KEGG   PATHWAY: lav04810
Entry
lav04810                    Pathway                                
Name
Regulation of actin cytoskeleton - Loxodonta africana (African savanna elephant)
Class
Cellular Processes; Cell motility
Pathway map
lav04810  Regulation of actin cytoskeleton
lav04810

Other DBs
GO: 0030036
Organism
Loxodonta africana (African savanna elephant) [GN:lav]
Gene
100668056  LPAR1; lysophosphatidic acid receptor 1 isoform X1 [KO:K04289]
100674529  LPAR2; lysophosphatidic acid receptor 2 [KO:K04291]
100656506  LPAR4; lysophosphatidic acid receptor 4 [KO:K04275]
100674432  LPAR5; lysophosphatidic acid receptor 5 [KO:K08390]
100670325  CXCL12; stromal cell-derived factor 1 [KO:K10031]
100660744  CXCR4; C-X-C chemokine receptor type 4 [KO:K04189]
100666651  F2; prothrombin [KO:K01313] [EC:3.4.21.5]
100668995  F2R; proteinase-activated receptor 1 [KO:K03914]
100661112  INS; insulin [KO:K04526]
100670137  EGF; LOW QUALITY PROTEIN: pro-epidermal growth factor [KO:K04357]
100663763  FGF1; fibroblast growth factor 1 [KO:K18496]
100657533  FGF2; fibroblast growth factor 2 [KO:K18497]
100663120  FGF10; fibroblast growth factor 10 [KO:K04358]
100668915  FGF6; fibroblast growth factor 6 [KO:K04358]
100658495  FGF16; LOW QUALITY PROTEIN: fibroblast growth factor 16 [KO:K04358]
100675766  FGF17; fibroblast growth factor 17 isoform X1 [KO:K04358]
100671479  FGF9; fibroblast growth factor 9 [KO:K04358]
100672847  FGF7; fibroblast growth factor 7 [KO:K04358]
100668860  FGF4; fibroblast growth factor 4 [KO:K04358]
100662939  FGF8; fibroblast growth factor 8 [KO:K04358]
100656834  FGF18; LOW QUALITY PROTEIN: fibroblast growth factor 18 [KO:K04358]
100656129  FGF5; fibroblast growth factor 5 [KO:K04358]
100669156  FGF22; LOW QUALITY PROTEIN: fibroblast growth factor 22 [KO:K04358]
100656791  FGF20; fibroblast growth factor 20 [KO:K04358]
100661893  FGF21; LOW QUALITY PROTEIN: fibroblast growth factor 21 [KO:K22429]
100668635  FGF23; fibroblast growth factor 23 [KO:K22428]
100663544  PDGFB; platelet-derived growth factor subunit B isoform X2 [KO:K17386]
100661451  PDGFD; platelet-derived growth factor D [KO:K05450]
100672750  PDGFC; platelet-derived growth factor C [KO:K05450]
100672734  INSRR; LOW QUALITY PROTEIN: insulin receptor-related protein [KO:K05086] [EC:2.7.10.1]
100659125  EGFR; epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
100662289  FGFR1; fibroblast growth factor receptor 1 isoform X3 [KO:K04362] [EC:2.7.10.1]
100664128  fibroblast growth factor receptor 2 isoform X1 [KO:K05093] [EC:2.7.10.1]
100674054  FGFR3; fibroblast growth factor receptor 3 isoform X1 [KO:K05094] [EC:2.7.10.1]
100672193  FGFR4; fibroblast growth factor receptor 4 isoform X1 [KO:K05095] [EC:2.7.10.1]
100670735  PDGFRA; platelet-derived growth factor receptor alpha isoform X1 [KO:K04363] [EC:2.7.10.1]
100671240  PDGFRB; platelet-derived growth factor receptor beta isoform X1 [KO:K05089] [EC:2.7.10.1]
100667853  FN1; fibronectin isoform X8 [KO:K05717]
100674420  ITGA1; integrin alpha-1 [KO:K06480]
100674705  ITGA2; integrin alpha-2 [KO:K06481]
100654429  ITGA2B; LOW QUALITY PROTEIN: integrin alpha-IIb [KO:K06476]
100671578  ITGA3; LOW QUALITY PROTEIN: integrin alpha-3 [KO:K06482]
100674409  ITGA4; integrin alpha-4 [KO:K06483]
100676951  ITGA5; integrin alpha-5 [KO:K06484]
100661035  ITGA6; integrin alpha-6 isoform X1 [KO:K06485]
100665471  ITGA7; LOW QUALITY PROTEIN: integrin alpha-7 [KO:K06583]
100674808  ITGA8; integrin alpha-8 [KO:K06584]
100660884  ITGA9; LOW QUALITY PROTEIN: integrin alpha-9 [KO:K06585]
