYD1; phospholemman isoform X1 [KO:K13360]
101134383  SLC9A1; sodium/hydrogen exchanger 1 isoform X1 [KO:K05742]
101149689  calcium release-activated calcium channel protein 1 [KO:K16056]
101125769  ATP2B2; plasma membrane calcium-transporting ATPase 2 isoform X1 [KO:K05850] [EC:7.2.2.10]
101129497  ATP2B1; plasma membrane calcium-transporting ATPase 1 isoform X1 [KO:K05850] [EC:7.2.2.10]
101151836  ATP2B3; plasma membrane calcium-transporting ATPase 3 isoform X1 [KO:K05850] [EC:7.2.2.10]
101146683  ATP2B4; plasma membrane calcium-transporting ATPase 4 isoform X1 [KO:K05850] [EC:7.2.2.10]
101134060  CACNA1C; voltage-dependent L-type calcium channel subunit alpha-1C isoform X2 [KO:K04850]
101140987  CACNA1D; voltage-dependent L-type calcium channel subunit alpha-1D isoform X1 [KO:K04851]
101131714  CACNA1F; voltage-dependent L-type calcium channel subunit alpha-1F [KO:K04853]
101150507  CACNA1S; voltage-dependent L-type calcium channel subunit alpha-1S [KO:K04857]
101125638  PDE3A; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A [KO:K19021] [EC:3.1.4.17]
101149202  PDE3B; cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B isoform X1 [KO:K13296] [EC:3.1.4.17]
101139726  PDE4B; 3',5'-cyclic-AMP phosphodiesterase 4B isoform X2 [KO:K13293] [EC:3.1.4.53]
101136008  PDE4C; 3',5'-cyclic-AMP phosphodiesterase 4C isoform X1 [KO:K13293] [EC:3.1.4.53]
101126994  PDE4D; 3',5'-cyclic-AMP phosphodiesterase 4D isoform X3 [KO:K13293] [EC:3.1.4.53]
101129423  PDE4A; 3',5'-cyclic-AMP phosphodiesterase 4A isoform X2 [KO:K13293] [EC:3.1.4.53]
101128119  PDE10A; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform X1 [KO:K18438] [EC:3.1.4.17 3.1.4.35]
Compound
C00020  AMP
C00042  Succinate
C00076  Calcium cation
C00080  H+
C00165  Diacylglycerol
C00186  (S)-Lactate
C00212  Adenosine
C00238  Potassium cation
C00288  HCO3-
C00334  4-Aminobutanoate
C00416  Phosphatidate
C00547  L-Noradrenaline
C00575  3',5'-Cyclic AMP
C00584  Prostaglandin E2
C00698  Cl-
C00780  Serotonin
C00788  L-Adrenaline
C01089  (R)-3-Hydroxybutanoate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C01312  Prostaglandin I2
C01330  Sodium cation
C01996  Acetylcholine
C03758  Dopamine
C20792  Oleoylethanolamide
C20793  3-Hydroxyoctanoate
Reference
PMID:11493633
  Authors
Fimia GM, Sassone-Corsi P
  Title
Cyclic AMP signalling.
  Journal
J Cell Sci 114:1971-2 (2001)
Reference
PMID:18323530
  Authors
Serezani CH, Ballinger MN, Aronoff DM, Peters-Golden M
  Title
Cyclic AMP: master regulator of innate immune cell function.
  Journal
Am J Respir Cell Mol Biol 39:127-32 (2008)
DOI:10.1165/rcmb.2008-0091TR
Reference
PMID:24281338
  Authors
Oldenburger A, Maarsingh H, Schmidt M
  Title
Multiple facets of cAMP signalling and physiological impact: cAMP compartmentalization in the lung.
  Journal
Pharmaceuticals (Basel) 5:1291-331 (2012)
DOI:10.3390/ph5121291
Reference
PMID:24613710
  Authors
Ahuja M, Jha A, Maleth J, Park S, Muallem S
  Title
cAMP and Ca signaling in secretory epithelia: Crosstalk and synergism.
  Journal
Cell Calcium 55:385-393 (2014)
DOI:10.1016/j.ceca.2014.01.006
Reference
PMID:22082266
  Authors
Shirshev SV
  Title
Role of Epac proteins in mechanisms of cAMP-dependent immunoregulation.
  Journal
Biochemistry (Mosc) 76:981-98 (2011)
DOI:10.1134/S000629791109001X
Reference
PMID:18176800
  Authors
Roscioni SS, Elzinga CR, Schmidt M
  Title
Epac: effectors and biological functions.
  Journal
Naunyn Schmiedebergs Arch Pharmacol 377:345-57 (2008)
DOI:10.1007/s00210-007-0246-7
Reference
PMID:24450633
  Authors
Roberts OL, Dart C
  Title
cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP).
  Journal
Biochem Soc Trans 42:89-97 (2014)
DOI:10.1042/BST20130253
Reference
PMID:16765984
  Authors
Schaub MC, Hefti MA, Zaugg M
  Title
Integration of calcium with the signaling network in cardiac myocytes.
  Journal
J Mol Cell Cardiol 41:183-214 (2006)
DOI:10.1016/j.yjmcc.2006.04.005
Reference
PMID:19874988
  Authors
Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J
  Title
The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications.
  Journal
J Am Coll Cardiol 54:1747-62 (2009)
DOI:10.1016/j.jacc.2009.05.015
Reference
PMID:15142747
  Authors
Saucerman JJ, McCulloch AD
  Title
Mechanistic systems models of cell signaling networks: a case study of myocyte adrenergic regulation.
