Gap junction - Homo sapiens (human)
Gap junctions contain intercellular channels that allow direct communication between the cytosolic compartments of adjacent cells. Each gap junction channel is formed by docking of two 'hemichannels', each containing six connexins, contributed by each neighboring cell. These channels permit the direct transfer of small molecules including ions, amino acids, nucleotides, second messengers and other metabolites between adjacent cells. Gap junctional communication is essential for many physiological events, including embryonic development, electrical coupling, metabolic transport, apoptosis, and tissue homeostasis. Communication through Gap Junction is sensitive to a variety of stimuli, including changes in the level of intracellular Ca2+, pH, transjunctional applied voltage and phosphorylation/dephosphorylation processes. This figure represents the possible activation routes of different protein kinases involved in Cx43 and Cx36 phosphorylation.
Cellular Processes; Cellular community - eukaryotes
Pathway map Ortholog table
D00491 Paclitaxel (JAN/USP/INN)
D00599 Carteolol hydrochloride (JP18/USP)
D01068 Vinblastine sulfate (JP18/USP)
D01105 Moperone hydrochloride (JAN)
D01769 Vindesine sulfate (JAN/USAN)
D01935 Vinorelbine tartrate (USP)
D02197 Vincristine sulfate (JP18/USP)
D02371 Clocapramine hydrochloride hydrate (JP18)
D02372 Perospirone hydrochloride hydrate (JAN)
D02605 Methoxypromazine maleate
D02641 Butaclamol hydrochloride (USAN)
D02670 Mazapertine succinate (USAN)
D02681 Piquindone hydrochloride (USAN)
D02683 Remoxipride hydrochloride (USAN)
D03059 Batabulin sodium (USAN)
D04645 Ixabepilone (JAN/USAN/INN)
D05062 Mivobulin isethionate (USAN)
D05333 Paclitaxel poliglumex (USAN/INN)
D06009 Tasidotin hydrochloride (USAN)
D06305 Vinepidine sulfate (USAN)
D06306 Vinglycinate sulfate (USAN)
D06307 Vinleurosine sulfate (USAN)
D06308 Vinrosidine sulfate (USAN)
D06309 Vinzolidine sulfate (USAN)
D06576 Cevipabulin fumarate (USAN)
D08889 Cevipabulin succinate (USAN)
D08914 Eribulin mesylate (USAN)
D09032 Vinflunine ditartrate (USAN)
D10030 Verubulin hydrochloride (USAN)
D10452 Cabazitaxel acetonate (JAN)
D11238 Lifastuzumab vedotin (USAN/INN)
D11494 Lisavanbulin (USAN/INN)
D11525 Enfortumab vedotin (USAN)
D11691 Tirbanibulin (USAN/INN)
D11692 Tirbanibulin mesylate (USAN)
D11814 Tisotumab vedotin (USAN/INN)
D12183 Farletuzumab ecteribulin (USAN)
Homo sapiens (human) [GN:
2697 GJA1; gap junction protein alpha 1 [KO: K07372]
1902 LPAR1; lysophosphatidic acid receptor 1 [KO: K04289]
2770 GNAI1; G protein subunit alpha i1 [KO: K04630]
2773 GNAI3; G protein subunit alpha i3 [KO: K04630]
2771 GNAI2; G protein subunit alpha i2 [KO: K04630]
5154 PDGFA; platelet derived growth factor subunit A [KO: K04359]
5155 PDGFB; platelet derived growth factor subunit B [KO: K17386]
56034 PDGFC; platelet derived growth factor C [KO: K05450]
80310 PDGFD; platelet derived growth factor D [KO: K05450]
2885 GRB2; growth factor receptor bound protein 2 [KO: K04364]
6654 SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1 [KO: K03099]
6655 SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2 [KO: K03099]
3265 HRAS; HRas proto-oncogene, GTPase [KO: K02833]
3845 KRAS; KRAS proto-oncogene, GTPase [KO: K07827]
4893 NRAS; NRAS proto-oncogene, GTPase [KO: K07828]
7280 TUBB2A; tubulin beta 2A class IIa [KO: K07375]
3356 HTR2A; 5-hydroxytryptamine receptor 2A [KO: K04157]
3357 HTR2B; 5-hydroxytryptamine receptor 2B [KO: K04157]
3358 HTR2C; 5-hydroxytryptamine receptor 2C [KO: K04157]
2911 GRM1; glutamate metabotropic receptor 1 [KO: K04603]
2915 GRM5; glutamate metabotropic receptor 5 [KO: K04604]
2767 GNA11; G protein subunit alpha 11 [KO: K04635]
3708 ITPR1; inositol 1,4,5-trisphosphate receptor type 1 [KO: K04958]
3709 ITPR2; inositol 1,4,5-trisphosphate receptor type 2 [KO: K04959]
3710 ITPR3; inositol 1,4,5-trisphosphate receptor type 3 [KO: K04960]
C00681 1-Acyl-sn-glycerol 3-phosphate
C01245 D-myo-Inositol 1,4,5-trisphosphate
Saez JC, Berthoud VM, Branes MC, Martinez AD, Beyer EC.
Plasma membrane channels formed by connexins: their regulation and functions.
Warn-Cramer BJ, Lau AF.
Regulation of gap junctions by tyrosine protein kinases.
Warn-Cramer BJ, Cottrell GT, Burt JM, Lau AF.
Regulation of connexin-43 gap junctional intercellular communication by mitogen-activated protein kinase.
Roerig B, Feller MB.
Neurotransmitters and gap junctions in developing neural circuits.
Synaptic modulation of neuronal coupling.
Cruciani V, Mikalsen SO.
Connexins, gap junctional intercellular communication and kinases.
Gap junctions and connexin-interacting proteins.
Connexin phosphorylation as a regulatory event linked to gap junction internalization and degradation.
Chemical gating of gap junction channels; roles of calcium, pH and calmodulin.
Bukauskas FF, Verselis VK.
Gap junction channel gating.
hsa04060 Cytokine-cytokine receptor interaction
hsa04070 Phosphatidylinositol signaling system
hsa04080 Neuroactive ligand-receptor interaction
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