100667832  ITGA10; LOW QUALITY PROTEIN: integrin alpha-10 [KO:K06586]
100670461  ITGA11; integrin alpha-11 isoform X1 [KO:K06587]
100671252  ITGAV; integrin alpha-V isoform X1 [KO:K06487]
100658239  ITGAL; integrin alpha-L [KO:K05718]
100662792  integrin alpha-M-like isoform X1 [KO:K06461]
100662231  integrin alpha-M-like [KO:K06461]
100674546  ITGAE; LOW QUALITY PROTEIN: integrin alpha-E [KO:K06524]
100664978  ITGB1; integrin beta-1 isoform X1 [KO:K05719]
100665256  ITGB2; integrin beta-2 isoform X1 [KO:K06464]
100660405  ITGB3; integrin beta-3 isoform X1 [KO:K06493]
100671877  ITGB4; LOW QUALITY PROTEIN: integrin beta-4 [KO:K06525]
100676335  ITGB5; integrin beta-5 [KO:K06588]
100664907  ITGB6; integrin beta-6 isoform X1 [KO:K06589]
100661118  ITGB7; integrin beta-7 isoform X1 [KO:K06590]
100661984  ITGB8; integrin beta-8 isoform X1 [KO:K06591]
100655555  KNG1; kininogen-1 [KO:K03898]
100674513  BDKRB1; B1 bradykinin receptor [KO:K03915]
100666730  BDKRB2; B2 bradykinin receptor [KO:K03916]
100674374  CHRM1; LOW QUALITY PROTEIN: muscarinic acetylcholine receptor M1 [KO:K04129]
100666496  CHRM2; muscarinic acetylcholine receptor M2 [KO:K04130]
100667215  CHRM3; muscarinic acetylcholine receptor M3 [KO:K04131]
100676992  CHRM4; muscarinic acetylcholine receptor M4 [KO:K04132]
100656243  CHRM5; muscarinic acetylcholine receptor M5 [KO:K04133]
100676780  C5; LOW QUALITY PROTEIN: complement C5 [KO:K03994]
100668994  C6; complement component C6 [KO:K03995]
100668433  C7; LOW QUALITY PROTEIN: complement component C7 [KO:K03996]
100660679  C8A; complement component C8 alpha chain [KO:K03997]
100670998  C8B; complement component C8 beta chain [KO:K03998]
104847226  C8G; complement component C8 gamma chain [KO:K03999]
100667578  C9; complement component C9 [KO:K04000]
100676444  GNA12; guanine nucleotide-binding protein subunit alpha-12 [KO:K04346]
100664965  GNA13; guanine nucleotide-binding protein subunit alpha-13 [KO:K04639]
111751488  GNG14; LOW QUALITY PROTEIN: putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14 [KO:K04347]
111750996  GNG12; guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12 [KO:K04347]
100661485  FGD1; LOW QUALITY PROTEIN: FYVE, RhoGEF and PH domain-containing protein 1 [KO:K05720]
100653978  FGD3; FYVE, RhoGEF and PH domain-containing protein 3 isoform X1 [KO:K05722]
100668436  PTK2; LOW QUALITY PROTEIN: focal adhesion kinase 1 [KO:K05725] [EC:2.7.10.2]
100675124  BCAR1; LOW QUALITY PROTEIN: breast cancer anti-estrogen resistance protein 1 [KO:K05726]
100659273  CRK; adapter molecule crk isoform X1 [KO:K04438]
100662046  CRKL; crk-like protein [KO:K04438]
100663543  DOCK1; dedicator of cytokinesis protein 1 [KO:K13708]
100675475  SRC; proto-oncogene tyrosine-protein kinase Src [KO:K05704] [EC:2.7.10.2]
100657379  SOS1; LOW QUALITY PROTEIN: son of sevenless homolog 1 [KO:K03099]
100656200  SOS2; son of sevenless homolog 2 isoform X1 [KO:K03099]
100661512  KRAS; GTPase KRas isoform X2 [KO:K07827]
100659051  NRAS; GTPase NRas [KO:K07828]
100656098  RRAS; ras-related protein R-Ras isoform X3 [KO:K07829]
100661156  RRAS2; ras-related protein R-Ras2 isoform X1 [KO:K07830]
100661766  MRAS; ras-related protein M-Ras isoform X1 [KO:K07831]
100658524  ARHGEF6; rho guanine nucleotide exchange factor 6 isoform X1 [KO:K05729]
100657948  PIK3CA; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [KO:K00922] [EC:2.7.1.153]
100658340  PIK3CB; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1 [KO:K00922] [EC:2.7.1.153]