  Journal
Prog Biophys Mol Biol 85:261-78 (2004)
DOI:10.1016/j.pbiomolbio.2004.01.005
Reference
PMID:21212391
  Authors
Yang JH, Saucerman JJ
  Title
Computational models reduce complexity and accelerate insight into cardiac signaling networks.
  Journal
Circ Res 108:85-97 (2011)
DOI:10.1161/CIRCRESAHA.110.223602
Reference
PMID:22022314
  Authors
Taggart P, Boyett MR, Logantha S, Lambiase PD
  Title
Anger, emotion, and arrhythmias: from brain to heart.
  Journal
Front Physiol 2:67 (2011)
DOI:10.3389/fphys.2011.00067
Reference
PMID:21852968
  Authors
Bozzi Y, Dunleavy M, Henshall DC
  Title
Cell signaling underlying epileptic behavior.
  Journal
Front Behav Neurosci 5:45 (2011)
DOI:10.3389/fnbeh.2011.00045
Reference
PMID:10880354
  Authors
Lizcano JM, Morrice N, Cohen P
  Title
Regulation of BAD by cAMP-dependent protein kinase is mediated via phosphorylation of a novel site, Ser155.
  Journal
Biochem J 349:547-57 (2000)
DOI:10.1042/bj3490547
Reference
PMID:21744067
  Authors
Gerlo S, Kooijman R, Beck IM, Kolmus K, Spooren A, Haegeman G
  Title
Cyclic AMP: a selective modulator of NF-kappaB action.
  Journal
Cell Mol Life Sci 68:3823-41 (2011)
DOI:10.1007/s00018-011-0757-8
Reference
PMID:7688165
  Authors
Lauder JM
  Title
Neurotransmitters as growth regulatory signals: role of receptors and second messengers.
  Journal
Trends Neurosci 16:233-40 (1993)
DOI:10.1016/0166-2236(93)90162-F
Reference
PMID:17077866
  Authors
Voglis G, Tavernarakis N
  Title
The role of synaptic ion channels in synaptic plasticity.
  Journal
EMBO Rep 7:1104-10 (2006)
DOI:10.1038/sj.embor.7400830
Reference
PMID:21346730
  Authors
Altarejos JY, Montminy M
  Title
CREB and the CRTC co-activators: sensors for hormonal and metabolic signals.
  Journal
Nat Rev Mol Cell Biol 12:141-51 (2011)
DOI:10.1038/nrm3072
Reference
PMID:24062645
  Authors
Bozzi Y, Borrelli E
  Title
The role of dopamine signaling in epileptogenesis.
  Journal
Front Cell Neurosci 7:157 (2013)
DOI:10.3389/fncel.2013.00157
Reference
PMID:14715909
  Authors
Ceulemans H, Bollen M
  Title
Functional diversity of protein phosphatase-1, a cellular economizer and reset button.
  Journal
Physiol Rev 84:1-39 (2004)
DOI:10.1152/physrev.00013.2003
Reference
PMID:16571352
  Authors
Lipinski RJ, Gipp JJ, Zhang J, Doles JD, Bushman W
  Title
Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling.
  Journal
Exp Cell Res 312:1925-38 (2006)
DOI:10.1016/j.yexcr.2006.02.019
Reference
PMID:21693691
  Authors
Lasala C, Schteingart HF, Arouche N, Bedecarras P, Grinspon RP, Picard JY, Josso N, di Clemente N, Rey RA
  Title
SOX9 and SF1 are involved in cyclic AMP-mediated upregulation of anti-Mullerian gene expression in the testicular prepubertal Sertoli cell line SMAT1.
  Journal
Am J Physiol Endocrinol Metab 301:E539-47 (2011)
DOI:10.1152/ajpendo.00187.2011
Reference
PMID:19460777
  Authors
Rosenkranz AC, Rauch BH, Freidel K, Schror K
  Title
Regulation of protease-activated receptor-1 by vasodilatory prostaglandins via NFAT.
  Journal
Cardiovasc Res 83:778-84 (2009)
DOI:10.1093/cvr/cvp163
Reference
PMID:11117527
  Authors
Lazennec G, Canaple L, Saugy D, Wahli W
  Title
Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators.
  Journal
Mol Endocrinol 14:1962-75 (2000)
DOI:10.1210/mend.14.12.0575
Reference
PMID:16460276
  Authors
Murthy KS
  Title
Signaling for contraction and relaxation in smooth muscle of the gut.
  Journal
Annu Rev Physiol 68:345-74 (2006)
DOI:10.1146/annurev.physiol.68.040504.094707
Reference
PMID:18064650
  Authors
Birukova AA, Zagranichnaya T, Alekseeva E, Bokoch GM, Birukov KG
  Title
Epac/Rap and PKA are novel mechanisms of ANP-induced Rac-mediated pulmonary endothelial barrier protection.
  Journal
J Cell Physiol 215:715-24 (2008)
DOI:10.1002/jcp.21354
Reference
PMID:9204709
  Authors
Houslay MD, Milligan G
  Title
Tailoring cAMP-signalling responses through isoform multiplicity.
  Journal
Trends Biochem Sci 22:217-24 (1997)
DOI:10.1016/S0968-0004(97)01050-5
Related
pathway
ggo00071  Fatty acid degradation
ggo04015  Rap1 signaling pathway
ggo04020  Calcium signaling pathway
ggo04151  PI3K-Akt signaling pathway
ggo04210  Apoptosis
ggo04260  Cardiac muscle contraction
ggo04340  Hedgehog signaling pathway
ggo04720  Long-term potentiation
ggo04740  Olfactory transduction
ggo04972  Pancreatic secretion
ggo04976  Bile secretion
KO pathway
ko04024   
LinkDB

DBGET integrated database retrieval system