100666266  PIK3CD; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
100653731  PIK3R1; phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1 [KO:K02649]
100665045  PIK3R2; phosphatidylinositol 3-kinase regulatory subunit beta [KO:K02649]
100675496  PIK3R3; phosphatidylinositol 3-kinase regulatory subunit gamma [KO:K02649]
100662747  VAV3; guanine nucleotide exchange factor VAV3 isoform X2 [KO:K05730]
100673242  VAV1; LOW QUALITY PROTEIN: proto-oncogene vav [KO:K05730]
100677422  VAV2; guanine nucleotide exchange factor VAV2 [KO:K05730]
100675466  TIAM1; LOW QUALITY PROTEIN: T-lymphoma invasion and metastasis-inducing protein 1 [KO:K05731]
100671404  ARAF; serine/threonine-protein kinase A-Raf isoform X3 [KO:K08845] [EC:2.7.11.1]
100664119  BRAF; serine/threonine-protein kinase B-raf [KO:K04365] [EC:2.7.11.1]
100655727  RAF1; RAF proto-oncogene serine/threonine-protein kinase isoform X1 [KO:K04366] [EC:2.7.11.1]
100653879  MOS; proto-oncogene serine/threonine-protein kinase mos [KO:K04367] [EC:2.7.11.1]
100667623  MAP2K1; dual specificity mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
100657587  MAP2K2; dual specificity mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
100658240  MAPK3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
100665157  MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
100663184  AKT2; RAC-beta serine/threonine-protein kinase isoform X1 [KO:K04456] [EC:2.7.11.1]
100657536  AKT3; RAC-gamma serine/threonine-protein kinase isoform X2 [KO:K04456] [EC:2.7.11.1]
100660187  AKT1; RAC-alpha serine/threonine-protein kinase [KO:K04456] [EC:2.7.11.1]
100662957  RGCC; regulator of cell cycle RGCC isoform X2 [KO:K26108]
100674589  ARHGEF1; rho guanine nucleotide exchange factor 1 isoform X2 [KO:K12330]
100661002  ARHGEF12; rho guanine nucleotide exchange factor 12 isoform X1 [KO:K07532]
100667574  ARHGAP35; rho GTPase-activating protein 35 [KO:K05732]
100677447  RHOA; transforming protein RhoA [KO:K04513]
100664204  RAC1; ras-related C3 botulinum toxin substrate 1 [KO:K04392]
100670080  RAC2; ras-related C3 botulinum toxin substrate 2 [KO:K07860]
100664103  CDC42; cell division control protein 42 homolog [KO:K04393]
100668003  LOW QUALITY PROTEIN: serine/threonine-protein kinase PAK 1-like [KO:K04409] [EC:2.7.11.1]
100664379  PAK2; serine/threonine-protein kinase PAK 2 [KO:K04410] [EC:2.7.11.1]
100668837  PAK3; serine/threonine-protein kinase PAK 3 [KO:K05733] [EC:2.7.11.1]
100661100  PAK4; serine/threonine-protein kinase PAK 4 isoform X1 [KO:K05734] [EC:2.7.11.1]
100666744  PAK5; serine/threonine-protein kinase PAK 5 [KO:K05736] [EC:2.7.11.1]
100660904  serine/threonine-protein kinase PAK 6 isoform X1 [KO:K05735] [EC:2.7.11.1]
100655656  ARHGEF7; rho guanine nucleotide exchange factor 7 isoform X4 [KO:K13710]
100663724  GIT1; ARF GTPase-activating protein GIT1 isoform X2 [KO:K05737]
100657418  ROCK1; rho-associated protein kinase 1 isoform X1 [KO:K04514] [EC:2.7.11.1]
100658857  ROCK2; rho-associated protein kinase 2 isoform X1 [KO:K17388] [EC:2.7.11.1]
100665634  MYLK4; myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
100656405  MYLK2; LOW QUALITY PROTEIN: myosin light chain kinase 2, skeletal/cardiac muscle [KO:K00907] [EC:2.7.11.18]
100677183  MYLK; myosin light chain kinase, smooth muscle isoform X2 [KO:K00907] [EC:2.7.11.18]
100660199  PPP1CB; serine/threonine-protein phosphatase PP1-beta catalytic subunit [KO:K06269] [EC:3.1.3.16]
100673814  PPP1CA; LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-alpha catalytic subunit [KO:K06269] [EC:3.1.3.16]
100671604  PPP1CC; serine/threonine-protein phosphatase PP1-gamma catalytic subunit [KO:K06269] [EC:3.1.3.16]
100673922  PPP1R12A; protein phosphatase 1 regulatory subunit 12A isoform X2 [KO:K06270]
100675940  PPP1R12B; protein phosphatase 1 regulatory subunit 12B isoform X3 [KO:K12329]
100669550  PPP1R12C; LOW QUALITY PROTEIN: protein phosphatase 1 regulatory subunit 12C [KO:K17457]
100654026  MYL5; LOW QUALITY PROTEIN: myosin light chain 5 [KO:K12753]
100657954  MYL7; myosin regulatory light chain 2, atrial isoform [KO:K12754]
100672436  MYL9; myosin regulatory light polypeptide 9 [KO:K12755]
100670066  MYL10; LOW QUALITY PROTEIN: myosin regulatory light chain 10 [KO:K12756]
100660456  myosin regulatory light chain 12B [KO:K12757]
100660948  myosin regulatory light polypeptide 9 [KO:K12757]
100655811  MYH14; myosin-14 isoform X1 [KO:K10352]
100668402  MYH11; myosin-11 [KO:K10352]
100668846  MYH10; myosin-10 [KO:K10352]
100671983  MYH9; LOW QUALITY PROTEIN: myosin-9 [KO:K10352]
100662066  DIAPH1; protein diaphanous homolog 1 isoform X1 [KO:K05740]
100661482  DIAPH2; protein diaphanous homolog 2 isoform X5 [KO:K05741]
104846349  SLC9A1; sodium/hydrogen exchanger 1 [KO:K05742]
100674713  PIP5K1A; phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3 [KO:K00889] [EC:2.7.1.68]
100655311  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X5 [KO:K00889] [EC:2.7.1.68]
100675521  PIP5K1B; phosphatidylinositol 4-phosphate 5-kinase type-1 beta [KO:K00889] [EC:2.7.1.68]
100668818  PIP4K2A; phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [KO:K00920] [EC:2.7.1.149]
100655090  PIP4K2B; phosphatidylinositol 5-phosphate 4-kinase type-2 beta [KO:K00920] [EC:2.7.1.149]
100655606  PIP4K2C; phosphatidylinositol 5-phosphate 4-kinase type-2 gamma isoform X1 [KO:K00920] [EC:2.7.1.149]
100672120  PIKFYVE; 1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]
100675310  LIMK1; LOW QUALITY PROTEIN: LIM domain kinase 1 [KO:K05743] [EC:2.7.11.1]
100656340  LIMK2; LIM domain kinase 2 isoform X1 [KO:K05744] [EC:2.7.11.1]
100660202  DIAPH3; protein diaphanous homolog 3 [KO:K05745]
100657467  BAIAP2; LOW QUALITY PROTEIN: brain-specific angiogenesis inhibitor 1-associated protein 2 [KO:K05627]
100662950  ENAH; protein enabled homolog isoform X1 [KO:K05746]
111747983  collagen alpha-1(I) chain-like [KO:K23612]
100661328  WASL; neural Wiskott-Aldrich syndrome protein [KO:K23612]
111751670  basic proline-rich protein-like [KO:K23612]
100675212  WASF2; wiskott-Aldrich syndrome protein family member 2 [KO:K05748]
100665263  cytoplasmic FMR1-interacting protein 1 [KO:K05749]
100674574  CYFIP2; cytoplasmic FMR1-interacting protein 2 isoform X1 [KO:K05749]
100665661  NCKAP1L; nck-associated protein 1-like isoform X1 [KO:K05750]
100673556  NCKAP1; nck-associated protein 1 [KO:K05750]
100655899  ABI2; abl interactor 2 isoform X1 [KO:K05751]
100659243  BRK1; protein BRICK1 [KO:K05752]
100654554  WASF1; wiskott-Aldrich syndrome protein family member 1 isoform X1 [KO:K05753]
100668085  ACTR2; actin-related protein 2 [KO:K17260]
100677423  ACTR3; actin-related protein 3 [KO:K18584]
100674901  ACTR3B; actin-related protein 3B [KO:K18584]
100660412  ARPC1B; LOW QUALITY PROTEIN: actin-related protein 2/3 complex subunit 1B [KO:K05757]
100660125  ARPC1A; actin-related protein 2/3 complex subunit 1A [KO:K05757]
100665290  ARPC2; actin-related protein 2/3 complex subunit 2 isoform X2 [KO:K05758]
100654357  ARPC3; actin-related protein 2/3 complex subunit 3 [KO:K05756]
100666528  ARPC5L; actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
100670140  ARPC5; actin-related protein 2/3 complex subunit 5 [KO:K05754]
100670743  ACTG1; actin, cytoplasmic 2 [KO:K05692]
100654618  ACTB; actin, cytoplasmic 1 [KO:K05692]
100673676  PFN4; profilin-4 isoform X2 [KO:K05759]
100662813  PFN3; profilin-3 [KO:K05759]
100654902  PFN1; profilin-1 [KO:K05759]
104846137  profilin-1-like [KO:K05759]
100673113  PFN2; profilin-2 [KO:K05759]
100671127  PXN; paxillin isoform X5 [KO:K05760]
100662045  EZR; ezrin isoform X1 [KO:K08007]
100665532  RDX; radixin isoform X2 [KO:K05762]
100674814  MSN; moesin isoform X1 [KO:K05763]
100668370  TMSB4X; thymosin beta-4 [KO:K05764]
111750095  thymosin beta-4-like [KO:K05764]
100663505  CFL2; cofilin-2 [KO:K05765]
100653593  CFL1; cofilin-1 isoform X1 [KO:K05765]
100671308  SSH2; protein phosphatase Slingshot homolog 2 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100674657  SSH3; protein phosphatase Slingshot homolog 3 isoform X2 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100668008  SSH1; protein phosphatase Slingshot homolog 1 isoform X1 [KO:K05766] [EC:3.1.3.16 3.1.3.48]
100654211  VCL; vinculin [KO:K05700]
100660209  IQGAP1; ras GTPase-activating-like protein IQGAP1 [KO:K16848]
100665906  IQGAP3; ras GTPase-activating-like protein IQGAP3 isoform X1 [KO:K05767]
100668714  IQGAP2; ras GTPase-activating-like protein IQGAP2 isoform X2 [KO:K05767]
100668622  SCIN; adseverin [KO:K05768]
100675647  GSN; gelsolin isoform X1 [KO:K05768]
100661051  ACTN1; alpha-actinin-1 isoform X2 [KO:K05699]
100655307  ACTN4; alpha-actinin-4 [KO:K05699]
100659017  APC; adenomatous polyposis coli protein isoform X2 [KO:K02085]
100671113  ARHGEF4; rho guanine nucleotide exchange factor 4 isoform X1 [KO:K05769]
100663813  SPATA13; spermatogenesis-associated protein 13 isoform X1 [KO:K05769]
Compound
C00681  1-Acyl-sn-glycerol 3-phosphate
C01996  Acetylcholine
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11554  1-Phosphatidyl-1D-myo-inositol 3,4-bisphosphate
Reference
PMID:14744429
  Authors
Burridge K, Wennerberg K.
  Title
Rho and Rac take center stage.
  Journal
Cell 116:167-79 (2004)
DOI:10.1016/S0092-8674(04)00003-0
Reference
PMID:11082269
  Authors
Schmitz AA, Govek EE, Bottner B, Van Aelst L.
  Title
Rho GTPases: signaling, migration, and invasion.
  Journal
Exp Cell Res 261:1-12 (2000)
DOI:10.1006/excr.2000.5049
Reference
PMID:11152757
  Authors
Takai Y, Sasaki T, Matozaki T.
  Title
Small GTP-binding proteins.
  Journal
Physiol Rev 81:153-208 (2001)
DOI:10.1152/physrev.2001.81.1.153
Reference
PMID:12700767
  Authors
Pollard TD.
  Title
The cytoskeleton, cellular motility and the reductionist agenda.
  Journal
Nature 422:741-5 (2003)
DOI:10.1038/nature01598
Reference
PMID:14657486
  Authors
Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.
  Title
Cell migration: integrating signals from front to back.
  Journal
Science 302:1704-9 (2003)
DOI:10.1126/science.1092053
Reference
PMID:11082272
  Authors
Sastry SK, Burridge K.
  Title
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics.
  Journal
Exp Cell Res 261:25-36 (2000)
DOI:10.1006/excr.2000.5043
Reference
PMID:10574699
  Authors
Fukata M, Nakagawa M, Kuroda S, Kaibuchi K.
  Title
Cell adhesion and Rho small GTPases.
  Journal
J Cell Sci 112 ( Pt 24):4491-500 (1999)
Related
pathway
lav04010  MAPK signaling pathway
lav04510  Focal adhesion
lav04520  Adherens junction
KO pathway
ko04810   
LinkDB

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